Closed Loop Ventilation Strategy in Intensive Care Unit (ICU) Patients

March 5, 2014 updated by: Cenk Kirakli, Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

Effect of a Closed Loop Ventilation Strategy on Reducing the Total Duration of Mechanical Ventilation of Intubated Intensive Care Unit Patients: A Randomized Controlled Trial

Adaptive support ventilation (ASV) is a closed loop ventilation mode that can act both like PCV and PSV automatically. Some studies suggest that ASV can reduce the weaning time in ICU patients. The investigators hypothesized that using ASV from the beginning of intubation can reduce the total duration of MV and LOS in the ICU when compared to conventional modes such as PCV+PSV

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

229

Phase

  • Phase 4

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Turkey
    • Yenisehir
      • Izmir, Yenisehir, Turkey, 35550
        • Izmir Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

19 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Description

Inclusion Criteria:

  • Intubated and mechanically ventilated ICU patients for more than 24 hours

Exclusion Criteria:

  • Patient with a tracheostomy
  • Patients under home mechanical ventilation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: ASV
Adaptive Support Ventilation
Device: Adaptive Support Ventilation
Ventilation protocol according to the patients ideal body weight
Active Comparator: PCV
Pressure Controlled Ventilation
Device: Pressure Controlled Ventilation
Ventilation protocol (6-8 ml/kg tidal volume) according to our ICU

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Duration of mechanical ventilation
Time Frame: 1 year
1 year

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital

Investigators

  • Principal Investigator: Cenk Kirakli, MD, Izmir Dr. Suat Seren Chest Diseases and Surgery Training Hospital

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

April 1, 2012

Primary Completion (Actual)

January 1, 2014

Study Completion (Actual)

January 1, 2014

Study Registration Dates

First Submitted

November 11, 2011

First Submitted That Met QC Criteria

November 15, 2011

First Posted (Estimate)

November 16, 2011

Study Record Updates

Last Update Posted (Estimate)

March 6, 2014

Last Update Submitted That Met QC Criteria

March 5, 2014

Last Verified

March 1, 2014

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • IGCEAH-ICU 2

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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