- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01611831
Efficacy of Acceptance and Commitment Therapy (ACT) in Group in Fibromyalgia (ACTGROUP)
Efficacy of Acceptance and Commitment Therapy (ACT) in Group in Fibromyalgia: a Randomized, Controlled Study.
The main objective is to assess the efficacy of Acceptance & Commitment Therapy (ACT) in group for the treatment of fibromyalgia. The secondary aims are: 1.- To assess the cost-effectiveness of ACT and 2.- To assess the efficacy of ACT in other variables such as anxiety, depression, pain or global function. 3.- To evaluate the usefulness or electroencephalographic cordance as a prognostic variable of the treatment.
HYPOTHESIS: ACT in group is effective for improvement of pain acceptance and other outcome variables (pain, anxiety, depression, global function) in fibromyalgia, and it is cost-effective. Cordance is an useful predictor of treatment efficacy in these patients.
DESIGN: Multicentre, randomized, controlled study, with parallel groups, and a 6-month follow-up period. Participants will be randomly allocated to one of two conditions: 1.- Group Acceptation & Commitment Therapy or 2.- Treatment as usual by his general practitioner. Patients diagnosed of fibromyalgia, according to the American College of Rheumatology, will be recruited in primary care. Assuming an alpha=0.05 and p=80%, using two tails, and calculating 5% of refusals, it will be necessary a sample size of 55 patients for each group of patients.
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
Study Type
Enrollment (Anticipated)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Zaragoza, Spain, 50009
- Mental Health Unit, Primary Care Center "Torrero-La Paz"
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Age: 18-65 year old
- Discontinuation drug treatment 7 days before the start of the trial
- Not having received psychological treatment previously or at least in the last 2 years
- Ability to understand Spanish
- Given consent to participate in the study
Exclusion Criteria:
- Age: <18 year old and > 65 year old
- Clinical or psychological disease that, at investigator's opinion, can interfere the psychological examination or the adherence to psychotherapy (dementia, alcohol or drug abuse, psychosis, severe personality disorder)
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: ACT in group
Patients assigned to this arm will receive Acceptation and Commitment Therapy (ACT) in groups of 8-12 patients.
Intervention has been protocolized.
Therapy will be administered by two experienced therapists (psychologists).
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A protocol based on the main research studies describing the therapy and adapted for fibromyalgia treatment by our research group will be used.
This protocol is available for the investigators.
There will be 9 group sessions of 90 minutes duration each.
Patients assigned to this arm will be allowed to occasionally take minor analgesics.
Other Names:
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Active Comparator: Improved Treatment as usual by General practitioner
Patients assigned to this arm will receive treatment as usual by their General Practitioner in the Primary Care center.
To enhance treatment, investigators participating in the trial will receive the Guidelines for fibromyalgia treatment in Primary Care handed by Health Service in Aragón.
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General practitioners (GPs) will administer treatment as usual to the patients with fibromyalgia.
To enhance the intervention, the Clinical Guidelines on the Treatment of Fibromyalgia approved by the Health Services of Aragon will be provided to the GPs.
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
GLOBAL FUNCTION
Time Frame: At baseline
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GLOBAL FUNCTION is assessed with the Fibromyalgia Impact Questionnaire (FIQ), a 10-item self report questionnaire to evaluate health status of patients with fibromyalgia.
The Spanish version will be used.
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At baseline
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GLOBAL FUNCTION
Time Frame: At month 3
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GLOBAL FUNCTION is assessed with the Fibromyalgia Impact Questionnaire (FIQ), a 10-item self report questionnaire to evaluate health status of patients with fibromyalgia.
The Spanish version will be used.
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At month 3
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GLOBAL FUNCTION
Time Frame: At month 6
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GLOBAL FUNCTION is assessed with the Fibromyalgia Impact Questionnaire (FIQ), a 10-item self report questionnaire to evaluate health status of patients with fibromyalgia.
The Spanish version will be used.
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At month 6
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GLOBAL FUNCTION
Time Frame: At month 9
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GLOBAL FUNCTION is assessed with the Fibromyalgia Impact Questionnaire (FIQ), a 10-item self report questionnaire to evaluate health status of patients with fibromyalgia.
The Spanish version will be used.
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At month 9
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Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
DEMOGRAPHIC AND CLINICAL DATA
Time Frame: At Baseline
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It has been designed a questionnaire to collect demographic data (sex, age, marital status, education level, job, work disability) and clinical data (psychiatric medical history, disease duration, main symptoms, medical comorbidity etc)
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At Baseline
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PAIN CATASTROPHIZING
Time Frame: At Baseline
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It is described as a negative and exaggerated reaction towards painful stimulus.
It is measured with the Pain Catastrophizing Scale that allows investigators to discriminate 3 sub-scales: rumination, magnification and helplessness.
The Spanish validation of this scale will be used.
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At Baseline
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ANXIETY AND DEPRESSION
Time Frame: At Baseline
|
They will be evaluated with the Hospital Anxiety and Depression Scale (HADS), a scale to detect anxiety and depression in people with medical diseases such as fibromyalgia.
It is a 14-item self report scale in which items are scored in a Likert scale from 1 to 4. It includes 2 subscales: anxiety and depression, scored independently.
The HADS has been validated in Spanish.
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At Baseline
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PSYCHIATRIC DIAGNOSIS
Time Frame: At baseline
|
The Standardized Polyvalent Psychiatric Interview (SPPI) will be used.
It is a psychiatric interview developed by our research group to assess psychiatric morbidity in primary care.
It allows the use of different diagnosis criteria like DSM-IV and ICD-10.
The Posttraumatic stress disorder will be assessed specifically as it has been shown to be related to a worse prognosis in fibromyalgia.
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At baseline
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PAIN
Time Frame: At baseline
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It will be assessed with The Analogue Visual Pain Scale.
Pain is self-reported by the patient in a visual analogue scale from 0 (pain absence) to 100 (the worst pain anyone can ever imagine)
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At baseline
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COST-EFFECTIVENESS ANALYSIS
Time Frame: At Baseline
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COST-EFFECTIVENESS ANALYSIS: Includes a) Drug profile, and b) Services.
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At Baseline
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PAIN ACCEPTANCE
Time Frame: At Baseline
|
Acceptance is related to a better adaptation to pain response, no matter the influence of outcomes such as depression, pain intensity or anxiety.
The Chronic Pain Acceptance Questionnaire will be used.
This outcome will be measured with the Spanish version validated by our research group.
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At Baseline
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CORDANCE
Time Frame: At baseline
|
CORDANCE: the Fast Fourier Transform (FFT) will be applied to artefact-free electroencephalogram activity segments to calculate absolute and relative powers for each electrode.
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At baseline
|
PAIN CATASTROPHIZING
Time Frame: At month 3
|
It is described as a negative and exaggerated reaction towards painful stimulus.
It is measured with the Pain Catastrophizing Scale that allows investigators to discriminate 3 sub-scales: rumination, magnification and helplessness.
The Spanish validation of this scale will be used.
|
At month 3
|
PAIN CATASTROPHIZING
Time Frame: At month 6
|
It is described as a negative and exaggerated reaction towards painful stimulus.
It is measured with the Pain Catastrophizing Scale that allows investigators to discriminate 3 sub-scales: rumination, magnification and helplessness.
The Spanish validation of this scale will be used.
|
At month 6
|
ANXIETY AND DEPRESSION
Time Frame: At month 3
|
They will be evaluated with the Hospital Anxiety and Depression Scale (HADS), a scale to detect anxiety and depression in people with medical diseases such as fibromyalgia.
It is a 14-item self report scale in which items are scored in a Likert scale from 1 to 4. It includes 2 subscales: anxiety and depression, scored independently.
The HADS has been validated in Spanish.
|
At month 3
|
ANXIETY AND DEPRESSION
Time Frame: At month 6
|
They will be evaluated with the Hospital Anxiety and Depression Scale (HADS), a scale to detect anxiety and depression in people with medical diseases such as fibromyalgia.
It is a 14-item self report scale in which items are scored in a Likert scale from 1 to 4. It includes 2 subscales: anxiety and depression, scored independently.
The HADS has been validated in Spanish.
|
At month 6
|
PAIN
Time Frame: At month 3
|
It will be assessed with The Analogue Visual Pain Scale.
Pain is self-reported by the patient in a visual analogue scale from 0 (pain absence) to 100 (the worst pain anyone can ever imagine)
|
At month 3
|
PAIN
Time Frame: At month 6
|
It will be assessed with The Analogue Visual Pain Scale.
Pain is self-reported by the patient in a visual analogue scale from 0 (pain absence) to 100 (the worst pain anyone can ever imagine)
|
At month 6
|
COST-EFFECTIVENESS ANALYSIS
Time Frame: At month 3
|
COST-EFFECTIVENESS ANALYSIS: Includes a) Drug profile, and b) Services.
|
At month 3
|
COST-EFFECTIVENESS ANALYSIS
Time Frame: At month 6
|
COST-EFFECTIVENESS ANALYSIS: Includes a) Drug profile, and b) Services.
|
At month 6
|
COST-EFFECTIVENESS ANALYSIS
Time Frame: At month 9
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COST-EFFECTIVENESS ANALYSIS: Includes a) Drug profile, and b) Services.
|
At month 9
|
PAIN ACCEPTANCE
Time Frame: At month 3
|
Acceptance is related to a better adaptation to pain response, no matter the influence of outcomes such as depression, pain intensity or anxiety.
The Chronic Pain Acceptance Questionnaire will be used.
This outcome will be measured with the Spanish version validated by our research group.
|
At month 3
|
PAIN ACCEPTANCE
Time Frame: At month 6
|
Acceptance is related to a better adaptation to pain response, no matter the influence of outcomes such as depression, pain intensity or anxiety.
The Chronic Pain Acceptance Questionnaire will be used.
This outcome will be measured with the Spanish version validated by our research group.
|
At month 6
|
PAIN ACCEPTANCE
Time Frame: At month 9
|
Acceptance is related to a better adaptation to pain response, no matter the influence of outcomes such as depression, pain intensity or anxiety.
The Chronic Pain Acceptance Questionnaire will be used.
This outcome will be measured with the Spanish version validated by our research group.
|
At month 9
|
CORDANCE
Time Frame: At month 3
|
CORDANCE: the Fast Fourier Transform (FFT) will be applied to artefact-free electroencephalogram activity segments to calculate absolute and relative powers for each electrode.
|
At month 3
|
Collaborators and Investigators
Sponsor
Investigators
- Principal Investigator: Marta Alda, Hospital Miguel Servet
Publications and helpful links
General Publications
- Hayes SC, Luoma JB, Bond FW, Masuda A, Lillis J. Acceptance and commitment therapy: model, processes and outcomes. Behav Res Ther. 2006 Jan;44(1):1-25. doi: 10.1016/j.brat.2005.06.006.
- Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P, et al. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum. 1990 Feb;33(2):160-72. doi: 10.1002/art.1780330203.
- Garcia-Campayo J, Magdalena J, Magallon R, Fernandez-Garcia E, Salas M, Andres E. A meta-analysis of the efficacy of fibromyalgia treatment according to level of care. Arthritis Res Ther. 2008;10(4):R81. doi: 10.1186/ar2455. Epub 2008 Jul 15.
- Garcia-Campayo J, Sanz-Carrillo C, Baringo T, Ceballos C. SPECT scan in somatization disorder patients: an exploratory study of eleven cases. Aust N Z J Psychiatry. 2001 Jun;35(3):359-63. doi: 10.1046/j.1440-1614.2001.00909.x.
- Leuchter AF, Cook IA, Lufkin RB, Dunkin J, Newton TF, Cummings JL, Mackey JK, Walter DO. Cordance: a new method for assessment of cerebral perfusion and metabolism using quantitative electroencephalography. Neuroimage. 1994 Jun;1(3):208-19. doi: 10.1006/nimg.1994.1006.
- McCracken LM, Vowles KE, Eccleston C. Acceptance of chronic pain: component analysis and a revised assessment method. Pain. 2004 Jan;107(1-2):159-66. doi: 10.1016/j.pain.2003.10.012.
- Cook DB, Lange G, Ciccone DS, Liu WC, Steffener J, Natelson BH. Functional imaging of pain in patients with primary fibromyalgia. J Rheumatol. 2004 Feb;31(2):364-78.
- McCracken LM. Learning to live with the pain: acceptance of pain predicts adjustment in persons with chronic pain. Pain. 1998 Jan;74(1):21-27. doi: 10.1016/S0304-3959(97)00146-2.
- Garcia-Campayo J, Pascual A, Alda M, Marzo J, Magallon R, Fortes S. The Spanish version of the FibroFatigue Scale: validation of a questionnaire for the observer's assessment of fibromyalgia and chronic fatigue syndrome. Gen Hosp Psychiatry. 2006 Mar-Apr;28(2):154-60. doi: 10.1016/j.genhosppsych.2005.12.001.
- Garcia-Campayo J, Pascual A, Alda M, Ramirez MTG. Coping with fibromialgia: usefulness of the Chronic Pain Coping Inventory-42. Pain. 2007 Nov;132 Suppl 1:S68-S76. doi: 10.1016/j.pain.2007.02.013. Epub 2007 Apr 2.
- Garcia Campayo J, Rodero B, Alda M, Sobradiel N, Montero J, Moreno S. [Validation of the Spanish version of the Pain Catastrophizing Scale in fibromyalgia]. Med Clin (Barc). 2008 Oct 18;131(13):487-92. doi: 10.1157/13127277. Spanish.
- Garcia-Campayo J, Serrano-Blanco A, Rodero B, Magallon R, Alda M, Andres E, Luciano JV, del Hoyo YL. Effectiveness of the psychological and pharmacological treatment of catastrophization in patients with fibromyalgia: a randomized controlled trial. Trials. 2009 Apr 23;10:24. doi: 10.1186/1745-6215-10-24.
Study record dates
Study Major Dates
Study Start
Primary Completion (Anticipated)
Study Completion (Anticipated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- PI11/024
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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