- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01718405
Genetic Polymorphism as Moderator of the Effect of an Acute Bout of Exercise on Cognitive Function
October 29, 2012 updated by: Hillel Yaffe Medical Center
Studies have shown that an acute bout of aerobic exercise positively effects cognition, mainly executive functioning; however the effect is not observed among all people and it is not clear whether only aerobic exercise can produce this effect or possibly also resistant exercise.
The main purpose of our study is to examine whether genetic variation is a moderator of this effect and whether resistant exercise is comparable to aerobic exercise in improving cognition following a single bout of exercise.
Study Overview
Status
Unknown
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Anticipated)
150
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Sharon Tsuk, PhD
- Phone Number: 972-522-640642
- Email: sharontsuk1@gmail.com
Study Locations
-
-
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Netanya, Israel
- Wingate Institute
-
Principal Investigator:
- Raffael Carasso, MD
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Sub-Investigator:
- Sharon Tsuk, PhD
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-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
20 years to 35 years (Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Physical Education Students
- Able to sign consent form
Exclusion Criteria:
- Competitive athletes
- Smokers
- Neurologic or psychologic orders
- Chronic diseases
- Head Injuries
- Hospitalization in the previous 3 months
- Pregnant
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Exercise Group
Each individual subject will give a blood sample for genetic analysis and undertake an exercise session and a rest session as a control.
Cognitive function will be tested before and after each session.
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The individual subjects will participate in 3 sessions of either aerobic exercise, resistance exercise or rest, in a random order.
Before and after each session, the subject will take computerized cognitive tests.
In the first evaluation session blood samples will be taken from each subject and will be analysed for genetic polymorphism.
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Cognitive Functioning After Exercise
Time Frame: Five minutes
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Computerized battery of tests evaluating cognitive functioning
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Five minutes
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Other Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Genetic Variation Associated with Different Cognitive Functioning
Time Frame: Two years
|
Genetic variation will be analyzed by extraction of genomic DNA from blood leukocytes, using a salting out procedure, and then by using polymerase chain reaction restriction fragment lengths polymorphism (PCR-RELP) methods for detection of single nucleotide polymorphism.
A mutation will be discriminated by digestion with specific restriction endonucleases.
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Two years
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start
November 1, 2012
Primary Completion (Anticipated)
November 1, 2015
Study Completion (Anticipated)
November 1, 2017
Study Registration Dates
First Submitted
October 10, 2012
First Submitted That Met QC Criteria
October 29, 2012
First Posted (Estimate)
October 31, 2012
Study Record Updates
Last Update Posted (Estimate)
October 31, 2012
Last Update Submitted That Met QC Criteria
October 29, 2012
Last Verified
October 1, 2012
More Information
Terms related to this study
Other Study ID Numbers
- 0049
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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