Studying the Effect of Capsinoids on Brown Fat Using Infrared Thermal Imaging.

Infrared Thermal Imaging for Assessing the Effect of Capsinoids on Brown Adipose Tissue Activity.

The primary hypothesis of this study is that consumption of capsinoids increases brown adipose tissue activity, detectable by infrared thermal imaging.

The secondary hypothesis is that consumption of capsinoids can affect an individual's glycaemic response.

Study Overview

• Status: Completed
• Conditions: Obesity; Diabetes; Impaired Glucose Tolerance
• Intervention / Treatment: Dietary supplement: Capsinoid/placebo and rice

Detailed Description

It has been recently established that brown adipose tissue (BAT) exists in adult humans. BAT is a thermogenic tissue which dissipates energy as heat. The primary objective of this study is to use thermal imaging to assess the effect of capsinoids on BAT activity in adult humans, and whether there is a relationship between the increase in energy expenditure and BAT activity after capsinoids intake. The secondary objective is to investigate whether capsinoids will have an effect on an individual's glycaemic response. Lean, healthy male volunteers will be recruited. There will be two test sessions which are randomized, where subjects will consume either capsinoids or placebo capsules, and a standardized amount of white rice (equivalent to 50g carbohydrates). Indirect calorimetry will be used to assess energy expenditure before and after consumption of the test meal. Thermal imaging of supraclavicular BAT, the primary BAT depot in humans, will be undertaken using an infrared thermal camera to assess changes in BAT temperature. Blood glucose levels will be monitored by finger prick blood sampling method. This study aims to investigate whether capsinoids consumption leads to changes in BAT temperatures detectable by the infrared thermal camera, to confirm the feasibility of using thermal imaging as a rapid, noninvasive, and reproducible way of studying BAT activity thus providing a platform to advance research in this emerging field of human BAT.

• Study Type: Interventional
• Enrollment (Actual): 40
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Singapore
  • Singapore, Singapore, 117599
    • Clinical Nutrition Research Centre

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 21 years to 30 years (ADULT)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Chinese ethnicity
• Male
• Healthy
• Age 21 - 30 years
• BMI 18.0 - 22.9 kg/m2
• Not on any prescribed medication
• Infrequent spicy food or chilli user (less than 3 times per week)

Exclusion Criteria:

• Smoker
• Fasting blood glucose > 5.5 mmol/L
• Resting blood pressure > 140/90 mmHg
• Any major medical conditions including diabetes, hypertension, cardiovascular disease, thyroid disorders
• Allergic or intolerant to foods presented in the study

Study Plan

How is the study designed?

Design Details

• Allocation: RANDOMIZED
• Interventional Model: CROSSOVER
• Masking: DOUBLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: Capsinoid arm; On capsinoids	Dietary supplement: Capsinoid/placebo and rice; The subject will ingest six capsinoid/placebo capsules and a standardized amount of white rice (equivalent to 50g carbohydrates). Each capsule consists 1.5mg of capsinoids, making a total dose of 9mg capsinoids.
PLACEBO_COMPARATOR: Placebo arm; Placebo	Dietary supplement: Capsinoid/placebo and rice; The subject will ingest six capsinoid/placebo capsules and a standardized amount of white rice (equivalent to 50g carbohydrates). Each capsule consists 1.5mg of capsinoids, making a total dose of 9mg capsinoids.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Temperature at supraclavicular region	The temperature at the supraclavicular region following consumption of capsinoids will be determined using infrared thermal imaging.	2.5 hours post-consumption

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Glycaemic response	The blood glucose response to capsinoids measured over 2.5 hours following their consumption.	2.5 hours post-consumption

Collaborators and Investigators

• Sponsor: Clinical Nutrition Research Centre, Singapore

Study record dates

Study Major Dates

• Study Start: November 1, 2013
• Primary Completion (ACTUAL): July 1, 2014
• Study Completion (ACTUAL): July 1, 2014

Study Registration Dates

• First Submitted: October 10, 2013
• First Submitted That Met QC Criteria: October 10, 2013
• First Posted (ESTIMATE): October 11, 2013

Study Record Updates

• Last Update Posted (ESTIMATE): February 2, 2016
• Last Update Submitted That Met QC Criteria: February 1, 2016
• Last Verified: February 1, 2016

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Hyperglycemia; Glucose Intolerance
• Other Study ID Numbers: 2013/00785