- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT01972542
The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk
The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk in Healthy People, Impaired Glucose Tolerance and Type 2 Diabetes
The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because of non-fasting state for more than 12 hours and importance of triglyceride-rich lipoprotein.
We aim to investigate the relationship of postprandial triglyceride after fat tolerance test and intima-medial thickness and to suggest normal reference of postprandial triglyceride after fat tolerance test. In addition, we evaluate the correlation of postprandial triglyceride and incretin secretion after fat tolerance test Ultimately, we want to estimate clinical importance of postprandial triglyceride in assessment of cardiovascular risk.
Study Overview
Status
Conditions
Intervention / Treatment
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
-
Seongnam, Korea, Republic of, 463-707
- Seoul National University Bundang Hospital
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- age : 19 ~ 70 yrs
- Type 2 diabetes : HbA1c <10%
- Prediabetic state : HbA1c 5.7~6.4%
Exclusion Criteria:
- Type 1 diabetes, secondary diabetes
- dipeptidyl peptidase-4 -inhibitor, glucagon-like peptide-1 agonist, thiazolidinediones users
- Thyroid disease with abnormal thyroid function test
- Liver disease with abnormal liver function test
- severe kidney disease
- pregnant or lactating women
- current smoker
- severe obesity
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Screening
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Active Comparator: Type 2 DM
Intervention : Oral fat tolerance test well or moderately controlled type 2 diabetes mellitus (HbA1c < 10%) No dipeptidyl peptidase-4 -inhibitor, Glucagon-like peptide-1 agonist, thiazolidinediones |
|
Active Comparator: Prediabetes
Intervention : Oral fat tolerance test Glucose 140-199 mg/dL after 75g oral glucose tolerance test HbA1c 5.7-6.4% |
|
Sham Comparator: Normal glucose tolerance
Intervention : Oral fat tolerance test No impaired fasting glucose and impaired glucose tolerance |
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Changes of Triglyceride
Time Frame: 8 hours
|
Blood sample : drawn by a catheter before the meal and every 1 hour after meal over the 8-hour period
|
8 hours
|
Secondary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
Changes of incretin
Time Frame: 8 hours
|
8 hours
|
Collaborators and Investigators
Investigators
- Principal Investigator: Soo Lim, MD, MPH, PhD, Seoul National University Bundang Hospital
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- SNUBH-ENDO4
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Diabetes
-
University of Colorado, DenverMassachusetts General Hospital; Beta Bionics, Inc.CompletedDiabetes Mellitus, Type 1 | Type 1 Diabetes | Diabetes type1 | Type 1 Diabetes Mellitus | Autoimmune Diabetes | Diabetes Mellitus, Insulin-Dependent | Juvenile-Onset Diabetes | Diabetes, Autoimmune | Insulin-Dependent Diabetes Mellitus 1 | Diabetes Mellitus, Insulin-Dependent, 1 | Diabetes Mellitus, Brittle | Diabetes Mellitus, Juvenile-Onset and other conditionsUnited States
-
Guang NingRecruitingType 2 Diabetes Mellitus | Type1 Diabetes Mellitus | Monogenetic Diabetes | Pancreatogenic Diabetes | Drug-Induced Diabetes Mellitus | Other Forms of Diabetes MellitusChina
-
University of Trás-os-Montes and Alto DouroCompletedType 2 Diabetes Mellitus | Diabetes-Related ComplicationsPortugal
-
Northern Care Alliance NHS Foundation TrustBrighter ABCompletedDiabetes type1 | Diabetes type2United Kingdom
-
VeraLight, Inc.InLight SolutionsUnknownGestational Diabetes | Insulin Dependent Diabetes | Non Insulin Dependent DiabetesUnited States
-
Garvan Institute of Medical ResearchWeizmann Institute of ScienceActive, not recruitingType 2 Diabetes Mellitus | Pre DiabetesAustralia
-
Taichung Veterans General HospitalNational Health Research Institutes, TaiwanRecruitingDiabetes Complications | Type 2 Diabetes | Maturity-Onset Diabetes of the Young (MODY)Taiwan
-
Oregon State UniversitySanofiCompletedType I or Type II Diabetes (Excludes Gestational Diabetes)
-
University of RoehamptonRecruitingType2 Diabetes Mellitus | Pre DiabetesUnited Kingdom
-
Peking Union Medical College HospitalUnknownType 2 Diabetes Mellitus | Type 1 Diabetes Mellitus | Gestational Diabetes Mellitus | Pancreatogenic Diabetes Mellitus | Pregestational Diabetes Mellitus | Diabetes Patients in Perioperative PeriodChina
Clinical Trials on Oral fat tolerance test
-
University of PennsylvaniaNational Heart, Lung, and Blood Institute (NHLBI)Recruiting
-
Universität des SaarlandesCompleted
-
University College DublinCompletedHealthy SubjectsIreland
-
University Hospital Schleswig-HolsteinUniversity of KielRecruitingParkinson Disease | Nutritional and Metabolic Diseases | Sugar IntakeGermany
-
VA Office of Research and DevelopmentKessler FoundationCompleted
-
University of AarhusDanish Diabetes AcademyCompletedType 2 Diabetes | NAFLDDenmark
-
Children's Hospital of PhiladelphiaCystic Fibrosis FoundationRecruitingCystic Fibrosis | Cystic Fibrosis-related DiabetesUnited States
-
Ankara City Hospital BilkentRecruitingGestational Diabetes | Glucose Intolerance During PregnancyTurkey
-
Christophe De BlockUnknownDiabetes Mellitus | Stress HyperglycemiaBelgium
-
Zhujiang HospitalRecruitingDiabetes Mellitus | Prediabetes | Gestational Diabetes Mellitus | ProteomicsChina