Does Asthma Phenotype Have Impact on Disease Control (Aperitif)

January 31, 2020 updated by: Vibeke Backer, Bispebjerg Hospital

Does Asthma Phenotype Have Impact on Disease Control - Can Detection of Inflammation and Hyper Responsiveness Ensure Stable Disease Faster

The application of biomarkers that are more closely associated with eosinophillic airway inflammation, such as measurements of FeNO level, cell count in induced sputum or bronchial reactivity could improve asthma control by better directing treatment. A systematic review and meta-analysis is to be conducted to assess the efficacy of tailoring asthma intervention on clinical symptoms compared with exhaled nitric oxide or induced sputum count.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Detailed Description

AHR used as outcome

Study Type

Observational

Enrollment (Actual)

80

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • Denmark
      • Copenhagen, Denmark, 2400
        • Respiratory research unit, Bispebjerg University Hospital
    • NV
      • Copenhagen, NV, Denmark, 2400
        • Department of Respiratory Medicine, L, Bispebjerg Hospital,

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

15 years to 100 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Probability Sample

Study Population

Newly referred asthma patients

Description

Inclusion Criteria:

  • positiv mannitol
  • asthma diagnose

Exclusion Criteria:

  • other lung disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Pulmicort
ICS and LABA - based on ACQ and FeNO
Drug: Pulmicort
ACQ and FeNO
Other Names:
  • RCT study

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Control of asthma based on an algorithm
Time Frame: 2 years
Based on ACQ and FeNO
2 years

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
The use of NO and sputum cell count as a marker in asthma management
Time Frame: 2 years
Based on ACQ and FeNO
2 years

Other Outcome Measures

Outcome Measure
Measure Description
Time Frame
the use of ACQ and miniAQLQ
Time Frame: 2 years
Based on ACQ and FeNO
2 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Bispebjerg Hospital

Investigators

  • Principal Investigator: Vibeke Backer, MD, Bispebjerg Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

November 1, 2012

Primary Completion (Actual)

January 1, 2015

Study Completion (Actual)

January 1, 2015

Study Registration Dates

First Submitted

November 1, 2013

First Submitted That Met QC Criteria

November 6, 2013

First Posted (Estimate)

November 7, 2013

Study Record Updates

Last Update Posted (Actual)

February 5, 2020

Last Update Submitted That Met QC Criteria

January 31, 2020

Last Verified

November 1, 2013

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Aperitif

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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