Tooth Loss in Periodontitis Patients

Tooth Loss in Periodontitis Patients on Long-term Maintenance in Private Practice

Tooth loss in periodontitis patients is associated with patient and site factors as well as with treatment provided. Not much is known about long-term tooth loss in periodontitis patients in private practice in the UK. The study plans to follow-up 200 subjects with periodontitis (and currently on maintenance therapy) for 5 years. The effect of treatment provided, site and patient risk factors on tooth loss will be studied.

Study Overview

• Status: Unknown
• Conditions: Periodontitis

• Study Type: Observational
• Enrollment (Actual): 200

Contacts and Locations

Study Locations

• United Kingdom
  • London, United Kingdom, W60SL
    • Ravenscourt Dental Practice
  • Herts
    • Bishop's Stortford, Herts, United Kingdom, CM23 3AZ
      • The Dentist

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 16 years to 75 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Probability Sample

Study Population

200 patients with periodontitis on maintenance therapy (after initial/ corrective periodontal therapy) will be included in the study

Description

INCLUSION CRITERIA:

1. Initial diagnosis of chronic or aggressive periodontitis (Lindhe et al. 1999, Lang et al. 1999), with at least two sites with PPD and CAL ≥5mm
2. Diagnosed and treated by the same periodontist (LN)
3. Willing to give written informed consent for study participation
4. Willing to undergo SPT as per standard of care for at least 5 years

EXCLUSION CRITERIA:

1. Serious medical history that prevents patients from undergoing dental treatment
2. History of rheumatic fever, heart murmur, mitral valve prolapse, artificial heart valve or other conditions requiring prophylactic antibiotic coverage prior to invasive dental procedures
3. Current alcohol or drug abuse
4. Self-reported pregnancy or lactation
5. Other severe acute or chronic medical or psychiatric condition or laboratory abnormality that may compromise trial participation and/or interpretation of trial results and, in the judgement of the investigator, would make the subject inappropriate for entry into this trial

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Tooth loss	5 years

Collaborators and Investigators

• Sponsor: University College, London
• Investigators: Principal Investigator: Luigi Nibali, PhD, UCL

Study record dates

Study Major Dates

• Study Start: June 1, 2014
• Primary Completion (Anticipated): May 1, 2020
• Study Completion (Anticipated): December 1, 2020

Study Registration Dates

• First Submitted: March 17, 2014
• First Submitted That Met QC Criteria: March 17, 2014
• First Posted (Estimate): March 19, 2014

Study Record Updates

• Last Update Posted (Actual): September 27, 2017
• Last Update Submitted That Met QC Criteria: September 26, 2017
• Last Verified: September 1, 2015

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Stomatognathic Diseases; Periodontal Diseases; Mouth Diseases; Tooth Diseases; Periodontitis; Tooth Loss
• Other Study ID Numbers: UCL 14/0110