Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease

Prevalence of Eosinophilic Esophagitis in Children With Celiac Disease and Prevalence of Celiac Disease in Children With Eosinophilic Esophagitis in a Tertiary Community Hospital

Celiac disease (CD) and eosinophilic esophagitis (EE) are distinct diseases of the gastrointestinal tract with specific clinico-pathological characteristics. In recent years, in the literature, several children who underwent upper gastrointestinal endoscopy for suspected CD, which was confirmed histologically, were also found to have coexistent EE. There are reports of coexistent CD and EE. We would like to see the prevalence of EE in children with CD and the prevalence of CD in children with EE in our population, and to do so would like to review medical records. Our objectives are to determine if children with celiac disease have a high prevalence of eosinophilic esophagitis.and to determine if children with eosinophilic esophagitis have increased risk of developing celiac disease.

Study Overview

• Status: Completed
• Conditions: Celiac Disease; Eosinophilic Esophagitis

• Study Type: Observational
• Enrollment (Actual): 56

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 2 years to 21 years (Child, Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Children seen in the Pediatric Gastroenterology clinic at St. John Hospital & Medical Center and diagnosed with celiac disease or eosinophilic esophagitis or both based on the endoscopic and histopathological findings.

Description

Inclusion Criteria:

• Seen in the Pediatric Gastroenterology clinic at St. John Hospital & Medical Center during study time frame
• Age 2-21 years old
• Diagnosed with CD or EE or both based on the endoscopic and histopathological findings .

Exclusion Criteria:

• Gastroesophageal reflux diagnosed by PH probe.
• History of chemical ingestion

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Review of histopathology reports of esophageal biopsies to record the number of eosinophils per high power field.	Retrospective chart review study, no contact made with patients, so no patient time is required, expected average of 2 years

Collaborators and Investigators

• Sponsor: St. John Health System, Michigan

Study record dates

Study Major Dates

• Study Start: February 1, 2011
• Primary Completion (Actual): June 1, 2013

Study Registration Dates

• First Submitted: July 10, 2014
• First Submitted That Met QC Criteria: July 14, 2014
• First Posted (Estimate): July 15, 2014

Study Record Updates

• Last Update Posted (Estimate): July 15, 2014
• Last Update Submitted That Met QC Criteria: July 14, 2014
• Last Verified: July 1, 2014

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Digestive System Diseases; Metabolic Diseases; Immune System Diseases; Hypersensitivity, Immediate; Hematologic Diseases; Gastrointestinal Diseases; Gastroenteritis; Intestinal Diseases; Hypersensitivity; Esophageal Diseases; Leukocyte Disorders; Malabsorption Syndromes; Eosinophilia; Celiac Disease; Eosinophilic Esophagitis; Esophagitis
• Other Study ID Numbers: SJ 0211-07