Comparison of Walking in Water and on Land in People With Chronic Obstructive Pulmonary Disease (COPD)

Determining the Metabolic Load of Walking in Water Compared to Walking on Land in People With COPD, Who Are Normal Weight and Obese, Compared to Peak Exercise Metabolic Response: a Prospective, Randomised Cross-over Pilot Trial

The purpose of this study is to evaluate the metabolic load during a single session of moderate intensity walking in water compared to walking on land (over-ground) in people with chronic obstructive pulmonary disease (COPD) who are normal weight and obese, compared with peak exercise metabolic response.

The hypothesis is that the metabolic load of walking at a moderate intensity in water will be greater than walking on land.

Study Overview

• Status: Terminated
• Conditions: Pulmonary Disease, Chronic Obstructive
• Intervention / Treatment: Behavioral: Water-based walking; Behavioral: Land-based walking

• Study Type: Interventional
• Enrollment (Actual): 14
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Netherlands
  • Horn, Netherlands
    • Centre of intergrated rehabilitation for chronic organ failure

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• diagnosis of COPD (FEV1/FVC <0.7) in a clinically stable state (no acute exacerbation of COPD within the previous 4 weeks)
• accepting of walking in water
• BMI >/= 21 kg/m2

Exclusion Criteria:

• long-term oxygen therapy
• contraindications to entering a hydrotherapy pool

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: COPD (normal weight); People with COPD (BMI 21 kg/m2 to 29 kg/m2)	Behavioral: Water-based walking; Participants will walk in the water for 15 minutes at an intensity rating of five on the modified Borg scale for dyspnoea or perceived exertion, whichever is the highest. Walking intensity will be measured every three minutes during each walking session. If the intensity level is reported as below five, participants will be encouraged to increase the intensity by increasing their walking speed. During walking in water, VO2 and VE will be measured breath-by-breath using the Oxycon mobile. Every three minutes during the walking, heart rate, oxygen saturation, dyspnoea and exertion will be measured.; Behavioral: Land-based walking; Participants will walk on land for 15 minutes at an intensity rating of five on the modified Borg scale for dyspnoea or perceived exertion, whichever is the highest. Walking intensity will be measured every three minutes during each walking session. If the intensity level is reported as below five, participants will be encouraged to increase the intensity by increasing their walking speed. During walking on land, VO2 and VE will be measured breath-by-breath using the Oxycon mobile. Every three minutes during the walking, heart rate, oxygen saturation, dyspnoea and exertion will be measured.
Experimental: COPD (obese); People with COPD (BMI >/= 30 kg/m2)	Behavioral: Water-based walking; Participants will walk in the water for 15 minutes at an intensity rating of five on the modified Borg scale for dyspnoea or perceived exertion, whichever is the highest. Walking intensity will be measured every three minutes during each walking session. If the intensity level is reported as below five, participants will be encouraged to increase the intensity by increasing their walking speed. During walking in water, VO2 and VE will be measured breath-by-breath using the Oxycon mobile. Every three minutes during the walking, heart rate, oxygen saturation, dyspnoea and exertion will be measured.; Behavioral: Land-based walking; Participants will walk on land for 15 minutes at an intensity rating of five on the modified Borg scale for dyspnoea or perceived exertion, whichever is the highest. Walking intensity will be measured every three minutes during each walking session. If the intensity level is reported as below five, participants will be encouraged to increase the intensity by increasing their walking speed. During walking on land, VO2 and VE will be measured breath-by-breath using the Oxycon mobile. Every three minutes during the walking, heart rate, oxygen saturation, dyspnoea and exertion will be measured.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Breath-by-breath oxygen consumption (VO2)	Day of assessment during study measurement period (15 minutes)

Secondary Outcome Measures

Outcome Measure	Time Frame
Minute ventilation (VE)	Day of assessment during study measurement period (15 minutes)

Other Outcome Measures

Outcome Measure	Time Frame
Dyspnoea, measured by the modified Borg 0-10 category ratio scale	Day of assessment during study measurement period (15 minutes)
Exertion, measured by the modified Borg 0-10 category ratio scale	Day of assessment during study measurement period (15 minutes)
Oxygen saturation	Day of assessment during study measurement period (15 minutes)
Heart rate	Day of assessment during study measurement period (15 minutes)

Collaborators and Investigators

• Sponsor: European Respiratory Society
• Collaborators: Center for Integrated Rehabilitation and Organ Failure Horn
• Investigators: Study Director: Martijn A Spruit, PhD, Centre of integrated rehabilitation for chronic organ failure

Study record dates

Study Major Dates

• Study Start: October 1, 2016
• Primary Completion (Actual): January 1, 2020
• Study Completion (Actual): January 1, 2020

Study Registration Dates

• First Submitted: April 7, 2016
• First Submitted That Met QC Criteria: April 27, 2016
• First Posted (Estimate): April 29, 2016

Study Record Updates

• Last Update Posted (Actual): August 25, 2021
• Last Update Submitted That Met QC Criteria: August 19, 2021
• Last Verified: August 1, 2021

More Information

Terms related to this study

• Keywords: Walking; Hydrotherapy
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Lung Diseases, Obstructive; Lung Diseases; Pulmonary Disease, Chronic Obstructive
• Other Study ID Numbers: ERS STRTF 2015 - 9368

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO