Peak Systolic Global Longitudinal Strain and Low Cardiac Output Syndrome After Cardiac Surgery

November 22, 2016 updated by: Jean François Brichant, University of Liege

This is a retrospective observational study to assess the relationship between peak systolic global longitudinal strain measured on pre-cardiopulmonary bypass trans-esophageal echo images predicts post-operative low cardiac output syndrome defined as the need for an inotropic support during 24 hours or longer.

Study Overview

Status

Completed

Conditions

Low Cardiac Output Syndrome After Adult Cardiac Surgery

Intervention / Treatment

Procedure: Cardiac surgery

Study Type

Observational

Enrollment (Actual)

275

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

18 years and older (Adult, Older Adult)

Accepts Healthy Volunteers

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Adult patients undergoing on-pump elective or urgence cardiac surgery

Description

Inclusion Criteria:

Cardiac surgery involving the use of cardiopulmonary bypass
Availability of pre-cardiopulmonary bypass trans-oesophageal echo images allowing measurement of the peak systolic global longitudinal strain

Exclusion Criteria:

Preoperative atrial fibrillation
Preoperative critical state
Emergent/salvage surgery
Heart transplant surgery
Left ventricular assist device implantation

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Post-operative low cardiac output syndrome Time Frame: 30 days	Need for pharmacological inotropic support during 24 hours or more post-operatively	30 days

Secondary Outcome Measures

Outcome Measure	Time Frame
Length of hospital stay Time Frame: 30 days	30 days
Length of intensive care unit stay Time Frame: 30 days	30 days
30-day or in hospital mortality Time Frame: 30 days	30 days
duration of post-operative mechanical ventilation Time Frame: 30 days	30 days
post-operative acute kidney injury Time Frame: 30 days	30 days
Need for readmission to the intensive care Time Frame: 30 days	30 days

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

University of Liege

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Amabili P, Benbouchta S, Roediger L, Senard M, Hubert MB, Donneau AF, Brichant JF, Hans GA. Low Cardiac Output Syndrome After Adult Cardiac Surgery: Predictive Value of Peak Systolic Global Longitudinal Strain. Anesth Analg. 2018 May;126(5):1476-1483. doi: 10.1213/ANE.0000000000002605.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start

June 1, 2016

Primary Completion (Actual)

September 1, 2016

Study Completion (Actual)