The Predictive Effect of the Inflammatory Response on the Evacuation of Mechanical Ventilation and the Mechanism

Infection and trauma take a important role in the acute respiratory failure.There are different causes and degrees of inflammatory reaction in the critically ill patient. The inflammatory reaction should also affect patients on mechanical ventilation dependence with body physiological response and disease prognosis in patients. Therefore, the investigators hypothesize that inflammation may have an important role in the prediction of weaning from mechanical ventilation.

Study Overview

• Status: Unknown
• Conditions: Systemic Inflammatory Response Syndrome; Ventilator Weaning

Detailed Description

In the process of mechanical ventilation, the patients were divided into two groups according to the failure of spontaneous breathing test and spontaneous breathing test.In the index of predicting mechanical ventilation, the investigators will take the index of inflammatory response, the function index of diaphragm and the amount of exhaled CO2 into account to reduce the failure rate of mechanical ventilation.

• Study Type: Observational
• Enrollment (Anticipated): 300

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 14 years to 80 years (Child, Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

The patient with oral or nasal tracheal intubation and mechanical ventilation in respiratory failure

Description

Inclusion Criteria:

• oral, nasal tracheal intubation and mechanical ventilation in patients with respiratory failure
• mechanical ventilation time over than 48 hours
• Glasgow score greater more than or equal to 13 points

Exclusion Criteria:

• Aged less than 14 years or more than 80 years old
• patients with neuromuscular disease
• pure heart failure pulmonary edema patients
• patients with tracheotomy

Study Plan

How is the study designed?

Number of groups / cohorts

4

Cohorts and Interventions

Group / Cohort
Success with SBT; The patient have a success in SBT.
Success with mechanical ventilation; Weaning from mechanical ventilation is successful
failure with SBT; The patient have a failure in SBT.
failure with mechanical ventilation; Weaning from mechanical ventilation is failed

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The relationship between mechanical ventilation of ventilator and inflammatory response	Through the study of mechanical ventilation weaning success and failure of patients with respiratory physiological indicators, blood, urine related inflammatory indicators, analysis of the relationship between inflammatory response and mechanical ventilation weaning.The test indicators include C- reactive protein, tumor necrosis factor and some interleukin for related.	January 2014 to December 2016

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The relationship between diaphragm movement function and weaning from mechanical ventilation	To study the relationship between the inflammatory response and the contractile function of diaphragm, which is helpful to judge the effect of inflammatory factors on the evacuation of mechanical ventilation.	January 2016 to December 2017
the output of CO2		January 2016 to December 2017

Collaborators and Investigators

• Sponsor: Beijing Chao Yang Hospital
• Investigators: Study Director: MA yingmin, professor, Beijing Chao Yang Hospital

Study record dates

Study Major Dates

• Study Start: May 1, 2014
• Primary Completion (Anticipated): April 1, 2017
• Study Completion (Anticipated): April 1, 2017

Study Registration Dates

• First Submitted: May 31, 2016
• First Submitted That Met QC Criteria: June 29, 2016
• First Posted (Estimate): June 30, 2016

Study Record Updates

• Last Update Posted (Estimate): June 30, 2016
• Last Update Submitted That Met QC Criteria: June 29, 2016
• Last Verified: June 1, 2016

More Information

Terms related to this study

• Keywords: Mechanical Ventilation; Inflammatory Factor
• Additional Relevant MeSH Terms: Pathologic Processes; Inflammation; Shock; Systemic Inflammatory Response Syndrome
• Other Study ID Numbers: 15210511726

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: YES