Dresden Glaucoma and Treatment Study (DGTS)

Dresden Glaucoma and Treatment Study: Analysis to Assure the Quality of Follow-up and Therapy of Glaucoma Patients in a Tertiary University Hospital Glaucoma Service.

To assure the quality of follow-up and treatment, data of glaucoma patients are stored and evaluated after anonymisation.

Study Overview

• Status: Recruiting
• Conditions: Glaucoma; Glaucoma, Open-Angle; Glaucoma, Angle-Closure; Glaucoma, Low Tension

Detailed Description

The aim of the study is to evaluate the quality of follow-up and treatment by means of consecutive data collection and anonymised analysis of all glaucoma patients of a tertiary university hospital glaucoma service.

Parameters being analyzed are:

Age, sex, refraction, family history, known duration of glaucoma, highest intraocular pressure before treatment, systemic and topical medication, previous ocular surgery.

24h Goldmann-applanation tonometry, biomicroscopy, gonioscopy, Heidelberg Retinal Tomograph (HRT), glaucoma diagnosis with Scanning-Laser-Polarimetry (GDx), optical coherence tomography (OCT), Pentacam, Ocular Response Analyzer (ORA), Corvis ST (Corneal Visualization with the Scheimpflug Technology), perimetry

• Study Type: Observational
• Enrollment (Estimated): 10000

Contacts and Locations

• Study Contact: Name: Karin R Pillunat, MD; Phone Number: +49 351 458 3274; Email: karin.pillunat@uniklinikum-dresden.de
• Study Contact Backup: Name: Lutz E Pillunat, MD, PhD; Phone Number: +49 351 458 3381; Email: lutze.pillunat@uniklinikum-dresden.de

Study Locations

• Germany
  • Saxony
    • Dresden, Saxony, Germany, 01307
      • Recruiting
      • University Eye Hospital, Medical Faculty, Technical University Dresden
      • Contact: Karin R Pillunat, MD; Phone Number: 3274 +49 351 458; Email: karin.pillunat@uniklinikum-dresden.de
      • Contact: Lutz E Pillunat, MD, PhD; Phone Number: 3381 +49 351 458; Email: lutze.pillunat@uniklinikum-dresden.de

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Glaucoma patients attending a tertiary University Hospital glaucoma Service.

Description

Inclusion Criteria:

• manifest glaucoma, ocular Hypertension, glaucoma suspect

Exclusion Criteria:

• under 18 years of age, corneal diseases

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Follow-up intervals	To find the best follow-up intervals for glaucoma patients.	20 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Assessment of treatment quality	What is the best treatment option for the individual patient?	20 years
Assessment of intraocular pressure-lowering efficacy and number of participants with treatment-related adverse events as assessed by CTCAE v4.0 of glaucoma laser therapy	Diurnal intraocular pressure, best corrected visual acuity, visual fields	20 years
Assessment of intraocular pressure-lowering efficacy and number of participants with treatment-related adverse events as assessed by CTCAE v4.0 of glaucoma laser therapy of glaucoma surgery	Diurnal intraocular pressure, best corrected visual acuity, visual fields	20 years

Collaborators and Investigators

• Sponsor: Technische Universität Dresden
• Investigators: Study Director: Lutz E Pillunat, MD, PhD, Medical faculty of the Technical University of Dresden, Germany

Study record dates

Study Major Dates

• Study Start: January 1, 2006
• Primary Completion (Estimated): December 1, 2030
• Study Completion (Estimated): December 1, 2030

Study Registration Dates

• First Submitted: November 7, 2016
• First Submitted That Met QC Criteria: November 8, 2016
• First Posted (Estimated): November 9, 2016

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: February 3, 2025
• Last Verified: February 1, 2025

More Information

Terms related to this study

• Keywords: Glaucoma Surgery; Laser Therapy; Follow-up intervals; Treatment Efficiency; Minimal Invasive Glaucoma Surgery (MIGS)
• Additional Relevant MeSH Terms: Eye Diseases; Optic Nerve Diseases; Ocular Hypertension; Glaucoma; Glaucoma, Open-Angle; Low Tension Glaucoma; Glaucoma, Angle-Closure
• Other Study ID Numbers: DGTS

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Individual participant data are only shared between researchers of our Institute.