Effect of Atmospheric Pollution on Obstructive Lung Diseases

Effect of Atmospheric Pollution Due to Particulate Matter on Obstructive Lung Diseases in San Nicolas, Buenos Aires Province, Argentina

Several studies have demonstrated the association between atmospheric pollution and chronic respiratory diseases. The magnitude of this association and its dependence of local factors are still unknown in Argentina, particularly for obstructive lung diseases like asthma and chronic obstructive pulmonary disease (COPD). The objective of this study is to assess the effect of atmospheric pollution due to particulate matter (PM) on asthma and COPD exacerbations in adults. A prospective cohort study will be carried out in patients attending the pulmonary service of a public hospital located in San Nicolas, Buenos Aires province, Argentina. Patients will be followed for 12 months after recruitment. The outcome variables will be the frequency of hospitalizations or emergency department consults for asthma or COPD exacerbations and related conditions, and the impact of COPD on a person's life as measured by the COPD assessment test (CAT) questionnaire. The exposure will be the pollution level in the particular address, measuring PM10 concentrations with portable equipment. Other variables as air temperature, humidity, and individual patient risk factors will be considered as potential confounders or effect modifiers. The associations will be estimated through regression models, i.e. logistic and Poisson regressions and recurrent event survival analysis. The results of this study should provide elements to estimate the risk of chronic respiratory diseases associated with atmospheric pollution, and to evaluate strategies for risk assessment in the local community.

Study Overview

• Status: Unknown
• Conditions: Lung Diseases, Obstructive

• Study Type: Observational
• Enrollment (Actual): 117

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

Patients attending the pulmonary service of a public hospital located in San Nicolas, Buenos Aires province, Argentina.

Description

Inclusion Criteria:

• Patients with asthma or COPD attending the pulmonary service.

Exclusion Criteria:

• Patients who refuse to participate in this study or to sign the informed consent document.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Asthma or COPD hospitalizations or emergency department visits	Asthma or COPD hospitalizations or emergency department visits measured by hospital records	12 months

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Quality of life associated with obstructive lung diseases	The quality of life associated with obstructive lung diseases will be measured with a short patient-completed questionnaire, the COPD Assessment Test (CAT).	12 months

Collaborators and Investigators

• Sponsor: National Council of Scientific and Technical Research, Argentina
• Investigators: Principal Investigator: Pablo Orellano, Dr.PH, National Scientific and Technical Research Council, Argentina

Study record dates

Study Major Dates

• Study Start (Actual): December 4, 2015
• Primary Completion (Anticipated): December 4, 2018
• Study Completion (Anticipated): December 4, 2018

Study Registration Dates

• First Submitted: February 15, 2017
• First Submitted That Met QC Criteria: February 16, 2017
• First Posted (Actual): February 23, 2017

Study Record Updates

• Last Update Posted (Actual): January 25, 2018
• Last Update Submitted That Met QC Criteria: January 23, 2018
• Last Verified: January 1, 2018

More Information

Terms related to this study

• Keywords: Lung Diseases, Obstructive; Air Pollution; Particulate Matter
• Additional Relevant MeSH Terms: Respiratory Tract Diseases; Lung Diseases; Lung Diseases, Obstructive
• Other Study ID Numbers: 2919/1191/15

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No