- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03088592
Electrophysiological Recordings of Deep Brain Stimulation in the Basal Ganglia (DBSMER)
October 26, 2022 updated by: Markey Olson, St. Joseph's Hospital and Medical Center, Phoenix
The pathology of Parkinson's disease (PD) and the mechanism of Deep Brain Stimulation surgery (DBS) are not completely understood.
The recording data that is used routinely as part of the procedure to map the target structures, however, may be analyzed in order to better understand the neural network dynamics in PD.
The purpose of the study is to perform simultaneous neural recordings from sub-cortical structures (e.g.
subthalamic nucleus [STN] or globus pallidus internus [GPi]) and the cerebral cortex.
These simultaneous recordings may provide insight in the pathology of PD and the mechanism of DBS.
The researchers will also study the effects of anesthesia level on neuron synchronization .
Recordings with micro-ECoG grid electrodes in the cortex show improved spatial resolution and these will be used to gain better understanding of cortical network dynamics and the synchronization with subcortical structures.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Detailed Description
Subjects will be identified exclusively from the researchers' clinical practice for evaluation of DBS surgical candidacy for Parkinson's disease.
Once it is determined that a patient is an appropriate candidate for DBS placement (multidisciplinary team consensus) and has met inclusion criteria,the researchers will discuss the study with the subject and explain the rationale for the study as well as the implications the subject's participation has to their treatment.
Informed consent will be obtained prior to study procedures being performed.
Subjects will be in the study from the time of enrollment before surgery until all post-operative visits and tests are completed, usually by 6 months after surgery.
Follow-up during this time will consist of the standard follow-up schedule that all patients who undergo DBS follow.
This includes a clinic visit at 10-14 days, 12 weeks, and 6 months after DBS surgery.
Subjects will also have a follow-up neurocognitive evaluation consisting of the same evaluative tests administered pre-operatively.
These post-operative visits are standard for all patients undergoing DBS for Parkinson's.
Study Type
Interventional
Enrollment (Actual)
34
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
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Arizona
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Phoenix, Arizona, United States, 85013
- St. Joseph's Hospital and Medical Center
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years to 85 years (Adult, Older Adult)
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
- Parkinson's disease per Queens Square criteria
- Appropriate DBS candidate for multi-disciplinary team consensus
- Age 18 - 85 years of age
- Motor skills allowing for capability to complete evaluations
- Medically cleared for undergoing anesthesia and DBS surgery
Exclusion Criteria:
- Dementia per DSM-V criteria
- Medical or other condition precluding MRI
- History of supraspinal CNS disease other than PD
- Alcohol use of more than 4 drinks per day
- Pregnancy
- History of suicide attempt
- Currently uncontrolled clinically significant depression (BDI>20)
- History of schizophrenia, delusions, or currently uncontrolled visual hallucinations
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: N/A
- Interventional Model: Single Group Assignment
- Masking: None (Open Label)
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Deep Brain Stimulation
After informed consent is obtained, the patients will undergo routine DBS pre-operative evaluation and diagnostic testing.
This includes a pre-operative 3T-MRI with and without gadolinium as well as pre-operative medical clearance by the patient's PCP or general practitioner and/or other medical specialist if necessary.
They will also receive a baseline clinical evaluation including both motor function (Unified Parkinson's Disease Rating Scale on and off anti-parkinsonian medication) quality of life assessment (Parkinson's disease Questionnaire-39) and a full neuropsychological evaluation, if not already completed as part of the routine DBS candidacy evaluation within 2 months of surgery.
Subjects will have medical clearance from their specialists and be be evaluated by an internal medicine physician prior to surgery and cleared to proceed.
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Subjects will have awake or asleep DBS surgery with STN or GPi placement.
Microelectrode recordings will define the electrophysiological target prior to lead implantation.
Cortical recordings will be done using µECoG grids (2.0 x 0.8 cm) placed over the cortex through the same burr hole used for lead implantation.
Neural recordings will be made continuously throughout the procedure: before, during, and after DBS, and at all levels of anesthesia.
A pulse generator will be connected and implanted either during the operation or within 7-10 days post-operatively.
Subjects will be admitted overnight for observation with anticipated discharge the next morning.
The researchers will also be collecting other routine data points (length of surgery, stereotactic accuracy, length of hospital stay, and post-operative complications).
Other Names:
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What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Neural Recordings
Time Frame: pre-operative; intra-operative ; 10-14 post-operative; 12 week post-operative; 6 months post-operative
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Simultaneous neural recordings from sub-cortical structures (e.g.
subthalamic nucleus [STN] or globus pallidus internus [GPi]) and the cerebral cortex will be collected.
Recordings include action potentials and local field potentials from sub-cortical structures while subdural microelectrocorticography grids will be used to record local field potential from the cerebral cortex.
Time, frequency, and phase relationships between action potentials and local field potentials will also be studied in the context of the level of anesthesia.
Analysis of these simultaneous recordings, including assessing any changes, may provide insight in the pathology of PD and the mechanism of DBS.
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pre-operative; intra-operative ; 10-14 post-operative; 12 week post-operative; 6 months post-operative
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Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Collaborators
Investigators
- Principal Investigator: Francisco A Ponce, MD, Barrow Brain and Spine physician with SJHMC privileges
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
February 1, 2016
Primary Completion (Actual)
March 1, 2022
Study Completion (Actual)
March 1, 2022
Study Registration Dates
First Submitted
March 2, 2017
First Submitted That Met QC Criteria
March 16, 2017
First Posted (Actual)
March 23, 2017
Study Record Updates
Last Update Posted (Actual)
October 28, 2022
Last Update Submitted That Met QC Criteria
October 26, 2022
Last Verified
October 1, 2022
More Information
Terms related to this study
Keywords
Additional Relevant MeSH Terms
Other Study ID Numbers
- PHX-16-0017-70-06
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
Yes
product manufactured in and exported from the U.S.
Yes
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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