- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03206580
Functional Mobility in the Elderly: Influence of Morphological, Neuromuscular and Training Parameters
June 7, 2024 updated by: Marco Aurélio Vaz, PhD, Federal University of Rio Grande do Sul
Functional Mobility in the Elderly: Influence of Morphological, Neuromuscular and Training
Life expectancy and elderly population are increasing.
Health professionals try to provide longevity with good quality of life for this population, through the functional independence maintenance.
In this context, physical exercise has an important role, specially the strength training.
The ability to produce muscle strength is positively associated with the functionality and independence of older people.
Different types of strength training can lead to different neuromuscular and functional gains.
These types of interventions can help health professionals to determine characteristics of training for the elderly, aiming the maintenance of their functional independence.
Thus, the purpose of this study is to determine the effects of a concentric strength training versus a concentric-eccentric strength training for knee flexors and extensors on structural, neuromuscular and functional parameters in older people, as well as to investigate the effect of a detraining period.
Additionally, the investigators will try to identify which structural and neuromuscular parameters of lower limbs are better related to the functionality.
Study Overview
Status
Completed
Conditions
Intervention / Treatment
Study Type
Interventional
Enrollment (Actual)
11
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Rio Grande Do Sul
-
Porto Alegre, Rio Grande Do Sul, Brazil, 90690-200
- Exercise Research Laboratory, School of Physical Education, Federal University of Rio Grande do Sul
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
65 years to 85 years (Older Adult)
Accepts Healthy Volunteers
Yes
Description
Inclusion Criteria:
- Male;
- 65 years of age or more;
- able to walk independently;
- not engaged in regular physical exercise.
Exclusion Criteria:
- Auditory, vestibular, visual and/or neuromusculoskeletal impairments that could influence the tests and the training;
- severe cognitive impairment;
- lower limb surgery;
- osteoporosis;
- lower limb pain.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Quadruple
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
|---|---|
|
Experimental: Concentric training
|
Subjects will be submitted to 8 weeks (16 sessions) of a concentric training for knee flexors and knee extensors.
This training will be performed in an isokinetic dynamometer at 70% of the subject's maximal voluntary isometric contraction.
|
|
Experimental: Concentric-eccentric training
|
Subjects will be submitted to 8 weeks (16 sessions) of a concentric-eccentric training for knee flexors and knee extensors.
This training will be performed in an isokinetic dynamometer at 70% of the subject's maximal voluntary isometric contraction.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Pennation angle of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Pennation angle at rest
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Thickness of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Muscle thickness at rest
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Fascicle length of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Fascicle length at rest
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Echo intensity of rectus femoris, vastus lateralis and biceps femoris, bilaterally.
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Echo intensity determined from a gray scale analysis of the muscles at rest
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Countermovement vertical jump
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Maximal vertical height in the countermovement jump
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Timed-up-&-go
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Time to rise from a chair, walk 3 meters, turn, walk back and sit again
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Unipodal static balance
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Range in anterior-posterior and medio-lateral center of pressure movement during unipodal evaluation during 30 seconds
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Gait speed
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Gait speed for walking 10 meters at self-selected speed
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Stair ascent and descent time
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Time to stair ascent and descent stairs
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
6-minutes walking test
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
The distance that the subjects can walk during 6 minutes
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Sit-to-stand
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Maximal number of repetitions during 30 seconds
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Power of knee extensors and knee flexors
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Power during maximal concentric and eccentric contractions
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Rate of torque production of knee extensors and knee flexors
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Rate of torque production during maximal isometric contractions
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Strength of knee extensors and knee flexors
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Maximal isometric strength
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Strength of knee extensors and knee flexors
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Maximal concentric strength
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
|
Strength of knee extensors and knee flexors
Time Frame: First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Maximal eccentric strength
|
First evaluation, change from first evaluation to baseline, change from baseline to 8 weeks of training, change from 8 weeks of training to 4 weeks of detraining and change from 4 weeks of detraining to 8 weeks of detraining
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
October 15, 2016
Primary Completion (Actual)
December 31, 2018
Study Completion (Actual)
December 31, 2018
Study Registration Dates
First Submitted
June 22, 2017
First Submitted That Met QC Criteria
June 29, 2017
First Posted (Actual)
July 2, 2017
Study Record Updates
Last Update Posted (Actual)
June 10, 2024
Last Update Submitted That Met QC Criteria
June 7, 2024
Last Verified
June 1, 2024
More Information
Terms related to this study
Keywords
Other Study ID Numbers
- UFRGS 2.034.508
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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