Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training

Structural and Metabolic Determinants of Sarcopenia and the Efficacy of Concentric vs. Eccentric Exercise Training: a Novel Temporospatial Approach

The first goal of this study is the follow young and older people over a period of 8 weeks to define the processes responsible for loss of muscle length and width in age-related muscle wasting (sarcopenia) and allow us to look at age-related differences in tendon. Secondly, we will assess two different exercise interventions for reversing human sarcopenia; one which involves shortening of the muscle and the other which involves lengthening, whilst also studying why these exercises work the way they do. This project will have significant implications for our understanding of the control of skeletal muscle and tendon size in humans, particularly in relation to sarcopenia and the surrounding health issues.

Study Overview

• Status: Completed
• Conditions: Healthy
• Intervention / Treatment: Behavioral: Concentric Exercise Training; Behavioral: Eccentric Exercise Training

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • Derbyshire
    • Derby, Derbyshire, United Kingdom, DE22 3DT
      • University of Nottingham

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 75 years (Adult, Older Adult)
• Accepts Healthy Volunteers: Yes
• Genders Eligible for Study: Male

Description

Inclusion Criteria:

• Healthy male volunteers
• Body mass index 18-30 kg/m2
• Aged 18-35 and 65-75 years

Exclusion Criteria:

• Participation in a formal exercise regime,
• A BMI < 18 or > 30 kg/m2,
• Active cardiovascular disease,
• Taking beta-adrenergic blocking agents, statins or non-steroidal anti-inflammatory drugs,
• Cerebrovascular disease,
• Respiratory disease,
• Metabolic disease,
• Active inflammatory bowel or renal disease,
• Malignancy,
• Recent steroid treatment (within 6 months) or hormone replacement therapy,
• Clotting dysfunction,
• Musculoskeletal or neurological disorders,
• Family history of early (<55y) death from cardiovascular disease

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Prevention
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

6

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
No Intervention: Old Control; Older individuals (65-75 y) with no exercise intervention
Experimental: Old Concentric; Older individuals (65-75 y) studied before and after 8 weeks concentric exercise training	Behavioral: Concentric Exercise Training; 8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets
Experimental: Old Eccentric; Older individuals (65-75 y) studied before and after 8 weeks eccentric exercise training	Behavioral: Eccentric Exercise Training; 8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets
No Intervention: Young Control; Young individuals (18-30 y) with no exercise intervention
Experimental: Young Concentric; Young individuals (18-30 y) studied before and after 8 weeks concentric exercise training	Behavioral: Concentric Exercise Training; 8 weeks concentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets
Experimental: Young Eccentric; Young individuals (18-30 y) studied before and after 8 weeks eccentric exercise training	Behavioral: Eccentric Exercise Training; 8 weeks eccentric exercise training, 3 x per week, 60% 1-RM; 4 x 12-15 repetitions, 2 min rest between sets

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle protein synthesis	Comparison of muscle protein synthesis using D2O in young and older individuals and in response to 8 weeks concentric or eccentric exercise training	0 - 8 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Tendon protein synthesis	Comparison of tendon protein synthesis in young and older individuals and in response to 8 weeks concentric or eccentric exercise training	0 - 8 weeks

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle function	Muscle strength, force and power in young and older individuals and in response to 8 weeks concentric or eccentric exercise training	0 - 8 weeks

Collaborators and Investigators

• Sponsor: University of Nottingham
• Collaborators: Biotechnology and Biological Sciences Research Council
• Investigators: Principal Investigator: Marco V Narici, PhD, University of Nottingham

Study record dates

Study Major Dates

• Study Start: May 1, 2014
• Primary Completion (Actual): May 1, 2017
• Study Completion (Actual): May 1, 2017

Study Registration Dates

• First Submitted: May 16, 2014
• First Submitted That Met QC Criteria: May 19, 2014
• First Posted (Estimate): May 20, 2014

Study Record Updates

• Last Update Posted (Actual): October 30, 2017
• Last Update Submitted That Met QC Criteria: October 27, 2017
• Last Verified: October 1, 2017

More Information

Terms related to this study

• Keywords: volunteers; young (18-30 y); older (65-75 y); age groups
• Additional Relevant MeSH Terms: Nervous System Diseases; Neurologic Manifestations; Neuromuscular Manifestations; Pathological Conditions, Anatomical; Muscular Atrophy; Atrophy; Sarcopenia
• Other Study ID Numbers: B13032014 SoMSGEM BBSRC3