High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes

The Effects of Different High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes

Aim: To assess whether there are different training effects on glucose concentration and cardiorespiratory parameters of different high-intensity training protocols in patients with type 2 diabetes.

Type 2 diabetes is a highly prevalent disease associated with cardiovascular disease leading to high levels of mortality, morbidity and health expenditure, characterized by impaired glucose control during activities and reduced aerobic exercise capacity .

Exercise training is the most effective way to improve compliance, reduce blood glucose concentration and increase insulin sensitivity. Training increases muscle capacity, oxidative capacity and glucose transport, peripheral insulin sensitivity is improved.

Exercise training with high-intensity interval (resting and exercise period) High Intensity Interval Training (HIIT) is a form of exercise training that has recently been widely used in the management of type 2 diabetes, including short duration high intensity exercise periods and lower severity or passive rest periods. There are different HIIT exercise training programs according to physiological responses in the literature. However, long-term and short-term HIIT training training programs were not compared in terms of their effect on glucose concentration and cardiorespiratory fitness. The aim of this study was to compare the effects of different HIIT exercise training programs so that exercise programs for patients with type 2 diabetes could be planned more effectively.

Study Overview

• Status: Completed
• Conditions: Diabetes
• Intervention / Treatment: Other: Short duration; Other: Long duration

Detailed Description

This study will be participated patients with Type 2 diabetes. Patients' laboratory values, pulmonary function test, respiratory muscle strength, exercise capacity, physical activity level, quality of life will be evaluated.

Pulmonary function test will be assesed with spirometer, respiratory muscle strength will be evaluated with mouth pressure. Exercise capacity will be evaluated using six minute walking test, incremental shuttle walk test, cycle ergometer. Muscle oxigeneration will be asssed with wearable lactate threshold predicting device. Physical activity level will be evaluated trial accelerometer.

Then, patients will be randomly divided two high intensity interval exercise training groups.

First group: short duration high intensity exercise training (Exercise load phase : 30sn %100 Patients performance, rest phase: 120sn %25 patients performance) Second group: Long duration high intensity interval exercise training (Exercise load phase : 4 dk %100 Patients performance, rest phase: 120sn %25 patients performance) All patients will participate three times a week during eight weeks. The muscle oxigeneration, blood glucose consantration, blood pressure, heart rate will be recorded before and after each exercise session. After 8 week, all test will be done again.

• Study Type: Interventional
• Enrollment (Actual): 36
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Turkey
  • State
    • Ankara, State, Turkey, 06100
      • Hacettepe University

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 64 years (ADULT)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• diagnosis of type 2 diabetes
• aged 18-64 years
• patients can walk and cooperative
• body mass index is less than 40 kg / m2

Exclusion Criteria:

Individuals have known lung disease,have undergone any cardiac event or surgery within the past six months, have uncontrolled hypertension, and have diabetic complications such as nephropathy, retinopathy and severe neuropathy.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: TREATMENT
• Allocation: RANDOMIZED
• Interventional Model: PARALLEL
• Masking: SINGLE

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
EXPERIMENTAL: short duration group; 30sn %100 Wmax 120sn %25 Wmax 3 sessions/week total 8 weeks	Other: Short duration; exercise Short duration high intensity training; Other Names: training
EXPERIMENTAL: long duration group; 4dk %85 Wmax 120sn %25 Wmax 3 sessions/week total 8 weeks	Other: Long duration; exercise Long duration high intensity training; Other Names: training

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
muscle oxigeneration	It is evaluate with wearable lactate threshold device on gastrocinemius	Change from baseline muscle oxigeneration at 8 weeks

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
The blood glucose consentration	It is evaluate with sample from blood	before and after 8 weeks
Functional Exercise capacity	İt is evaluated with six minute walk test	before and after 8 weeks
Maximal exercise capacity	İt is evaluated using with incremental shuttle test	before and after 8 weeks
Symptom limited maximal exercise capacity	İt is evaluated with cycle ergometer test	before and after 8 weeks
Lipit profile-High density lipoprotein cholesterol	High density lipoprotein cholesterol wiil be assesed	before and after 8 weeks
Lipit profile- low density lipoprotein cholesterol	low density lipoprotein cholesterol wiil be assesed	before and after 8 weeks
Lipit profile- trigliseride	trigliseride wiil be assesed	before and after 8 weeks
pulmonary parameter-Forced vital capacity	Forced vital capacity will be evaluated	before and after 8 weeks
pulmonary parameter-Forced vital capacity in the first second	Forced vital capacity in the first second will be evaluated	before and after 8 weeks
pulmonary parameter-Mid expiratory flow rate	Mid expiratory flow rate will be evaluated	before and after 8 weeks
pulmonary parameter-Peak expiratory flow	Peak expiratory flow will be evaluated	before and after 8 weeks
Respiratory muscle strength	It is evaluated with mouth pressure	before and after 8 weeks
Physical activity level	ıt is assessed using accelerometer	before and after 8 weeks

Collaborators and Investigators

• Sponsor: Hacettepe University
• Investigators: Principal Investigator: Cemile Bozdemir Özel, McS, Hacettepe University Physiotherapy and Rehabilitation

Study record dates

Study Major Dates

• Study Start (ACTUAL): March 2, 2018
• Primary Completion (ACTUAL): September 20, 2018
• Study Completion (ACTUAL): January 17, 2020

Study Registration Dates

• First Submitted: February 6, 2018
• First Submitted That Met QC Criteria: April 2, 2018
• First Posted (ACTUAL): April 3, 2018

Study Record Updates

• Last Update Posted (ACTUAL): April 9, 2020
• Last Update Submitted That Met QC Criteria: April 7, 2020
• Last Verified: April 1, 2020

More Information

Terms related to this study

• Keywords: diabetes; high intensity interval training; cardiorespiratory fitness
• Additional Relevant MeSH Terms: Glucose Metabolism Disorders; Metabolic Diseases; Endocrine System Diseases; Diabetes Mellitus; Physiological Effects of Drugs; Adrenergic Agents; Neurotransmitter Agents; Molecular Mechanisms of Pharmacological Action; Autonomic Agents; Peripheral Nervous System Agents; Adrenergic alpha-Agonists; Adrenergic Agonists; Respiratory System Agents; Sympathomimetics; Vasoconstrictor Agents; Nasal Decongestants; Oxymetazoline
• Other Study ID Numbers: KA17069

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No