Effects of Aerobic and Resistance Training on Abdominal Fat Loss

Study the effects of different exercise modes on total and regional adiposity variation in subcutaneous and visceral adipose tissue (VAT and SAT). The investigators hypothesize that total abdominal will improve for all the exercise groups compared to the control group. When comparing intervention groups: 1) no differences on the degree of improvement in total abdominal fat depots (VAT and SAT) 2) different degree of change when comparing specific sections at VAT and SAT are expected.

Study Overview

• Status: Terminated
• Conditions: Obesity, Abdominal
• Intervention / Treatment: Other: Resistance Training; Other: Aerobic Training

• Study Type: Interventional
• Enrollment (Actual): 18
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United States
  • Illinois
    • Edwardsville, Illinois, United States, 62026
      • Southern Illinois University of Edwardsville

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 35 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: Female

Description

Inclusion Criteria:

• 30 - 39.9 kg/m2 BMI
• White/Caucasian
• Female
• Sedentary

Exclusion Criteria:

• Known cardiovascular, pulmonary, metabolic disease
• Pregnant females
• Any excluded criteria with MRI scans (i.e. certain metal implants, recent tattoos)
• Diabetic
• Hypertension
• Cigarette smoking
• MRI related contraindications (metal, no removable devices, etc.)

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: None (Open Label)

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Resistance Training Group; Resistance training will consist of 3 whole body circuits per week for 3 weeks lasting approximately 1 hour per session. All major muscle groups will be involved (leg press, bent-over-row, bench press, back squat, dumbbell jump squats, dead-lifts, and weighted abdominal crunches). Each participant will go through each circuit three times with 30 seconds between each exercise and 2 minutes between each set.	Other: Resistance Training; High-intensity Resistance Training Group
Experimental: Aerobic Training Group; Aerobic interval training will consist of 3 sessions/week for 3 weeks for approximately 45-50 minutes per session depending on exercise energy expenditure. There will be two periods of intervals. The first period will be 3 minutes of high-intensity activity and the second period will be reduced to moderate-intensity for 2 minutes. The speed/incline will change depending on the participants perception or Borg's rating of perceived exertion. Intensity will be measured using Lactate levels after each session.	Other: Aerobic Training; Aerobic Interval Training Group
No Intervention: Control Group; The control group must attend sessions but will not exercise.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in Visceral Abdominal Tissue (VAT)	Changes in VAT will be measured using Magnetic Resonance Imaging	2 assessment periods: at baseline and week 4

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Changes in Subcutaneous Abdominal Tissue (SAT)	Changes in SAT will be measured using Magnetic Resonance Imaging	2 assessment periods: at baseline and week 4
Changes in Muscular Strength	Changes in muscular strength will be assessed by one-repetition maximum test on leg press and bench press	2 assessment periods: at baseline and week 4
Changes in Cardiorespiratory Function	Changes in cardiorespiratory will measured on a treadmill with a metabolic cart	2 assessment periods: at baseline and week 4
Changes in fat mass (kg)	Changes in fat mass will be measured using dual-energy x-ray absorptiometry	2 assessment periods: at baseline and week 4
Changes in relative body fat (%BF)	Changes in body composition (relative body fat, lean body mass and fat mass) will be measured using dual-energy x-ray absorptiometry	2 assessment periods: at baseline and week 4
Changes in relative lean body mass (kg)	Changes in lean body mass will be measured using dual-energy x-ray absorptiometry	2 assessment periods: at baseline and week 4
Changes in Lipid profile (TG, Total Cholesterol, HDL2 HDL3, LDL)	Samples will be processed to obtain serum and plasma, and stored at -80°c until analysis	2 assessment periods: at baseline and week 4
Changes in concentration of Troponin	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Changes in concentration of Fibrinogen	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Changes in concentration of C-reactive protein (CRP)	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Changes in concentration of IL-6	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Changes in concentration of IL-10	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4
Changes in concentration of TNF-alpha	Will be performed using a Luminex MAGPIX System with xPONENT 4.2	2 assessment periods: at baseline and week 4

Collaborators and Investigators

• Sponsor: Southern Illinois University Edwardsville
• Collaborators: Washington University School of Medicine
• Investigators: Principal Investigator: Maria Fernandez del Valle, PhD, Southern Illinois University of Edwardsville

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2017
• Primary Completion (Actual): April 1, 2020
• Study Completion (Actual): May 1, 2020

Study Registration Dates

• First Submitted: September 5, 2018
• First Submitted That Met QC Criteria: October 5, 2018
• First Posted (Actual): October 9, 2018

Study Record Updates

• Last Update Posted (Actual): October 4, 2021
• Last Update Submitted That Met QC Criteria: September 27, 2021
• Last Verified: March 1, 2021

More Information

Terms related to this study

• Keywords: Exercise; Intervention; Visceral Adipose Tissue; Abdominal Fat; Subcutaneous Adipose Tissue
• Additional Relevant MeSH Terms: Overnutrition; Nutrition Disorders; Obesity; Obesity, Abdominal
• Other Study ID Numbers: 16-1208-4C-2

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No