Chemoradiation With or Without Atezolizumab in Treating Patients With Limited Stage Small Cell Lung Cancer

Limited Stage Small Cell Lung Cancer (LS-SCLC): A Phase III Randomized Study of Chemoradiation Versus Chemoradiation Plus Atezolizumab

Sponsors

Lead Sponsor: National Cancer Institute (NCI)

Collaborator: NRG Oncology

Source National Cancer Institute (NCI)
Brief Summary

This phase III trial studies how well chemotherapy and radiation therapy (chemoradiation) with or without atezolizumab works in treating patients with limited stage small cell lung cancer. Drugs used in chemotherapy, such as etoposide, cisplatin, and carboplatin, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Radiation therapy uses high energy x-rays to kill tumor cells and shrink tumors. Immunotherapy with monoclonal antibodies, such as atezolizumab, may help the body's immune system attack the cancer, and may interfere with the ability of tumor cells to grow and spread. Giving chemoradiation with or without atezolizumab may work better in treating patients with limited stage small cell lung cancer.

Detailed Description

PRIMARY OBJECTIVE: I. To compare overall survival (OS) for patients with LS-SCLC treated with chemoradiation +/- atezolizumab. SECONDARY OBJECTIVES: I. To compare progression free survival (PFS) for patients with limited stage small cell lung cancer (LS-SCLC) treated with chemoradiation +/- atezolizumab. II. To determine overall response rate (ORR), rates of local control, and distant metastases free survival with chemoradiation +/- atezolizumab. III. To characterize immune mediated and non-immune mediated toxicity from chemoradiotherapy plus atezolizumab. IV. To compare quality of life, as measured by the Functional Assessment of Cancer Therapy-Trial Outcome Index (FACT-TOI), for patients undergoing chemoradiation +/- atezolizumab. V. To evaluate the quality-adjusted survival, using scores from the 5-level EuroQol 5-dimensional questionnaire (EQ-5D-5L), of chemoradiation +/- atezolizumab for patients with LS-SCLC. VI. To characterize fatigue, as measured by the Patient-Reported Outcomes Measurement Information System (PROMIS), following chemoradiation +/- atezolizumab. VII. To determine the association of blood based tumor mutational burden (bTMB) and tissue-based tumor mutational burden (tTMB) with clinical outcome. EXPLORATORY OBJECTIVES: I. To collect biospecimens at baseline, day 1 and 3 months after the end of chemoradiotherapy, to allow for future analyses. II. To characterize patient-reported symptomatic toxicities measured by the Patient-Reported Outcomes - Common Terminology Criteria for Adverse Events (PRO-CTCAE). OUTLINE: Patients are randomized to 1 of 2 arms. ARM I: Patients receive etoposide intravenously (IV) on days 1-3 and cisplatin IV or carboplatin IV on day 1. Cycles repeat every 21 days for 3 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo three-dimensional conformal radiation therapy (3D-CRT) or intensity-modulated radiation therapy (IMRT) twice daily (BID) for approximately 3 weeks or once daily (QD) for approximately 6-7 weeks in the absence of disease progression or unacceptable toxicity. ARM II: Patients receive treatment as in Arm I. Patients also receive atezolizumab IV over 30-60 minutes on day 1 or 2 of each chemotherapy cycle. Cycles repeat every 3 weeks for 17 cycles (1 year) in the absence of disease progression or unacceptable toxicity. After completion of study treatment, patients are followed up every 3 months for 2 years, then every 6 months for 3 years, then annually thereafter.

Overall Status Recruiting
Start Date 2019-05-28
Completion Date 2026-12-28
Primary Completion Date 2026-12-28
Phase Phase 3
Study Type Interventional
Primary Outcome
Measure Time Frame
Overall survival (OS) Time from randomization to the date of death due to any cause, assessed up to 5 years
Secondary Outcome
Measure Time Frame
Progression free survival (PFS) Time from randomization to any documented progression or death due to any cause, whichever occurs first, assessed up to 5 years
Incidence of adverse events Up to 5 years
Objective response rate (ORR) Up to 5 years
Local control Up to 5 years
Distant metastases-free survival (DMFS) Time between the date of randomization and the first date of documented distant metastases or death due to any cause, whichever occurs first, assessed up to 5 years
Quality of life (QoL) Up to 15 months after the end of the 4th cycle of chemotherapy
Quality-adjusted survival Up to 2 years
Level of fatigue Up to 2 years
Blood based tumor mutational burden (bTMB) and tissue-based tumor mutational burden (tTMB) Up to 5 years
Enrollment 506
Condition
Intervention

Intervention Type: Radiation

Intervention Name: 3-Dimensional Conformal Radiation Therapy

Description: Undergo 3D-CRT

Intervention Type: Drug

Intervention Name: Atezolizumab

Description: Given IV

Arm Group Label: Arm II (etoposide, cisplatin, carboplatin, radiation therapy)

Intervention Type: Drug

Intervention Name: Carboplatin

Description: Given IV

Intervention Type: Drug

Intervention Name: Cisplatin

Description: Given IV

Intervention Type: Drug

Intervention Name: Etoposide

Description: Given IV

Intervention Type: Radiation

Intervention Name: Intensity-Modulated Radiation Therapy

Description: Undergo IMRT

Intervention Type: Other

Intervention Name: Quality-of-Life Assessment

Description: Ancillary studies

Other Name: Quality of Life Assessment

Intervention Type: Other

Intervention Name: Questionnaire Administration

Description: Ancillary studies

Eligibility

Criteria:

Inclusion Criteria: - Pathologically (histologically or cytologically) proven diagnosis of limited stage small cell lung cancer (Stage Tx, T1-T4, N0-3, M0, American Joint Committee on Cancer [AJCC] staging, 8th edition [Ed.]), within 60 days prior to registration - Patients must have received one cycle of platinum/etoposide chemotherapy pre-registration (prior to study entry). Study registration must be within 21 days from day 1 of the pre-registration cycle of chemotherapy. - Patients must have had measurable disease (per Response Evaluation Criteria in Solid Tumors [RECIST], version 1.1) prior to the required cycle of platinum/etoposide chemotherapy - Minimal staging requirements include: - History/physical examination within 30 days prior to registration - Positron emission tomography (PET)/computed tomography (CT) scan for staging within 60 days prior to registration - CT chest/abdomen with IV contrast (unless contraindicated based on kidney function) within 60 days prior to registration; - Note: If contrast allergy exists, premedication per institutional guidelines should be performed prior to obtaining CT with contrast. The only exception to this is a documented life-threatening allergy - Magnetic resonance imaging (MRI) scan of the brain with contrast (preferred) or CT scan of the brain with contrast (allowable if there is a contraindication with MRI with contrast) within 30 days prior to registration - Eastern Cooperative Oncology Group (ECOG) performance status of 0-2 within 30 days prior to registration - Absolute neutrophil count (ANC) >= 1, 500/cells/mm^3 (prior to pre-registration cycle) - Platelet count >= 100,000 cells/mm^3 (prior to pre-registration cycle) - Hemoglobin >= 9 g/dL (prior to pre-registration cycle) - Total bilirubin =< 1.5 x upper limit of normal (ULN) (prior to pre-registration cycle) - Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase [SGOT]) and alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase [SGPT]) =< 2.0 x ULN (prior to pre-registration cycle) - Glomerular filtration rate (GFR) >= 30 mL/min/1.73 m^2 (within 30 days prior to registration) - Patients presenting with a pleural effusion will be eligible if thoracentesis is cytologically negative and non-bloody or if pleural fluid is too small a volume to effectively sample by thoracentesis and does not show increased metabolic activity on CT/PET imaging - Negative serum pregnancy test within 14 days of registration for pre-menopausal women of childbearing potential - The patient or a legally authorized representative must provide study-specific informed consent prior to study entry - Hepatitis B/C testing prior to enrollment for patients that have not been tested before. Note: This is required even if the patient has never shown or had symptoms of hepatitis - Human immunodeficiency virus (HIV)-infected patients on effective anti-retroviral therapy with undetectable viral load within 6 months are eligible for this trial Exclusion Criteria: - Definitive clinical or radiologic evidence of metastatic disease - Definitive surgical resection of small cell lung cancer - Prior invasive malignancy (except non-melanomatous skin cancer, localized prostate cancer, or any early stage cancer treated with curative intent resection) unless disease free for a minimum of 2 years (carcinoma in situ of the breast, oral cavity, or cervix are all permissible) - More than 1 cycle of prior platinum-based chemotherapy for SCLC prior to enrollment; note that prior chemotherapy for a different cancer is allowable - Any prior atezolizumab or other immunotherapy agent - Prior radiotherapy to the lungs or mediastinum that would result in clinically significant overlap of radiation therapy fields; prior tangent fields for breast cancer with minimal overlap with target volumes are allowed per approval of study principal investigators (PIs) - Patients with cytologically positive pleural or pericardial fluid are not eligible - An active, known or suspected autoimmune disease. Patients are permitted to enroll if they have vitiligo, type I diabetes mellitus, residual hypothyroidism due to autoimmune condition only requiring hormone replacement, psoriasis not requiring systemic treatment, or conditions not expected to recur in the absence of an external trigger - Active or prior documented inflammatory bowel disease (e.g., Crohn's disease, ulcerative colitis) - History of allogeneic organ transplant - History of primary immunodeficiency - Severe, active co-morbidity defined as follows: - Known clinically significant liver disease, including active viral, alcoholic, or other hepatitis, cirrhosis, fatty liver, and inherited liver disease - Any other diseases, metabolic dysfunction, physical examination finding, or clinical laboratory finding giving reasonable suspicion of a disease or condition that contraindicates the use of an investigational drug or that may affect the interpretation of the results or render the patient at high risk from treatment complications - Active tuberculosis - Active hepatitis B (chronic or acute) or hepatitis C infection. Note that if hepatitis status is unknown, hepatitis B/C testing is required - Patients with past or resolved hepatitis B infection (defined as having a negative hepatitis B surface antigen [HBsAg]) test, a positive anti-HBc (antibody to hepatitis B core antigen), and a negative viral deoxyribonucleic acid (DNA) test (only obtained if HBsAg is found positive) are eligible - Patients positive for hepatitis C virus (HCV) antibody are eligible only if polymerase chain reaction (PCR) is negative for HCV ribonucleic acid (RNA). (The HCV RNA test must be performed for patients who have a positive HCV antibody test.) - Known immunosuppressive disease, for example history of bone marrow transplant or chronic lymphocytic leukemia (CLL) - Chronic obstructive pulmonary disease (COPD) requiring chronic oral steroid therapy of > 10 mg prednisone daily or equivalent at the time of registration. Inhaled corticosteroids are not exclusionary - Unstable angina and/or congestive heart failure requiring hospitalization within the last 3 months - Transmural myocardial infarction within the last 3 months - Clinically significant interstitial lung disease - A condition requiring systemic treatment with either corticosteroids (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days of study drug administration. Inhaled or topical steroids and adrenal replacement doses > 10 mg daily prednisone equivalents are permitted in the absence of active autoimmune disease - Pregnancy or women of childbearing potential and men who are sexually active and not willing/able to use medically acceptable forms of contraception for the duration of study treatment and for 180 days after the last dose of study drug (Arm 2); this exclusion is necessary because the treatment involved in this study may be significantly teratogenic

Gender:

All

Minimum Age:

18 Years

Maximum Age:

N/A

Healthy Volunteers:

No

Overall Official
Last Name Role Affiliation
Kristin A Higgins Principal Investigator NRG Oncology
Location
Facility: Status: Contact: Investigator:
University of Alabama at Birmingham Cancer Center | Birmingham, Alabama, 35233, United States Recruiting Site Public Contact 205-934-0220 [email protected] Drexell H. Boggs Principal Investigator
Fairbanks Memorial Hospital | Fairbanks, Alaska, 99701, United States Recruiting Site Public Contact 907-458-3043 [email protected] Nicholas DiBella Principal Investigator
Banner MD Anderson Cancer Center | Gilbert, Arizona, 85234, United States Recruiting Site Public Contact 602-747-9738 Theresa Liu-Dumlao Principal Investigator
CTCA at Western Regional Medical Center | Goodyear, Arizona, 85338, United States Recruiting Site Public Contact 623-207-3000 Marnee M. Spierer Principal Investigator
Banner University Medical Center - Tucson | Tucson, Arizona, 85719, United States Recruiting Site Public Contact [email protected] Ricklie A. Julian Principal Investigator
University of Arizona Cancer Center-North Campus | Tucson, Arizona, 85719, United States Recruiting Site Public Contact 800-327-2873 Ricklie A. Julian Principal Investigator
Baptist Memorial Hospital and Fowler Family Cancer Center - Jonesboro | Jonesboro, Arkansas, 72401, United States Recruiting Site Public Contact 870-936-7066 [email protected] Raymond U. Osarogiagbon Principal Investigator
University of Arkansas for Medical Sciences | Little Rock, Arkansas, 72205, United States Recruiting Site Public Contact 501-686-8274 Sanjay Maraboyina Principal Investigator
Sutter Auburn Faith Hospital | Auburn, California, 95602, United States Recruiting Site Public Contact 415-209-2686 [email protected] Deepti Behl Principal Investigator
Alta Bates Summit Medical Center-Herrick Campus | Berkeley, California, 94704, United States Recruiting Site Public Contact 415-209-2686 [email protected] Deepti Behl Principal Investigator
City of Hope Comprehensive Cancer Center | Duarte, California, 91010, United States Recruiting Site Public Contact 800-826-4673 [email protected] Arya Amini Principal Investigator
Los Angeles County-USC Medical Center | Los Angeles, California, 90033, United States Recruiting Site Public Contact 323-865-0451 Jason C. Ye Principal Investigator
USC / Norris Comprehensive Cancer Center | Los Angeles, California, 90033, United States Recruiting Site Public Contact 323-865-0451 Jason C. Ye Principal Investigator
Memorial Medical Center | Modesto, California, 95355, United States Recruiting Site Public Contact 415-209-2686 [email protected] Deepti Behl Principal Investigator
Sutter Roseville Medical Center | Roseville, California, 95661, United States Recruiting Site Public Contact 415-209-2686 [email protected] Deepti Behl Principal Investigator
Sutter Medical Center Sacramento | Sacramento, California, 95816, United States Recruiting Site Public Contact 415-209-2686 [email protected] Deepti Behl Principal Investigator
University of California Davis Comprehensive Cancer Center | Sacramento, California, 95817, United States Recruiting Site Public Contact 916-734-3089 Megan E. Daly Principal Investigator
California Pacific Medical Center-Pacific Campus | San Francisco, California, 94115, United States Suspended
Gene Upshaw Memorial Tahoe Forest Cancer Center | Truckee, California, 96161, United States Recruiting Site Public Contact 530-582-6450 Megan E. Daly Principal Investigator
University of Colorado Hospital | Aurora, Colorado, 80045, United States Recruiting Site Public Contact 720-848-0650 Jose M. Pacheco Principal Investigator
Penrose-Saint Francis Healthcare | Colorado Springs, Colorado, 80907, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
UCHealth Memorial Hospital Central | Colorado Springs, Colorado, 80909, United States Recruiting Site Public Contact 719-365-2406 Jose M. Pacheco Principal Investigator
Memorial Hospital North | Colorado Springs, Colorado, 80920, United States Recruiting Site Public Contact 719-364-6700 Jose M. Pacheco Principal Investigator
Poudre Valley Hospital | Fort Collins, Colorado, 80524, United States Recruiting Site Public Contact 970-297-6150 Jose M. Pacheco Principal Investigator
Cancer Care and Hematology-Fort Collins | Fort Collins, Colorado, 80528, United States Recruiting Site Public Contact 412-339-5294 [email protected] Jose M. Pacheco Principal Investigator
UCHealth Greeley Hospital | Greeley, Colorado, 80631, United States Recruiting Site Public Contact 412-339-5294 [email protected] Jose M. Pacheco Principal Investigator
Medical Center of the Rockies | Loveland, Colorado, 80538, United States Recruiting Site Public Contact 970-203-7083 Jose M. Pacheco Principal Investigator
Beebe South Coastal Health Campus | Frankford, Delaware, 19945, United States Recruiting Site Public Contact 302-645-3100 [email protected] Gregory A. Masters Principal Investigator
Helen F Graham Cancer Center | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Medical Oncology Hematology Consultants PA | Newark, Delaware, 19713, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Beebe Health Campus | Rehoboth Beach, Delaware, 19971, United States Recruiting Site Public Contact 302-645-3100 [email protected] Gregory A. Masters Principal Investigator
Boca Raton Regional Hospital | Boca Raton, Florida, 33486, United States Recruiting Site Public Contact 561-955-4800 Samuel M. Richter Principal Investigator
UM Sylvester Comprehensive Cancer Center at Coral Gables | Coral Gables, Florida, 33146, United States Recruiting Site Public Contact 305-243-2647 Raphael L. Yechieli Principal Investigator
UM Sylvester Comprehensive Cancer Center at Deerfield Beach | Deerfield Beach, Florida, 33442, United States Recruiting Site Public Contact 305-243-2647 Raphael L. Yechieli Principal Investigator
Holy Cross Hospital | Fort Lauderdale, Florida, 33308, United States Recruiting Site Public Contact 954-267-7748 Christopher M. Reynolds Principal Investigator
Lee Memorial Health System | Fort Myers, Florida, 33901, United States Suspended
Regional Cancer Center-Lee Memorial Health System | Fort Myers, Florida, 33905, United States Suspended
University of Florida Health Science Center - Gainesville | Gainesville, Florida, 32610, United States Recruiting Site Public Contact 352-273-8010 [email protected] Frederic J. Kaye Principal Investigator
The Watson Clinic | Lakeland, Florida, 33805, United States Recruiting Site Public Contact 863-680-7780 Galina Vugman Principal Investigator
University of Miami Miller School of Medicine-Sylvester Cancer Center | Miami, Florida, 33136, United States Recruiting Site Public Contact 305-243-2647 Raphael L. Yechieli Principal Investigator
Miami Cancer Institute | Miami, Florida, 33176, United States Recruiting Site Public Contact 786-596-2000 Rupesh R. Kotecha Principal Investigator
Orlando Health Cancer Institute | Orlando, Florida, 32806, United States Recruiting Site Public Contact 321-841-7246 [email protected] Justin M. Rineer Principal Investigator
Sacred Heart Hospital | Pensacola, Florida, 32504, United States Recruiting Site Public Contact 850-416-4611 [email protected] Tarek Eldawy (Mohamed) Principal Investigator
UM Sylvester Comprehensive Cancer Center at Plantation | Plantation, Florida, 33324, United States Recruiting Site Public Contact 305-243-2647 Raphael L. Yechieli Principal Investigator
Moffitt Cancer Center | Tampa, Florida, 33612, United States Recruiting Site Public Contact 800-679-0775 [email protected] Bradford A. Perez Principal Investigator
Grady Health System | Atlanta, Georgia, 30303, United States Recruiting Site Public Contact 404-489-9164 Kristin A. Higgins Principal Investigator
Emory University Hospital Midtown | Atlanta, Georgia, 30308, United States Recruiting Site Public Contact 888-946-7447 Kristin A. Higgins Principal Investigator
Piedmont Hospital | Atlanta, Georgia, 30309, United States Recruiting Site Public Contact 404-425-7943 [email protected] Adam W. Nowlan Principal Investigator
Emory University Hospital/Winship Cancer Institute | Atlanta, Georgia, 30322, United States Recruiting Site Public Contact 404-778-1868 Kristin A. Higgins Principal Investigator
Emory Saint Joseph's Hospital | Atlanta, Georgia, 30342, United States Recruiting Site Public Contact 404-851-7115 Kristin A. Higgins Principal Investigator
Piedmont Fayette Hospital | Fayetteville, Georgia, 30214, United States Recruiting Site Public Contact 412-339-5294 [email protected] Adam W. Nowlan Principal Investigator
CTCA at Southeastern Regional Medical Center | Newnan, Georgia, 30265, United States Active, not recruiting
Memorial Health University Medical Center | Savannah, Georgia, 31404, United States Suspended
Lewis Cancer and Research Pavilion at Saint Joseph's/Candler | Savannah, Georgia, 31405, United States Recruiting Site Public Contact 912-819-5704 [email protected] Mark A. Taylor Principal Investigator
Hawaii Cancer Care - Savio | 'Aiea, Hawaii, 96701, United States Recruiting Site Public Contact 808-539-2273 [email protected] Kenneth N. Sumida Principal Investigator
Pali Momi Medical Center | 'Aiea, Hawaii, 96701, United States Recruiting Site Public Contact 808-486-6000 Kenneth N. Sumida Principal Investigator
The Cancer Center of Hawaii-Pali Momi | 'Aiea, Hawaii, 96701, United States Recruiting Site Public Contact 808-678-9000 Kenneth N. Sumida Principal Investigator
Hawaii Cancer Care Inc - Waterfront Plaza | Honolulu, Hawaii, 96813, United States Recruiting Site Public Contact 808-524-6115 [email protected] Kenneth N. Sumida Principal Investigator
Queen's Cancer Cenrer - POB I | Honolulu, Hawaii, 96813, United States Recruiting Site Public Contact 808-532-0315 Kenneth N. Sumida Principal Investigator
Queen's Medical Center | Honolulu, Hawaii, 96813, United States Recruiting Site Public Contact 808-545-8548 Kenneth N. Sumida Principal Investigator
Straub Clinic and Hospital | Honolulu, Hawaii, 96813, United States Recruiting Site Public Contact 808-522-4333 Kenneth N. Sumida Principal Investigator
Kuakini Medical Center | Honolulu, Hawaii, 96817, United States Recruiting Site Public Contact 808-547-9816 Kenneth N. Sumida Principal Investigator
Queen's Cancer Center - Kuakini | Honolulu, Hawaii, 96817, United States Recruiting Site Public Contact 808-531-8521 Kenneth N. Sumida Principal Investigator
The Cancer Center of Hawaii-Liliha | Honolulu, Hawaii, 96817, United States Recruiting Site Public Contact 808-547-6881 Kenneth N. Sumida Principal Investigator
Saint Alphonsus Cancer Care Center-Boise | Boise, Idaho, 83706, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Boise | Boise, Idaho, 83712, United States Recruiting Site Public Contact 208-381-2774 [email protected] Krishna C. Alluri Principal Investigator
Saint Alphonsus Cancer Care Center-Caldwell | Caldwell, Idaho, 83605, United States Recruiting Site Public Contact 734-712-3671 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Fruitland | Fruitland, Idaho, 83619, United States Recruiting Site Public Contact 208-381-2774 [email protected] Krishna C. Alluri Principal Investigator
Saint Luke's Cancer Institute - Meridian | Meridian, Idaho, 83642, United States Recruiting Site Public Contact 208-381-2774 [email protected] Krishna C. Alluri Principal Investigator
Saint Alphonsus Medical Center-Nampa | Nampa, Idaho, 83686, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint Luke's Cancer Institute - Nampa | Nampa, Idaho, 83686, United States Recruiting Site Public Contact 208-381-2774 [email protected] Krishna C. Alluri Principal Investigator
Saint Luke's Cancer Institute - Twin Falls | Twin Falls, Idaho, 83301, United States Recruiting Site Public Contact 208-381-2774 [email protected] Krishna C. Alluri Principal Investigator
Alton Memorial Hospital | Alton, Illinois, 62002, United States Recruiting Site Public Contact 618-463-7323 Clifford G. Robinson Principal Investigator
Rush - Copley Medical Center | Aurora, Illinois, 60504, United States Recruiting Site Public Contact 630-978-6212 [email protected] Priyank P. Patel Principal Investigator
Illinois CancerCare-Bloomington | Bloomington, Illinois, 61704, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Canton | Canton, Illinois, 61520, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Carthage | Carthage, Illinois, 62321, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Northwestern University | Chicago, Illinois, 60611, United States Recruiting Site Public Contact 312-695-1301 [email protected] Nisha A. Mohindra Principal Investigator
Rush University Medical Center | Chicago, Illinois, 60612, United States Recruiting Site Public Contact 312-942-5498 [email protected] Gaurav Marwaha Principal Investigator
University of Illinois | Chicago, Illinois, 60612, United States Recruiting Site Public Contact 312-355-3046 Lawrence E. Feldman Principal Investigator
Carle on Vermilion | Danville, Illinois, 61832, United States Recruiting Site Public Contact 800-446-5532 [email protected] Priyank P. Patel Principal Investigator
Decatur Memorial Hospital | Decatur, Illinois, 62526, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
Carle Physician Group-Effingham | Effingham, Illinois, 62401, United States Recruiting Site Public Contact 800-446-5532 [email protected] Priyank P. Patel Principal Investigator
Crossroads Cancer Center | Effingham, Illinois, 62401, United States Recruiting Site Public Contact 217-876-4762 [email protected] Bryan A. Faller Principal Investigator
Elmhurst Memorial Hospital | Elmhurst, Illinois, 60126, United States Recruiting Site Public Contact 630-758-5460 [email protected] Brian C. Myre Principal Investigator
Illinois CancerCare-Eureka | Eureka, Illinois, 61530, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Galesburg | Galesburg, Illinois, 61401, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Western Illinois Cancer Treatment Center | Galesburg, Illinois, 61401, United States Recruiting Site Public Contact 309-344-2831 Bryan A. Faller Principal Investigator
Ingalls Memorial Hospital | Harvey, Illinois, 60426, United States Recruiting Site Public Contact 708-915-4673 [email protected] James A. Wallace Principal Investigator
Illinois CancerCare-Kewanee Clinic | Kewanee, Illinois, 61443, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Northwestern Medicine Lake Forest Hospital | Lake Forest, Illinois, 60045, United States Recruiting Site Public Contact [email protected] Nisha A. Mohindra Principal Investigator
Illinois CancerCare-Macomb | Macomb, Illinois, 61455, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Carle Physician Group-Mattoon/Charleston | Mattoon, Illinois, 61938, United States Recruiting Site Public Contact 800-446-5532 [email protected] Priyank P. Patel Principal Investigator
Loyola University Medical Center | Maywood, Illinois, 60153, United States Recruiting Site Public Contact 708-226-4357 Matthew M. Harkenrider Principal Investigator
Good Samaritan Regional Health Center | Mount Vernon, Illinois, 62864, United States Recruiting Site Public Contact 618-242-4600 Jay W. Carlson Principal Investigator
Edward Hospital/Cancer Center | Naperville, Illinois, 60540, United States Recruiting Site Public Contact 630-646-6075 Brian C. Myre Principal Investigator
Illinois CancerCare-Ottawa Clinic | Ottawa, Illinois, 61350, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Pekin | Pekin, Illinois, 61554, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Peoria | Peoria, Illinois, 61615, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
OSF Saint Francis Radiation Oncology at Peoria Cancer Center | Peoria, Illinois, 61615, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Methodist Medical Center of Illinois | Peoria, Illinois, 61636, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
OSF Saint Francis Medical Center | Peoria, Illinois, 61637, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Illinois CancerCare-Peru | Peru, Illinois, 61354, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Edward Hospital/Cancer Center?Plainfield | Plainfield, Illinois, 60585, United States Recruiting Site Public Contact 630-646-6075 [email protected] Brian C. Myre Principal Investigator
Illinois CancerCare-Princeton | Princeton, Illinois, 61356, United States Recruiting Site Public Contact 309-243-3605 [email protected] Bryan A. Faller Principal Investigator
Memorial Medical Center | Springfield, Illinois, 62781, United States Recruiting Site Public Contact 217-788-3528 Bryan A. Faller Principal Investigator
Carle Cancer Center | Urbana, Illinois, 61801, United States Recruiting Site Public Contact 800-446-5532 [email protected] Priyank P. Patel Principal Investigator
Midwestern Regional Medical Center | Zion, Illinois, 60099, United States Recruiting Site Public Contact 412-339-5294 [email protected] Bruce Gershenhorn Principal Investigator
IU Health North Hospital | Carmel, Indiana, 46032, United States Recruiting Site Public Contact 317-278-5632 [email protected] Greg Durm Principal Investigator
Parkview Regional Medical Center | Fort Wayne, Indiana, 46845, United States Recruiting Site Public Contact 877-784-4673 Takefumi Komiya Principal Investigator
Goshen Center for Cancer Care | Goshen, Indiana, 46526, United States Recruiting Site Public Contact 574-364-2973 [email protected] Ebenezer A. Kio Principal Investigator
Indiana University/Melvin and Bren Simon Cancer Center | Indianapolis, Indiana, 46202, United States Recruiting Site Public Contact 317-278-5632 [email protected] Greg Durm Principal Investigator
Community Cancer Center East | Indianapolis, Indiana, 46219, United States Recruiting Site Public Contact 317-497-2823 [email protected] Daniel W. Weed Principal Investigator
Community Cancer Center South | Indianapolis, Indiana, 46227, United States Recruiting Site Public Contact 317-497-2823 [email protected] Daniel W. Weed Principal Investigator
Franciscan Health Indianapolis | Indianapolis, Indiana, 46237, United States Recruiting Site Public Contact 317-528-7060 Michael S. Eaton Principal Investigator
Community Cancer Center North | Indianapolis, Indiana, 46256, United States Recruiting Site Public Contact 317-497-2823 [email protected] Daniel W. Weed Principal Investigator
Community Howard Regional Health | Kokomo, Indiana, 46904, United States Recruiting Site Public Contact 765-453-8571 [email protected] Daniel W. Weed Principal Investigator
Franciscan Health Mooresville | Mooresville, Indiana, 46158, United States Recruiting Site Public Contact 317-834-3603 Michael S. Eaton Principal Investigator
Baptist Health Floyd | New Albany, Indiana, 47150, United States Recruiting Site Public Contact 412-339-5294 [email protected] Wangjian Zhong Principal Investigator
McFarland Clinic PC - Ames | Ames, Iowa, 50010, United States Recruiting Site Public Contact 515-239-4734 [email protected] Debra M. Prow Principal Investigator
Physicians' Clinic of Iowa PC | Cedar Rapids, Iowa, 52402, United States Recruiting Site Public Contact 319-297-2900 William P. Fusselman Principal Investigator
Mercy Hospital | Cedar Rapids, Iowa, 52403, United States Recruiting Site Public Contact 319-365-4673 Deborah W. Wilbur Principal Investigator
Oncology Associates at Mercy Medical Center | Cedar Rapids, Iowa, 52403, United States Recruiting Site Public Contact 319-363-2690 Deborah W. Wilbur Principal Investigator
Medical Oncology and Hematology Associates-West Des Moines | Clive, Iowa, 50325, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Mercy Cancer Center-West Lakes | Clive, Iowa, 50325, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Greater Regional Medical Center | Creston, Iowa, 50801, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Medical Oncology and Hematology Associates-Laurel | Des Moines, Iowa, 50314, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Mercy Medical Center - Des Moines | Des Moines, Iowa, 50314, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Mercy Medical Center-West Lakes | West Des Moines, Iowa, 50266, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
University of Kansas Cancer Center | Kansas City, Kansas, 66160, United States Recruiting Site Public Contact 913-588-3671 [email protected] Fen Wang Principal Investigator
Olathe Health Cancer Center | Olathe, Kansas, 66061, United States Recruiting Site Public Contact 913-355-8000 [email protected] Fen Wang Principal Investigator
University of Kansas Cancer Center-Overland Park | Overland Park, Kansas, 66210, United States Recruiting Site Public Contact 913-588-3671 [email protected] Fen Wang Principal Investigator
Salina Regional Health Center | Salina, Kansas, 67401, United States Recruiting Site Public Contact 785-452-7038 [email protected] Fen Wang Principal Investigator
University of Kansas Hospital-Westwood Cancer Center | Westwood, Kansas, 66205, United States Recruiting Site Public Contact 913-588-3671 [email protected] Fen Wang Principal Investigator
Ascension Via Christi Hospitals Wichita | Wichita, Kansas, 67214, United States Recruiting Site Public Contact 800-362-0070 [email protected] Shaker R. Dakhil Principal Investigator
Saint Elizabeth Medical Center South | Edgewood, Kentucky, 41017, United States Recruiting Site Public Contact 859-301-4725 [email protected] Colleen M. Darnell Principal Investigator
Baptist Health Lexington | Lexington, Kentucky, 40503, United States Suspended
Saint Joseph Hospital East | Lexington, Kentucky, 40509, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Norton Hospital Pavilion and Medical Campus | Louisville, Kentucky, 40202, United States Recruiting Site Public Contact 502-629-2500 [email protected] John T. Hamm Principal Investigator
The James Graham Brown Cancer Center at University of Louisville | Louisville, Kentucky, 40202, United States Recruiting Site Public Contact 502-562-3429 Neal E. Dunlap Principal Investigator
Baptist Health Louisville | Louisville, Kentucky, 40207, United States Recruiting Site Public Contact 502-897-8592 [email protected] Wangjian Zhong Principal Investigator
Norton Audubon Hospital and Medical Campus | Louisville, Kentucky, 40217, United States Recruiting Site Public Contact 502-629-3465 John T. Hamm Principal Investigator
Norton Brownsboro Hospital and Medical Campus | Louisville, Kentucky, 40241, United States Recruiting Site Public Contact 412-339-5294 [email protected] John T. Hamm Principal Investigator
Baptist Health Paducah | Paducah, Kentucky, 42003, United States Recruiting Site Public Contact 270-575-2928 Wangjian Zhong Principal Investigator
LSU Health Baton Rouge-North Clinic | Baton Rouge, Louisiana, 70805, United States Recruiting Site Public Contact 225-215-1353 [email protected] David S. Hanson Principal Investigator
Louisiana Hematology Oncology Associates LLC | Baton Rouge, Louisiana, 70809, United States Recruiting Site Public Contact 225-215-1353 [email protected] David S. Hanson Principal Investigator
Mary Bird Perkins Cancer Center | Baton Rouge, Louisiana, 70809, United States Recruiting Site Public Contact 225-215-1353 [email protected] David S. Hanson Principal Investigator
Our Lady of the Lake Physicians Group - Medical Oncology | Baton Rouge, Louisiana, 70809, United States Recruiting Site Public Contact 225-215-1353 [email protected] David S. Hanson Principal Investigator
Medical Center of Baton Rouge | Baton Rouge, Louisiana, 70816, United States Recruiting Site Public Contact 225-761-5346 [email protected] Suma P. Satti Principal Investigator
Mary Bird Perkins Cancer Center - Covington | Covington, Louisiana, 70433, United States Suspended
Mary Bird Perkins Cancer Center - Houma | Houma, Louisiana, 70360, United States Recruiting Site Public Contact 225-215-1353 [email protected] David S. Hanson Principal Investigator
Terrebonne General Medical Center | Houma, Louisiana, 70360, United States Recruiting Site Public Contact 985-850-6300 [email protected] David S. Hanson Principal Investigator
University Medical Center New Orleans | New Orleans, Louisiana, 70112, United States Recruiting Site Public Contact 504-210-3539 [email protected] Brian C. Boulmay Principal Investigator
Ochsner Medical Center Jefferson | New Orleans, Louisiana, 70121, United States Recruiting Site Public Contact 504-703-8712 [email protected] Suma P. Satti Principal Investigator
MaineHealth Coastal Cancer Treatment Center | Bath, Maine, 04530, United States Recruiting Site Public Contact 412-339-5294 [email protected] Matthew D. Cheney Principal Investigator
Waldo County General Hospital | Belfast, Maine, 04915, United States Recruiting Site Public Contact 207-338-2500 Matthew D. Cheney Principal Investigator
MaineHealth/SMHC Cancer Care and Blood Disorders-Biddeford | Biddeford, Maine, 04005, United States Recruiting Site Public Contact [email protected] Matthew D. Cheney Principal Investigator
Stephens Memorial Hospital | Norway, Maine, 04268, United States Recruiting Site Public Contact 207-396-8670 [email protected] Matthew D. Cheney Principal Investigator
Maine Medical Center-Bramhall Campus | Portland, Maine, 04102, United States Recruiting Site Public Contact 207-885-7565 Matthew D. Cheney Principal Investigator
Penobscot Bay Medical Center | Rockport, Maine, 04856, United States Recruiting Site Public Contact 207-396-8670 [email protected] Matthew D. Cheney Principal Investigator
MaineHealth Cancer Care Center of York County | Sanford, Maine, 04073, United States Recruiting Site Public Contact 207-459-1600 Matthew D. Cheney Principal Investigator
MaineHealth/SMHC Cancer Care and Blood Disorders-Sanford | Sanford, Maine, 04073, United States Recruiting Site Public Contact [email protected] Matthew D. Cheney Principal Investigator
Maine Medical Center- Scarborough Campus | Scarborough, Maine, 04074, United States Recruiting Site Public Contact 207-396-8090 [email protected] Matthew D. Cheney Principal Investigator
Maine Medical Partners - South Portland | South Portland, Maine, 04106, United States Recruiting Site Public Contact 207-396-8670 [email protected] Matthew D. Cheney Principal Investigator
University of Maryland/Greenebaum Cancer Center | Baltimore, Maryland, 21201, United States Recruiting Site Public Contact 800-888-8823 Pranshu Mohindra Principal Investigator
Saint Agnes Hospital | Baltimore, Maryland, 21229, United States Recruiting Site Public Contact 410-368-2910 Richard S. Hudes Principal Investigator
UM Upper Chesapeake Medical Center | Bel Air, Maryland, 21014, United States Suspended
Central Maryland Radiation Oncology in Howard County | Columbia, Maryland, 21044, United States Recruiting Site Public Contact 443-546-1300 Pranshu Mohindra Principal Investigator
UM Baltimore Washington Medical Center/Tate Cancer Center | Glen Burnie, Maryland, 21061, United States Recruiting Site Public Contact 410-553-8100 Pranshu Mohindra Principal Investigator
Dana-Farber Cancer Institute | Boston, Massachusetts, 02215, United States Recruiting Site Public Contact 877-442-3324 David E. Kozono Principal Investigator
UMass Memorial Medical Center - University Campus | Worcester, Massachusetts, 01655, United States Recruiting Site Public Contact 508-856-3216 [email protected] William V. Walsh Principal Investigator
Saint Joseph Mercy Hospital | Ann Arbor, Michigan, 48106, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Bronson Battle Creek | Battle Creek, Michigan, 49017, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
McLaren Cancer Institute-Bay City | Bay City, Michigan, 48706, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
Saint Joseph Mercy Brighton | Brighton, Michigan, 48114, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Saint Joseph Mercy Canton | Canton, Michigan, 48188, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Caro Cancer Center | Caro, Michigan, 48723, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Saint Joseph Mercy Chelsea | Chelsea, Michigan, 48118, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
GenesisCare USA - Clarkston | Clarkston, Michigan, 48346, United States Recruiting Site Public Contact 941-833-5700 [email protected] Frank A. Vicini Principal Investigator
McLaren Cancer Institute-Clarkston | Clarkston, Michigan, 48346, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
Henry Ford Macomb Hospital-Clinton Township | Clinton Township, Michigan, 48038, United States Recruiting Site Public Contact 313-916-3721 [email protected] Eleanor M. Walker Principal Investigator
Beaumont Hospital - Dearborn | Dearborn, Michigan, 48124, United States Recruiting Site Public Contact 248-551-7695 Inga S. Grills Principal Investigator
Henry Ford Hospital | Detroit, Michigan, 48202, United States Recruiting Site Public Contact 313-916-3721 [email protected] Eleanor M. Walker Principal Investigator
Ascension Saint John Hospital | Detroit, Michigan, 48236, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
GenesisCare USA - Farmington Hills | Farmington Hills, Michigan, 48334, United States Recruiting Site Public Contact 941-833-5700 [email protected] Frank A. Vicini Principal Investigator
Beaumont Hospital - Farmington Hills | Farmington Hills, Michigan, 48336, United States Recruiting Site Public Contact 248-551-7695 Inga S. Grills Principal Investigator
Genesys Hurley Cancer Institute | Flint, Michigan, 48503, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
McLaren Cancer Institute-Flint | Flint, Michigan, 48532, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
Singh and Arora Hematology Oncology PC | Flint, Michigan, 48532, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
Spectrum Health at Butterworth Campus | Grand Rapids, Michigan, 49503, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Allegiance Health | Jackson, Michigan, 49201, United States Recruiting Site Public Contact 313-916-3721 [email protected] Eleanor M. Walker Principal Investigator
West Michigan Cancer Center | Kalamazoo, Michigan, 49007, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
McLaren-Greater Lansing | Lansing, Michigan, 48910, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
Mid-Michigan Physicians-Lansing | Lansing, Michigan, 48912, United States Suspended
Sparrow Hospital | Lansing, Michigan, 48912, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
McLaren Cancer Institute-Lapeer Region | Lapeer, Michigan, 48446, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
GenesisCare USA - Macomb | Macomb, Michigan, 48044, United States Recruiting Site Public Contact 941-833-5700 [email protected] Frank A. Vicini Principal Investigator
GenesisCare USA - Madison Heights | Madison Heights, Michigan, 48071, United States Recruiting Site Public Contact 941-833-5700 [email protected] Frank A. Vicini Principal Investigator
McLaren Cancer Institute-Macomb | Mount Clemens, Michigan, 48043, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
Ascension Providence Hospitals - Novi | Novi, Michigan, 48374, United States Recruiting Site Public Contact 248-849-5332 [email protected] Adam M. Forman Principal Investigator
McLaren Cancer Institute-Northern Michigan | Petoskey, Michigan, 49770, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
21st Century Oncology-Pontiac | Pontiac, Michigan, 48341, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
McLaren-Port Huron | Port Huron, Michigan, 48060, United States Recruiting Site Public Contact 313-576-9790 [email protected] Amit K. Bhatt Principal Investigator
William Beaumont Hospital-Royal Oak | Royal Oak, Michigan, 48073, United States Recruiting Site Public Contact 248-551-7695 Inga S. Grills Principal Investigator
Ascension Saint Mary's Hospital | Saginaw, Michigan, 48601, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Oncology Hematology Associates of Saginaw Valley PC | Saginaw, Michigan, 48604, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Lakeland Medical Center Saint Joseph | Saint Joseph, Michigan, 49085, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Marie Yeager Cancer Center | Saint Joseph, Michigan, 49085, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Henry Ford Macomb Health Center - Shelby Township | Shelby, Michigan, 48315, United States Recruiting Site Public Contact 313-916-1784 [email protected] Eleanor M. Walker Principal Investigator
Ascension Providence Hospitals - Southfield | Southfield, Michigan, 48075, United States Recruiting Site Public Contact 248-849-5332 [email protected] Adam M. Forman Principal Investigator
Ascension Saint Joseph Hospital | Tawas City, Michigan, 48764, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
William Beaumont Hospital - Troy | Troy, Michigan, 48085, United States Recruiting Site Public Contact 248-551-7695 Inga S. Grills Principal Investigator
GenesisCare USA - Troy | Troy, Michigan, 48098, United States Recruiting Site Public Contact 941-833-5700 [email protected] Frank A. Vicini Principal Investigator
Saint John Macomb-Oakland Hospital | Warren, Michigan, 48093, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Saint Mary's Oncology/Hematology Associates of West Branch | West Branch, Michigan, 48661, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Metro Health Hospital | Wyoming, Michigan, 49519, United States Recruiting Site Public Contact 616-391-1230 [email protected] Kathleen J. Yost Principal Investigator
Mayo Clinic Health System in Albert Lea | Albert Lea, Minnesota, 56007, United States Recruiting Site Public Contact 855-776-0015 Konstantinos Leventakos Principal Investigator
Sanford Joe Lueken Cancer Center | Bemidji, Minnesota, 56601, United States Recruiting Site Public Contact 218-333-5000 [email protected] Preston D. Steen Principal Investigator
Fairview Ridges Hospital | Burnsville, Minnesota, 55337, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
Saint Luke's Hospital of Duluth | Duluth, Minnesota, 55805, United States Suspended
Fairview Southdale Hospital | Edina, Minnesota, 55435, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
Unity Hospital | Fridley, Minnesota, 55432, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
Mayo Clinic Health Systems-Mankato | Mankato, Minnesota, 56001, United States Recruiting Site Public Contact 855-776-0015 Konstantinos Leventakos Principal Investigator
Minnesota Oncology Hematology PA-Maplewood | Maplewood, Minnesota, 55109, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
Abbott-Northwestern Hospital | Minneapolis, Minnesota, 55407, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
Hennepin County Medical Center | Minneapolis, Minnesota, 55415, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
North Memorial Medical Health Center | Robbinsdale, Minnesota, 55422, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
Mayo Clinic in Rochester | Rochester, Minnesota, 55905, United States Recruiting Site Public Contact 855-776-0015 Konstantinos Leventakos Principal Investigator
Coborn Cancer Center at Saint Cloud Hospital | Saint Cloud, Minnesota, 56303, United States Recruiting Site Public Contact 877-229-4907 [email protected] Donald J. Jurgens Principal Investigator
Park Nicollet Clinic - Saint Louis Park | Saint Louis Park, Minnesota, 55416, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
Regions Hospital | Saint Paul, Minnesota, 55101, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
Baptist Cancer Center-Grenada | Grenada, Mississippi, 38901, United States Recruiting Site Public Contact 901-226-1366 BC[email protected] Raymond U. Osarogiagbon Principal Investigator
Baptist Memorial Hospital and Cancer Center-Union County | New Albany, Mississippi, 38652, United States Recruiting Site Public Contact 901-226-1366 [email protected] Raymond U. Osarogiagbon Principal Investigator
Baptist Memorial Hospital and Cancer Center-Oxford | Oxford, Mississippi, 38655, United States Recruiting Site Public Contact 901-226-1366 [email protected] Raymond U. Osarogiagbon Principal Investigator
Baptist Memorial Hospital and Cancer Center-Desoto | Southhaven, Mississippi, 38671, United States Recruiting Site Public Contact 901-226-1366 [email protected] Raymond U. Osarogiagbon Principal Investigator
Parkland Health Center-Bonne Terre | Bonne Terre, Missouri, 63628, United States Suspended
Saint Francis Medical Center | Cape Girardeau, Missouri, 63703, United States Recruiting Site Public Contact 573-334-2230 [email protected] Bryan A. Faller Principal Investigator
Saint Luke's Hospital | Chesterfield, Missouri, 63017, United States Recruiting Site Public Contact 314-205-6936 Joseph Sokhn Principal Investigator
Siteman Cancer Center at West County Hospital | Creve Coeur, Missouri, 63141, United States Recruiting Site Public Contact 800-600-3606 [email protected] Clifford G. Robinson Principal Investigator
Parkland Health Center - Farmington | Farmington, Missouri, 63640, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Capital Region Southwest Campus | Jefferson City, Missouri, 65109, United States Suspended
Freeman Health System | Joplin, Missouri, 64804, United States Recruiting Site Public Contact 417-347-4030 [email protected] Jay W. Carlson Principal Investigator
University of Kansas Cancer Center - North | Kansas City, Missouri, 64154, United States Recruiting Site Public Contact 913-588-3671 [email protected] Fen Wang Principal Investigator
University of Kansas Cancer Center - Lee's Summit | Lee's Summit, Missouri, 64064, United States Recruiting Site Public Contact 913-588-3671 [email protected] Fen Wang Principal Investigator
University of Kansas Cancer Center at North Kansas City Hospital | North Kansas City, Missouri, 64116, United States Recruiting Site Public Contact 913-588-3671 [email protected] Fen Wang Principal Investigator
Delbert Day Cancer Institute at PCRMC | Rolla, Missouri, 65401, United States Suspended
Heartland Regional Medical Center | Saint Joseph, Missouri, 64506, United States Recruiting Site Public Contact 816-271-7937 [email protected] Jay W. Carlson Principal Investigator
Washington University School of Medicine | Saint Louis, Missouri, 63110, United States Recruiting Site Public Contact 800-600-3606 [email protected] Clifford G. Robinson Principal Investigator
Siteman Cancer Center-South County | Saint Louis, Missouri, 63129, United States Recruiting Site Public Contact 800-600-3606 [email protected] Clifford G. Robinson Principal Investigator
Missouri Baptist Medical Center | Saint Louis, Missouri, 63131, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Siteman Cancer Center at Christian Hospital | Saint Louis, Missouri, 63136, United States Recruiting Site Public Contact 800-600-3606 [email protected] Clifford G. Robinson Principal Investigator
Mercy Hospital Saint Louis | Saint Louis, Missouri, 63141, United States Recruiting Site Public Contact 314-251-7066 Jay W. Carlson Principal Investigator
Siteman Cancer Center at Saint Peters Hospital | Saint Peters, Missouri, 63376, United States Recruiting Site Public Contact 800-600-3606 [email protected] Clifford G. Robinson Principal Investigator
Sainte Genevieve County Memorial Hospital | Sainte Genevieve, Missouri, 63670, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Mercy Hospital Springfield | Springfield, Missouri, 65804, United States Recruiting Site Public Contact 417-269-4520 Jay W. Carlson Principal Investigator
CoxHealth South Hospital | Springfield, Missouri, 65807, United States Recruiting Site Public Contact 417-269-4520 Jay W. Carlson Principal Investigator
Missouri Baptist Sullivan Hospital | Sullivan, Missouri, 63080, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Missouri Baptist Outpatient Center-Sunset Hills | Sunset Hills, Missouri, 63127, United States Recruiting Site Public Contact 314-996-5569 Bryan A. Faller Principal Investigator
Billings Clinic Cancer Center | Billings, Montana, 59101, United States Recruiting Site Public Contact 800-996-2663 [email protected] John M. Schallenkamp Principal Investigator
Bozeman Deaconess Hospital | Bozeman, Montana, 59715, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
Saint James Community Hospital and Cancer Treatment Center | Butte, Montana, 59701, United States Recruiting Site Public Contact 406-723-2621 Marwan Massouh Principal Investigator
Kalispell Regional Medical Center | Kalispell, Montana, 59901, United States Recruiting Site Public Contact 406-969-6060 [email protected] John M. Schallenkamp Principal Investigator
CHI Health Saint Francis | Grand Island, Nebraska, 68803, United States Suspended
CHI Health Good Samaritan | Kearney, Nebraska, 68847, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Cancer Partners of Nebraska - Pine Lake | Lincoln, Nebraska, 68516, United States Recruiting Site Public Contact 402-327-7363 [email protected] Mark J. Stavas Principal Investigator
Southeast Nebraska Cancer Center - 68th Street Place | Lincoln, Nebraska, 68516, United States Recruiting Site Public Contact 402-327-7363 [email protected] Mark J. Stavas Principal Investigator
Nebraska Methodist Hospital | Omaha, Nebraska, 68114, United States Recruiting Site Public Contact 402-354-5144 Timothy Dorius Principal Investigator
Alegent Health Immanuel Medical Center | Omaha, Nebraska, 68122, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
Alegent Health Bergan Mercy Medical Center | Omaha, Nebraska, 68124, United States Recruiting Site Public Contact 308-398-6518 [email protected] Richard L. Deming Principal Investigator
OptumCare Cancer Care at Charleston | Las Vegas, Nevada, 89102, United States Recruiting Site Public Contact 702-384-0013 [email protected] John A. Ellerton Principal Investigator
Radiation Oncology Centers of Nevada Central | Las Vegas, Nevada, 89106, United States Recruiting Site Public Contact 702-384-0013 [email protected] John A. Ellerton Principal Investigator
Radiation Oncology Centers of Nevada Southeast | Las Vegas, Nevada, 89119, United States Recruiting Site Public Contact 702-384-0013 [email protected] John A. Ellerton Principal Investigator
OptumCare Cancer Care at Fort Apache | Las Vegas, Nevada, 89148, United States Recruiting Site Public Contact 702-384-0013 [email protected] John A. Ellerton Principal Investigator
Renown Regional Medical Center | Reno, Nevada, 89502, United States Suspended
New Hampshire Oncology Hematology PA-Concord | Concord, New Hampshire, 03301, United States Recruiting Site Public Contact 603-224-2556 Douglas J. Weckstein Principal Investigator
Dartmouth Hitchcock Medical Center | Lebanon, New Hampshire, 03756, United States Recruiting Site Public Contact 800-639-6918 [email protected] Gregory A. Russo Principal Investigator
Solinsky Center for Cancer Care | Manchester, New Hampshire, 03103, United States Recruiting Site Public Contact 800-339-6484 Douglas J. Weckstein Principal Investigator
Ocean Medical Center | Brick, New Jersey, 08724, United States Recruiting Site Public Contact 732-206-8384 Jatin Desani Principal Investigator
The Cancer Institute of New Jersey Hamilton | Hamilton, New Jersey, 08690, United States Recruiting Site Public Contact 609-631-6946 Salma K. Jabbour Principal Investigator
Southern Ocean County Medical Center | Manahawkin, New Jersey, 08050, United States Recruiting Site Public Contact 609-978-3429 Jatin Desani Principal Investigator
Jersey Shore Medical Center | Neptune, New Jersey, 07753, United States Recruiting Site Public Contact 732-776-4240 Jatin Desani Principal Investigator
Rutgers Cancer Institute of New Jersey | New Brunswick, New Jersey, 08903, United States Recruiting Site Public Contact 732-235-7356 Salma K. Jabbour Principal Investigator
Capital Health Medical Center-Hopewell | Pennington, New Jersey, 08534, United States Recruiting Site Public Contact 609-394-4130 [email protected] Khanh Nguyen Principal Investigator
Riverview Medical Center/Booker Cancer Center | Red Bank, New Jersey, 07701, United States Recruiting Site Public Contact 732-530-2382 Jatin Desani Principal Investigator
Robert Wood Johnson University Hospital Somerset | Somerville, New Jersey, 08876, United States Recruiting Site Public Contact 908-685-2481 [email protected] Salma K. Jabbour Principal Investigator
University of New Mexico Cancer Center | Albuquerque, New Mexico, 87102, United States Recruiting Site Public Contact 505-925-0366 [email protected] Atul Kumar Principal Investigator
Montefiore Medical Center-Einstein Campus | Bronx, New York, 10461, United States Recruiting Site Public Contact 718-379-6866 [email protected] Nitin Ohri Principal Investigator
Montefiore Medical Center - Moses Campus | Bronx, New York, 10467, United States Recruiting Site Public Contact 718-379-6866 [email protected] Nitin Ohri Principal Investigator
Arnot Ogden Medical Center/Falck Cancer Center | Elmira, New York, 14905, United States Active, not recruiting
Glens Falls Hospital | Glens Falls, New York, 12801, United States Recruiting Site Public Contact 518-926-6700 Christopher J. Anker Principal Investigator
Mount Sinai Chelsea | New York, New York, 10011, United States Recruiting Site Public Contact 212-824-7309 [email protected] Pinaki R. Dutta Principal Investigator
Mount Sinai West | New York, New York, 10019, United States Recruiting Site Public Contact 212-824-7309 [email protected] Pinaki R. Dutta Principal Investigator
Mount Sinai Hospital | New York, New York, 10029, United States Recruiting Site Public Contact 212-824-7309 [email protected] Pinaki R. Dutta Principal Investigator
University of Rochester | Rochester, New York, 14642, United States Recruiting Site Public Contact 585-275-5830 Yuhchyau Chen Principal Investigator
State University of New York Upstate Medical University | Syracuse, New York, 13210, United States Recruiting Site Public Contact 315-464-5476 Stephen L. Graziano Principal Investigator
Atrium Health Stanly/LCI-Albemarle | Albemarle, North Carolina, 28002, United States Recruiting Site Public Contact 800-804-9376 Daniel R. Carrizosa Principal Investigator
Randolph Hospital | Asheboro, North Carolina, 27203, United States Recruiting Site Public Contact 336-832-0836 [email protected] Vinay K. Gudena Principal Investigator
Messino Cancer Centers | Asheville, North Carolina, 28806, United States Recruiting Site Public Contact 828-212-7021 [email protected] Christopher H. Chay Principal Investigator
Cone Health Cancer Center at Alamance Regional | Burlington, North Carolina, 27215, United States Recruiting Site Public Contact 336-538-7725 [email protected] Vinay K. Gudena Principal Investigator
Carolinas Medical Center/Levine Cancer Institute | Charlotte, North Carolina, 28203, United States Recruiting Site Public Contact 800-804-9376 Daniel R. Carrizosa Principal Investigator
Atrium Health Pineville/LCI-Pineville | Charlotte, North Carolina, 28210, United States Recruiting Site Public Contact 980-442-2000 Daniel R. Carrizosa Principal Investigator
Levine Cancer Institute-SouthPark | Charlotte, North Carolina, 28211, United States Recruiting Site Public Contact 980-442-2000 Daniel R. Carrizosa Principal Investigator
Atrium Health University City/LCI-University | Charlotte, North Carolina, 28262, United States Recruiting Site Public Contact 800-804-9376 Daniel R. Carrizosa Principal Investigator
Levine Cancer Institute-Ballantyne | Charlotte, North Carolina, 28277, United States Recruiting Site Public Contact 800-804-9376 Daniel R. Carrizosa Principal Investigator
Atrium Health Cabarrus/LCI-Concord | Concord, North Carolina, 28025, United States Recruiting Site Public Contact 800-804-9376 Daniel R. Carrizosa Principal Investigator
Cone Health Cancer Center | Greensboro, North Carolina, 27403, United States Recruiting Site Public Contact 336-832-0821 [email protected] Vinay K. Gudena Principal Investigator
Margaret R Pardee Memorial Hospital | Hendersonville, North Carolina, 28791, United States Recruiting Site Public Contact 828-696-4716 [email protected] James E. Radford Principal Investigator
Novant Health Cancer Institute - Kernersville | Kernersville, North Carolina, 27284, United States Recruiting Site Public Contact 336-718-8335 [email protected] Garrett B. Sherwood Principal Investigator
Atrium Health Union/LCI-Union | Monroe, North Carolina, 28112, United States Recruiting Site Public Contact 980-442-2000 Daniel R. Carrizosa Principal Investigator
Novant Health Cancer Institute - Mount Airy | Mount Airy, North Carolina, 27030, United States Suspended
FirstHealth of the Carolinas-Moore Regional Hospital | Pinehurst, North Carolina, 28374, United States Recruiting Site Public Contact 910-715-3500 [email protected] Charles S. Kuzma Principal Investigator
Novant Health Cancer Institute - Statesville | Statesville, North Carolina, 28625, United States Suspended
Novant Health Cancer Institute - Thomasville | Thomasville, North Carolina, 27360, United States Suspended
Novant Health Cancer Institute - Wilkesboro | Wilkesboro, North Carolina, 28659, United States Suspended
Novant Health Forsyth Medical Center | Winston-Salem, North Carolina, 27103, United States Recruiting Site Public Contact 336-718-8335 [email protected] Garrett B. Sherwood Principal Investigator
Wake Forest University Health Sciences | Winston-Salem, North Carolina, 27157, United States Recruiting Site Public Contact 336-713-6771 Michael K. Farris Principal Investigator
Sanford Bismarck Medical Center | Bismarck, North Dakota, 58501, United States Recruiting Site Public Contact 701-323-5760 [email protected] Preston D. Steen Principal Investigator
Sanford Roger Maris Cancer Center | Fargo, North Dakota, 58122, United States Recruiting Site Public Contact 701-234-6161 [email protected] Preston D. Steen Principal Investigator
Altru Cancer Center | Grand Forks, North Dakota, 58201, United States Recruiting Site Public Contact 701-780-6520 Grant R. Seeger Principal Investigator
Trinity Cancer Care Center | Minot, North Dakota, 58701, United States Recruiting Site Public Contact 800-862-0005 Patanit Watanaboonyakhet Principal Investigator
Summa Health System - Akron Campus | Akron, Ohio, 44304, United States Recruiting Site Public Contact 330-375-4221 [email protected] Bradley T. Clifford Principal Investigator
UHHS-Chagrin Highlands Medical Center | Beachwood, Ohio, 44122, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
Cleveland Clinic Mercy Hospital | Canton, Ohio, 44708, United States Recruiting Site Public Contact 888-293-4673 Mitchell Haut Principal Investigator
Aultman Health Foundation | Canton, Ohio, 44710, United States Recruiting Site Public Contact 330-363-7274 [email protected] Shruti Trehan Principal Investigator
Geauga Hospital | Chardon, Ohio, 44024, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
Adena Regional Medical Center | Chillicothe, Ohio, 45601, United States Recruiting Site Public Contact 877-779-7585 [email protected] Timothy D. Moore Principal Investigator
University of Cincinnati Cancer Center-UC Medical Center | Cincinnati, Ohio, 45219, United States Recruiting Site Public Contact 513-584-7698 [email protected] Emily C. Daugherty Principal Investigator
Case Western Reserve University | Cleveland, Ohio, 44106, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
MetroHealth Medical Center | Cleveland, Ohio, 44109, United States Recruiting Site Public Contact 216-778-8526 [email protected] William Tse Principal Investigator
Cleveland Clinic Cancer Center/Fairview Hospital | Cleveland, Ohio, 44111, United States Recruiting Site Public Contact 866-223-8100 [email protected] Gregory M. M. Videtic Principal Investigator
Cleveland Clinic Foundation | Cleveland, Ohio, 44195, United States Recruiting Site Public Contact 866-223-8100 [email protected] Gregory M. M. Videtic Principal Investigator
Ohio State University Comprehensive Cancer Center | Columbus, Ohio, 43210, United States Recruiting Site Public Contact 800-293-5066 [email protected] Meng X. Welliver Principal Investigator
Mount Carmel East Hospital | Columbus, Ohio, 43213, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Riverside Methodist Hospital | Columbus, Ohio, 43214, United States Recruiting Site Public Contact 614-566-4475 [email protected] Timothy D. Moore Principal Investigator
Grant Medical Center | Columbus, Ohio, 43215, United States Recruiting Site Public Contact 614-566-4475 [email protected] Timothy D. Moore Principal Investigator
The Mark H Zangmeister Center | Columbus, Ohio, 43219, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
Mount Carmel Health Center West | Columbus, Ohio, 43222, United States Recruiting Site Public Contact 614-234-5433 [email protected] Timothy D. Moore Principal Investigator
Doctors Hospital | Columbus, Ohio, 43228, United States Recruiting Site Public Contact 614-566-3275 [email protected] Timothy D. Moore Principal Investigator
Delaware Health Center-Grady Cancer Center | Delaware, Ohio, 43015, United States Recruiting Site Public Contact 740-615-0227 [email protected] Timothy D. Moore Principal Investigator
OhioHealth Mansfield Hospital | Mansfield, Ohio, 44903, United States Recruiting Site Public Contact 419-526-8018 [email protected] Timothy D. Moore Principal Investigator
Cleveland Clinic Cancer Center Mansfield | Mansfield, Ohio, 44906, United States Recruiting Site Public Contact 866-223-8100 [email protected] Gregory M. M. Videtic Principal Investigator
Marietta Memorial Hospital | Marietta, Ohio, 45750, United States Recruiting Site Public Contact 800-523-3977 [email protected] Timothy D. Moore Principal Investigator
Hillcrest Hospital Cancer Center | Mayfield Heights, Ohio, 44124, United States Recruiting Site Public Contact 866-223-8100 [email protected] Gregory M. M. Videtic Principal Investigator
UH Seidman Cancer Center at Lake Health Mentor Campus | Mentor, Ohio, 44060, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
UH Seidman Cancer Center at Southwest General Hospital | Middleburg Heights, Ohio, 44130, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
Licking Memorial Hospital | Newark, Ohio, 43055, United States Recruiting Site Public Contact 740-348-4000 [email protected] Timothy D. Moore Principal Investigator
University Hospitals Parma Medical Center | Parma, Ohio, 44129, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
Southern Ohio Medical Center | Portsmouth, Ohio, 45662, United States Recruiting Site Public Contact 614-488-2118 [email protected] Timothy D. Moore Principal Investigator
University Hospitals Portage Medical Center | Ravenna, Ohio, 44266, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
North Coast Cancer Care | Sandusky, Ohio, 44870, United States Recruiting Site Public Contact 866-223-8100 [email protected] Gregory M. M. Videtic Principal Investigator
UH Seidman Cancer Center at Firelands Regional Medical Center | Sandusky, Ohio, 44870, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
Cleveland Clinic Cancer Center Strongsville | Strongsville, Ohio, 44136, United States Recruiting Site Public Contact 866-223-8100 [email protected] Gregory M. M. Videtic Principal Investigator
University Hospitals Sharon Health Center | Wadsworth, Ohio, 44281, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
University of Cincinnati Cancer Center-West Chester | West Chester, Ohio, 45069, United States Recruiting Site Public Contact 513-584-7698 [email protected] Emily C. Daugherty Principal Investigator
UH Seidman Cancer Center at Saint John Medical Center | Westlake, Ohio, 44145, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
UHHS-Westlake Medical Center | Westlake, Ohio, 44145, United States Recruiting Site Public Contact 800-641-2422 [email protected] Tithi Biswas Principal Investigator
Cleveland Clinic Wooster Family Health and Surgery Center | Wooster, Ohio, 44691, United States Recruiting Site Public Contact 866-223-8100 [email protected] Gregory M. M. Videtic Principal Investigator
Genesis Healthcare System Cancer Care Center | Zanesville, Ohio, 43701, United States Recruiting Site Public Contact 740-454-5232 [email protected] Timothy D. Moore Principal Investigator
Cancer Centers of Southwest Oklahoma Research | Lawton, Oklahoma, 73505, United States Recruiting Site Public Contact 877-231-4440 Raid Aljumaily Principal Investigator
University of Oklahoma Health Sciences Center | Oklahoma City, Oklahoma, 73104, United States Recruiting Site Public Contact 405-271-8777 [email protected] Raid Aljumaily Principal Investigator
Mercy Hospital Oklahoma City | Oklahoma City, Oklahoma, 73120, United States Recruiting Site Public Contact 405-752-3402 Jay W. Carlson Principal Investigator
Cancer Treatment Centers of America | Tulsa, Oklahoma, 74133, United States Active, not recruiting
Legacy Mount Hood Medical Center | Gresham, Oregon, 97030, United States Recruiting Site Public Contact 503-413-2150 Andrew Y. Kee Principal Investigator
Providence Newberg Medical Center | Newberg, Oregon, 97132, United States Recruiting Site Public Contact 503-215-2614 [email protected] Krishna C. Alluri Principal Investigator
Legacy Good Samaritan Hospital and Medical Center | Portland, Oregon, 97210, United States Recruiting Site Public Contact 800-220-4937 [email protected] Andrew Y. Kee Principal Investigator
Providence Portland Medical Center | Portland, Oregon, 97213, United States Suspended
Providence Saint Vincent Medical Center | Portland, Oregon, 97225, United States Recruiting Site Public Contact 503-215-2614 [email protected] Krishna C. Alluri Principal Investigator
Lehigh Valley Hospital-Cedar Crest | Allentown, Pennsylvania, 18103, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Lehigh Valley Hospital - Muhlenberg | Bethlehem, Pennsylvania, 18017, United States Recruiting Site Public Contact 734-712-3671 [email protected] Christopher M. Reynolds Principal Investigator
Crozer-Keystone Regional Cancer Center at Broomall | Broomall, Pennsylvania, 19008, United States Recruiting Site Public Contact 610-284-8237 [email protected] Rachelle M. Lanciano Principal Investigator
Bryn Mawr Hospital | Bryn Mawr, Pennsylvania, 19010, United States Recruiting Site Public Contact 484-476-2649 [email protected] Albert S. DeNittis Principal Investigator
Christiana Care Health System-Concord Health Center | Chadds Ford, Pennsylvania, 19317, United States Recruiting Site Public Contact 302-623-4450 [email protected] Gregory A. Masters Principal Investigator
Geisinger Medical Center | Danville, Pennsylvania, 17822, United States Recruiting Site Public Contact 570-271-5251 [email protected] Raghava Reddy Levaka Veera Principal Investigator
Northeast Radiation Oncology Center | Dunmore, Pennsylvania, 18512, United States Suspended
Ephrata Cancer Center | Ephrata, Pennsylvania, 17522, United States Recruiting Site Public Contact 717-721-4840 Chanh T. Huynh Principal Investigator
Adams Cancer Center | Gettysburg, Pennsylvania, 17325, United States Recruiting Site Public Contact 877-441-7957 Chanh T. Huynh Principal Investigator
Crozer Regional Cancer Center at Brinton Lake | Glen Mills, Pennsylvania, 19342, United States Recruiting Site Public Contact 610-284-8237 Rachelle M. Lanciano Principal Investigator
Cherry Tree Cancer Center | Hanover, Pennsylvania, 17331, United States Suspended
Lancaster General Ann B Barshinger Cancer Institute | Lancaster, Pennsylvania, 17601, United States Recruiting Site Public Contact 717-544-0511 Samuel J. Kerr Principal Investigator
Lancaster General Hospital | Lancaster, Pennsylvania, 17602, United States Recruiting Site Public Contact 717-544-5511 Samuel J. Kerr Principal Investigator
Sechler Family Cancer Center | Lebanon, Pennsylvania, 17042, United States Recruiting Site Public Contact 717-741-8303 [email protected] Chanh T. Huynh Principal Investigator
Geisinger Medical Oncology-Lewisburg | Lewisburg, Pennsylvania, 17837, United States Recruiting Site Public Contact 570-374-8555 [email protected] Raghava Reddy Levaka Veera Principal Investigator
Riddle Memorial Hospital | Media, Pennsylvania, 19063, United States Recruiting Site Public Contact 484-476-2649 [email protected] Albert S. DeNittis Principal Investigator
Bryn Mawr Health Center | Newtown Square, Pennsylvania, 19073, United States Recruiting Site Public Contact 484-476-2649 [email protected] Albert S. DeNittis Principal Investigator
Paoli Memorial Hospital | Paoli, Pennsylvania, 19301, United States Recruiting Site Public Contact 484-476-2649 [email protected] Albert S. DeNittis Principal Investigator
Thomas Jefferson University Hospital | Philadelphia, Pennsylvania, 19107, United States Recruiting Site Public Contact 215-600-9151 [email protected] Maria Werner-Wasik Principal Investigator
Eastern Regional Medical Center | Philadelphia, Pennsylvania, 19124, United States Active, not recruiting
Guthrie Medical Group PC-Robert Packer Hospital | Sayre, Pennsylvania, 18840, United States Recruiting Site Public Contact 800-836-0388 Thomas J. Gergel Principal Investigator
Reading Hospital | West Reading, Pennsylvania, 19611, United States Recruiting Site Public Contact 610-988-9323 Terrence P. Cescon Principal Investigator
Geisinger Wyoming Valley/Henry Cancer Center | Wilkes-Barre, Pennsylvania, 18711, United States Recruiting Site Public Contact 570-271-5251 [email protected] Raghava Reddy Levaka Veera Principal Investigator
Lankenau Medical Center | Wynnewood, Pennsylvania, 19096, United States Recruiting Site Public Contact 484-476-2649 [email protected] Albert S. DeNittis Principal Investigator
WellSpan Health-York Cancer Center | York, Pennsylvania, 17403, United States Recruiting Site Public Contact 877-441-7957 Chanh T. Huynh Principal Investigator
Rhode Island Hospital | Providence, Rhode Island, 02903, United States Recruiting Site Public Contact 401-444-1488 Paul P. Koffer Principal Investigator
AnMed Health Cancer Center | Anderson, South Carolina, 29621, United States Recruiting Site Public Contact 864-512-4651 [email protected] Jay B. Nayak Principal Investigator
Saint Joseph's/Candler - Bluffton Campus | Bluffton, South Carolina, 29910, United States Recruiting Site Public Contact 912-819-5704 [email protected] Mark A. Taylor Principal Investigator
Medical University of South Carolina | Charleston, South Carolina, 29425, United States Recruiting Site Public Contact 843-792-9321 [email protected] John M. Wrangle Principal Investigator
Saint Francis Hospital | Greenville, South Carolina, 29601, United States Recruiting Site Public Contact 864-603-6213 [email protected] Robert D. Siegel Principal Investigator
Prisma Health Cancer Institute - Faris | Greenville, South Carolina, 29605, United States Recruiting Site Public Contact 864-522-2066 [email protected]g Ki Y. Chung Principal Investigator
Saint Francis Cancer Center | Greenville, South Carolina, 29607, United States Recruiting Site Public Contact 864-603-6213 [email protected] Robert D. Siegel Principal Investigator
Prisma Health Cancer Institute - Eastside | Greenville, South Carolina, 29615, United States Recruiting Site Public Contact 864-522-2066 [email protected] Ki Y. Chung Principal Investigator
Prisma Health Cancer Institute - Greer | Greer, South Carolina, 29650, United States Recruiting Site Public Contact 864-522-2066 [email protected] Ki Y. Chung Principal Investigator
Gibbs Cancer Center-Pelham | Greer, South Carolina, 29651, United States Recruiting Site Public Contact 864-560-6104 [email protected] Abderrahim Khomani Principal Investigator
South Carolina Cancer Specialists PC | Hilton Head Island, South Carolina, 29926-3827, United States Recruiting Site Public Contact 912-819-5704 [email protected] Mark A. Taylor Principal Investigator
The Radiation Oncology Center-Hilton Head/Bluffton | Hilton Head Island, South Carolina, 29926, United States Recruiting Site Public Contact 912-819-5704 [email protected] Mark A. Taylor Principal Investigator
Rock Hill Radiation Therapy Center | Rock Hill, South Carolina, 29730, United States Recruiting Site Public Contact 800-804-9376 Daniel R. Carrizosa Principal Investigator
Levine Cancer Institute-Rock Hill | Rock Hill, South Carolina, 29732, United States Recruiting Site Public Contact 800-804-9376 Daniel R. Carrizosa Principal Investigator
Prisma Health Cancer Institute - Seneca | Seneca, South Carolina, 29672, United States Recruiting Site Public Contact 864-522-2066 [email protected] Ki Y. Chung Principal Investigator
Spartanburg Medical Center | Spartanburg, South Carolina, 29303, United States Recruiting Site Public Contact 864-560-6104 [email protected] Abderrahim Khomani Principal Investigator
Rapid City Regional Hospital | Rapid City, South Dakota, 57701, United States Recruiting Site Public Contact 605-716-3982 [email protected] Michael J. Swartz Principal Investigator
Sanford Cancer Center Oncology Clinic | Sioux Falls, South Dakota, 57104, United States Recruiting Site Public Contact 605-312-3320 [email protected] Preston D. Steen Principal Investigator
Sanford USD Medical Center - Sioux Falls | Sioux Falls, South Dakota, 57117-5134, United States Recruiting Site Public Contact 605-312-3320 [email protected] Preston D. Steen Principal Investigator
Baptist Memorial Hospital and Cancer Center-Collierville | Collierville, Tennessee, 38017, United States Recruiting Site Public Contact 901-226-1366 [email protected] Raymond U. Osarogiagbon Principal Investigator
Thompson Cancer Survival Center | Knoxville, Tennessee, 37916, United States Recruiting Site Public Contact 865-331-1812 Grant M. Clark Principal Investigator
Baptist Memorial Hospital and Cancer Center-Memphis | Memphis, Tennessee, 38120, United States Recruiting Site Public Contact 901-226-1366 [email protected] Raymond U. Osarogiagbon Principal Investigator
MD Anderson in The Woodlands | Conroe, Texas, 77384, United States Recruiting Site Public Contact 866-632-6789 [email protected] Stephen G. Chun Principal Investigator
Houston Methodist Hospital | Houston, Texas, 77030, United States Recruiting Site Public Contact 713-790-2700 Jun Zhang Principal Investigator
M D Anderson Cancer Center | Houston, Texas, 77030, United States Recruiting Site Public Contact 877-632-6789 [email protected] Stephen G. Chun Principal Investigator
MD Anderson West Houston | Houston, Texas, 77079, United States Recruiting Site Public Contact 877-632-6789 [email protected] Stephen G. Chun Principal Investigator
Houston Methodist West Hospital | Houston, Texas, 77094, United States Recruiting Site Public Contact 832-522-2873 Jun Zhang Principal Investigator
MD Anderson League City | League City, Texas, 77573, United States Recruiting Site Public Contact 877-632-6789 [email protected] Stephen G. Chun Principal Investigator
MD Anderson in Sugar Land | Sugar Land, Texas, 77478, United States Recruiting Site Public Contact 877-632-6789 [email protected] Stephen G. Chun Principal Investigator
Houston Methodist Sugar Land Hospital | Sugar Land, Texas, 77479, United States Recruiting Site Public Contact 281-242-2873 Jun Zhang Principal Investigator
Houston Methodist The Woodlands Hospital | The Woodlands, Texas, 77385, United States Recruiting Site Public Contact 713-790-2700 [email protected] Jun Zhang Principal Investigator
Huntsman Cancer Institute/University of Utah | Salt Lake City, Utah, 84112, United States Recruiting Site Public Contact 888-424-2100 [email protected] Shiven Patel Principal Investigator
Central Vermont Medical Center/National Life Cancer Treatment | Berlin, Vermont, 05602, United States Recruiting Site Public Contact 802-225-5400 Christopher J. Anker Principal Investigator
University of Vermont Medical Center | Burlington, Vermont, 05401, United States Recruiting Site Public Contact 802-656-4101 [email protected] Christopher J. Anker Principal Investigator
Norris Cotton Cancer Center-North | Saint Johnsbury, Vermont, 05819, United States Recruiting Site Public Contact 802-473-4100 Gregory A. Russo Principal Investigator
University of Virginia Cancer Center | Charlottesville, Virginia, 22908, United States Recruiting Site Public Contact 434-243-6303 [email protected] Richard D. Hall Principal Investigator
Augusta Health Center for Cancer and Blood Disorders | Fishersville, Virginia, 22939, United States Recruiting Site Public Contact 540-332-5960 Kelvin B. Raybon Principal Investigator
VCU Massey Cancer Center at Stony Point | Richmond, Virginia, 23235, United States Recruiting Site Public Contact [email protected] Erin R. Alesi Principal Investigator
Virginia Commonwealth University/Massey Cancer Center | Richmond, Virginia, 23298, United States Recruiting Site Public Contact [email protected] Erin R. Alesi Principal Investigator
Providence Regional Cancer System-Aberdeen | Aberdeen, Washington, 98520, United States Recruiting Site Public Contact 360-412-8958 [email protected] Krishna C. Alluri Principal Investigator
Harrison HealthPartners Hematology and Oncology-Bremerton | Bremerton, Washington, 98310, United States Suspended
Harrison Medical Center | Bremerton, Washington, 98310, United States Suspended
Providence Regional Cancer System-Lacey | Lacey, Washington, 98503, United States Recruiting Site Public Contact 360-412-8958 [email protected] Krishna C. Alluri Principal Investigator
Legacy Salmon Creek Hospital | Vancouver, Washington, 98686, United States Recruiting Site Public Contact 503-413-2150 Andrew Y. Kee Principal Investigator
Edwards Comprehensive Cancer Center | Huntington, West Virginia, 25701, United States Recruiting Site Public Contact 304-399-6617 Maria R. Tria Tirona Principal Investigator
West Virginia University Healthcare | Morgantown, West Virginia, 26506, United States Recruiting Site Public Contact 304-293-7374 [email protected] Parvez M. Shaikh Principal Investigator
Wheeling Hospital/Schiffler Cancer Center | Wheeling, West Virginia, 26003, United States Recruiting Site Public Contact 304-243-6442 Parvez M. Shaikh Principal Investigator
Langlade Hospital and Cancer Center | Antigo, Wisconsin, 54409, United States Recruiting Site Public Contact 715-623-9869 [email protected] Harish G. Ahuja Principal Investigator
ThedaCare Regional Cancer Center | Appleton, Wisconsin, 54911, United States Recruiting Site Public Contact 920-364-3605 [email protected] Qiaofang (lisa) Chen Principal Investigator
Aurora Cancer Care-Southern Lakes VLCC | Burlington, Wisconsin, 53105, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Marshfield Medical Center-EC Cancer Center | Eau Claire, Wisconsin, 54701, United States Recruiting Site Public Contact 800-782-8581 [email protected] David F. Lee Principal Investigator
Mayo Clinic Health System-Eau Claire Clinic | Eau Claire, Wisconsin, 54701, United States Recruiting Site Public Contact 855-776-0015 Konstantinos Leventakos Principal Investigator
Aurora Health Care Germantown Health Center | Germantown, Wisconsin, 53022, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Aurora Cancer Care-Grafton | Grafton, Wisconsin, 53024, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Bellin Memorial Hospital | Green Bay, Wisconsin, 54301, United States Recruiting Site Public Contact 920-435-8326 Hassan I. Tahsildar Principal Investigator
Aurora BayCare Medical Center | Green Bay, Wisconsin, 54311, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
UW Cancer Center Johnson Creek | Johnson Creek, Wisconsin, 53038, United States Suspended
Aurora Cancer Care-Kenosha South | Kenosha, Wisconsin, 53142, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Gundersen Lutheran Medical Center | La Crosse, Wisconsin, 54601, United States Recruiting Site Public Contact 608-775-2385 [email protected] Collin D. Driscoll Principal Investigator
Mayo Clinic Health System-Franciscan Healthcare | La Crosse, Wisconsin, 54601, United States Recruiting Site Public Contact 855-776-0015 Konstantinos Leventakos Principal Investigator
University of Wisconsin Hospital and Clinics | Madison, Wisconsin, 53792, United States Recruiting Site Public Contact 800-622-8922 Andrew M. Baschnagel Principal Investigator
Aurora Bay Area Medical Group-Marinette | Marinette, Wisconsin, 54143, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Marshfield Medical Center-Marshfield | Marshfield, Wisconsin, 54449, United States Recruiting Site Public Contact 800-782-8581 [email protected] David F. Lee Principal Investigator
Aurora Cancer Care-Milwaukee | Milwaukee, Wisconsin, 53209, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Aurora Saint Luke's Medical Center | Milwaukee, Wisconsin, 53215, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Aurora Sinai Medical Center | Milwaukee, Wisconsin, 53233, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Zablocki Veterans Administration Medical Center | Milwaukee, Wisconsin, 53295, United States Recruiting Site Public Contact 888-469-6614 Elizabeth M. Gore Principal Investigator
Marshfield Clinic-Minocqua Center | Minocqua, Wisconsin, 54548, United States Recruiting Site Public Contact 800-782-8581 [email protected] David F. Lee Principal Investigator
ProHealth D N Greenwald Center | Mukwonago, Wisconsin, 53149, United States Recruiting Site Public Contact [email protected] Timothy R. Wassenaar Principal Investigator
Cancer Center of Western Wisconsin | New Richmond, Wisconsin, 54017, United States Recruiting Site Public Contact 952-993-1517 [email protected] Paul W. Sperduto Principal Investigator
ProHealth Oconomowoc Memorial Hospital | Oconomowoc, Wisconsin, 53066, United States Recruiting Site Public Contact 262-928-7878 Timothy R. Wassenaar Principal Investigator
Vince Lombardi Cancer Clinic - Oshkosh | Oshkosh, Wisconsin, 54904, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Aurora Cancer Care-Racine | Racine, Wisconsin, 53406, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Marshfield Medical Center-Rice Lake | Rice Lake, Wisconsin, 54868, United States Recruiting Site Public Contact 800-782-8581 [email protected] David F. Lee Principal Investigator
Vince Lombardi Cancer Clinic-Sheboygan | Sheboygan, Wisconsin, 53081, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Marshfield Clinic Stevens Point Center | Stevens Point, Wisconsin, 54482, United States Recruiting Site Public Contact 800-782-8581 [email protected] David F. Lee Principal Investigator
Aurora Medical Center in Summit | Summit, Wisconsin, 53066, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Vince Lombardi Cancer Clinic-Two Rivers | Two Rivers, Wisconsin, 54241, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
UW Cancer Center at ProHealth Care | Waukesha, Wisconsin, 53188, United States Recruiting Site Public Contact 262-928-5539 [email protected] Timothy R. Wassenaar Principal Investigator
Aspirus Regional Cancer Center | Wausau, Wisconsin, 54401, United States Recruiting Site Public Contact 877-405-6866 Harish G. Ahuja Principal Investigator
Aurora Cancer Care-Milwaukee West | Wauwatosa, Wisconsin, 53226, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Aurora West Allis Medical Center | West Allis, Wisconsin, 53227, United States Recruiting Site Public Contact 414-302-2304 [email protected] Shamsuddin Virani Principal Investigator
Diagnostic and Treatment Center | Weston, Wisconsin, 54476, United States Recruiting Site Public Contact 888-799-3989 [email protected] David F. Lee Principal Investigator
Marshfield Medical Center - Weston | Weston, Wisconsin, 54476, United States Recruiting Site Public Contact 800-782-8581 [email protected] David F. Lee Principal Investigator
Aspirus Cancer Care - Wisconsin Rapids | Wisconsin Rapids, Wisconsin, 54494, United States Recruiting Site Public Contact 715-422-7718 Harish G. Ahuja Principal Investigator
Saitama Medical University International Medical Center | Saitama, 350-1298, Japan Recruiting Site Public Contact 81-49-276-2028 Kyoichi Kaira Principal Investigator
Location Countries

Japan

United States

Verification Date

2021-07-01

Responsible Party

Type: Sponsor

Has Expanded Access No
Condition Browse
Number Of Arms 2
Arm Group

Label: Arm I (etoposide, cisplatin, carboplatin, radiation therapy)

Type: Experimental

Description: Patients receive etoposide IV on days 1-3 and cisplatin IV or carboplatin IV on day 1. Cycles repeat every 21 days for 3 cycles in the absence of disease progression or unacceptable toxicity. Patients also undergo 3D-CRT or IMRT BID for approximately 3 weeks or QD for approximately 6-7 weeks in the absence of disease progression or unacceptable toxicity.

Label: Arm II (etoposide, cisplatin, carboplatin, radiation therapy)

Type: Active Comparator

Description: Patients receive treatment as in Arm I. Patients also receive atezolizumab IV over 30-60 minutes on day 1 or 2 of each chemotherapy cycle. Cycles repeat every 3 weeks for 17 cycles (1 year) in the absence of disease progression or unacceptable toxicity.

Patient Data Yes
Study Design Info

Allocation: Randomized

Intervention Model: Parallel Assignment

Primary Purpose: Treatment

Masking: None (Open Label)

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact [email protected]. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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