Galactose Mediated Glycogen Resynthesis

Galactose Mediated Glycogen Resynthesis and the Effects on Metabolism During Subsequent Exercise

This study will compare short-term post-exercise muscle glycogen synthesis following combined galactose-glucose, glucose alone or galactose alone ingestion.

Study Overview

• Status: Completed
• Conditions: Exercise
• Intervention / Treatment: Other: Glucose alone; Other: Galactose alone; Other: Glucose and galactose

Detailed Description

Lactose, the sugar contained within milk, consists of glucose and galactose. Post-exercise consumption of a carbohydrate mixture containing glucose with galactose has been shown to accelerate liver glycogen repletion as compared to glucose-only provision. However, the extent to which galactose-glucose combinations influence post-exercise muscle glycogen storage has yet to be determined.

Therefore, this study will investigate whether short-term muscle glycogen storage after strenuous endurance exercise is enhanced by combined galactose-glucose or glucose only ingestion as compared to the ingestion of galactose alone.

• Study Type: Interventional
• Enrollment (Actual): 9
• Phase: Not Applicable

Contacts and Locations

Study Locations

• United Kingdom
  • West Midlands
    • Birmingham, West Midlands, United Kingdom, B15 2TT
      • School of Sport, Exercise and Rehabilitation Sciences

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years to 45 years (Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:.

• Body mass index in the range: 18.5 - 27.5 kg/m2
• Participates in endurance-based exercise (e.g. cycling, running, rowing) at least 3 times per week
• Aerobic fitness: VO2max >45 ml/kg/min (men), >40 ml/kg/min (women)

Exclusion Criteria:

• Lidocaine allergy
• Current participation in another scientific/clinical study
• Bleeding disorder/s
• Current or recent smoker to include vaping (last 60 days)
• Vegan
• Existence of food intolerances
• Poor recent health as indicated in the general health questionnaire
• Engage in uncommon eating practices (e.g. sustained periods of fasting)
• Diagnosed with galactosemia

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: Randomized
• Interventional Model: Crossover Assignment
• Masking: Double

Number of Arms

3

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Glucose alone; Participants will complete a glycogen depleting bout of exercise followed by the provision of glucose-alone over 4 hours of recovery before a subsequent bout of exercise.	Other: Glucose alone; Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose-alone over 4 hours of recovery before a subsequent bout of exercise.
Experimental: Galactose alone; Participants will complete a glycogen depleting bout of exercise followed by the provision of galactose-alone over 4 hours of recovery before a subsequent bout of exercise.	Other: Galactose alone; Young men or women will complete a glycogen depleting bout of exercise followed by the provision of galactose-alone over 4 hours of recovery before a subsequent bout of exercise.
Experimental: Glucose and galactose; Participants will complete a glycogen depleting bout of exercise followed by the provision of glucose and galactose over 4 hours of recovery before a subsequent bout of exercise.	Other: Glucose and galactose; Young men or women will complete a glycogen depleting bout of exercise followed by the provision of glucose and galactose over 4 hours of recovery before a subsequent bout of exercise.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Muscle glycogen synthesis rates (mmol/kg/dm/h)	Muscle glycogen synthesis rates over the post-exercise recovery period	4 hours

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Carbohydrate oxidation rates (g/min)	Total, exogenous and endogenous carbohydrate oxidation during a secondary bout of exercise	Up to 90 minutes
Fat oxidation rates (g/min)	Fat oxidation during a secondary bout of exercise	Up to 90 minutes
Plasma glucose (mmol/L)	Plasma glucose during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Serum insulin (mU/L)	Serum insulin during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Plasma galactose (mmol/L)	Plasma galactose during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Plasma lactate (mmol/L)	Plasma lactate during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Plasma non-esterified fatty acids (mmol/L)	Plasma non-esterified fatty acids during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Plasma glycerol (umol/L)	Plasma glycerol during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours
Plasma glucagon (pmol/L)	Plasma glucagon during the post-exercise recovery period and during a secondary bout of exercise	Up to 6 hours

Collaborators and Investigators

• Sponsor: University of Birmingham
• Collaborators: Dairy Management Inc.
• Investigators: Principal Investigator: Gareth Wallis, PhD, University of Birmingham

Study record dates

Study Major Dates

• Study Start (Actual): July 1, 2019
• Primary Completion (Actual): May 1, 2020
• Study Completion (Actual): May 1, 2020

Study Registration Dates

• First Submitted: March 29, 2019
• First Submitted That Met QC Criteria: April 3, 2019
• First Posted (Actual): April 4, 2019

Study Record Updates

• Last Update Posted (Actual): January 4, 2023
• Last Update Submitted That Met QC Criteria: January 3, 2023
• Last Verified: December 1, 2022

More Information

Terms related to this study

• Other Study ID Numbers: ERN_19-0308

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No