The Pathogenesis of Human Senile Cataract

April 6, 2019 updated by: Haidong Zou, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

The Pathogenesis of Age-related Cataract

To study the pathological mechanism of cataract by genomics, transcriptomics, and proteomics.

Study Overview

Status

Unknown

Conditions

Intervention / Treatment

Detailed Description

Tissue samples and aqueous humor samples will be collected from each individual patients by cataract surgery. After sample treatment, different techniques will be applied for analysis. And bioinformatics approach is applied for data treatment and analysis.The data of genomics, transcriptomics, and proteomics will be analyzed for study of pathological mechanism of cataract.

Study Type

Observational

Enrollment (Anticipated)

20

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • China
      • Shanghai, China, 200080
        • Recruiting
        • Department of Ophthalmology, Shanghai General Hospital, Shanghai Jiao Tong University
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

5 years to 94 years (Child, Adult, Older Adult)

Accepts Healthy Volunteers

No

Genders Eligible for Study

All

Sampling Method

Non-Probability Sample

Study Population

Patients with the explicit diagnosis of cataract are willing to undergo cataract surgery.

Description

Inclusion Criteria:

  • Patients with the explicit diagnosis of cataract (including senile cataract, congenital cataract, complicated cataract, metabolic cataract, traumatic cataract, etc.) in the operated eye are willing to undergo cataract surgery.

Exclusion Criteria:

  • Patients whose cataracts need not be operated
  • Patients with any contraindications to cataract surgery
  • Patients are unwilling to undergo cataract surgery

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
cataract in old age
Procedure: phacoemulsification
cataract in young age
Procedure: phacoemulsification

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Characterization of miRNA in micro-scale human aqueous humor
Time Frame: 12 month
method development for miRNA detection in aqueous humor
12 month
Favored amplification recovery via protection-chromatin immunoprecipitation-Seq of human eye tissue samples
Time Frame: 24 month
low-cell-number epigenome profiling for study of cataract
24 month
Study of cataract by genomics, transcriptomics, and proteomics approaches
Time Frame: 36 month
detect histone H3 lysine 4 trimethylation (H3K4me3) of aqueous humor of cataract patients by genomics, transcriptomics, and proteomics methods
36 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

December 7, 2016

Primary Completion (Anticipated)

December 30, 2019

Study Completion (Anticipated)

June 30, 2020

Study Registration Dates

First Submitted

April 4, 2019

First Submitted That Met QC Criteria

April 6, 2019

First Posted (Actual)

April 9, 2019

Study Record Updates

Last Update Posted (Actual)

April 9, 2019

Last Update Submitted That Met QC Criteria

April 6, 2019

Last Verified

April 1, 2019

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Shanghai1st-cataract-001

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

UNDECIDED

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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