- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04098848
Intradialytic Exercise on the Fatigue, Sleep Disorder, Arterial Stiffness and Endothelial Function in Uremic Patients
The Effect of Intradialytic Exercise on the Fatigue, Sleep Disorder, Arterial Stiffness and Endothelial Function in Uremic Patients
Study Overview
Status
Conditions
Intervention / Treatment
Detailed Description
The endothelium is a key regulator of vascular homeostasis and chronic exposure to vascular risk factors alters the regulatory properties of the endothelium, which progresses toward a pro-inflammatory pattern, senescence, and apoptosis. Endothelial cell integrity and function are critical to the prevention of atherosclerosis, and therefore endothelial cell injury and dysfunction are major steps in the development and progression of cardiovascular disease. Endothelial dysfunction may be the landmark of active disease process through the course of atherosclerotic cardiovascular disease, and a significant risk factor for future cardiovascular events.
Several studies had reported that not only medical treatment but also exercise could improve physical and vascular functions, dialytic efficiency, quality of sleep, fatigue and depression et al. Exercise could be classified to aerobic, Anaerobic exercise and resistance et. Several studies have shown that regular cycling exercise in hemodialysis patients could improve physical activity, sleep quality, and reduce fatigability. Therefore, exercise plays an important role in hemodialysis patients. According to these benefits, the investigator's study was designed to explore the effects of intradialytic cycling exercise on sleep quality and fatigability, adipokines and myokinins levels in hemodialysis patients.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
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Hualien City, Taiwan
- Buddhist Tzu Chi General Hospital
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Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Regular hemodialysis more than 3 months with 4 hours a time, thrice a week
- Eligible to sign permit
Exclusion Criteria:
- Could not sign permit or do not want to join the trial
- Infection
- Amputation of any one of the lower limb
- Hemodynamic unstable
- Acute myocardial infarction (AMI) in recent 6 months
- Unstable heart condition, such as unstable angina, arrythmia
- Deep vein thrombosis (DVT)
- History of kidney transplantation
- Vascular access over lower limb
Study Plan
How is the study designed?
Design Details
- Primary Purpose: TREATMENT
- Allocation: RANDOMIZED
- Interventional Model: PARALLEL
- Masking: NONE
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
EXPERIMENTAL: Intradialytic exercise
Cycling exercise 30 minutes a time, three times a week during hemodialysis
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Intradialytic cycling exercise for 30 minutes a time
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NO_INTERVENTION: Control group
not participate in cycling exercise during hemodialysis
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Change of the Functional Assessment of Chronic Illness Therapy -Fatigue (FACIT-F) score for 2 years
Time Frame: pre-test and then every 3 months for 2 years
|
Compare the FACIT-F score before, during and after intradialytic cycling exercise FACIT-F score is from 0-52 points; higher score represents less fatigue.
|
pre-test and then every 3 months for 2 years
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Change of the Pittsburgh Sleep Quality Index (PSQI) score for 2 years
Time Frame: pre-test and then every 3 months for 2 years
|
Compare the PSQI score before, during and after intradialytic cycling exercise PSQI score is from 0-21 points; score>=5 means poor sleeping quality.
|
pre-test and then every 3 months for 2 years
|
Change of the carotid-femoral pulse wave velocity (cfPWV) for 2 years
Time Frame: pre-test and then every 3 months for 2 years
|
Compare the cfPWV before, during and after intradialytic cycling exercise cfPWV measurement: a measure of aortic wall stiffness, increases markedly with age. Each set of pulse wave and ECG data to calculate the mean time difference between R-wave and pulse wave on a beat-to-beat basis, with an average of 10 consecutive cardiac cycles. The cfPWV will be calculated using the distance and mean time difference between the two recorded points. Patients with cfPWV values of > 10 m/s were classified in the high arterial stiffness group, whereas those with cfPWV values of ≤10 m/s were assigned to the low arterial stiffness group. |
pre-test and then every 3 months for 2 years
|
Change of the cardio-ankle vascular index (CAVI) for 2 years
Time Frame: pre-test and then every 3 months for 2 years
|
Compare the CAVI before, during and after intradialytic cycling exercise CAVI is a novel and accurate method, independent of the effect of blood pressure, and is used as a predictor of arterial stiffness (AS) AS was defined as a CAVI ≥ 9 |
pre-test and then every 3 months for 2 years
|
Change of the brachial-ankle pulse wave velocity (baPWV) for 2 years
Time Frame: pre-test and then every 3 months for 2 years
|
Compare the baPWV before, during and after intradialytic cycling exercise baPWV is one measure arterial stiffness using brachial to ankle arterial wave analyses and has been used to assess peripheral arterial stiffness (PAS) baPWV value >14.0 m/s on either side was considered high PAS. |
pre-test and then every 3 months for 2 years
|
Change of the aortic augmentation index(AI) measurements for 2 years
Time Frame: pre-test and then every 3 months for 2 years
|
Compare the AI before, during and after intradialytic cycling exercise AI of central blood pressure have been widely used as clinical indices of arterial stiffness AI is an indirect measure of central arterial stiffness, but mainly a direct measure of central wave reflection |
pre-test and then every 3 months for 2 years
|
Change of the brachial flow-mediated vasodilatation (bFMD) for 2 years
Time Frame: pre-test and then every 3 months for 2 years
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Compare the bFMD before, during and after intradialytic cycling exercise Endothelial function is often quantified by FMD, which represents the endothelium-dependent relaxation of a conduit artery-typically the brachial artery - due to an increased blood flow. |
pre-test and then every 3 months for 2 years
|
Change of the digital thermal monitoring (DTM) for 2 years
Time Frame: pre-test and then every 3 months for 2 years
|
Compare the DTM before, during and after intradialytic cycling exercise DTM is a simple noninvasive method to measure endothelial function and vascular reactivity that is correlated with atherosclerosis risk factors and coronary artery disease Vascular reactivity index (VRI) < 1.0: the poor vascular reactivity, 1.0 ≤ VRI < 2.0: the intermediate vascular reactivity, and VRI ≥ 2.0: the good vascular reactivity. |
pre-test and then every 3 months for 2 years
|
Collaborators and Investigators
Investigators
- Principal Investigator: Yu-Hsien Lai, Attending Physician
Study record dates
Study Major Dates
Study Start (ACTUAL)
Primary Completion (ACTUAL)
Study Completion (ACTUAL)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (ACTUAL)
Study Record Updates
Last Update Posted (ACTUAL)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- IRB106-139-A
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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