- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT03337464
Single Exercise Bout in Parkinson's Disease (PD)
The Effects of a Single Bout of Exercise in Parkinson's Disease.
Study Overview
Detailed Description
Purpose: To assess 15 subjects with PD and 15 healthy controls, who exercise on a regular basis, before, during and after 30 minutes of pedaling exercise intervention. The investigators will assess subjects for alterations in motor cortex assessment, cognition and mood as measured by EMG/EEG, motor assessment and several batteries of questionnaires. Findings from this study will lay the foundation for long-term studies.
Hypotheses: The investigators anticipate to observe an altered involvement of motor cortex during steady pedaling in individuals suffering from PD. In healthy control subjects it is anticipated that changes in cognition will be observable.
Justification: Hindered movement initiation and continuing locomotion is a common syndrome in PD with profound impact on the patient's mobility and quality of life. So far, the underlying pathophysiology is not completely understood. Since the observation that cortical activity contributes to the muscle activity during locomotion-like tasks underpins the importance of corticospinal function in humans, it is of importance to examine whether this cortical involvement is altered and displays abnormalities in patients with PD. Thus, the approach of corticomuscular coupling during a locomotion-like task would allow for better understanding of the pathophysiology of PD, a prerequisite to develop therapies. Findings of this study will lay the foundation for future long-term studies.
Additionally, by examining the oscillatory EEG patterns during the exercise intervention, the investigator will be able to read out the dose response curve in real time, which will provide information on the optimum intensity and duration of exercise. Findings will help to design future studies and to develop efficient exercise therapy interventions for people with PD.
People living with PD often suffer from cognitive decline, depression, and fatigue. By assessing cognitive function before and after the exercise intervention, there will be laid a foundation for future studies investigating the effect of exercise on cognition. The collected pilot data will be relevant to learn more about the effects of exercise on mood and fatigue as well as concomitant obstacles and facilitators during exercise interventions in patients with PD.
Objectives: The primary objective of this study is to investigate if activity that arises in the motor cortex and contributes to the muscle activity during moderate pedaling is altered in patients with PD compared to healthy gender- and age-matched controls. Thus, to better understand the role of the motor cortex and its contribution in simple automated repetitive tasks in patients with PD there will be analysis of the coherence of the coupling between EEG and EMG from active leg muscles during cycling on a stationary bicycle both in subjects with PD and age and gender matched healthy controls.
Study Type
Enrollment (Actual)
Phase
- Not Applicable
Contacts and Locations
Study Locations
-
-
British Columbia
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Vancouver, British Columbia, Canada, V6T 2B5
- Pacific Parkinson's Research Centre
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Description
Inclusion Criteria:
- Adult between 40-80 years
- Hoehn and Yahr stage I-III
- Exercise on a regular basis (at least 100 minutes of aerobic exercise per week)
- Montreal Cognitive Assessment score >/= 24
- Able to communicate with study personnel
- Able to be informed of the nature of the study and willing to give written consent form
Exclusion Criteria:
- Hoehn and Yahr stages IV-V
- Significant cardiovascular disease
- Previous stroke
- Not exercising on a regular basis
- Functional disabling dyskinesia
- Functional disabling dystonia
- Smoker
- Significant neurological or psychiatric illness other than PD
- Dementia
- Severe depression
- Significant musculoskeletal disorder (e.g. arthritis)
- Significant metabolic disorder (e.g. diabetes)
- Brain surgery in the past
- Currently taking beta blocker medication
Study Plan
How is the study designed?
Design Details
- Primary Purpose: Treatment
- Allocation: Non-Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Experimental: Parkinson's disease
Subjects with Parkinson's disease
|
5 x 3 minute bouts of cycling exercise separated by 3 minute rest periods
|
Active Comparator: Control
Subjects without Parkinson's disease
|
5 x 3 minute bouts of cycling exercise separated by 3 minute rest periods
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
EEG-EMG coherence
Time Frame: The change from immediately before, during, and immediatly after the single bout of exercise.
|
Coherence of the coupling between EEG and EMG from active leg muscles during cycling on a stationary bicycle both in subjects with PD and age and gender matched healthy controls.
|
The change from immediately before, during, and immediatly after the single bout of exercise.
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Motor function
Time Frame: Immediately before and after the single bout of exercise.
|
Examine motor function with the Movement disorders society unified Parkinson's disease rating scale motor section (MDS-UPDRS III)
|
Immediately before and after the single bout of exercise.
|
Motor function
Time Frame: Immediately before and after the single bout of exercise.
|
Examine motor function with the finger tapping
|
Immediately before and after the single bout of exercise.
|
Motor function
Time Frame: Immediately before and after the single bout of exercise.
|
Examine motor function with the Purdue pegboard
|
Immediately before and after the single bout of exercise.
|
Motor function
Time Frame: Immediately before and after the single bout of exercise.
|
Examine motor function with the Timed-up-and-go (TUG)
|
Immediately before and after the single bout of exercise.
|
Cognitive function
Time Frame: Immediately before, after and at 3 hours following the single bout of exercise.
|
Examine cognitive function with Montreal cognitive assessment (MoCA)
|
Immediately before, after and at 3 hours following the single bout of exercise.
|
Cognitive function
Time Frame: Immediately before, after and at 3 hours following the single bout of exercise.
|
Examine cognitive function with Verbal fluency
|
Immediately before, after and at 3 hours following the single bout of exercise.
|
Cognitive function
Time Frame: Immediately before, after and at 3 hours following the single bout of exercise.
|
Examine cognitive function with trail making test (A and B) and reaction time
|
Immediately before, after and at 3 hours following the single bout of exercise.
|
Mood function
Time Frame: Immediately before, after and at 3 hours following the single bout of exercise.
|
Examine mood with the Positive and Negative Affect Schedule.
|
Immediately before, after and at 3 hours following the single bout of exercise.
|
Mood function
Time Frame: Immediately before, after and at 3 hours following the single bout of exercise.
|
Examine mood with the Starkein Apathy scale
|
Immediately before, after and at 3 hours following the single bout of exercise.
|
Collaborators and Investigators
Investigators
- Principal Investigator: Silke Cresswell, MD, Pacific Parkinson's Research Centre
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- H13-00084
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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