Rabies Treatment by Exposure of Patient to X-Ray

Effect of X-ray on Rabies Virus in Vivo

x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients.

Study Overview

• Status: Unknown
• Conditions: Treatment of Rabies
• Intervention / Treatment: Radiation: x ray exposure

Detailed Description

x-ray has been proven to kill Rabies virus in vitro, so the investigators can use it in treatment of rabies infected patients.

this can be done by exposure of infected , manifested patient who didn't receive prophylaxis or delayed in receiving immunoglobulins .

also can be applied to patients who have the injury in upper body near the CNS..

it's just an idea and the investigators need help to approve its effect and the investigators believe it will really work and give a new, rapid , cheap and very effective treatment to a 100% fatal disease..

the investigator also predict good results when x ray applied to some localized infections beside its current lines of treatment..

• Study Type: Interventional
• Enrollment (Anticipated): 4
• Phase: Early Phase 1

Contacts and Locations

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Child; Adult; Older Adult
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• patient bitten by rabid animal with signs and symptoms

Exclusion Criteria:

• bitten by non rabid animal

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Non-Randomized
• Interventional Model: Parallel Assignment
• Masking: Double

Number of Arms

4

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: rabies patient 1; not received immunoglobulins and symptomatic	Radiation: x ray exposure; exposure of whole body to x ray
Experimental: rabies patient 2; received immunoglobulins and symptomatic	Radiation: x ray exposure; exposure of whole body to x ray
Experimental: rabies patient 3; not received immunoglobulins and not yet symptomatic	Radiation: x ray exposure; exposure of whole body to x ray
Experimental: rabies patient 4; received immunoglobulins and not symptomatic	Radiation: x ray exposure; exposure of whole body to x ray

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
the number of rabies infected, symptomatic patients who survived after x-ray exposure	detecting effect of x-ray exposure on treating Rabies	7 month

Collaborators and Investigators

• Sponsor: National Institute For Research On Endemic Diseases And Liver, Egypt

Study record dates

Study Major Dates

• Study Start (Anticipated): March 1, 2020
• Primary Completion (Anticipated): July 1, 2020
• Study Completion (Anticipated): July 1, 2020

Study Registration Dates

• First Submitted: January 13, 2020
• First Submitted That Met QC Criteria: February 6, 2020
• First Posted (Actual): February 7, 2020

Study Record Updates

• Last Update Posted (Actual): February 18, 2020
• Last Update Submitted That Met QC Criteria: February 14, 2020
• Last Verified: February 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: RNA Virus Infections; Virus Diseases; Infections; Mononegavirales Infections; Rhabdoviridae Infections; Rabies
• Other Study ID Numbers: X-Ray as a treatment of Rabies

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: Undecided

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No