Outcomes in Hospitalized Older Patients With COVID-19

COVIDAge Study- Hospital Des Trois-Chêne

In December 2019, the first patients infected with the 2019 novel coronavirus (2019-nCoV) were diagnosed in Wuhan. The clinical presentation and course of Severe Acute Respiratory Syndrome-CoV-2 (SARS-CoV-2) infection is poorly understood in older patients and is certainly different from the general population. This project is designed to better understand and to determine clinical, biological and radiological markers of poor adverse outcomes in hospitalized older patients diagnosed with COVID-19.

Study Overview

• Status: Completed
• Conditions: Coronavirus Infection; Old Age; Debility; Elderly Infection; Sars-CoV2

• Study Type: Observational
• Enrollment (Actual): 230

Contacts and Locations

Study Locations

• Switzerland
  • Geneva, Switzerland, 1256
    • Department of Rehabilitation and Geriatrics

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 65 years and older (Older Adult)
• Accepts Healthy Volunteers: N/A
• Genders Eligible for Study: All

• Sampling Method: Non-Probability Sample

Study Population

All the patients hospitalized in our geriatrics department with Sars-Cov-2 infection

Description

Inclusion Criteria:

• Diagnosis of COVID-19, defined by a positive polymerase chain reaction (PCR) test for SARS-CoV-2 detection, obtained by a nasopharyngeal swab or sputum sample.
• Or patients with negative virus detection in the PCR test, but with a high clinical suspicion will also be considered with COVID-19.

Exclusion Criteria:

- Presence of document indicating a refusal to participate in a research study.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To evaluate the relative contributions of comorbidities on intra-hospitalized death	We measure functional score of comorbidities	1 month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
To evaluate the relative contributions of functional characteristics on intra-hospitalized death	We measure Functional Independence Measure scale	1 month
To explore specific clinical profiles that may influence COVID-19 disease outcomes in the elderly based on geriatrics syndromes	We describe the role fo geriatric syndrome such as delirium, falls	1 month

Collaborators and Investigators

• Sponsor: University Hospital, Geneva

Study record dates

Study Major Dates

• Study Start (Actual): March 13, 2020
• Primary Completion (Actual): April 14, 2020
• Study Completion (Actual): April 14, 2020

Study Registration Dates

• First Submitted: April 29, 2020
• First Submitted That Met QC Criteria: May 8, 2020
• First Posted (Actual): May 12, 2020

Study Record Updates

• Last Update Posted (Actual): May 12, 2020
• Last Update Submitted That Met QC Criteria: May 8, 2020
• Last Verified: May 1, 2020

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Pathologic Processes; Coronaviridae Infections; Nidovirales Infections; RNA Virus Infections; Virus Diseases; Disease Attributes; Coronavirus Infections; Infections; Communicable Diseases; Frailty
• Other Study ID Numbers: 2020-00819

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: UNDECIDED

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No