- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT04912752
Copy Number Variation in CHRNA7 Gene in Migraine and Gene Expression
May 31, 2021 updated by: Şenay Görücü Yılmaz, University of Gaziantep
Copy Number Variation in Migraine and Gene Expression
Migraine is a common and possible hereditary disease.
Copy number variation (CNV) is a phenomenon in which parts of the genome are repeated and the number of repeats in the genome varies between individuals in the human population.The CHRNA7 gene has a major role in the neuropsychiatric phenotypes observed in patients.
The 15q13.3 gain/loss variation in this gene may be associated with migraine.
Study Overview
Detailed Description
Migraine is a common neurological disorder.
Although they have different genetic bases according to their types, cholinergic receptors after calcium channels play an important role in the clinic and genetics of the disease.
Neuronal acetylcholine receptor subunit alpha-7, also known as nAChRα7, is a protein that in humans is encoded by the CHRNA7 gene.
Study Type
Interventional
Enrollment (Actual)
200
Phase
- Not Applicable
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Locations
-
-
Şehitkamil
-
Gaziantep, Şehitkamil, Turkey, 27310
- Medicine
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Child
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Genders Eligible for Study
All
Description
Inclusion Criteria:
Migraine
Exclusion Criteria:
Vascular problems
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
- Primary Purpose: Basic Science
- Allocation: Randomized
- Interventional Model: Parallel Assignment
- Masking: Single
Arms and Interventions
Participant Group / Arm |
Intervention / Treatment |
---|---|
Other: Case-Control
Copy number variation
|
Copy number variation effect on migraine disease
|
Experimental: Case-Control 1
Gene expression
|
Copy number variation effect on migraine disease
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
CNV number
Time Frame: 1 year
|
CNV number effect on migraine
|
1 year
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Mehmet Fatih Özaltun, MD, Assist
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
April 5, 2020
Primary Completion (Actual)
December 10, 2020
Study Completion (Actual)
January 2, 2021
Study Registration Dates
First Submitted
May 21, 2021
First Submitted That Met QC Criteria
May 31, 2021
First Posted (Actual)
June 3, 2021
Study Record Updates
Last Update Posted (Actual)
June 3, 2021
Last Update Submitted That Met QC Criteria
May 31, 2021
Last Verified
May 1, 2021
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- 2020/12
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
No
IPD Plan Description
manuscript not yet published
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Migraine
-
Austrian Migraine Registry CollaborationMedical University of Vienna; Medical University Innsbruck; Austrian Headache...RecruitingMigraine | Chronic Migraine | Migraine Without Aura | Migraine With Aura | Episodic MigraineAustria
-
Tonix Pharmaceuticals, Inc.PremierCompletedChronic Migraine | Chronic Migraine, Headache | Chronic Migraine Without Aura | Aura MigraineUnited States
-
Harvard University Faculty of MedicineBrigham and Women's Hospital; Palmer Center for Chiropractic Research (PCCR)CompletedMigraine | Migraine Disorders | Migraine Without Aura | Migraine With Aura | Migraine, ClassicUnited States
-
University of FlorenceAzienda Ospedaliera Città della Salute e della Scienza di Torino; University... and other collaboratorsRecruitingMigraine | Chronic Migraine | Migraine Without Aura | Migraine With AuraItaly
-
Notre-Dame Hospital, Montreal, Quebec, CanadaAllerganCompletedChronic Migraine | Migraine Without Aura | Migraine With AuraCanada
-
Glostrup University Hospital, CopenhagenUnknownChronic Migraine | Migraine Without Aura | Migraine With AuraDenmark
-
Fondazione I.R.C.C.S. Istituto Neurologico Carlo...CompletedMigraine With Aura | Migraine in ChildrenItaly
-
CoolTech LLCObvioHealthRecruitingMigraine | Migraine Without Aura | Migraine With Aura | Episodic MigraineUnited States
-
Norwegian University of Science and TechnologyAstraZeneca; St. Olavs Hospital; Kragerø Tablettproduksjon as, NorwayCompletedChronic Migraine | Migraine Without Aura | Migraine With AuraNorway
-
The Cleveland ClinicWithdrawnMigraine | Migraine Disorders | Headache Disorders, Primary | Migraine Headache | Migraine Without Aura | Migraine With Aura | Headache, MigraineUnited States
Clinical Trials on Migraine CNV
-
Chen Zi-JiangChinese Academy of SciencesCompleted
-
Central Hospital, Nancy, FranceCompletedGenetic Disease | CNV | Genetic Counseling | Array CGHFrance
-
Xinhua Hospital, Shanghai Jiao Tong University...Changhai Hospital; Shanghai Zhongshan Hospital; Southwest Hospital, China; West... and other collaboratorsActive, not recruiting
-
Karolinska University HospitalCompleted
-
Wake Forest University Health SciencesNational Center for Complementary and Integrative Health (NCCIH)Not yet recruiting
-
Children's Hospital Medical Center, CincinnatiRecruiting
-
Eli Lilly and CompanyWake Forest University Health SciencesCompleted
-
Scion NeuroStimTerminatedInterventionUnited States, United Kingdom