Fatigue and Kinematics During Isometric Activity of the Upper Limbs in Young and Older Adults

Relationship Between Perceive Effort, Physiological and Kinematic Changes During Upper Limbs Isometric Activity and Its Relationship With the Socio-demographic Characteristics

The aim of this study is to understand the relationship between perceived effort and physiological and kinematic variables caused by isometric activity of the upper limbs, as well as its relationship with socio-demographic characteristics, level of activity and quality of life.

Study Overview

• Status: Completed
• Conditions: Fatigue
• Intervention / Treatment: Other: Isometric activity

• Study Type: Interventional
• Enrollment (Actual): 60
• Phase: Not Applicable

Contacts and Locations

Study Locations

• Portugal
  • Lisboa, Portugal, 1300-125
    • Escola Superior de Saúde da Cruz Vermelha Portuguesa - Lisboa

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No
• Genders Eligible for Study: All

Description

Inclusion Criteria:

• Healthy
• Minimum age of 18 years;

Exclusion Criteria:

• Unable to provide written consent
• History of heart, cardiovascular and / or respiratory disease,
• Known untreated hypertension, cardiomyopathy, or exercise intolerance
• Presence of cognitive or neurological disorders
• Neuromuscular or orthopaedic disorder that limits the movement of the upper limb to 90° flexion or the maintenance of that position
• BMI ≥ 40

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Basic Science
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Isometric activity; All participants will be included in this arm	Other: Isometric activity; Participants will do elevation of upper limbs and mantain a 90º degree flexion position in an unsupported way.; Other Names: Isometric task

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Change from Baseline in perceived effort on the Borg category-ratio 10-point scale (CR 10)	The perceived effort will be measured with Borg CR 10 scale. Possible scores range from 0 (no exertion at all) to 10 (extremely strong).	From baseline to end of activity, up to 15 minutes
Change from Baseline in heart rate	Heart rate (heart beatings per minute) measured before and during activity to track cardiovascular changes during activity.	From baseline to end of activity, up to 15 minutes
Change from Baseline in respiratory rate	Respiratory rate (respiratory cycles per minute) measured before and during activity to track changes in respiratory function during activity.	From baseline to end of activity, up to 15 minutes
Change from Baseline in heart rate variability (HRV)	Interval (in milliseconds) between consecutive heartbeats measured before and during activity to track changes in autonomic function during activity.	From baseline to end of activity, up to 15 minutes
Change from Baseline in electrodermal activity (EDA)	Electrical conductance (in microsiemens -µS) between two points of the hand over time measured before and during activity to track changes in autonomic function during activity.	From baseline to end of activity, up to 15 minutes
Change from Baseline in muscle action potential amplitude through surface electromyography (sEMG)	Muscle action potential amplitude (in millivolts - ms) in surface electromyographic signal measured before and during activity to track muscular fatigue signs.	From baseline to end of activity, up to 15 minutes
Change from Baseline in muscle action potential duration through surface electromyography (sEMG)	Muscle action potential duration (in milliseconds - ms) in surface electromyographic signal measured before and during activity to track muscular fatigue signs.	From baseline to end of activity, up to 15 minutes
Change from Baseline in muscle action potential frequency through surface electromyography (sEMG)	Muscle action potential frequency (in hertz - Hz) of surface electromyographic signal measured before and during activity to track muscular fatigue signs.	From baseline to end of activity, up to 15 minutes
Change from Baseline in respiratory pattern through inertial motion units (IMU) from baseline and during activity	Angular range of motion (in degrees) of rib cage and abdominal wall during upper limb activity measured before and during activity to track changes in respiratory pattern during activity	From baseline to end of activity, up to 15 minutes
Change from Baseline in upper limb motion angular acceleration through inertial motion units (IMU) system	Angular acceleration (in m/s^2) of the arm measured before and during activity to track small movements of upper limb during isometric activity	From baseline to end of activity, up to 15 minutes

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Health Status	Health Status will be measured with Medical Outcomes Study (MOS) Short Form Health Survey 36 Item version 2 which measure health status of populations and individuals. Possible scores range from 0 0 (worst health status) to 100 (best health status).	Before isometric activity
Physical activity level	Physical activity level will be measured using European Prospective Investigation into Cancer and Nutrition Physical Activity Questionnaire (EPIC-PAQ) that allows to estimate energy expenditure through self-report assessment of the intensity and average duration (per day, week and month) of physical activity performed by the participants in three distinct dimensions (professional, domestic and leisure). Participants are classified as ACTIVE if they perform: at least 150 minutes per week of moderate physical activity; OR at least 75 minutes per week of vigorous physical activity; OR at least 150 minutes per week of a combination of moderate-intensity activity. If they don't present any of the conditions described, they will be categorized as SEDENTARY.	Before isometric activity

Collaborators and Investigators

• Sponsor: Escola Superior de Saude da Cruz Vermelha Portuguesa - Lisboa
• Investigators: Study Director: Daniel López López, PhD, Universidade da Coruña

Study record dates

Study Major Dates

• Study Start (Actual): October 1, 2021
• Primary Completion (Actual): February 28, 2022
• Study Completion (Actual): February 28, 2022

Study Registration Dates

• First Submitted: June 4, 2021
• First Submitted That Met QC Criteria: June 16, 2021
• First Posted (Actual): June 24, 2021

Study Record Updates

• Last Update Posted (Actual): March 31, 2022
• Last Update Submitted That Met QC Criteria: March 30, 2022
• Last Verified: March 1, 2022

More Information

Terms related to this study

• Keywords: Performance; Respiration; Perceived; Kinematics
• Additional Relevant MeSH Terms: Fatigue
• Other Study ID Numbers: ESSCVP_FIS01/2021

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: No

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No