- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05257733
Evaluation of the Diagnostic Contributions of Nerve Ultrasound in Chronic Inflammatory Demyelinating Polyneuropathy Associating Systemic Diseases (CIDP Echo-nerf) (CIDP echo-nerf)
Evaluation of the Diagnostic Contributions of Nerve Ultrasound in Chronic Inflammatory Demyelinating Polyneuropathy Associating Systemic Diseases
Chronic inflammatory demyelinating polyradiculoneuritis (CIDP) is an autoimmune disorder of the peripheral nervous system, most commonly affecting the myelin sheath. The pathophysiology of CIDP is not completely understood, but both humoral and cellular immunity appear to be involved in the genesis of this disease. Some diseases are particularly associated with CIDP such as diabetes, monoclonal gammopathies and hematological diseases.
CIDP can occur before, after or simultaneously with the onset of systemic diseases. The systemic diseases most often seen in association with polyneuropathies are lupus, Gougerot-Sjögren's syndrome and sarcoidosis.
Ultrasound of peripheral nerves is a useful and accessible tool. In CIDP, this examination can reveal diffuse or segmental nerve hypertrophy. In addition to the size of the nerve, this exploration analyzes the echogenicity and the aspect of the different fascicles within the nerve. S. Goedee et al have shown that nerve ultrasound has very good diagnostic parameters and low interobserver variability in the diagnosis of CIDP. F. Härtig et al suggests that nerve ultrasound can predict the therapeutic response and describes 3 main patterns: hypoechoic enlargement (active inflammation), nerve enlargement with hyperechoic add-on fascicles (axonal degeneration) and almost no enlargement ("cured" CIDP).
Study Overview
Status
Intervention / Treatment
Detailed Description
Study Type
Contacts and Locations
Study Locations
-
-
-
Nîmes, France, 30029
- CHU de Nimes
-
-
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Sampling Method
Study Population
Description
Inclusion Criteria:
- Patients followed at Nîmes University Hospital between 2012 and 2021
- Age > 18 years
- Diagnosis of definite CIDP or possible CIDP according to the new EFNS/PNS 2021 criteria
- Diagnosis of definite CIDP/CIDP possible with systemic diseases and respectively diagnosis of definite CIDP/CIDP possible for the control group confirmed by electroneuromyography, concordant with the clinical examination
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Retrospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
CIDP associated with systemic diseases
Patients with CIDP associated with systemic diseases
|
pure observationnal study
|
CIDP without systemic diseases
Patients with CIDP without other systemic diseases
|
pure observationnal study
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
Median nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of median nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
ulnar nerve at wrist cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of ulnar nerve at wrist cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
ulnar at mid-arm nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of ulnar nerve at mid-arm cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
ulnar nerve at elbow cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of ulnar nerve at elbow cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
radial nerve cross-sectional area
Time Frame: Day of diagnosis of CIDP
|
Comparison of radial nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Day of diagnosis of CIDP
|
superficial radial branch nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of superficial radial branch nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
vagus nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of vagus nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
C6 root nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of C6 root nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
C5 root nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of C5 root nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
sural nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of sural nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
superficial fibula nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of superficial fibula nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
tibial nerve at ankle cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of tibial nerve at ankle cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
popliteal nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of popliteal nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
fibular nerve at neck cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of fibular nerve at neck cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
fibular at supra-neck nerve cross-sectional area
Time Frame: Base line, Day 0
|
Comparison of fibular at supra-neck nerve cross-sectional area on nerve ultrasound in patients with definite PIDC/PIDC with associated systemic disease with that of patients with PIDC/PIDC without systemic disease
|
Base line, Day 0
|
Collaborators and Investigators
Investigators
- Study Director: Anissa MEGZARI, Centre Hospitalier Universitaire de Nîmes
Publications and helpful links
General Publications
- Schmidt B, Toyka KV, Kiefer R, Full J, Hartung HP, Pollard J. Inflammatory infiltrates in sural nerve biopsies in Guillain-Barre syndrome and chronic inflammatory demyelinating neuropathy. Muscle Nerve. 1996 Apr;19(4):474-87. doi: 10.1002/(SICI)1097-4598(199604)19:43.0.CO;2-9.
- Sommer C, Koch S, Lammens M, Gabreels-Festen A, Stoll G, Toyka KV. Macrophage clustering as a diagnostic marker in sural nerve biopsies of patients with CIDP. Neurology. 2005 Dec 27;65(12):1924-9. doi: 10.1212/01.wnl.0000188879.19900.b7.
- Spies JM, Westland KW, Bonner JG, Pollard JD. Intraneural activated T cells cause focal breakdown of the blood-nerve barrier. Brain. 1995 Aug;118 ( Pt 4):857-68. doi: 10.1093/brain/118.4.857.
- Madia F, Frisullo G, Nociti V, Conte A, Luigetti M, Del Grande A, Patanella AK, Iorio R, Tonali PA, Batocchi AP, Sabatelli M. pSTAT1, pSTAT3, and T-bet as markers of disease activity in chronic inflammatory demyelinating polyradiculoneuropathy. J Peripher Nerv Syst. 2009 Jun;14(2):107-17. doi: 10.1111/j.1529-8027.2009.00220.x.
- Press R, Pashenkov M, Jin JP, Link H. Aberrated levels of cerebrospinal fluid chemokines in Guillain-Barre syndrome and chronic inflammatory demyelinating polyradiculoneuropathy. J Clin Immunol. 2003 Jul;23(4):259-67. doi: 10.1023/a:1024532715775.
- Mei FJ, Ishizu T, Murai H, Osoegawa M, Minohara M, Zhang KN, Kira J. Th1 shift in CIDP versus Th2 shift in vasculitic neuropathy in CSF. J Neurol Sci. 2005 Jan 15;228(1):75-85. doi: 10.1016/j.jns.2004.10.001. Epub 2004 Nov 12.
- Kurihara M, Kurata Y, Sugimoto I, Hatanaka Y, Sakurai Y. High PR3-ANCA positivity in a patient with chronic inflammatory demyelinating polyneuropathy. eNeurologicalSci. 2016 Oct 5;6:4-5. doi: 10.1016/j.ensci.2016.10.001. eCollection 2017 Mar.
- Greenberg SA. P-ANCA vasculitic neuropathy with 12-year latency between onset of neuropathy and systemic symptoms. BMC Neurol. 2002 Oct 31;2(1):10. doi: 10.1186/1471-2377-2-10.
- Abraham H, Kuzhively J, Rizvi SW. Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): An Uncommon Manifestation of Systemic Lupus Erythematosus (SLE). Am J Case Rep. 2017 Sep 12;18:980-983. doi: 10.12659/ajcr.903541.
- Siddiqui K, Cahalane E, Keogan M, Hardiman O. Chronic ataxic neuropathy with cold agglutinins: atypical phenotype and response to anti-CD20 antibodies. Neurology. 2003 Nov 11;61(9):1307-8. doi: 10.1212/wnl.61.9.1307. No abstract available.
- Rodriguez Y, Vatti N, Ramirez-Santana C, Chang C, Mancera-Paez O, Gershwin ME, Anaya JM. Chronic inflammatory demyelinating polyneuropathy as an autoimmune disease. J Autoimmun. 2019 Aug;102:8-37. doi: 10.1016/j.jaut.2019.04.021. Epub 2019 May 6.
- Seeliger T, Prenzler NK, Gingele S, Seeliger B, Korner S, Thiele T, Bonig L, Suhs KW, Witte T, Stangel M, Skripuletz T. Neuro-Sjogren: Peripheral Neuropathy With Limb Weakness in Sjogren's Syndrome. Front Immunol. 2019 Jul 11;10:1600. doi: 10.3389/fimmu.2019.01600. eCollection 2019.
- Wolbert J, Cheng MI, Meyer zu Horste G, Su MA. Deciphering immune mechanisms in chronic inflammatory demyelinating polyneuropathies. JCI Insight. 2020 Feb 13;5(3):e132411. doi: 10.1172/jci.insight.132411.
Study record dates
Study Major Dates
Study Start (Actual)
Primary Completion (Estimated)
Study Completion (Estimated)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Actual)
Study Record Updates
Last Update Posted (Actual)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
- Pathologic Processes
- Nervous System Diseases
- Immune System Diseases
- Autoimmune Diseases of the Nervous System
- Demyelinating Diseases
- Autoimmune Diseases
- Disease Attributes
- Neuromuscular Diseases
- Peripheral Nervous System Diseases
- Chronic Disease
- Polyneuropathies
- Polyradiculoneuropathy
- Polyradiculoneuropathy, Chronic Inflammatory Demyelinating
Other Study ID Numbers
- LOCAL/2022/II-01
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
Studies a U.S. FDA-regulated device product
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
Clinical Trials on Chronic Inflammatory Demyelinating Polyradiculoneuropathy
-
UCB Biopharma SRLCompletedChronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)United States, Belgium, Denmark, France, Germany, Netherlands, Spain, United Kingdom
-
Nagoya UniversityJapan Agency for Medical Research and Development; Zenyaku Kogyo Co., Ltd.CompletedChronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)Japan
-
TakedaRTI Health Solutions; Baxalta Innovations GmbH, now part of ShireCompletedChronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)United States
-
Johns Hopkins UniversityGenzyme, a Sanofi CompanyWithdrawnChronic Inflammatory Demyelinating NeuropathyUnited States
-
UCB Biopharma S.P.R.L.CompletedChronic Inflammatory Demyelinating Polyradiculoneuropathy (CIDP)United States, Belgium, Denmark, France, Germany, Netherlands, Spain, United Kingdom
-
OctapharmaRecruitingPediatric Chronic Inflammatory Demyelinating PolyneuropathyUnited States
-
SanofiRecruitingChronic Inflammatory Demyelinating Polyradiculoneuropathy | Polyneuropathy, Inflammatory Demyelinating, ChronicUnited States
-
Assistance Publique Hopitaux De MarseilleCompletedChronic Inflammatory Demyelinating PolyradiculoneuropathyFrance
-
OctapharmaTerminatedChronic Inflammatory Demyelinating Polyradiculoneuropathy
-
University of AarhusCompletedChronic Inflammatory Demyelinating PolyradiculoneuropathyDenmark
Clinical Trials on None, pure observationnal study
-
Centre Hospitalier Universitaire de NīmesCompletedCerebellar AtaxiaFrance
-
Centre Hospitalier Universitaire de NīmesRecruiting
-
Centre Hospitalier Universitaire de NīmesCompletedStroke | Hemorrhage | Cerebral Amyloid AngiopathyFrance
-
Centre Hospitalier Universitaire de NīmesCompletedStroke | Stenoses, CarotidFrance
-
Centre Hospitalier Universitaire de NīmesCompletedCerebral Amyloid Angiopathy | Hypertensive ArteriopathyFrance
-
Centre Hospitalier Universitaire de NīmesCompletedCerebral Amyloid Angiopathy | SiderosisFrance
-
Kansas City Heart Rhythm Research FoundationNot yet recruitingCardiac ArrhythmiasUnited States
-
AstraZenecaRecruitingNon-Small Cell Lung CancerUnited States
-
Taysha Gene Therapies, Inc.Withdrawn
-
University of Castilla-La ManchaRecruitingKnee OsteoarthritisSpain