Potential Impact of the Use of the Application VentilO

Frequency of Respiratory Acidosis and Alkalosis in the Emergency and Intensive Care Department of the IUCPQ-UL. Potential Impact of the Use of the Application VentilO

Mechanical ventilation is a vital support associated with the treatment of patients with acute respiratory failure and in other indications such as surgery under general anesthesia, coma or shock. Optimization of settings during mechanical ventilation and implementation of protective ventilation help to avoid ventilation-induced injury, ensure adequate oxygenation and maintain adequate carbon dioxide concentration to avoid respiratory acidosis or alkalosis.

Similarly, there is also no clear recommendation, to our knowledge, for the initial setting of the respiratory rate. Therefore, initial settings are not always adequate and in the literature the frequency of respiratory acidosis is very high, reaching about half of the patients receiving mechanical ventilation.

VentilO, is an application that is available on smart phones. This educational application provides clinicians with initial settings and optimization of these settings based on gender, height, weight, body temperature and patient type. The algorithm used is based on published data regarding ventilatory requirements in different populations and the anatomical and instrumental dead space of patients.

The purpose of our study is to:

1. Assess whether ventilatory settings after intubation are appropriate.
2. To compare the ventilatory adjustments made by clinicians with those proposed by the VentilO appalication.

Study Overview

• Status: Active, not recruiting
• Conditions: Mechanical Ventilation Complication
• Intervention / Treatment: Other: VentilO application

• Study Type: Observational
• Enrollment (Actual): 100

Contacts and Locations

Study Locations

• Canada
  • Quebec
    • Québec, Quebec, Canada, G1V4G5
      • Institut Universitaire de cardiologie et de pneumologie de Quebec

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: 18 years and older (Adult, Older Adult)
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Intubated patients during their stay in the IUCPQ-UL emergency or intensive care department

Description

Inclusion Criteria:

• Adults (> or = 18 years old)
• New endotracheal intubation

Exclusion Criteria:

• Absence of arterial (or capillary) gas within two hours of intubation
• Absence of patient sizes available throughout the medical record

Study Plan

How is the study designed?

Number of groups / cohorts

1

Cohorts and Interventions

Group / Cohort

Intervention / Treatment

Intubated patient during their stay in the IUCPQ-UL emergency or intensive care department

Other: VentilO application; This educational application provides clinicians with combinations of tidal volume and respiratory rate based on gender, height, weight, body temperature and patient type. The algorithm used is based on published data regarding ventilatory requirements in different populations (i.e. from intubated patients for scheduled surgery to the most severe ICU patients) and anatomical and instrumental dead space. The objective of this application is to help implement personalized protective ventilation in intubated patients according to their characteristics. After patient data entry in the VentilO appllication we will compare the recommended settings (for mechanical ventilation) vs the real clinicial settings done by clinician after patient intubation.We will evaluated the potential effect of the VentilO recommendation on the first arterial (or capillary) blood gases compared to the real settings.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
acid-base abnormalities on arterial (or capillary) blood gases	evaluate the frequency of acid-base abnormalities, either acidosis or alkalosis, of respiratory or mixed origin on the first arterial gases after intubation. Respiratory acidosis is defined as a pH < 7.35 with a PaCO2 > 45 mmHg, and respiratory alkalosis as a pH > 7.45 with a PaCO2 < 35 mmHg)	on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
Improvement acid-base abnormalities with the VentilO application	In case of respiratory acidosis: minute ventilation proposed by VentilO > set minute ventilation;; In case of respiratory alkalosis: proposed minute ventilation by VentilO < set minute ventilation	on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
Impairement acid-base abnormalities with the VentilO application	In case of respiratory acidosis: proposed minute ventilation by VentilO < set minute ventilation; In case of respiratory alkalosis: minute ventilation proposed by VentilO > set minute ventilation	on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Occurence of optimal arterial (or capillary) blood gases result	An optimal arterial (or capillary) blood gases as defined by a pH between 7.35 and 7.45 with a PaCO2 between 36 and 45 mmHg	on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
Severity of unbalance of arterial (or capillary) blood gases result	For acid-base abnormalities, they will be evaluated according to their level of severity: the frequency of moderate (pH between 7.30 and 7.34) and severe (pH < 7.30) acidoses, and the frequency of moderate (pH between 7.46 and 7.50) and severe (pH > 7.50) alkaloses. The frequency of moderate (PaCO2 between 46 and 50 mmHg) and severe (PaCO2 > 50 mmHg) hypercapnia, and the frequency of moderate (PaCO2 between 31 and 35 mmHg) and severe (PaCO2 < 31 mmHg) hypocapnia	on the first result available of arterial(or capillary) blood gases after intubation; 2 hours maximum post intubation
hemodynamic instabilities	arterial hypotension requiring vascular filling > 1000 ml and/or use of vasopressors or inotropes such as levophed or adrenaline at > 0.05 mcg/kg/min)	Between Hour0 to Hour1 after intubation
ICU length of stay	ICU length of stay - ICU admission through ICU discharge	up to 90 days. ICU stay - ICU admission through ICU discharge or until death if occured
Hospital length of stay	Hospital length of stay - Emergency department admission through hospital discharge	up to 90 days. ICU stay - Emergency department admission through hospital discharge or until death if occured
ICU mortality	Occurence of death during ICU stay	up to 90 days. ICU admission through until death if occured

Collaborators and Investigators

• Sponsor: Laval University

Study record dates

Study Major Dates

• Study Start (Actual): December 5, 2022
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): December 1, 2026

Study Registration Dates

• First Submitted: October 17, 2022
• First Submitted That Met QC Criteria: October 17, 2022
• First Posted (Actual): October 20, 2022

Study Record Updates

• Last Update Posted (Estimated): August 28, 2025
• Last Update Submitted That Met QC Criteria: August 27, 2025
• Last Verified: August 1, 2025

More Information

Terms related to this study

• Other Study ID Numbers: 22267

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No