- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT05761093
- Original Trial
Patient and Physician Benefit/ Risk Preferences for Treatment of mPC in Hong Kong: a Discrete Choice Experiment
May 4, 2025 updated by: NG Chi Fai, Chinese University of Hong Kong
A Study to Evaluate Patient and Physician Benefit/ Risk Preferences for Treatment of Metastatic Prostate Cancer (mPC) in Hong Kong: a Discrete Choice Experiment
The objective of this study is to examine the preference weightings in term of risk/ benefit attributes of treatment in physician and prostate cancer patients from different stages of disease.
Study Overview
Status
Recruiting
Conditions
Study Type
Observational
Enrollment (Estimated)
306
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Chi Fai Ng, MD
- Phone Number: 35052625
- Email: ngcf@surgery.cuhk.edu.hk
Study Locations
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-
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Sha Tin, Hong Kong
- Recruiting
- Prince of Wales Hospital
-
Contact:
- Chi Fai NG, MD
- Phone Number: 3505 2625
- Email: ngcf@surgery.cuhk.edu.hk
-
-
Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
18 years and older (Adult, Older Adult)
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
300 consecutive patients with metastatic prostate cancer (150 mHSPC and 150 mCRPC) within 5 years will be recruited
Description
Inclusion Criteria:
- aged 18 years or older,
- diagnosis of metastatic prostate cancer within 5 years,
- able to read and write,
- accepting and signing the informed consent
Exclusion Criteria:
- if patients are unable to complete the survey by themselves due to physical or psychological reasons,
- deemed ineligible by treating physicians if patients are unable to complete the survey by themselves due to physical or psychological reasons,
- deemed ineligible by treating physicians
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
Patient preferences for treatment attributes in prostate cancer from different stages of disease
Time Frame: 15 minutes (Once through survey)
|
Derived from discrete choice experiment
|
15 minutes (Once through survey)
|
|
The Preference weighting from Physicians involved in the treatment of prostate cancer in term of risk/benefit attributes of treatment.
Time Frame: 15 minutes (Once through survey)
|
Derived from discrete choice experiment.
|
15 minutes (Once through survey)
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
To examine the effect of socio-economic status on preference weighing
Time Frame: 15 minutes (Once through survey)
|
Derived from discrete choice experiment
|
15 minutes (Once through survey)
|
|
To examine their willingness of trading off survival with improving QOL
Time Frame: 15 minutes (Once through survey
|
Derived from discrete choice experiment
|
15 minutes (Once through survey
|
|
To examine the status of comorbidities on preference weighing
Time Frame: 15 minutes (Once through survey)
|
Derived from discrete choice experiment
|
15 minutes (Once through survey)
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Investigators
- Principal Investigator: Chi Fai NG, MD, Chinese University of Hong Kong
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Gravis G, Fizazi K, Joly F, Oudard S, Priou F, Esterni B, Latorzeff I, Delva R, Krakowski I, Laguerre B, Rolland F, Theodore C, Deplanque G, Ferrero JM, Pouessel D, Mourey L, Beuzeboc P, Zanetta S, Habibian M, Berdah JF, Dauba J, Baciuchka M, Platini C, Linassier C, Labourey JL, Machiels JP, El Kouri C, Ravaud A, Suc E, Eymard JC, Hasbini A, Bousquet G, Soulie M. Androgen-deprivation therapy alone or with docetaxel in non-castrate metastatic prostate cancer (GETUG-AFU 15): a randomised, open-label, phase 3 trial. Lancet Oncol. 2013 Feb;14(2):149-58. doi: 10.1016/S1470-2045(12)70560-0. Epub 2013 Jan 8.
- Ryan M, Farrar S. Using conjoint analysis to elicit preferences for health care. BMJ. 2000 Jun 3;320(7248):1530-3. doi: 10.1136/bmj.320.7248.1530. No abstract available.
- Sartor O, de Bono JS. Metastatic Prostate Cancer. N Engl J Med. 2018 Feb 15;378(7):645-657. doi: 10.1056/NEJMra1701695. Epub 2018 Feb 7. No abstract available.
- Feldman-Stewart D, Brundage MD, Van Manen L, Svenson O. Patient-focussed decision-making in early-stage prostate cancer: insights from a cognitively based decision aid. Health Expect. 2004 Jun;7(2):126-41. doi: 10.1111/j.1369-7625.2004.00271.x.
- Aning JJ, Wassersug RJ, Goldenberg SL. Patient preference and the impact of decision-making aids on prostate cancer treatment choices and post-intervention regret. Curr Oncol. 2012 Dec;19(Suppl 3):S37-44. doi: 10.3747/co.19.1287.
- Hauber AB, Arellano J, Qian Y, Gonzalez JM, Posner JD, Mohamed AF, Gatta F, Tombal B, Body JJ. Patient preferences for treatments to delay bone metastases. Prostate. 2014 Nov;74(15):1488-97. doi: 10.1002/pros.22865. Epub 2014 Aug 17.
- Uemura H, Matsubara N, Kimura G, Yamaguchi A, Ledesma DA, DiBonaventura M, Mohamed AF, Basurto E, McKinnon I, Wang E, Concialdi K, Narimatsu A, Aitoku Y. Patient preferences for treatment of castration-resistant prostate cancer in Japan: a discrete-choice experiment. BMC Urol. 2016 Nov 4;16(1):63. doi: 10.1186/s12894-016-0182-2. Erratum In: BMC Urol. 2017 Mar 28;17(1):20. doi: 10.1186/s12894-017-0210-x.
- Fizazi K, Shore N, Tammela TL, Ulys A, Vjaters E, Polyakov S, Jievaltas M, Luz M, Alekseev B, Kuss I, Kappeler C, Snapir A, Sarapohja T, Smith MR; ARAMIS Investigators. Darolutamide in Nonmetastatic, Castration-Resistant Prostate Cancer. N Engl J Med. 2019 Mar 28;380(13):1235-1246. doi: 10.1056/NEJMoa1815671. Epub 2019 Feb 14.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Actual)
September 7, 2022
Primary Completion (Estimated)
December 31, 2025
Study Completion (Estimated)
March 31, 2026
Study Registration Dates
First Submitted
February 28, 2023
First Submitted That Met QC Criteria
February 28, 2023
First Posted (Actual)
March 9, 2023
Study Record Updates
Last Update Posted (Actual)
May 6, 2025
Last Update Submitted That Met QC Criteria
May 4, 2025
Last Verified
May 1, 2025
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- CRE-2022.301
Plan for Individual participant data (IPD)
Plan to Share Individual Participant Data (IPD)?
NO
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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