Maca in Healthy Subjects After Strenuous Endurance Exercise

March 9, 2023 updated by: Taipei Medical University

Effects of Lepidium Meyenii (Maca) Extract Supplementation on Immune Function, Inflammatory Responses, Oxidative Stress After Strenuous Endurance Exercise

The aim of this study is to investigate Lepidium meyenii (Maca) extract supplementation on exercise-induced responses of the biochemical, and physiological parameters.

Study Overview

Status

Active, not recruiting

Conditions

Healthy

Intervention / Treatment

Detailed Description

Thirty healthy male participants were divided into Maca group (2.25 g of Maca extract, twice per day for 12 weeks) and placebo group (n = 15). All participants conducted a graded exercise test on treadmill to determine the maximal oxygen consumption (VO2max) before and after supplementation, and the speed equivalent to 70% VO2max was conducted for an exhaustive endurance exercise test by treadmill for 1 hours, followed by 90% VO2max until exhaustion.The time to exhaustion, peak oxygen consumption, maximal heart rate and average heart rate will be recorded during the exercise period. Venous blood samples will be drawn before, immediately after, 2-hour after, 4-hour after, and 24-hour after the exhaustive endurance exercise test. Data was analyzed by Two-way mixed design ANOVA.

Study Type

Interventional

Enrollment (Anticipated)

Phase

Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Taiwan
- - Taipei, Taiwan, 110
    - Taipei Medical University

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

20 years to 40 years (Adult)

Accepts Healthy Volunteers

Yes

Genders Eligible for Study

Male

Description

Inclusion Criteria:

The volunteers included have conditions as stated below :

male adult whose no history of cardiovascular, liver, kidney and diabetes disease
no acute sport injury
did not participated in any clinical trials or research in the last 3 months before our experiment
no supplements were taken during the experimental period
were requested to maintain their regular daily life style and avoid alcohol intake

Exclusion Criteria:

The volunteers were excluded if they have the situation stated below:

history of cardiovascular, liver, kidney and diabetes disease
acute sport injury
participated in any clinical trials or experimental research in the last 3 months before our experiment
taking supplement during the experimental period
did not maintain their regular eating habit or drink alcohol

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Non-Randomized
Interventional Model: Parallel Assignment
Masking: Double

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo group	Dietary supplement: placebo 2.25 g of starch, twice per day for 12 weeks
Experimental: maca group	Dietary supplement: maca 2.25 g of Maca extract, twice per day for 12 weeks Other Names: Panion & BF Biotech Inc.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Time Frame
Concentration of leukocyte Time Frame: before exercise	before exercise
Concentration of leukocyte Time Frame: immediately after exercise	immediately after exercise
Concentration of leukocyte Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of leukocyte Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of leukocyte Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of neutrophil Time Frame: before exercise	before exercise
Concentration of neutrophil Time Frame: immediately after exercise	immediately after exercise
Concentration of neutrophil Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of neutrophil Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of neutrophil Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of lymphocyte Time Frame: beore exercise	beore exercise
Concentration of lymphocyte Time Frame: immediately after exercise	immediately after exercise
Concentration of lymphocyte Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of lymphocyte Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of lymphocyte Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of GSH Time Frame: before exercise	before exercise
Concentration of GSH Time Frame: immediately after exercise	immediately after exercise
Concentration of GSH Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of GSH Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of GSH Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of CD4+ Time Frame: before exercise	before exercise
Concentration of CD4+ Time Frame: immediately after exercise	immediately after exercise
Concentration of CD4+ Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of CD4+ Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of CD4+ Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of CD8+ Time Frame: before exercise	before exercise
Concentration of CD8+ Time Frame: immediately after exercise	immediately after exercise
Concentration of CD8+ Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of CD8+ Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of CD8+ Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of CD19+ Time Frame: before exercise	before exercise
Concentration of CD19+ Time Frame: immediately after exercise	immediately after exercise
Concentration of CD19+ Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of CD19+ Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of CD19+ Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of CD56+ Time Frame: before after exercise	before after exercise
Concentration of CD56+ Time Frame: immediately after exercise	immediately after exercise
Concentration of CD56+ Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of CD56+ Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of CD56+ Time Frame: 24-hour after exercise	24-hour after exercise
IConcentration of GSSG Time Frame: before exercise	before exercise
Concentration of GSSG Time Frame: immediately after exercise	immediately after exercise
Concentration of GSSG Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of GSSG Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of GSSG Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of CK-MB Time Frame: before exercise	before exercise
Concentration of CK-MB Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of CK-MB Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of CK-MB Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of CK-MB Time Frame: immediately after exercise	immediately after exercise
Concentration of TNF-α Time Frame: before exercise	before exercise
Concentration of TNF-α Time Frame: immediately after exercise	immediately after exercise
Concentration of TNF-α Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of TNF-α Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of TNF-α Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of IL-1β Time Frame: before exercise	before exercise
Concentration of IL-1β Time Frame: immediately after exercise	immediately after exercise
Concentration of IL-1β Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of IL-1β Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of IL-1β Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of IFN-γ Time Frame: before exercise	before exercise
Concentration of IFN-γ Time Frame: immediately after exercise	immediately after exercise
Concentration of IFN-γ Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of IFN-γ Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of IFN-γ Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of IL-2 Time Frame: before exercise	before exercise
Concentration of IL-2 Time Frame: immediately after exercise	immediately after exercise
Concentration of IL-2 Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of IL-2 Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of IL-2 Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of IL-4 Time Frame: before exercise	before exercise
Concentration of IL-4 Time Frame: immediately after exercise	immediately after exercise
Concentration of IL-4 Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of IL-4 Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of IL-4 Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of IL-8 Time Frame: before exercise	before exercise
Concentration of IL-8 Time Frame: immediately after exercise	immediately after exercise
Concentration of IL-8 Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of IL-8 Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of IL-8 Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of IL-10 Time Frame: before exercise	before exercise
Concentration of IL-10 Time Frame: immediately after exercise	immediately after exercise
Concentration of IL-10 Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of IL-10 Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of IL-10 Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of TBARS Time Frame: before exercise	before exercise
Concentration of TBARS Time Frame: immediately after exercise	immediately after exercise
Concentration of TBARS Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of TBARS Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of TBARS Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of PC Time Frame: before exercise	before exercise
Concentration of PC Time Frame: immediately after exercise	immediately after exercise
Concentration of PC Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of PC Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of PC Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of SOD Time Frame: before exercise	before exercise
Concentration of SOD Time Frame: immediately after exercise	immediately after exercise
Concentration of SOD Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of SOD Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of SOD Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of catalase Time Frame: before exercise	before exercise
Concentration of catalase Time Frame: immediately after exercise	immediately after exercise
Concentration of catalase Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of catalase Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of catalase Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of GPx Time Frame: before exercise	before exercise
Concentration of GPx Time Frame: immediately after exercise	immediately after exercise
Concentration of GPx Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of GPx Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of GPx Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of CK Time Frame: before exercise	before exercise
Concentration of CK Time Frame: immediately after exercise	immediately after exercise
Concentration of CK Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of CK Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of CK Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of LDH Time Frame: before exercise	before exercise
Concentration of LDH Time Frame: immediately after exercise	immediately after exercise
Concentration of LDH Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of LDH Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of LDH Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of IL-6 Time Frame: before exercise	before exercise
Concentration of IL-6 Time Frame: immediately after exercise	immediately after exercise
Concentration of IL-6 Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of IL-6 Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of IL-6 Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of cTnI Time Frame: before exercise	before exercise
Concentration of cTnI Time Frame: immediately after exercise	immediately after exercise
Concentration of cTnI Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of cTnI Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of cTnI Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of NT proBNP Time Frame: before exercise	before exercise
Concentration of NT proBNP Time Frame: immediately after exercise	immediately after exercise
Concentration of NT proBNP Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of NT proBNP Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of NT proBNP Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of testosterone Time Frame: before exercise	before exercise
Concentration of testosterone Time Frame: immediately after exercise	immediately after exercise
Concentration of testosterone Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of testosterone Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of testosterone Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of LH Time Frame: before exercise	before exercise
Concentration of LH Time Frame: immediately after exercise	immediately after exercise
Concentration of LH Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of LH Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of LH Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of FSH Time Frame: before exercise	before exercise
Concentration of FSH Time Frame: immediately after exercise	immediately after exercise
Concentration of FSH Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of FSH Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of FSH Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of NO Time Frame: before exercise	before exercise
Concentration of NO Time Frame: immediately after exercise	immediately after exercise
Concentration of NO Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of NO Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of NO Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of GOT Time Frame: before exercise	before exercise
Concentration of GOT Time Frame: immediately after exercise	immediately after exercise
Concentration of GOT Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of GOT Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of GOT Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of GPT Time Frame: before exercise	before exercise
Concentration of GPT Time Frame: immediately after exercise	immediately after exercise
Concentration of GPT Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of GPT Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of GPT Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of BUN Time Frame: before exercise	before exercise
Concentration of BUN Time Frame: immediately after exercise	immediately after exercise
Concentration of BUN Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of BUN Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of BUN Time Frame: 24-hour after exercise	24-hour after exercise
Concentration of creatinine Time Frame: before exercise	before exercise
Concentration of creatinine Time Frame: immediately after exercise	immediately after exercise
Concentration of creatinine Time Frame: 2-hour after exercise	2-hour after exercise
Concentration of creatinine Time Frame: 4-hour after exercise	4-hour after exercise
Concentration of creatinine Time Frame: 24-hour after exercise	24-hour after exercise

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Taipei Medical University

Collaborators

Panion & BF Biotech Inc.

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

April 14, 2022

Primary Completion (Anticipated)

December 1, 2023

Study Completion (Anticipated)

December 1, 2023

Study Registration Dates

First Submitted

February 20, 2023

First Submitted That Met QC Criteria

March 9, 2023

First Posted (Actual)

March 22, 2023

Study Record Updates

Last Update Posted (Actual)

March 22, 2023

Last Update Submitted That Met QC Criteria

March 9, 2023

Last Verified

February 1, 2023

More Information

Terms related to this study

Other Study ID Numbers

N202103118
MOST110-2410-H-038-013 (Other Grant/Funding Number: National Science and Technology Council)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Healthy

University of Vermont Medical Center
Avocado Nutrition Center

Recruiting

Avocado and Postprandial Responses

Healthy | Healthy Volunteers | Healthy Subjects | Healthy Volunteer | Healthy Adult | Healthy Volunteers Only | Healthy Male and Female Subjects | Healthy Non-smokers

United States
Dragonfly Therapeutics

Recruiting

A Study to Evaluate the Safety of Increasing Doses of DF5112 in Healthy Adults (DF5112)

Healthy | Healthy Participants | Healthy Adult Females | Volunteer | Healthy Adult Male

Australia
University of Palermo

Completed

Neck Static Stretching Acutely Reduces Blood Pressure Through Reduction of Tissue Stiffness

Healthy | Healthy Volunteers | Healthy Subjects | Healthy Participants | Static Stretching | Stretch | Stretching

Italy
Prevent Age Resort "Pervaya Liniya"

Recruiting

First Line Prevent Age Study (FLIPS)

Healthy Aging | Healthy Diet | Healthy Lifestyle

Russian Federation
Yale University

Not yet recruiting

Health-related Benefits of Introducing Table Olives Into the Diet of Young Adults: Olives For Health

Healthy Diet | Healthy Lifestyle | Healthy Nutrition | Cholesterol

United States
Maastricht University Medical Center

Completed

Reference Gait Data for Healthy Subjects

Healthy Volunteers | Healthy Subjects | Healthy Adults

Netherlands
Umm Al-Qura University

Active, not recruiting

Effect of Magnesium Supplementation on Sleep Quality and Cognitive Function in Saudi Adults

Healthy | Healthy Participants | Healthy Adult | Healthy Women | Healthy Adult Females | Healthy Adult Participants | Healthy Young Adults | Healthy Adult Female Participants | Healthy Adult Male | Poor Sleep Quality | Healthy (Controls) | Poor Sleeping Quality | Healthy Adult Male Subjects | Health Adult Subjects

Saudi Arabia
University of Palermo

Completed

Roller Massage and Blood Pressure

Healthy Participants | Healthy Adult Participants | Healthy Young Adults

Italy
University Hospital, Strasbourg, France
ICube Laboratory

Not yet recruiting

Effects of Repetitive Transcranial Magnetic Stimulation on Two Cerebellar Targets (StimCervelet)

Healthy | Healthy Adult

France
Beijing Tide Pharmaceutical Co., Ltd

Recruiting

Phase I Study of CPD704 Inhalation Suspension in Healthy Subjects

Healthy | Healthy Participants

China

Clinical Trials on maca

China Medical University Hospital
National Science and Technology Council; China Medical University, Taiwan

Completed

Effects of Maca Supplementation on Badminton-specific Exercise Performance

Healthy | Athletes

Taiwan
Taipei Medical University

Not yet recruiting

Maca Extract in Sexual Dysfunction Male

Sexual Dysfunction Male

Taiwan
Massachusetts General Hospital

Completed

Safety and Effectiveness Study of Maca Root to Treat Antidepressant-Induced Sexual Dysfunction

Depression | Sexual Dysfunction

United States
Massachusetts General Hospital
National Alliance for Research on Schizophrenia and Depression

Terminated

Study of Maca Root to Treat Sexual Dysfunction Associated With the Treatment Regimen for Bipolar Disorder in Females

Sexual Dysfunction | Bipolar Disorder

United States
Massachusetts General Hospital
National Institutes of Health (NIH); National Center for Complementary and... and other collaborators

Completed

Study of Maca Root for the Treatment of Antidepressant-Induced Sexual Dysfunction in Females

Antidepressant Induced Sexual Dysfunction

United States
National Taiwan Sport University

Completed

The Impact of MACA Supplementation on Basketball-related Performance

Sports

Taiwan
Natural Wellness Egypt

Completed

A Clinical Trial to Investigate the Efficacy and Safety of Tongkat Ali Maca Plus

Erectile Dysfunction

Egypt
Universidade do Vale do Sapucai
Irmandade da Santa Casa de Misericordia de Sao Paulo

Unknown

Effects of Lepidium Meyenii Walp on Sexual Function in Postmenopausal Women (maca)

Sexual Dysfunction, Physiological

Brazil

Maca in Healthy Subjects After Strenuous Endurance Exercise

Effects of Lepidium Meyenii (Maca) Extract Supplementation on Immune Function, Inflammatory Responses, Oxidative Stress After Strenuous Endurance Exercise

Study Overview

Status

Conditions

Intervention / Treatment

Detailed Description

Study Type

Enrollment (Anticipated)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Genders Eligible for Study

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Time Frame

Collaborators and Investigators

Sponsor

Collaborators

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Anticipated)

Study Completion (Anticipated)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Other Study ID Numbers

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product

Clinical Trials on Healthy

Clinical Trials on maca

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in United Arab Emirates

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations