Effect of Pomegranate Seed Powder on Markers of Metabolic Syndrome

Therapeutic Effects of Pomegranate Seed Powder on Metabolic Syndrome Markers

Metabolic syndrome is a public health concern worldwide and in Pakistan as well. Abdominal obesity, hyperglycemia, hypertriglyceridemia, hypertension, and low HDL cholesterol are its hallmarks while pomegranate seed's unique chemical composition has sparked research into the health benefits in same arena as weight control, blood lipid profile changes, and other metabolic disturbances. It's high time to study therapeutic efficiency of Pomegranate seed powder against metabolic syndrome.

Study Overview

• Status: Recruiting
• Conditions: Metabolic Syndrome
• Intervention / Treatment: Dietary supplement: Pomegranate seed powder

Detailed Description

Metabolic syndrome, accumulation of certain metabolic risk factors, such as abdominal obesity, hyperglycemia, hypertriglyceridemia, hypertension, and low HDL cholesterol, has been noted as one of the most important risk factors for the epidemic of type 2 diabetes and cardiovascular disease in the 21st century. It has become a significant public health concern and a global epidemic with a prevalence rate of about 25% among American adults. Multiple researches have demonstrated the effectiveness of pomegranate in the management of diabetes, inflammatory conditions, obesity, and blood lipid levels, and consequently metabolic syndrome. Various pomegranate components have the potential to substitute anti-diabetic medications as well Pomegranate seed's unique chemical composition has sparked research into the health benefits, such as weight control, blood lipid profile changes, and other metabolic disorders.

seed powder can influence the patient's metabolic syndrome-related indicators.

Hypothesis:

Pomegranate seed powder can be effective to treat the individuals with impaired metabolism.

Methodology:

In a clinical trial, patients of metabolic syndrome (n=50) will be given pomegranate seed powder dose for over 8 weeks, twice a day. Biochemical outcomes including blood pressure, FBG, cholesterol, hemoglobin level will be determined before and after the completion of trial in addition to patient's weight. Finally, using one-way ANOVA and T-test, collected data will be analyzed.

Expected outcome: The study will explore the potential of pomegranate seed powder in treating metabolic syndrome's risk factors. Therefore, our findings on the studied parameters of patient will assist future researchers in developing tested, evidence-based recommendations.

• Study Type: Interventional
• Enrollment (Estimated): 50
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Shahbano Zahid, Mphil; Phone Number: +923095563643; Email: shahbanozahid265@gmail.com
• Study Contact Backup: Name: Dr. Asif Ali, PhD; Phone Number: 296 +923017151530; Email: asif.ali@uvas.edu.pk

Study Locations

• Pakistan
  • Punjab
    • Lahore, Punjab, Pakistan, 54000
      • Recruiting
      • University of Veterinary and Animal sciences Lahore
      • Contact: Dr. Asif Ali, PhD; Phone Number: 296 03017151530; Email: asif.ali@uvas.edu.pk

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: No

Description

Inclusion Criteria:

• BMI > 25kg/m2
• Dyslipidemia
• Altered blood glucose level
• Age 30-55 ( male and female)

Exclusion Criteria:

• Thyroid disorder
• Liver disease
• Kidney disorder
• Cancer etc

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Supportive Care
• Allocation: N/A
• Interventional Model: Single Group Assignment
• Masking: None (Open Label)

Number of Arms

1

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Metabolic syndrome Patients; Pomegranate seed powder is administered for alleviating symptoms of metabolic syndrome	Dietary supplement: Pomegranate seed powder; 10 g powder / day; Other Names: Punica granatum

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Lipid Profile	The change in Lipid Profile, after consuming Pomegranate seed powder for 7 weeks will be assessed, to look for improvements.	7 weeks
Fasting Glucose	The change in Blood Glucose level, after consuming Pomegranate seed powder for 7 weeks will be assessed, to look for improvements.	7 weeks
Blood Pressure	The change in both systolic and diastolic blood pressure after consuming Pomegranate seed powder for 7 weeks will be assessed, to look for improvements.	7 weeks
Weight	The change in weight, after consuming Pomegranate seed powder for 7 weeks will be assessed, to look for improvements.	7 weeks

Collaborators and Investigators

• Sponsor: Asif Ali
• Investigators: Study Director: Dr. Asif Ali, Mphil, University of Veterinary and Animal sciences Lahore

Study record dates

Study Major Dates

• Study Start (Actual): February 20, 2023
• Primary Completion (Estimated): July 20, 2023
• Study Completion (Estimated): August 24, 2023

Study Registration Dates

• First Submitted: April 11, 2023
• First Submitted That Met QC Criteria: July 10, 2023
• First Posted (Actual): July 13, 2023

Study Record Updates

• Last Update Posted (Actual): July 13, 2023
• Last Update Submitted That Met QC Criteria: July 10, 2023
• Last Verified: July 1, 2023

More Information

Terms related to this study

• Keywords: Diabetes; Obesity; Dyslipidemia; Hypertension; Insulin Resistance; Metabolic Syndrome; Pomegranate seed powder
• Additional Relevant MeSH Terms: Pathologic Processes; Glucose Metabolism Disorders; Metabolic Diseases; Disease; Insulin Resistance; Hyperinsulinism; Syndrome; Metabolic Syndrome
• Other Study ID Numbers: UVAS (Other Identifier: UNIVERSITY OF VETERINARY & ANIMAL SCIENCES, LAHORE)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Intervention study, data will be confidential to maintain patients privacy, enrollment of patients with their consent

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No