A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)

August 10, 2026 updated by: Boehringer Ingelheim

A Phase 3, Randomised, Double-blind, Parallel-group, Event-driven, Cardiovascular Safety Study With BI 456906 Administered Subcutaneously Compared With Placebo in Participants With Overweight or Obesity With Established Cardiovascular Disease (CVD) or Chronic Kidney Disease, and/or at Least Two Weight-related Complications or Risk Factors for CVD

This study is open to adults who are at least 18 years old and have a body mass index (BMI) of 27 kg/m2 or more. People can take part if they have cardiovascular or chronic kidney disease. People who have at least 2 health problems related to their weight or risks of cardiovascular disease can participate. Participants must have previously tried to lose weight by changing their diet.

The purpose of this study is to find out whether people with overweight or obesity who take a medicine called survodutide (BI 456906) are less or more likely to develop serious cardiovascular problems. It also aims to find out whether health parameters like blood pressure improve. Overweight and obesity are linked to cardiovascular disease. Survodutide is a medicine that is developed to help people with obesity or overweight to lose weight.

Participants are divided into 3 groups of almost equal size. 2 groups get different doses of survodutide and 1 group gets placebo. Placebo looks like survodutide but does not contain any medicine. Every participant has a 2 in 3 chance of getting survodutide. Participants inject survodutide or placebo under the skin once a week. All participants also receive counselling on diet and physical activity.

Participants are in the study for up to 2 years and 3 months. During this time, it is planned that participants visit the study site up to 21 times and attend remote visits by video calls. During these visits, the doctors check participants' cardiovascular and overall health. The results are compared between survodutide and placebo groups. The study staff also takes note of any unwanted effects.

Study Overview

Status

Completed

Conditions

Obesity

Intervention / Treatment

Study Type

Interventional

Enrollment (Actual)

5531

Phase

Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

Argentina
- - Buenos Aires, Argentina, C1056ABJ
    - Centro de Investigaciones Metabólicas (CINME)
  - CABA, Argentina, C1060ABN
    - CEDIC - Centro de Investigacion Clinica
  - CABA, Argentina, C1128AAF
    - Mautalen- Salud e Investigacion
  - Ciudad Autonoma Buenos Aires, Argentina, C1430CKE
    - Glenny Corp. S.A. Bioclinica Argentina
  - Ciudad Autonoma Buenos Aires, Argentina, C1425AGC
    - Centro Medico Dra Laura Maffei
  - Ciudad Autonoma de Bs As, Argentina, C1120AAC
    - Centro Médico Viamonte
  - Ciudad Autonoma de Bs As, Argentina, C1180AAX
    - Sanatorio Guemes
  - Ciudad Autonoma de Buenos Aire, Argentina, 1405
    - Consultorio de Investigación Clínica EMO SRL
  - Ciudad Autonoma de Buenos Aire, Argentina, 1602
    - CIPREC
  - Córdoba, Argentina, X5000AVE
    - CIDIM - Centro Integral de Diagnostico por Imagenes Marchegiani
  - Mar del Plata, Argentina, B7600FZN
    - Instituto de Investigaciones Clinicas Mar Del Plata
  - Mar del Plata, Argentina, 7600
    - Centro de Investigaciones Medicas Mar Del Plata
  - Parque Velez Sarsfield, Argentina, X5016KEH
    - Hospital Privado - Centro Medico de Cordoba S.A.
  - Villa Luro, Argentina, 1407
    - CEMEDIC - Centro de Especialidades Medicas
Australia
- New South Wales
  - Camperdown, New South Wales, Australia, 2050
    - The Boden Initiative
  - Charlestown, New South Wales, Australia, 2290
    - Novatrials
  - St Leonards, New South Wales, Australia, 2065
    - Royal North Shore Hospital-St Leonards-66471
- Queensland
  - Taringa, Queensland, Australia, 4068
    - Momentum Clinical Research - Taringa
  - Wellers Hill, Queensland, Australia, 4121
    - Momentum Clinical Research Taringa
- South Australia
  - Adelaide, South Australia, Australia, 5000
    - Royal Adelaide Hospital
  - Leabrook, South Australia, Australia, 5068
    - Advara Heart Care-Leabrook-69072
  - Oaklands Park, South Australia, Australia, 5046
    - Southern Adelaide Diabetes & Endocrine Services
- Victoria
  - Clayton, Victoria, Australia, 3168
    - Victorian Heart Hospital
  - Parkville, Victoria, Australia, 3050
    - Royal Melbourne Hospital
- Western Australia
  - Joondalup, Western Australia, Australia, 6027
    - Advara Heart Care-Joondalup-69073
Austria
- - Graz, Austria, 8036
    - Medical University of Graz
  - Innsbruck, Austria, 6020
    - Medical University of Innsbruck
  - Linz, Austria, 4021
    - Convent Hospital Barmherzige Brüder
  - Salzburg, Austria, 5020
    - LKH Salzburg University Hospital
  - Stockerau, Austria, 2000
    - Hospital Stockerau
  - Vienna, Austria, 1090
    - AKH - Medical University of Vienna
  - Vienna, Austria, 1030
    - Klinik Landstraße
  - Vienna, Austria, 1060
    - Private Practice - Dr. Ursula Hanusch-Enserer
Belgium
- - Bruges, Belgium, 8000
    - AZ Sint-Jan Brugge
  - Edegem, Belgium, 2650
    - Universitair Ziekenhuis Antwerpen
  - Leuven, Belgium, 3000
    - UZ Leuven
Brazil
- - Belém, Brazil, 66073-005
    - Hospital Universitário João de Barros Barreto
  - Brasília, Brazil, 70200-730
    - L2IP -Instituto de Pesquisas Clínicas Ltda.
  - Brasília, Brazil, 72145-450
    - Chronos Pesquisa Clinica
  - Curitiba, Brazil, 81520-060
    - Cline Research Center
  - Fortaleza, Brazil, 60160-230
    - Instituto de Estudos e Pesquisas Clínicas IEP-CE
  - Rio de Janeiro, Brazil, 20241-180
    - Instituto Brasil de Pesquisa Clinica (IBPClin)
  - São José dos Campos, Brazil, 12243-280
    - ISPEM - Instituto São José dos Campos em Pesquisas Médicas
  - São Paulo, Brazil, 01228-000
    - CPQuali Pesquisa Clínica Ltda
  - São Paulo, Brazil, 01221-020
    - Irmandade da Santa Casa de Misericórdia de São Paulo - IPEC - Instituto de Pesquisa Clínica
  - São Paulo, Brazil, 01236-030
    - BR Trials
  - São Paulo, Brazil, 05403-900
    - Hospital Das Clinicas Da Faculdade De Medicina Da USP
  - São Paulo, Brazil, 04266-010
    - CEPIC - Centro Paulista de Investigacao Clinica e Servicos
Bulgaria
- - Byala, Bulgaria, 7100
    - MHAT "Yuliya Vrevska" EOOD, Byala
  - Dobrich, Bulgaria, 9300
    - MHAT - Dobrich, AD
  - Dupnitsa, Bulgaria, 2600
    - Multy profile hospital for active treatment Sv.Ivan Rilski
  - Plovdiv, Bulgaria, 4000
    - Multiprofile Hospital for Active Treatment Trimontsium OOD
  - Plovdiv, Bulgaria, 4004
    - MHAT "St. Caridad"
  - Sliven, Bulgaria, 8800
    - Multy Profile Hospital for active treatment Hadzhi Dimirar
  - Sofia, Bulgaria, 1431
    - Alexandrovska University Hospital
  - Sofia, Bulgaria, 1527
    - UMHAT "Tsaritsa Yoanna-ISUL" EAD
  - Sofia, Bulgaria, 1784
    - Medical Center Synexus Sofia EOOD
  - Sofia, Bulgaria, 1202
    - Diagnostic & Consultancy Center "Ascendent", Sofia
  - Sofia, Bulgaria, 1431
    - Diagnostic Consultative Center Alexandrovska
  - Sofia, Bulgaria, 1582
    - ASOMHIDC - Individual practice "Cardio Tonus" EOOD
  - Yambol, Bulgaria, 8600
    - Medical Center Berbatov
  - Yambol, Bulgaria, 8600
    - MHAT St Panteleimon
Canada
- - Québec, Canada, G1G 5X1
    - Recherche Clinique Sigma Inc.
- Alberta
  - Calgary, Alberta, Canada, T2V 4J2
    - C-ENDO Diabetes & Endocrinology Clinic
  - Calgary, Alberta, Canada, T2T 5C7
    - Richmond Road Diagnostic & Treatment Centre
  - Red Deer, Alberta, Canada, T4P 1K4
    - CARe Clinic (Red Deer)
- British Columbia
  - Surrey, British Columbia, Canada, V3V 0C6
    - SMH Cardiology Clinical Trials Inc.
  - Victoria, British Columbia, Canada, V8R 1B2
    - Victoria Heart Institute Foundation
- Manitoba
  - Winnipeg, Manitoba, Canada, R3C 0N2
    - Winnipeg Clinic
- Nova Scotia
  - Halifax, Nova Scotia, Canada, B3H 1V7
    - QEII Health Sciences Centre
- Ontario
  - Brampton, Ontario, Canada, L6S 0C6
    - Centricity Research (Brampton)
  - Cambridge, Ontario, Canada, N1R 6V6
    - Cambridge Cardiac Care Centre
  - Etobicoke, Ontario, Canada, M9R 4E1
    - Centricity Research (Etobicoke)
  - Hamilton, Ontario, Canada, L8L 5G8
    - The Wharton Medical Clinic Clinical Trials Inc.
  - Hamilton, Ontario, Canada, L8L 5G4
    - Premier Clinical Trial Network
  - London, Ontario, Canada, N6G 2M1
    - Western Centre for Public Health & Family Medicine (LHRI)
  - Oshawa, Ontario, Canada, L1J 2K9
    - Centricity Research (Oshawa)
  - Sarnia, Ontario, Canada, N7T 4X3
    - Bluewater Clinical Research
  - Toronto, Ontario, Canada, M3J 0K2
    - Canadian Phase Onward Inc.
  - Toronto, Ontario, Canada, M6G 1M2
    - Diabetes Heart Research Centre
  - Toronto, Ontario, Canada, M4G 3E8
    - Centricity Research (Bayview)
  - Waterloo, Ontario, Canada, N2T 0C1
    - Clinical Research Solutions Inc. (Waterloo)
- Quebec
  - Chicoutimi, Quebec, Canada, G7H 7K9
    - Ecogene-21
  - Montreal, Quebec, Canada, H1T 1C8
    - Montreal Heart Institute
  - Montreal, Quebec, Canada, H3G 1A4
    - Montreal General Hospital - McGill University Health Centre
  - Terrebonne, Quebec, Canada, J6X 4P7
    - Centre de Médecine Métabolique de Lanaudière
  - Trois-Rivières, Quebec, Canada, G9A 4P3
    - Diex Recherche (Trois-Rivieres)
China
- - Beijing, China, 100020
    - Beijing Chao-Yang Hospital
  - Beijing, China, 100034
    - Peking University First Hospital
  - Beijing, China, 101200
    - Beijing Pinggu Hospital
  - Changchun, China, 130041
    - The Second Hospital of Jilin University
  - Changzhou, China, 213004
    - Changzhou Second People's Hospital
  - Chongqing, China, 400016
    - Second Affiliated Hospital Chongqing Medical University
  - Hangzhou, China, 310006
    - Hangzhou First People's Hospital
  - Harbin, China, 150599
    - Forth Clinical Hospital of Harbin Medical University
  - Hengyang, China, 421001
    - The First Affiliated Hospital of University of South China
  - Huai'an, China, 223300
    - Huai'an First People's Hospital
  - Huzhou, China, 313000
    - Huzhou Central Hospital
  - Jinan, China, 250013
    - Center Hospital of Jinan
  - Lishui, China, 323020
    - Lishui Municipal Central Hospital
  - Luoyang, China, 471000
    - The First Affiliated Hospital of Henan University of Science and Technology
  - Nanchang, China, 330008
    - Nanchang People's Hospital
  - Nanjing, China, 210008
    - Nanjing Drum Tower Hospital
  - Nanjing, China, 210009
    - Zhongda Hospital Southeast University
  - Nanjing, China, 210011
    - The Second Affiliated Hospital of Nanjing Medical University
  - Nanjing, China, 211100
    - Nanjing Jiangning Hospital
  - Nanyang, China, 473007
    - The First Affiliated Hospital of Nanyang Medical College
  - Ningbo, China, 315010
    - The First Affiliated Hospital of Ningbo University
  - Qinhuangdao, China, 066099
    - First Hospital of Qinhuangdao
  - Shanghai, China, 200240
    - Shanghai Fifth People's Hospital affiliated to Fudan University
  - Shanghai, China, 200032
    - Zhongshan Hospital Affiliated to Fudan University
  - Shanghai, China, 200051
    - Tongren hospital, Shanghai Jiaotong University School of Medicine
  - Shanghai, China, 200071
    - Shanghai Municipal Hospital of Traditional Chinese Medicine
  - Shanghai, China, 201200
    - Shanghai Pudong New District People's Hospital
  - Shijiazhuang, China, 050000
    - The Second Hospital of Hebei Medical University
  - Suzhou, China, 215000
    - Suzhou Science & Technology Town Hospital
  - Xi'an, China, 710061
    - First Affiliated Hospital of Xi'an JiaoTong University
  - Xi'an, China, 710077
    - The First Affiliated Hospital of Xi'an Medical University
  - Xi'an, China, 1710068
    - Shaanxi Provincial People's Hospital
  - Xianyang, China, 712000
    - Xianyang Hospital of Yan'an University
  - Zhenjiang, China, 212013
    - Affiliated Hospital of Jiangsu University
Czechia
- - Brno, Czechia, 656 91
    - St. Anna Hospital
  - Havířov, Czechia, 73601
    - DIKa centrum s.r.o.
  - Karlovy Vary, Czechia, 360 17
    - Center for Osteoporosis Therapy
  - Krnov, Czechia, 79401
    - Diabetology Krnov
  - Náchod, Czechia, 547 01
    - Internal and Diabetes Clinic
  - Olomouc, Czechia, 77900
    - PreventaMed, s.r.o.
  - Ostrava-Poruba, Czechia, 708 52
    - University Hospital Ostrava
  - Pilsen, Czechia, 301 00
    - Internal ambulance Dialine s.r.o.
  - Prague, Czechia, 120 00
    - Synexus Czech s.r.o.
  - Prague, Czechia, 128 08
    - General Faculty Hospital, Prague
  - Prague, Czechia, 130 00
    - OB Klinika
  - Prague, Czechia, 140 21
    - Institute for Clinical and Experimental Medicine-Prague-66083
  - Prague, Czechia, 181 00
    - ResTrial s.r.o.
Denmark
- - Aarhus N, Denmark, 8200
    - Aarhus University Hospital
  - Copenhagen, Denmark, 2100
    - Copenhagen University Hospital, Rigshospitalet
  - Herlev, Denmark, 2730
    - Herlev and Gentofte Hospital
  - Herning, Denmark, 7400
    - Regionshospitalet Gødstrup
  - Hvidovre, Denmark, 2650
    - Hvidovre Hospital
Finland
- - Helsinki, Finland, 00180
    - CRST Helsinki Oy
  - Jyväskylä, Finland, 40620
    - StudyCor Oy
  - Pori, Finland, 28100
    - Terveystalo Pori Lääkäritalo
  - Tampere, Finland, 33520
    - Tampere University Hospital
  - Turku, Finland, FI-20100
    - Terveystalo Pulssi, Turku
Germany
- - Aachen, Germany, 52074
    - Universitätsklinikum Aachen, AöR
  - Berlin, Germany, 12559
    - DRK Kliniken Berlin Köpenick
  - Berlin, Germany, 10787
    - Velocity Clinical Research Germany GmbH, Berlin
  - Berlin, Germany, 12627
    - Synexus Clinical Research GmbH, Berlin
  - Cologne, Germany, 50937
    - Universitatsklinikum Koln (AoR)
  - Düsseldorf, Germany, 40225
    - Universitatsklinikum Dusseldorf
  - Erlangen, Germany, 91054
    - Universitätsklinikum Erlangen
  - Frankfurt, Germany, 60596
    - IKF Pneumologie GmbH & Co. KG
  - Frankfurt, Germany, 60313
    - Synexus Clinical Research GmbH, Frankfurt
  - Freiburg im Breisgau, Germany, 79106
    - Universitatsklinikum Freiburg
  - Hanover, Germany, 30625
    - Medizinische Hochschule Hannover
  - Heidelberg, Germany, 69115
    - St. Josefskrankenhaus Heidelberg
  - Homburg, Germany, 66421
    - Universität des Saarlandes
  - Kiel, Germany, 24105
    - Universitätsklinikum Schleswig-Holstein, Campus Kiel
  - Leipzig, Germany, 04103
    - Synexus Clinical Research GmbH, Leipzig
  - Leipzig, Germany, 04177
    - Velocity Clinical Research Germany GmbH, Leipzig
  - Mainz, Germany, 55131
    - Universitätsmedizin der Johannes Gutenberg-Universität Mainz
  - Münster, Germany, 48149
    - Westfälische Wilhelms-Universität Münster
  - Pohlheim, Germany, 35415
    - CEDA Research GBR
  - Tübingen, Germany, 72076
    - Universitatsklinikum Tubingen
Greece
- - Athens, Greece, 11527
    - General Hospital of Athens "Laiko"
  - Haidari-Athens, Greece, 12462
    - Attikon University Hospital
  - Heraklion, Crete, Greece, 71110
    - University General Hospital of Heraklion
  - Ioannina, Greece, 45 500
    - Univ. Gen. Hosp. of Ioannina
  - Larissa, Greece, 415 00
    - University General Hospital of Larissa
  - P. Faliro, Greece, 17562
    - Iatriko of Athens Group/ Iatriko of P. Faliro
  - Psychikó, Greece, 11525
    - Iatriko Psychikou
  - Thessaloniki, Greece, 54636
    - University General Hospital of Thessaloniki AHEPA
  - Thessaloniki, Greece, 546 42
    - Gen. Hosp. of Thessaloniki "Hippokation", Department of Endocrinology
Hong Kong
- - Hong Kong, Hong Kong
    - Tung Wah Hospital
  - Hong Kong, Hong Kong, 999077
    - Queen Mary Hospital
  - Hong Kong, Hong Kong, 999077
    - Prince of Wales Hospital-Hong Kong-20715
Hungary
- - Baja, Hungary, 6500
    - Lausmed Kft.
  - Budapest, Hungary, 1122
    - Semmelweis University
  - Budapest, Hungary, 1106
    - Bajcsy-Zsilinszky Hospital and Clinic
  - Budapest, Hungary, 1036
    - Synexus Hungary Healthcare Service Ltd.
  - Budapest, Hungary, 1062
    - Central Hospital of Northern Pest - Military Hospital
  - Budapest, Hungary, 1036
    - Obudai Egeszegugyi Centrum Kft.
  - Debrecen, Hungary, 4032
    - University Debrecen Hospital
  - Gyula, Hungary, 5700
    - Synexus Hungary Healthcare Service Ltd
  - Gyula, Hungary, 5700
    - Trial Pharma Kft
  - Gödöllő, Hungary, 2100
    - Erzsebet Nursing Home
  - Hatvan, Hungary, 3000
    - BKS Research Ltd
  - Kalocsa, Hungary, 6300
    - Studium Egeszseghaz Kft.
  - Kaposvár, Hungary, 7400
    - Somogy County Kaposi Mor Teaching Hospital
  - Zalaegerszeg, Hungary, 8900
    - SYNEXUS Hungary Health Care Services Ltd-Zalaegerszeg-69406
  - Zalaegerszeg, Hungary, 8900
    - Obudai Egeszegugyi Centrum
India
- - Aurangabad, India, 431 010
    - Kamalnayan Bajaj Hospital
  - Bikaner, India, 334 003
    - S.P. Medical College & Associated Group of Hospitals
  - Chennai, India, 600006
    - Apollo Speciality Hospital
  - Kanpur, India, 208002
    - LPS Institute of Cardiology
  - Maharashtra, India, 440012
    - Shrikrishna Hrudayalaya and Critical Care Centre
  - New Delhi, India, 110060
    - Sir Gangaram Hospital
  - New Delhi, India, 110 062
    - Batra Hospital and Medical Research Centre
  - Surat, India, 395001
    - Shri B.D. Mehta Mahavir Heart Institute
Ireland
- - Dublin, Ireland, D04 T6F4
    - St. Vincent's University Hospital
  - Galway, Ireland, H91 T861
    - University Hospital Galway
Italy
- - Bergamo, Italy, 24125
    - Humanitas Gavazzeni
  - Latina, Italy, 04100
    - Ospedale S.M. Goretti
  - Milan, Italy, 20100
    - IRCCS Multimedica
  - Milan, Italy, 20138
    - Centro Cardiologico Monzino-IRCCS
  - Palermo, Italy, 90127
    - Policlinico "Paolo Giaccone"
  - Roma, Italy, 00128
    - Università Campus Bio-Medico - ROMA
  - Roma, Italy, 00161
    - AOU Policlinico Umberto I
  - Roma, Italy, 00195
    - Fondazione Policlinico Universitario Agostino Gemelli IRCCS
  - Siena, Italy, 53100
    - A.O.U. Senese
  - Torino, Italy, 10126
    - Azienda Ospedaliera Universitaria Citta della Salute e della Scienza di Torino
Japan
- - Aichi, Nagoya, Japan, 455-8530
    - Chubu Rosai Hospital
  - Aichi, Nagoya, Japan, 451-8511
    - Meitetsu Hospital
  - Aichi, Nagoya, Japan, 454-0933
    - Nagoya Kyoritsu Hospital
  - Aichi, Nagoya, Japan, 457-8511
    - Daido Clinic
  - Chiba, Matsudo, Japan, 271-0077
    - Seikeikai New Tokyo Heart Clinic
  - Fukuoka, Okawa, Japan, 831-0016
    - Takagi Hospital
  - Fukushima, Koriyama, Japan, 963-8851
    - Seino Internal Medicine Clinic
  - Ibaraki, Mito, Japan, 311-4153
    - Iryouhouijneiwakai Minamiakatsuka Clinic
  - Kanagawa, Kawasaki, Japan, 212-0024
    - Matsuba Clinic
  - Kanagawa, Sagamihara, Japan, 252-5188
    - Sagamihara Kyodo Hospital
  - Kanagawa, Yokohama, Japan, 234-0054
    - Saiseikai Yokohamashi Nanbu Hospital
  - Kochi, Kochi, Japan, 780-0863
    - Takeshita Hospital
  - Kyoto, Kuse-gun, Japan, 613-0034
    - Kyoto Okamoto Memorial Hospital
  - Miyagi, Sendai, Japan, 980-0011
    - Sato Hospital
  - Okinawa, Urasoe, Japan, 901-2102
    - Urasoe General Hospital
  - Osaka, Osaka, Japan, 543-8922
    - Osaka Keisatsu Hospital
  - Saitama, Kawaguchi, Japan, 332-8558
    - Saiseikai Kawaguchi Hospital
  - Saitama, Koshigaya, Japan, 343-8577
    - Koshigaya Municipal Hospital
  - Saitama, Sayama, Japan, 350-1305
    - Saitama Sekishikai Hospital
  - Saitama, Sayama, Japan, 350-1305
    - Sayama General Clinic
  - Shiga, Omihachiman, Japan, 523-0082
    - Omihachiman Community Medical Center
  - Tokyo, Hachioji, Japan, 192-0918
    - Minamino Cardiovascular Hospital
  - Tokyo, Suginami-ku, Japan, 168-0065
    - NewHeart Watanabe Institute
  - Wakayama, Wakayama, Japan, 640-8158
    - Saiseikai Wakayama Hospital
Kazakhstan
- - Almaty, Kazakhstan, 050013
    - Academy of Preventive Medicine, Clinic "Vitalem"
  - Almaty, Kazakhstan, 050000
    - Institute of Gastroenterology, Hepatology and Metabolism LLP
  - Astana, Kazakhstan, 010000
    - Multidisciplinary City Hospital №1 of the Akimat of Astana
  - Astana, Kazakhstan, 010001
    - National Research Medical Center (NNMC)
Mexico
- - Chihuahua City, Mexico, 31110
    - Medical Center Metas S.C.
  - Cuernavaca, Mexico, 62250
    - Instituto de Diabetes, Obesidad y Nutrición S.C.
  - Culiacán, Mexico, 80230
    - Centro Para El Desarrollo de La Medicina Y de Asistencia Medica Especializada S.C.
  - Mexico City, Mexico, 06700
    - Clinica Omega Diabetes
  - Monterrey, Mexico, 64060
    - Cardiolink Clin Trials S.C.
  - México, Mexico, C.P. 11650
    - CEDOPEC-Ctro Esp en Diab, Obesidad y Prev de Enf Cardiovasc
Netherlands
- - Arnhem, Netherlands, 6815 AD
    - Rijnstate Hospital
  - Haarlem, Netherlands, 2035 RC
    - Spaarne Ziekenhuis
  - Utrecht, Netherlands, 3582 KE
    - Diakonessenhuis Utrecht
  - Veldhoven, Netherlands, 5504 DB
    - Máxima Medisch Centrum
New Zealand
- - Auckland, New Zealand, 1010
    - Optimal Clinical Trials
  - Christchurch, New Zealand, 8013
    - Pacific Clinical Research Network - Forte Christchurch
  - Papatoetoe, New Zealand, 2025
    - Middlemore Clinical Trials
  - Rotorua, New Zealand, 3010
    - Pacific Clinical Research Network - Rotorua
  - Waikanae, New Zealand, 5036
    - Momentum Clinical Research
  - Waikanae Beach, New Zealand, 5036
    - Momentum Kāpiti Coast
- Migration Data
  - Palmerston North, Migration Data, New Zealand, 4414
    - Momentum Palmerston North
Norway
- - Drammen, Norway, 3004
    - Vestre Viken HF, Drammen Sykehus
  - Lørenskog, Norway, 1478
    - Akershus Universitetssykehus HF
  - Trondheim, Norway, 7030
    - St. Olavs Hospital, Universitetssykehuset i Trondheim
  - Tønsberg, Norway, N-3116
    - Sykehuset i Vestfold, Avd. Tønsberg
Poland
- - Bialystok, Poland, 15-276
    - Uniwersytecki Szpital Kliniczny w Bialymstoku
  - Bialystok, Poland, 15-481
    - Trial Medica
  - Bydgoszcz, Poland, 85-605
    - Centrum Medyczne INTERCOR Sp. z o.o.
  - Bydgoszcz, Poland, 85231
    - NZOZ Medical Center KERmed
  - Częstochowa, Poland, 42202
    - Synexus Poland, Branch in Czestochowa
  - Gdansk, Poland, 80-382
    - Synexus Polska SCM Sp. z o.o. Gdansku, Gdansk
  - Gdynia, Poland, 81-537
    - Synexus Polska Sp. z o.o. Oddzial w Gdyni, Gdynia
  - Grudziądz, Poland, 86300
    - Przychodnie Grudziadz sp.zo.o
  - Katowice, Poland, 40-282
    - Silmedic Sp. z o.o.
  - Katowice, Poland, 40-748
    - Vita Longa Sp. z o.o.
  - Katowice, Poland, 40-040
    - Synexus Polska Sp. z o.o. Oddzial w Katowicach, Katowice
  - Katowice, Poland, 40772
    - Salvia Lekston I Madej Sp. J.
  - Krakow, Poland, 31-261
    - Diab-Endo-Met Medical Center
  - Krakow, Poland, 31271
    - Unicardia Specialist Medical Center
  - Lodz, Poland, 90127
    - Synexus Lodz Medical Center
  - Lodz, Poland, 91-034
    - Med-Gastr Medical Center
  - Lublin, Poland, 20-011
    - Clinical Best Solutions
  - Lublin, Poland, 20718
    - EKAMED sp. z o.o.
  - Olsztyn, Poland, 10 165
    - Futuremeds Sp. z o.o. Olsztyn
  - Poznan, Poland, 60-702
    - Synexus Poland, Branch in Poznan
  - Poznan, Poland, 60589
    - Metabolic Health Center Pawel Bogdanski
  - Poznan, Poland, 61-655
    - Private Practice Dr. Ewa Krzyzagorska
  - Przemyśl, Poland, 37-700
    - Padre Pio Regional Hospital in Przemysl
  - Rzeszów, Poland, 35-055
    - Centrum Medyczne Medyk
  - Skierniewice, Poland, 96100
    - Velocity Nova Sp. z.o.o.
  - Sopot, Poland, 81-717
    - NZOZ Procordis, Cardiology Research Center of Sopot
  - Staszów, Poland, 28200
    - Velocity Nova Sp z o.o.
  - Swidnica, Poland, 58-100
    - Dc-Med
  - Warsaw, Poland, 00710
    - Nbr Polska
  - Warsaw, Poland, 02-677
    - ETG Warszawa
  - Warsaw, Poland, 00710
    - Clinical Best Solutions Sp. z o.o. S.K.
  - Warsaw, Poland, 02-672
    - Centrum Medyczne Synexus
  - Warsaw, Poland, 02-507
    - Panstwowy Instytut Medyczny Ministerstwa Spraw Wewnetrznych i Administracji
  - Wroclaw, Poland, 50-381
    - Synexus Poland, Branch in Wroclaw
Portugal
- - Alcabideche, Portugal, 2755-009
    - Hospital de Cascais Dr. José de Almeida
  - Aveiro, Portugal, 3814-501
    - ULS da Região de Aveiro
  - Braga, Portugal, 4710-243
    - ULS Braga
  - Coimbra, Portugal, 3000-075
    - CHUC - Centro Hospitalar e Universitario de Coimbra, EPE
  - Guimarães, Portugal, 4835-044
    - ULS do Alto Ave
  - Lisbon, Portugal, 1500-650
    - Hospital da Luz
  - Lisbon, Portugal, 1069-166
    - ULS de São José
  - Lisbon, Portugal, 1250-189
    - APDP - Associação Protectora dos Diabéticos de Portugal
  - Ponte de Lima, Portugal, 4990-029
    - Cardiolima - Centro Diagnostico Cardio-pulmonar de Ponte de Lima, Lda.
  - Santa Maria da Feira, Portugal, 4520-211
    - ULS de Entre Douro e Vouga
  - Torres Novas, Portugal, 2350-325
    - UCARDIO
  - Vila Nova de Gaia, Portugal, 4400-346
    - Hospital da Luz Arrábida
Puerto Rico
- - Bayamón, Puerto Rico, 00959
    - Advanced Clinical Research
  - Ponce, Puerto Rico, 00716
    - Ponce School of Medicine/CAIMED Center
Saudi Arabia
- - Dammam, Saudi Arabia, 31444
    - King Fahad Specialist Hospital - Research Center
  - Jeddah, Saudi Arabia, 21589
    - King AbdulAziz University Hospital
  - Riyadh, Saudi Arabia, 11211
    - King Faisal Specialist Hospital and Research Center
  - Riyadh, Saudi Arabia, 11623
    - King Saud Medical City
Slovakia
- - Bratislava, Slovakia, 811 08
    - METABOL KLINIK s.r.o., Bratislava
  - Bratislava, Slovakia, 85101
    - MEDISPEKTRUM s.r.o., Bratislava
  - Košice, Slovakia, 04001
    - Medical Group Kosice s.r.o
  - Lučenec, Slovakia, 984 01
    - IN-DIA s.r.o., Lucenec
  - Nové Zámky, Slovakia, 940 01
    - FUNKYSTUFF s.r.o.
  - Rožňava, Slovakia, 04801
    - DIAB sro
South Korea
- - Busan, South Korea, 602-739
    - Pusan National University Hospital
  - Cheongju-si, South Korea, 28644
    - Chungbuk National University Hospital
  - Daegu, South Korea, 42601
    - Keimyung University Dongsan Hospital
  - Daegu, South Korea, 705-717
    - Yeungnam University Medical Center
  - Daejeon, South Korea, 35015
    - Chungnam National University Hospital
  - Gwangju, South Korea, 61469
    - Chonnam National University Hospital
  - Seongnam, South Korea, 13620
    - Seoul National University Bundang Hospital
  - Seoul, South Korea, 03080
    - Seoul National University Hospital
  - Seoul, South Korea, 05278
    - Kyung Hee University Hospital at Gangdong
  - Seoul, South Korea, 03722
    - Severance Hospital
  - Seoul, South Korea, 02841
    - Korea University Anam Hospital
  - Seoul, South Korea, 06273
    - Gangnam Severance Hospital
  - Seoul, South Korea, 02447
    - Kyung Hee University Hospital
  - Seoul, South Korea, 08308
    - Korea University Guro Hospital
Spain
- - Alicante, Spain, 03010
    - Hospital General Universitario de Alicante
  - Badajoz, Spain, 06080
    - Hospital Universitario de Badajoz
  - Barcelona, Spain, 08036
    - Hospital Clinic De Barcelona
  - Barcelona, Spain, 08035
    - Hospital Universitari Vall d'Hebron
  - Barcelona, Spain, 08022
    - Centro Médico Teknon
  - Bilbao, Spain, 48013
    - Hospital de Basurto
  - Girona, Spain, 17007
    - Hospital Universitari de Girona Doctor Josep Trueta
  - Granada, Spain, 18016
    - Hospital Universitario San Cecilio
  - Madrid, Spain, 28046
    - Hospital Universitario La Paz
  - Málaga, Spain, 29010
    - Hospital Universitario Virgen de la Victoria
  - Pozuelo de Alarcón, Spain, 28223
    - Hospital Quironsalud Madrid
  - Santander, Spain, 39008
    - Hospital Universitario Marques De Valdecilla
  - Santiago de Compostela, Spain, 15706
    - Complexo Hospitalario Universitario De Santiago
  - Seville, Spain, 41010
    - Hospital Quironsalud Infanta Luisa
  - Valencia, Spain, 46017
    - Hospital Dr. Peset
Taiwan
- - Changhua, Taiwan, 500
    - Changhua Christian Hospital
  - Chia-Yi City, Taiwan, 40705
    - Chia-Yi Christian Hospital
  - Tainan, Taiwan, 704
    - NCKUH
  - Taipei, Taiwan, 10048
    - National Taiwan University Hospital
  - Taoyuan County, Taiwan, 333
    - Chang Gung Memorial Hospital, Linkou
Turkey (Türkiye)
- - Adana, Turkey (Türkiye), 01220
    - Adana City Hospital
  - Adana, Turkey (Türkiye), 01240
    - Baskent University Hospital
  - Antalya, Turkey (Türkiye), 7058
    - Akdeniz UTF Endokrinoloji ve Metabolizma Hastaliklari BD
  - Battalgazi, Turkey (Türkiye), 44280
    - Inonu Uni. Med. Fac., Battalgazi
  - Bursa, Turkey (Türkiye), 16330
    - Bursa Yuksek Ihtisas EAH
  - Diyarbakır, Turkey (Türkiye), 21100
    - Dicle Universitesi Tip Fakultesi
  - Istanbul, Turkey (Türkiye), 34010
    - Koc Universitesi Hastanesi
  - Istanbul, Turkey (Türkiye), 34098
    - Istanbul Universitesi Cerrahpasa Tip Fakultesi-Istanbul-1433
  - Istanbul, Turkey (Türkiye), 34303
    - Acibadem Universitesi Atakent Hastanesi
  - Istanbul, Turkey (Türkiye), 34384
    - İstanbul Prof.Dr. Cemil Taşçıoğlu City Hospital
  - Istanbul, Turkey (Türkiye), 34899
    - Marmara Universitesi Tip Fakultesi
  - Zonguldak, Turkey (Türkiye), 67600
    - Zonguldak Bulent Ecevit UTF
  - Çapa, Turkey (Türkiye), 34390
    - Istanbul Universitesi Istanbul Tip Fakultesi
United Kingdom
- - Airdrie, United Kingdom, ML6 0JS
    - University Hospital Monklands
  - Antrim, United Kingdom, BT41 2RL
    - Antrim Area Hospital
  - Blackpool, United Kingdom, FY4 3AD
    - Waterloo Medical Centre
  - Cardiff, United Kingdom, CF15 9SS
    - Synexus - Cardiff
  - Chorley, United Kingdom, PR7 7NA
    - Synexus - Lancashire
  - Dundee, United Kingdom, DD1 9SY
    - Ninewells Hospital & Medical School
  - Edinburgh, United Kingdom, EH4 2XU
    - Wellcome Trust Clinical Research Facility, Edinburgh
  - Glasgow, United Kingdom, G51 4TF
    - Queen Elizabeth University Hospital
  - Glasgow, United Kingdom, ML4 3NJ
    - Synexus - Glasgow
  - Hexham, United Kingdom, NE46 1QJ
    - Synexus - Hexham
  - Leicester, United Kingdom, LE5 4PW
    - Leicester General Hospital
  - Lincoln, United Kingdom, LN2 5QY
    - Lincoln County Hospital
  - Liverpool, United Kingdom, L22 0LG
    - Synexus - Merseyside
  - London, United Kingdom, EC1M 6BQ
    - William Harvey Research Limited
  - Londonderry, United Kingdom, BT47 6SB
    - Altnagelvin Area Hospital
  - Manchester, United Kingdom, M13 9WL
    - Manchester Royal Infirmary
  - Manchester, United Kingdom, M15 6SE
    - Synexus - Manchester
  - Newcastle upon Tyne, United Kingdom, NE2 4HH
    - Royal Victoria Infirmary
  - Newcastle upon Tyne, United Kingdom, NE6 1SG
    - FutureMeds - Newcastle
  - Swansea, United Kingdom, SA2 8PP
    - Swansea University Medical School
  - Wishaw, United Kingdom, ML2 0QB
    - University Hospital Wishaw
United States
- Alabama
  - Birmingham, Alabama, United States, 35211
    - Cardiology P.C.
  - Daphne, Alabama, United States, 36526
    - AMR Daphne
  - Mobile, Alabama, United States, 36608
    - Mobile Heart Specialists, PC
  - Mobile, Alabama, United States, 36608
    - AMR Mobile
- Arizona
  - Chandler, Arizona, United States, 85225
    - The Institute for Liver Health II DBA Arizona Clinical Trials
  - Sun City West, Arizona, United States, 85375
    - Clinical Research Institute of Arizona, LLC
  - Tempe, Arizona, United States, 85281
    - AMR Phoenix
  - Tucson, Arizona, United States, 85712
    - Arizona Liver Health-Tucson-67516
  - Yuma, Arizona, United States, 85364
    - Yuma Clinical Trials
- Arkansas
  - Little Rock, Arkansas, United States, 72204
    - Lynn Institute of the Ozarks
- California
  - Huntington Park, California, United States, 90255
    - Velocity Clinical Research-Huntington Park
  - La Mesa, California, United States, 91942
    - Velocity Clinical Research, San Diego
  - Los Angeles, California, United States, 90017
    - Velocity Clinical Research - Los Angeles
  - Montclair, California, United States, 91763
    - Catalina Research Institute, LLC
  - Northridge, California, United States, 91325
    - Valley Clinical Trials, Inc.
  - San Ramon, California, United States, 94583
    - NorCal Endocrinology and Internal Medicine
  - Santa Ana, California, United States, 92704
    - Velocity Clinical Research, Santa Ana
  - Santa Rosa, California, United States, 95405
    - NorthBay Clinical Research, LLC
  - Van Nuys, California, United States, 91405
    - Velocity Clinical Research-Van Nuys-70286
- Colorado
  - Colorado Springs, Colorado, United States, 80907
    - Peak Gastroenterology Associates-Colorado Springs-62256
- Connecticut
  - Bridgeport, Connecticut, United States, 06610
    - Bridgeport Hospital
  - Hamden, Connecticut, United States, 06517
    - CMR of Greater New Haven, LLC
  - Waterbury, Connecticut, United States, 06708
    - Chase Medical Research, LLC
- Florida
  - Boca Raton, Florida, United States, 33434
    - Excel Medical Clinical Trials
  - Boca Raton, Florida, United States, 33431
    - Proactive Clinical Research
  - Clearwater, Florida, United States, 33765
    - Clinical Research of West Florida, Inc.
  - Crystal River, Florida, United States, 34429
    - Nature Coast Clinical Research-Crystal River-62355
  - Cutler Bay, Florida, United States, 33157
    - Beautiful Minds Clinical Research Center
  - Fort Myers, Florida, United States, 33912
    - AMR Fort Myers
  - Fort Myers, Florida, United States, 33912
    - Covenant Metabolic Specialists, LLC - Fort Myers
  - Hallandale, Florida, United States, 33009
    - Velocity Clinical Research-Hallandale Beach-67888
  - Jacksonville, Florida, United States, 32205
    - Westside Center for Clinical Research
  - Leesburg, Florida, United States, 34748
    - Clinical Site Partners LLC
  - Miami, Florida, United States, 33135
    - Verus Clinical Research Corporation
  - Miami, Florida, United States, 33135
    - Flourish Research - Miami
  - Pembroke Pines, Florida, United States, 33024
    - Center for Diabetes, Obesity and Metabolism
  - Pinellas Park, Florida, United States, 33781
    - Synexus-Pinellas Park-69294
  - Saint Augustine, Florida, United States, 32086
    - East Coast Institute for Research, LLC-Saint Augustine-63032
  - Sweetwater, Florida, United States, 33172
    - Lenus Research & Medical Group
  - Tampa, Florida, United States, 33615
    - Santos Research Center, Corp.
  - University Park, Florida, United States, 34201
    - Covenant Metabolic Specialists, LLC - Sarasota
- Georgia
  - Albany, Georgia, United States, 31707
    - Javara-Albany-67356
  - Columbus, Georgia, United States, 31904
    - Centricity Research Columbus Georgia Multispecialty
  - Fayetteville, Georgia, United States, 30214
    - Javara-Fayetteville-67354
  - Johns Creek, Georgia, United States, 30024
    - NSC Research Inc
  - Macon, Georgia, United States, 31210
    - The Jones Center Clinical Research, LLC
  - Marietta, Georgia, United States, 30067
    - Urban Family Practice Associates, PC
  - Savannah, Georgia, United States, 31406
    - Javara-Savannah-67450
- Illinois
  - Arlington Heights, Illinois, United States, 60005
    - Endeavor Health Clinical Operations - Northwest Community Healthcare
  - Chicago, Illinois, United States, 60607
    - Cedar Crosse Research Center
  - Chicago, Illinois, United States, 60643
    - Research by Design, LLC
- Indiana
  - Evansville, Indiana, United States, 47714
    - Medisphere Medical Research Center
- Iowa
  - Ames, Iowa, United States, 50010
    - McFarland Clinic PC
  - West Des Moines, Iowa, United States, 50266
    - Iowa Diabetes and Endocrinology Research Center
- Kansas
  - El Dorado, Kansas, United States, 67042
    - AMR El Dorado
  - Newton, Kansas, United States, 67114
    - AMR Newton
  - Wichita, Kansas, United States, 67226
    - AMR Clinical Wichita
- Kentucky
  - Owensboro, Kentucky, United States, 42303
    - Research Integrity, LLC
- Louisiana
  - Bossier City, Louisiana, United States, 71111
    - Grace Research, LLC-Bossier City-51040
  - Hammond, Louisiana, United States, 70403
    - Heart Clinic of Hammond
  - Marrero, Louisiana, United States, 70072
    - Tandem Clinical Research
  - New Orleans, Louisiana, United States, 70119
    - AMR New Orleans
  - Shreveport, Louisiana, United States, 71105
    - Grace Research, LLC-Shreveport-64616
- Maryland
  - Annapolis, Maryland, United States, 21401
    - Javara Inc.-Annapolis-68997
  - Baltimore, Maryland, United States, 21229
    - Ascension Saint Agnes Heart Care
  - Oxon Hill, Maryland, United States, 20745
    - MD Medical Research
- Massachusetts
  - Boston, Massachusetts, United States, 02215
    - Beth Israel Deaconess Medical Center
  - Boston, Massachusetts, United States, 02115
    - Brigham and Women's Hospital
- Michigan
  - Ann Arbor, Michigan, United States, 48105
    - Domino's Farms
  - Flint, Michigan, United States, 48532
    - Elite Research Center, LLC
  - Grand Rapids, Michigan, United States, 49546
    - Healthy Heart Cardiology
- Minnesota
  - Rochester, Minnesota, United States, 55905
    - Mayo Clinic, Rochester
- Mississippi
  - Diamondhead, Mississippi, United States, 39525
    - The National Diabetes & Obesity Research Institute
  - Fayette, Mississippi, United States, 39069
    - Prime Health and Wellness
  - Gulfport, Mississippi, United States, 39503
    - Velocity Clinical Research-Gulfport-68930
- Missouri
  - Kansas City, Missouri, United States, 64111
    - Clinical Research Consultants, LLC
  - Kansas City, Missouri, United States, 64114
    - AMR Kansas City
  - Springfield, Missouri, United States, 65807
    - Clinvest Research LLC
  - St Louis, Missouri, United States, 63141
    - Sundance Clinical Research, LLC
- Montana
  - Butte, Montana, United States, 59701
    - Mercury Street Medical
- Nebraska
  - Elkhorn, Nebraska, United States, 68022
    - Skyline Medical Center
  - Fremont, Nebraska, United States, 68025
    - Methodist Physicians Clinic
- Nevada
  - Las Vegas, Nevada, United States, 89119
    - AMR Las Vegas
- New Jersey
  - Bridgewater, New Jersey, United States, 08807
    - Advanced Heart Care, LLC
  - Linden, New Jersey, United States, 07036
    - NJ Heart LLC
  - Warren Township, New Jersey, United States, 07059
    - IMA Clinical Research-Warren-69742
- New Mexico
  - Albuquerque, New Mexico, United States, 87109
    - IMA Clinical Research Albuquerque
- New York
  - Binghamton, New York, United States, 13905
    - Velocity Clinical Research - Binghamton
  - New York, New York, United States, 10017
    - Synexus Clinical Research US, Inc.
  - Saratoga Springs, New York, United States, 12866
    - Saratoga Clinical Research, LLC
- North Carolina
  - Cary, North Carolina, United States, 27518
    - Accellacare of Cary
  - Chapel Hill, North Carolina, United States, 27514
    - The University of North Carolina at Chapel Hill
  - Charlotte, North Carolina, United States, 28210
    - Javara-Charlotte-67884
  - Mooresville, North Carolina, United States, 28117
    - Accellacare-Mooresville-69123
  - New Bern, North Carolina, United States, 28562
    - Centricity Research (New Bern)
  - Winston-Salem, North Carolina, United States, 27104
    - Wake Forest University Health Sciences-Winston-Salem-69719
- Ohio
  - Cincinnati, Ohio, United States, 45242
    - Velocity Clinical Research-Cincinnati-69044
  - Columbus, Ohio, United States, 43213
    - Centricity Research-Columbus-68879
  - Columbus, Ohio, United States, 43212
    - Synexus Clinical Research-Columbus-69427
  - Dublin, Ohio, United States, 43016
    - Aventiv Research Inc.-Dublin-62009
  - Westlake, Ohio, United States, 44145
    - Clinical Research Institute of Ohio, LLC
- Oklahoma
  - Edmond, Oklahoma, United States, 73013
    - Tekton Research-Edmond-68875
  - Norman, Oklahoma, United States, 73072
    - Lynn Institute of Norman
  - Norman, Oklahoma, United States, 73069
    - AMR Norman
  - Oklahoma City, Oklahoma, United States, 73112
    - Lynn Health Science Institute
  - Oklahoma City, Oklahoma, United States, 73135
    - South Oklahoma Heart Research Group
- Oregon
  - Medford, Oregon, United States, 97504
    - Velocity Clinical Research-Medford-69053
- Pennsylvania
  - Beaver, Pennsylvania, United States, 15009
    - Heritage Valley Medical Group
  - Camp Hill, Pennsylvania, United States, 17011
    - Capital Area Research, LLC
  - Philadelphia, Pennsylvania, United States, 19114
    - Tristar Clinical Investigations PC
  - Pittsburgh, Pennsylvania, United States, 15236
    - Preferred Primary Care Physicians-Pittsburgh-63932
  - Uniontown, Pennsylvania, United States, 15401
    - Preferred Primary Care Physicians-Uniontown-69137
- Rhode Island
  - East Greenwich, Rhode Island, United States, 02818
    - Velocity Clinical Research-East Greenwich-68873
- South Carolina
  - Anderson, South Carolina, United States, 29621
    - Synexus - Anderson
  - Anderson, South Carolina, United States, 29621
    - Velocity Clinical Research-Anderson-69093
  - Gaffney, South Carolina, United States, 29340
    - Velocity Clinical Research-Gaffney-69046
  - Greenville, South Carolina, United States, 29607
    - Tribe Clinical Research LLC
  - Greenville, South Carolina, United States, 29615
    - Velocity Clinical Research-Greenville-69045
  - North Charleston, South Carolina, United States, 29405
    - Coastal Carolina Research Center
  - Union, South Carolina, United States, 29379
    - Velocity Clinical Research-Union-68888
- Tennessee
  - Bristol, Tennessee, United States, 37620
    - Internal Medicine and Pediatric Associates of Bristol, PC
  - Chattanooga, Tennessee, United States, 37404
    - Chattanooga Research & Medicine, PLLC
  - Knoxville, Tennessee, United States, 37909
    - Alliance for Multispecialty Research, LLC-Knoxville-69693
  - Knoxville, Tennessee, United States, 37912
    - Accellacare of Knoxville-Knoxville-69135
  - Knoxville, Tennessee, United States, 37938
    - Accellacare of Knoxville-Knoxville-69714
  - Memphis, Tennessee, United States, 38119
    - Clinical Neuroscience Solutions, Inc-Memphis-65988
  - Nashville, Tennessee, United States, 37203
    - Clinical Research Associates, Inc
- Texas
  - Amarillo, Texas, United States, 79124
    - Amarillo Medical Specialists
  - Austin, Texas, United States, 78759
    - Velocity Clinical Research, Austin
  - Brownsville, Texas, United States, 78526
    - Headlands Research - Brownsville
  - Conroe, Texas, United States, 77384
    - Privia Medical Group Gulf Coast, PLLC
  - Dallas, Texas, United States, 75230
    - Velocity Clinical Research-Dallas-69170
  - Fort Worth, Texas, United States, 76133
    - Javara Inc. - Fort Worth
  - Houston, Texas, United States, 77079
    - Houston Research Institute
  - San Antonio, Texas, United States, 78229
    - IMA Clinical Research San Antonio
  - San Antonio, Texas, United States, 78258
    - Tekton Research-San Antonio-68916
  - San Marcos, Texas, United States, 78666
    - Javara Inc. and Privia Medical Group Gulf Coast, PLLC
  - Stephenville, Texas, United States, 76401
    - Javara Inc.-Stephenville-68996
  - Tomball, Texas, United States, 77375
    - DM Clinical Research - Martin Diagnostic Clinic
  - Waco, Texas, United States, 76710
    - Velocity Clinical Research, Waco
- Utah
  - Draper, Utah, United States, 84020
    - Physicians' Research Options. LLC
  - Layton, Utah, United States, 84041
    - Alliance for Multispecialty Research, LLC-Layton-69691
  - Salt Lake City, Utah, United States, 84106
    - Synexus Clinical Research-Salt Lake City-69293
  - St. George, Utah, United States, 84790
    - Chrysalis Clinical Research
  - West Jordan, Utah, United States, 84088
    - Velocity Clinical Research-West Jordan-69043
- Virginia
  - Arlington, Virginia, United States, 22206
    - Washington Center for Weight Management and Research, Inc.
  - Falls Church, Virginia, United States, 22044
    - Seven Corners Medical Center
  - Norfolk, Virginia, United States, 23510
    - Eastern Virginia Medical School
  - Winchester, Virginia, United States, 22601
    - Selma Medical Associates, Winchester
- Washington
  - Seattle, Washington, United States, 98105
    - Velocity Clinical Research, Seattle
  - Spokane, Washington, United States, 99218
    - Velocity Clinical Research-Spokane-69716
- Wisconsin
  - Kenosha, Wisconsin, United States, 53144
    - Clinical Investigation Specialists, Inc.-Kenosha-69111
  - Wauwatosa, Wisconsin, United States, 53226
    - Allegiance Research Specialists

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

Adult
Older Adult

Accepts Healthy Volunteers

Description

Inclusion Criteria:

Male or female, age ≥18 years at the time of signing informed consent, and at least the legal age of consent in countries where it is >18 years.
Body mass index (BMI) ≥27 kg/m2 at screening with established cardiovascular disease (CVD) and/or at least 2 weight-related complications or risk factors for CVD OR BMI ≥30 kg/m2 at screening with established CVD or chronic kidney disease (CKD), and/or at least 2 weight-related complications or risk factors for CVD.

Further inclusion criteria apply.

Exclusion criteria:

Previous treatment with glucagon-like peptide-1 receptor (GLP-1R) agonists within 3 months before screening.
Type 1 diabetes.
Less than 3 months between the last dose of GLP-1R agonists and GLP-1R agonist/insulin/glucose-dependent insulinotropic polypeptide (GIP) combinations and screening.
Known clinically significant gastric emptying abnormality (e.g., severe diabetic gastroparesis or gastric outlet obstruction).

Further exclusion criteria apply.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Primary Purpose: Treatment
Allocation: Randomized
Interventional Model: Parallel Assignment
Masking: Quadruple

Number of Arms

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Placebo Comparator: Placebo	Combination product: Placebo once weekly subcutaneous injection, pre-filled syringe
Experimental: survodutide 3.6 mg	Combination product: survodutide once weekly subcutaneous injection, pre-filled syringe Other Names: BI 456906
Experimental: survodutide 6.0 mg	Combination product: survodutide once weekly subcutaneous injection, pre-filled syringe Other Names: BI 456906

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, non-fatal MI, ischaemia related coronary revascularisation, or HFE (to demonstrate non-inferiority) Time Frame: up to Week 114	Heart failure events (HFE) includes hospitalisation for heart failure (HHF), emergency room visit, urgent care visit, or urgent outpatient heart failure (HF) visit (5-point major adverse cardiac event (5P-MACE)) CV-Cardiovascular MI-Myocardial infarction	up to Week 114

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, or non-fatal MI (3-point major adverse cardiac event (3P-MACE)) (to demonstrate non-inferiority) Time Frame: up to Week 114		up to Week 114
Absolute change in systolic blood pressure (SBP) (mmHg) from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Absolute change in waist circumference (cm) from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Absolute change in Kansas City Cardiomyopathy Questionnaire Total Symptom Score (KCCQ-TSS) from baseline to Week 72 in trial participants with HF at baseline Time Frame: At Baseline and at Week 72	KCCQ-TSCC scale score range is from 0 to 100 where low score means patient not doing well and higher score means patient doing better.	At Baseline and at Week 72
Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, non-fatal MI, ischaemia related coronary revascularisation, or HFE (to demonstrate superiority) Time Frame: up to Week 114		up to Week 114
Percentage change in body weight from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Absolute change in diastolic blood pressure (DBP) (mmHg) from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Absolute change in aspartate aminotransferase (AST) (U/L) from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Absolute change in alanine aminotransferase (ALT) (U/L) from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Absolute change in glycosylated haemoglobin A1c (HbA1c) (mmol/mol) from baseline to Week 72 in trial participants with type 2 diabetes mellitus (T2DM) Time Frame: Baseline and at Week 72		Baseline and at Week 72
Absolute change in HbA1c (%) from baseline to Week 72 in trial participants with T2DM Time Frame: Baseline and at Week 72		Baseline and at Week 72
Time to onset of T2DM in trial participants without T2DM at baseline Time Frame: up to Week 114		up to Week 114
Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, non-fatal MI, or ischaemia related coronary revascularisation (4-point major adverse cardiac event (4P-MACE)) Time Frame: up to Week 114		up to Week 114
Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, non-fatal MI, or HFE (3P-MACE+ HFE) Time Frame: up to Week 114		up to Week 114
Time to first occurrence of any of the adjudicated components of the composite endpoint consisting of: CV death, non-fatal stroke, or non-fatal MI (3P-MACE) Time Frame: up to Week 114		up to Week 114
Time to all-cause mortality Time Frame: up to Week 114		up to Week 114
Achievement of body weight reduction ≥5% from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Achievement of body weight reduction ≥10% from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Achievement of body weight reduction ≥15% from baseline to Week 72 Time Frame: Baseline and at Week 72		Baseline and at Week 72
Time to first occurrence of adjudicated CV death or adjudicated HFE Time Frame: up to Week 114		up to Week 114
Time to first occurrence of adjudicated CV death or adjudicated HHF Time Frame: up to Week 114		up to Week 114
Time to first occurrence of adjudicated HFE Time Frame: up to Week 114		up to Week 114
Time to adjudicated CV death Time Frame: up to Week 114		up to Week 114
Time to first occurrence of adjudicated non-fatal MI Time Frame: up to Week 114		up to Week 114
Time to first occurrence of adjudicated non-fatal stroke Time Frame: up to Week 114		up to Week 114
Time to first occurrence of adjudicated ischaemia related coronary revascularisation Time Frame: up to Week 114		up to Week 114
A composite of death, number of adjudicated HFEs, time to first adjudicated HFE and change from baseline in KCCQ-TSS at 72 weeks assessed by the win ratio in trial participants with HF at baseline Time Frame: At baseline and at 72 Weeks	Win ratio will be assessed as below: The primary efficacy endpoint will be analyzed using the clinical benefit approach comparing every participant in the BI 456906 arm to every participant in the placebo arm to determine a winner. A winner in the pair-wise comparison has a delayed time to the occurrence of death; if that cannot be determined, a winner has fewer HFEs; if the number of HFEs is the same a winner has a delayed time to the occurrence of first HFE; if that rule does not determine a winner, a winner has a more favorable (less increase or more decrease) change in KCCQ-CSS between baseline and at 72 weeks, otherwise the pair will be recorded as tied. The estimated net benefit (win ratio is then calculated as the total number of wins in the BI 456906 group across all strata divided by the total number of losses) will be provided. KCCQ-TSCC scale score range is from 0 to 100 where low score means patient not doing well and higher score means patient doing better.	At baseline and at 72 Weeks

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Boehringer Ingelheim

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

General Publications

Kosiborod MN, Platz E, Wharton S, le Roux CW, Brueckmann M, Ajaz Hussain S, Unseld A, Startseva E, Kaplan LM; SYNCHRONIZE-CVOT Trial Committees and Investigators. Survodutide for the Treatment of Obesity: Rationale and Design of the SYNCHRONIZE Cardiovascular Outcomes Trial. JACC Heart Fail. 2024 Dec;12(12):2101-2109. doi: 10.1016/j.jchf.2024.09.004. Epub 2024 Oct 23.

Helpful Links

Related Info

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 20, 2023

Primary Completion (Actual)

June 1, 2026

Study Completion (Actual)

June 30, 2026

Study Registration Dates

First Submitted

September 27, 2023

First Submitted That Met QC Criteria

October 4, 2023

First Posted (Actual)

October 11, 2023

Study Record Updates

Last Update Posted (Actual)

August 11, 2026

Last Update Submitted That Met QC Criteria

August 10, 2026

Last Verified

August 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

1404-0040
2022-502442-27-00 (Registry Identifier: CTIS)
U1111-1289-0174 (Registry Identifier: WHO registry)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Once the criteria in section 'time frame' are fulfilled, researchers can use the following link https:// www.mystudywindow.com/msw/datasharing to request access to the clinical study documents regarding this study, and upon a signed "Document Sharing Agreement". Furthermore, researchers can request access to the clinical study data, for this and other listed studies, after the submission of a research proposal and according to the terms outlined in the website.

IPD Sharing Time Frame

After structured results have been posted, all regulatory activities are completed in the US and EU for the product and indication, and after the primary manuscript has been accepted for publication.

IPD Sharing Access Criteria

For study documents - upon signing of a 'Document Sharing Agreement'.For study data -1. after the submission and approval of the research proposal (checks will be performed by the sponsor and/or the independent review panel, including checking that the planned analysis does not compete with sponsor's publication plan); 2. and upon signing of a legal agreement.

IPD Sharing Supporting Information Type

STUDY_PROTOCOL
SAP
CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

A Study to Test the Effect of Survodutide (BI 456906) on Cardiovascular Safety in People With Overweight or Obesity (SYNCHRONIZE™ - CVOT)

Study Overview

Status

Conditions

Intervention / Treatment

Study Type

Enrollment (Actual)

Phase

Contacts and Locations

Study Locations

Participation Criteria

Eligibility Criteria

Ages Eligible for Study

Accepts Healthy Volunteers

Description

Study Plan

How is the study designed?

Design Details

Number of Arms

Arms and Interventions

Participant Group / Arm

Intervention / Treatment

What is the study measuring?

Primary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Secondary Outcome Measures

Outcome Measure

Measure Description

Time Frame

Collaborators and Investigators

Sponsor

Publications and helpful links

General Publications

Helpful Links

Study record dates

Study Major Dates

Study Start (Actual)

Primary Completion (Actual)

Study Completion (Actual)

Study Registration Dates

First Submitted

First Submitted That Met QC Criteria

First Posted (Actual)

Study Record Updates

Last Update Posted (Actual)

Last Update Submitted That Met QC Criteria

Last Verified

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

IPD Plan Description

IPD Sharing Time Frame

IPD Sharing Access Criteria

IPD Sharing Supporting Information Type

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Studies a U.S. FDA-regulated device product