Exercise Inhibit Innate Immune Response and Ameliorate Chronic Pancreatitis

July 30, 2024 updated by: Changhai Hospital

An Observational Study on the Role of Exercise in the Disease Progression of Chronic Pancreatitis.

The goal of this observational study is to learn about the effects of different physical exercise on disease progression in patients with chronic pancreatitis. The main question it aims to answer is:

Can physical exercise alleviate the disease progression of chronic pancreatitis?

Currently, the investigators have followed up with participants through a telephone questionnaire for six months to investigate whether the participants have engaged in physical exercise and to assess the disease progression of chronic pancreatitis.

Study Overview

Status

Completed

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Actual)

121

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Locations

  • China
    • Shanghai
      • Shanghai, Shanghai, China, 200433
        • Changhai Hospital

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Probability Sample

Study Population

The 105 patients with CP were categorized into the sedentary group (CP-Sed, n = 54) and exercise group (CP-Ex, n = 51) based on self-reported exercise time per day during the six-month follow-up post the diagnosis of CP. Physical exercise time was recorded at four levels: 15 min/d, 30 min/d, 45 min/d, and 60 min/d or more.

Description

Inclusion Criteria:

  • Clinical diagnosis of chronic pancreatitis
  • Must be adhere to the guidelines of the American Gastroenterological Association

Exclusion Criteria:

  • Autoimmune pancreatitis
  • Pancreatic cancer diagnosed within 2 years after the onset of CP
  • Use of drugs or toxins, or presence of viral infections

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Non-Chronic Pancreatitis (Non-CP)
Patients diagnosed without chronic pancreatitis based on imaging results were categorized into the Non-CP group.
Chronic Pancreatitis-non-exercise (CP-non-exercise)
Patients diagnosed with chronic pancreatitis based on imaging results, while simultaneously not engaging in physical exercise, were categorized into the CP-non-exercise group.
Chronic Pancreatitis-exercise (CP-exercise)
Patients diagnosed with chronic pancreatitis based on imaging results, while concurrently adhering to physical exercise, were categorized into the CP-exercise group.
Behavioral: Physical exercise
The CP-exercise group was categorized based on patients' self-reported daily exercise time into four levels: 15 minutes/day, 30 minutes/day, 45 minutes/day, and ≥60 minutes/day. Additionally, resistance exercise and endurance exercise were distinguished based on patients' self-reported exercise modalities, including swimming, jogging, brisk walking, practicing Tai Chi, and dumbbell training.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Physical Exercise Can Alleviate the Disease Progression of Chronic Pancreatitis.
Time Frame: Six months
The investigators collected data on patients' exercise time and modalities through telephone questionnaires. The impact of exercise on patients with chronic pancreatitis was determined by assessing VAS scores.
Six months

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Changhai Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

May 18, 2023

Primary Completion (Actual)

March 24, 2024

Study Completion (Actual)

March 24, 2024

Study Registration Dates

First Submitted

March 25, 2024

First Submitted That Met QC Criteria

July 30, 2024

First Posted (Actual)

August 2, 2024

Study Record Updates

Last Update Posted (Actual)

August 2, 2024

Last Update Submitted That Met QC Criteria

July 30, 2024

Last Verified

July 1, 2024

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • Exercise (ABCSG)

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

Clinical Trials on Chronic Pancreatitis

Clinical Trials on Physical exercise

Search Similar Trials

Sponsors and Collaborators

Medical Conditions

Drug Interventions

CROs by country

CROs in Azerbaijan

Conditions

Rare Diseases

Drug Interventions

Dietary Supplements

Sponsor/Collaborators

Locations

Subscribe