A Study to Evaluate Zilovertamab Vedotin (MK-2140) Combination With Rituximab Plus Cyclophosphamide, Doxorubicin, and Prednisone (R-CHP) Versus Rituximab Plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) in Participants With Previously Untreated DLBCL (MK-2140-010)

June 5, 2026 updated by: Merck Sharp & Dohme LLC

A Randomized, Open-Label, Multicenter, Phase 3 Study of Zilovertamab Vedotin (MK-2140) in Combination With R-CHP Versus R-CHOP in Participants With Previously Untreated Diffuse Large B-Cell Lymphoma (DLBCL) (waveLINE-010)

The purpose of this study is to evaluate if zilovertamab vedotin with standard treatment can help people live longer without the cancer growing or spreading than people who receive standard treatment alone.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

1046

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • Argentina
      • CABA, Argentina, C1199ABB
        • Recruiting
        • Hospital Italiano de Buenos Aires ( Site 0304)
        • Contact:
          • Study Coordinator
          • Phone Number: (011) 4959-0550
      • San Juan, Argentina, J5400ARW
        • Completed
        • Clinica EL Castaño ( Site 0312)
    • Buenos Aires
      • Caba., Buenos Aires, Argentina, C1430EGF
        • Recruiting
        • Clinica Adventista Belgrano ( Site 0309)
        • Contact:
          • Study Coordinator
          • Phone Number: +5491140141500
      • Mar del Plata, Buenos Aires, Argentina, B7600FZO
        • Recruiting
        • Instituto de Investigaciones Clinicas Mar del Plata ( Site 0306)
        • Contact:
          • Study Coordinator
          • Phone Number: +542234963224
      • Pilar, Buenos Aires, Argentina, B1629AHJ
        • Recruiting
        • Hospital Universitario Austral ( Site 0307)
        • Contact:
          • Study Coordinator
          • Phone Number: +541158239252
    • Buenos Aires F.D.
      • Buenos Aires, Buenos Aires F.D., Argentina, C1118AAT
        • Recruiting
        • Hospital Aleman ( Site 0301)
        • Contact:
          • Study Coordinator
          • Phone Number: +541148232574
    • Santa Fe Province
      • Rosario, Santa Fe Province, Argentina, S2000CEJ
        • Recruiting
        • Fundacion Estudios Clinicos ( Site 0311)
        • Contact:
          • Study Coordinator
          • Phone Number: +54 (0341) 2221472
    • Tucumán Province
      • San Miguel de Tucumán, Tucumán Province, Argentina, T4000IKO
        • Completed
        • C.I.C.E. 9 de Julio ( Site 0305)
  • Australia
    • Queensland
      • Douglas, Queensland, Australia, 4814
        • Recruiting
        • Townsville University Hospital ( Site 3006)
        • Contact:
          • Study Coordinator
          • Phone Number: +61744333549
    • South Australia
      • Adelaide, South Australia, Australia, 5000
        • Recruiting
        • Royal Adelaide Hospital ( Site 3001)
        • Contact:
          • Study Coordinator
          • Phone Number: 0870745898
    • Victoria
      • Ballarat, Victoria, Australia, 3350
        • Recruiting
        • Grampians Health ( Site 3003)
        • Contact:
          • Study Coordinator
          • Phone Number: +61353204000
      • Melbourne, Victoria, Australia, 3076
        • Recruiting
        • Northern Hospital ( Site 3002)
        • Contact:
          • Study Coordinator
          • Phone Number: +61384058000
    • Western Australia
      • Perth, Western Australia, Australia, 6000
        • Recruiting
        • Royal Perth Hospital-Haematology ( Site 3004)
        • Contact:
          • Study Coordinator
          • Phone Number: +61864775013
  • Belgium
    • Antwerpen
      • Mechelen, Antwerpen, Belgium, 2800
        • Recruiting
        • AZ Sint-Maarten, Campus Leopoldstraat 2 ( Site 1102)
        • Contact:
          • Study Coordinator
          • Phone Number: +32(0)15/89.10.10
    • Hainaut
      • Mons, Hainaut, Belgium, 7000
        • Recruiting
        • ASBL CHU Helora - Hôpital de Mons - Site Kennedy ( Site 1103)
        • Contact:
          • Study Coordinator
          • Phone Number: +3265413744
  • Brazil
      • São Paulo, Brazil, 01321-001
        • Recruiting
        • Hospital Paulistano ( Site 0406)
        • Contact:
          • Study Coordinator
          • Phone Number: +551131411083
      • São Paulo, Brazil, 05403-010
        • Recruiting
        • Hospital das Clinicas FMUSP ( Site 0402)
        • Contact:
          • Study Coordinator
          • Phone Number: +5511975458304
    • Paraná
      • Cascavel, Paraná, Brazil, 85802-080
        • Recruiting
        • CEONC ( Site 0412)
        • Contact:
          • Study Coordinator
          • Phone Number: 049988422678
      • Curitiba, Paraná, Brazil, 82520-060
        • Recruiting
        • Hospital Erasto Gaertner ( Site 0401)
        • Contact:
          • Study Coordinator
          • Phone Number: +5541999846033
    • Rio Grande do Norte
      • Natal, Rio Grande do Norte, Brazil, 59062-000
        • Recruiting
        • Liga Norte Riograndense Contra o Cancer ( Site 0407)
        • Contact:
          • Study Coordinator
          • Phone Number: +5584999278442
    • Santa Catarina
      • Florianópolis, Santa Catarina, Brazil, 88020-210
        • Recruiting
        • CEPEN - Centro de Pesquisa e Ensino em Oncologia de Santa Catarina ( Site 0403)
        • Contact:
          • Study Coordinator
          • Phone Number: +554833804828
    • São Paulo
      • Ribeirão Preto, São Paulo, Brazil, 14026-610
        • Recruiting
        • Hope ( Site 0413)
        • Contact:
          • Study Coordinator
          • Phone Number: +55 16 98813-0059
      • SJRP, São Paulo, Brazil, 15090-000
        • Recruiting
        • F. F. R. M. São Jose do Rio Preto ( Site 0404)
        • Contact:
          • Study Coordinator
          • Phone Number: +55 17 99788 6883
      • São Carlos, São Paulo, Brazil, 13561-130
        • Recruiting
        • Clinica Advanze ( Site 0411)
        • Contact:
          • Study Coordinator
          • Phone Number: 55163371-1320
  • Canada
    • Alberta
      • Edmonton, Alberta, Canada, T6G 1Z2
        • Suspended
        • Cross Cancer Institute ( Site 0205)
    • Nova Scotia
      • Halifax, Nova Scotia, Canada, B3H 2Y9
        • Recruiting
        • Queen Elizabeth II Health Sciences Centre ( Site 0207)
        • Contact:
          • Study Coordinator
          • Phone Number: 902-473-4642
    • Ontario
      • Hamilton, Ontario, Canada, L8V 5C2
        • Recruiting
        • Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0208)
        • Contact:
          • Study Coordinator
          • Phone Number: 9053879495
      • Oshawa, Ontario, Canada, L1G 2B9
        • Recruiting
        • Lakeridge Health - The R.S. McLaughlin Durham Regional Cancer Centre (MDRCC) ( Site 0206)
        • Contact:
          • Study Coordinator
          • Phone Number: 9055768711
      • Toronto, Ontario, Canada, M4N 3M5
        • Recruiting
        • Sunnybrook Research Institute ( Site 0204)
        • Contact:
          • Study Coordinator
          • Phone Number: 4164804662
  • Chile
    • Biobio
      • Concepción, Biobio, Chile, 4070196
        • Recruiting
        • Biocenter ( Site 0510)
        • Contact:
          • Study Coordinator
          • Phone Number: +56412858421
    • Coquimbo Region
      • La Serena, Coquimbo Region, Chile, 1720430
        • Recruiting
        • IC La Serena Research ( Site 0504)
        • Contact:
          • Study Coordinator
          • Phone Number: +56958646664
    • Los Ríos Region
      • Valdivia, Los Ríos Region, Chile, 5112129
        • Recruiting
        • Oncocentro Valdivia ( Site 0506)
        • Contact:
          • Study Coordinator
          • Phone Number: +56632632200
    • Region M. de Santiago
      • Santiago, Region M. de Santiago, Chile, 7500653
        • Recruiting
        • Centro de Estudios Clínicos SAGA ( Site 0508)
        • Contact:
          • Study Coordinator
          • Phone Number: +56991612199
      • Santiago, Region M. de Santiago, Chile, 7500921
        • Recruiting
        • FALP ( Site 0501)
        • Contact:
          • Study Coordinator
          • Phone Number: +5622712 8000
      • Santiago, Region M. de Santiago, Chile, 7580206
        • Recruiting
        • Clinica Inmunocel ( Site 0503)
        • Contact:
          • Study Coordinator
          • Phone Number: +56224376600
      • Santiago, Region M. de Santiago, Chile, 7650018
        • Recruiting
        • Clínica RedSalud Vitacura ( Site 0512)
        • Contact:
          • Study Coordinator
          • Phone Number: +56 223954046
      • Santiago, Region M. de Santiago, Chile, 8420383
        • Recruiting
        • Bradfordhill ( Site 0502)
        • Contact:
          • Study Coordinator
          • Phone Number: +56229490970
    • Valparaiso
      • Viña del Mar, Valparaiso, Chile, 2540488
        • Recruiting
        • Centro de Investigaciones ( Site 0511)
        • Contact:
          • Study Coordinator
          • Phone Number: +56323245375
  • China
    • Anhui
      • Hefei, Anhui, China, 230031
        • Recruiting
        • Anhui Provincial Cancer Hospital ( Site 3124)
        • Contact:
          • Study Coordinator
          • Phone Number: +8655165327666
    • Beijing Municipality
      • Beijing, Beijing Municipality, China, 100096
        • Recruiting
        • Peking University Third Hospital ( Site 3102)
        • Contact:
          • Study Coordinator
          • Phone Number: 010-82266699
      • Beijing, Beijing Municipality, China, 100142
        • Recruiting
        • Beijing Cancer Hospital ( Site 3101)
        • Contact:
          • Study Coordinator
          • Phone Number: 010-88121122
    • Chongqing Municipality
      • Chongqing, Chongqing Municipality, China, 400030
        • Recruiting
        • Chongqing Cancer Hospital ( Site 3113)
        • Contact:
          • Study Coordinator
          • Phone Number: 023-65301682
    • Fujian
      • Fuzhou, Fujian, China, 350014
        • Recruiting
        • Fujian Provincial Cancer Hospital. ( Site 3119)
        • Contact:
          • Study Coordinator
          • Phone Number: 059162752082
      • Xiamen, Fujian, China, 361003
        • Recruiting
        • The First Affiliated Hospital of Xiamen University ( Site 3120)
        • Contact:
          • Study Coordinator
          • Phone Number: +8605922137255
    • Guangdong
      • Guangzhou, Guangdong, China, 510280
        • Recruiting
        • Zhujiang Hospital of Southern Medical University ( Site 3122)
        • Contact:
          • Study Coordinator
          • Phone Number: 020-62782020
      • Guangzhou, Guangdong, China, 510060
        • Recruiting
        • Sun Yat-sen University Cancer Center ( Site 3121)
        • Contact:
          • Study Coordinator
          • Phone Number: 020-87343765
    • Guangxi
      • Nanning, Guangxi, China, 530021
        • Recruiting
        • Affiliated Cancer Hospital of Guangxi Medical University ( Site 3123)
        • Contact:
          • Study Coordinator
          • Phone Number: 0771-5323002
    • Guizhou
      • Guiyang, Guizhou, China, 550004
        • Recruiting
        • The Affiliated Hospital of Guizhou Medical University ( Site 3112)
        • Contact:
          • Study Coordinator
          • Phone Number: 0851-86740793
    • Hubei
      • Wuhan, Hubei, China, 430079
        • Recruiting
        • Hubei Cancer Hospital ( Site 3125)
        • Contact:
          • Study Coordinator
          • Phone Number: 027-87670003
    • Jiangsu
      • Nantong, Jiangsu, China, 226001
        • Recruiting
        • Affiliated Hospital of Nantong University ( Site 3117)
        • Contact:
          • Study Coordinator
          • Phone Number: +8618252100915
    • Jiangxi
      • Nanchang, Jiangxi, China, 330029
        • Recruiting
        • Jiangxi Cancer Hospital ( Site 3118)
        • Contact:
          • Study Coordinator
          • Phone Number: 0791-88317256
    • Jilin
      • Changchun, Jilin, China, 130021
        • Recruiting
        • The First Hospital Of Jilin University ( Site 3103)
        • Contact:
          • Study Coordinator
          • Phone Number: 0431-88782222
    • Shandong
      • Jinan, Shandong, China, 250117
        • Recruiting
        • Shandong Cancer Hospital ( Site 3108)
        • Contact:
          • Study Coordinator
          • Phone Number: 053167626063
      • Linyi, Shandong, China, 276001
        • Recruiting
        • LinYi Cancer Hospital ( Site 3104)
        • Contact:
          • Study Coordinator
          • Phone Number: +865398127192
    • Shanghai Municipality
      • Shanghai, Shanghai Municipality, China, 200032
        • Recruiting
        • Fudan University Shanghai Cancer Center ( Site 3115)
        • Contact:
          • Study Coordinator
          • Phone Number: +862164175590
    • Shanxi
      • Taiyuan, Shanxi, China, 030013
        • Recruiting
        • Shanxi Cancer Hospital ( Site 3106)
        • Contact:
          • Study Coordinator
          • Phone Number: 0351-4651606
      • Xi’an, Shanxi, China, 710061
        • Recruiting
        • 1st Affil Hosp of Med College of Xi'an Jiaotong University ( Site 3107)
        • Contact:
          • Study Coordinator
          • Phone Number: 029-85324094
    • Sichuan
      • Chengdu, Sichuan, China, 610041
        • Recruiting
        • Sichuan Cancer Hospital. ( Site 3111)
        • Contact:
          • Study Coordinator
          • Phone Number: 02885420243
      • Chengdu, Sichuan, China, 610041
        • Recruiting
        • West China Hospital, Sichuan University ( Site 3110)
        • Contact:
          • Study Coordinator
          • Phone Number: 028-85422114
    • Tianjin Municipality
      • Tianjin, Tianjin Municipality, China, 301617
        • Recruiting
        • Institute of Hematology and Blood Diseases Hosp CAMS&PUMC ( Site 3105)
        • Contact:
          • Study Coordinator
          • Phone Number: 022 23608030
    • Yunnan
      • Kunming, Yunnan, China, 650118
        • Recruiting
        • Yunnan Province Cancer Hospital ( Site 3109)
        • Contact:
          • Study Coordinator
          • Phone Number: 0871-68185656
    • Zhejiang
      • Hangzhou, Zhejiang, China, 310009
        • Recruiting
        • The First Affiliated Hospital, Zhejiang Medical University ( Site 3116)
        • Contact:
          • Study Coordinator
          • Phone Number: 0571-87236668
  • Colombia
    • Antioquia
      • Medellín, Antioquia, Colombia, 050034
        • Recruiting
        • Hospital Pablo Tobon Uribe ( Site 0604)
        • Contact:
          • Study Coordinator
          • Phone Number: +57 604 4459753
    • Bogota D.C.
      • Bogotá, Bogota D.C., Colombia, 110231
        • Active, not recruiting
        • Hospital Universitario San Ignacio ( Site 0607)
    • Departamento de Córdoba
      • Montería, Departamento de Córdoba, Colombia, 230002
        • Recruiting
        • IMAT S.A.S ( Site 0603)
        • Contact:
          • Study Coordinator
          • Phone Number: +57 604 7832333
    • Risaralda Department
      • Pereira, Risaralda Department, Colombia, 660001
        • Recruiting
        • Oncologos del Occidente ( Site 0601)
        • Contact:
          • Study Coordinator
          • Phone Number: 573002558656
    • Valle del Cauca Department
      • Cali, Valle del Cauca Department, Colombia, 760032
        • Recruiting
        • Fundación Valle del Lili ( Site 0602)
        • Contact:
          • Study Coordinator
          • Phone Number: 3158971414
  • Denmark
    • Central Jutland
      • Aarhus, Central Jutland, Denmark, 8200
        • Recruiting
        • University College Hospital, Department of Haematology ( Site 1303)
        • Contact:
          • Study Coordinator
          • Phone Number: +45 78455848
      • Herning, Central Jutland, Denmark, 7400
        • Recruiting
        • Regionshospitalet Gødstrup ( Site 1301)
        • Contact:
          • Study Coordinator
          • Phone Number: +45 78430000
    • North Denmark
      • Aalborg, North Denmark, Denmark, 9000
        • Recruiting
        • Aalborg University Hospital ( Site 1302)
        • Contact:
          • Study Coordinator
          • Phone Number: +4597662238
    • Region Syddanmark
      • Odense, Region Syddanmark, Denmark, 5000
        • Recruiting
        • Odense Universitetshospital ( Site 1304)
        • Contact:
          • Study Coordinator
          • Phone Number: +45 6541 1152
  • France
    • Alpes-Maritimes
      • Nice, Alpes-Maritimes, France, 06189
        • Recruiting
        • Centre Antoine-Lacassagne ( Site 1514)
        • Contact:
          • Study Coordinator
          • Phone Number: +33492031000
    • Charente-Maritime
      • La Rochelle, Charente-Maritime, France, 17000
        • Recruiting
        • Hopital Saint Louis, Centre Hospitalier de La Rochelle ( Site 1511)
        • Contact:
          • Study Coordinator
          • Phone Number: +33546458867.
    • Cote-d Or
      • Dijon, Cote-d Or, France, 21000
        • Recruiting
        • CHU Dijon Bourgogne ( Site 1516)
        • Contact:
          • Study Coordinator
          • Phone Number: +33380669237
    • Isere
      • La Tronche, Isere, France, 38700
        • Recruiting
        • CHU GRENOBLE ALPES ( Site 1518)
        • Contact:
          • Study Coordinator
          • Phone Number: +33476765755
    • Limousin
      • Limoges, Limousin, France, 87042
        • Recruiting
        • Centre Hospitalier Universitaire de Limoges - Hôpital Dupuytren ( Site 1512)
        • Contact:
          • Study Coordinator
          • Phone Number: +33555056651
    • Moselle
      • Metz, Moselle, France, 57085
        • Recruiting
        • Centre Hospitalier Régional Metz Thionville - Hôpital de Mercy ( Site 1515)
        • Contact:
          • Study Coordinator
          • Phone Number: +33387553363
    • Nord
      • Dunkirk, Nord, France, 59385
        • Recruiting
        • Centre Hospitalier de Dunkerque ( Site 1513)
        • Contact:
          • Study Coordinator
          • Phone Number: +330328285633
    • Puy-de-Dome
      • Clermont-Ferrand, Puy-de-Dome, France, 63100
        • Recruiting
        • Centre Hospitalier Universitaire Estaing ( Site 1508)
        • Contact:
          • Study Coordinator
          • Phone Number: 33473752291
    • Pyrenees-Atlantiques
      • Bayonne, Pyrenees-Atlantiques, France, 64100
        • Recruiting
        • Centre Hospitalier de la Cote Basque ( Site 1509)
        • Contact:
          • Study Coordinator
          • Phone Number: +33533788254
    • Seine-Maritime
      • Rouen, Seine-Maritime, France, 76038
        • Recruiting
        • Centre Henri Becquerel ( Site 1517)
        • Contact:
          • Study Coordinator
          • Phone Number: 02.76.67.30.45
    • Var
      • Toulon, Var, France, 83800
        • Recruiting
        • HIA Sainte Anne ( Site 1506)
        • Contact:
          • Study Coordinator
          • Phone Number: +33483162506
    • Vaucluse
      • Avignon, Vaucluse, France, 84000
        • Recruiting
        • Centre Hospitalier d'Avignon ( Site 1505)
        • Contact:
          • Study Coordinator
          • Phone Number: 33432759330
    • Vendee
      • La Roche-sur-Yon, Vendee, France, 85000
        • Recruiting
        • CHD Vendee ( Site 1502)
        • Contact:
          • Study Coordinator
          • Phone Number: +33251446173
    • Île-de-France Region
      • Saint-Cloud, Île-de-France Region, France, 92210
        • Recruiting
        • Institut Curie - site Saint-Cloud ( Site 1501)
        • Contact:
          • Study Coordinator
          • Phone Number: 01 47 11 17 92
  • Greece
    • Attica
      • Athens, Attica, Greece, 106 76
        • Recruiting
        • Evangelismos General Hospital of Athens ( Site 1602)
        • Contact:
          • Study Coordinator
          • Phone Number: 0030 2132041721
      • Athens, Attica, Greece, 115 26
        • Recruiting
        • General Hospital of Athens "Laiko"-Hematology Department ( Site 1603)
        • Contact:
          • Study Coordinator
          • Phone Number: 0030 2136060981
      • Athens, Attica, Greece, 124 62
        • Recruiting
        • Attikon University General Hospital of Athens ( Site 1604)
        • Contact:
          • Study Coordinator
          • Phone Number: 0030 2105832318
    • Evros
      • Alexandroupoli, Evros, Greece, 681 00
        • Recruiting
        • University General Hospital of Alexandroupoli ( Site 1601)
        • Contact:
          • Study Coordinator
          • Phone Number: 0030 2551353739
  • Guatemala
      • Guatemala City, Guatemala, 01009
        • Recruiting
        • MEDI-K ( Site 0701)
        • Contact:
          • Study Coordinator
          • Phone Number: +50222912323
      • Guatemala City, Guatemala, 01010
        • Recruiting
        • CELAN,S.A ( Site 0702)
        • Contact:
          • Study Coordinator
          • Phone Number: +502 55275016
      • Guatemala City, Guatemala, 01010
        • Recruiting
        • Cen Integral Onco Gastro y Hemato Onco Guatemala S.A. ( Site 0703)
        • Contact:
          • Study Coordinator
          • Phone Number: +502 30147611
  • Hong Kong
      • Hong Kong, Hong Kong
        • Recruiting
        • Queen Mary Hospital ( Site 3201)
        • Contact:
          • Study Coordinator
          • Phone Number: 85222553838
      • Hong Kong, Hong Kong
        • Recruiting
        • Princess Margaret Hospital ( Site 3202)
        • Contact:
          • Study Coordinator
          • Phone Number: 85229901111
  • Hungary
      • Budapest, Hungary, 1122
        • Recruiting
        • Orszagos Onkologiai Intezet ( Site 1705)
        • Contact:
          • Study Coordinator
          • Phone Number: +36 1 224 8600 #3775
    • Hajdú-Bihar
      • Budapest, Hajdú-Bihar, Hungary, 1088
        • Recruiting
        • Semmelweis University-Belgyógyászati és Hematológiai Klinika ( Site 1703)
        • Contact:
          • Study Coordinator
          • Phone Number: +3614591500
      • Debrecen, Hajdú-Bihar, Hungary, 4032
        • Recruiting
        • Debreceni Egyetem Klinikai Kozpont ( Site 1702)
        • Contact:
          • Study Coordinator
          • Phone Number: +3652255601
    • Szabolcs-Szatmár-Bereg
      • Nyíregyháza, Szabolcs-Szatmár-Bereg, Hungary, 4400
        • Recruiting
        • Szabolcs Szatmár Bereg Vármegyei Oktatókórház ( Site 1704)
        • Contact:
          • Study Coordinator
          • Phone Number: +3642599700/1060
    • Tolna County
      • Szekszárd, Tolna County, Hungary, 7100
        • Recruiting
        • Tolna Vármegyei Balassa János Kórház ( Site 1710)
        • Contact:
          • Study Coordinator
          • Phone Number: +36 74 501 603
  • Israel
      • Haifa, Israel, 3436212
        • Recruiting
        • Carmel Hospital ( Site 1903)
        • Contact:
          • Study Coordinator
          • Phone Number: 04-8250844
      • Jerusalem, Israel, 9112001
        • Recruiting
        • Hadassah Medical Center ( Site 1901)
        • Contact:
          • Study Coordinator
          • Phone Number: 97226778180
      • Tel Aviv, Israel, 6423906
        • Recruiting
        • Sourasky Medical Center ( Site 1904)
        • Contact:
          • Study Coordinator
          • Phone Number: 9723-6973782
      • Tiberias, Israel, 15208
        • Recruiting
        • Poria Medical Center ( Site 1902)
        • Contact:
          • Study Coordinator
          • Phone Number: 972-4-662759
  • Italy
      • Ancona, Italy, 60126
        • Recruiting
        • AOU delle Marche Ospedali Riuniti di Ancona ( Site 2011)
        • Contact:
          • Study Coordinator
          • Phone Number: +390715964562
      • Brescia, Italy, 25123
        • Recruiting
        • Azienda Ospedaliera Spedali Civili di Brescia-Hemathology ( Site 2001)
        • Contact:
          • Study Coordinator
          • Phone Number: +390303995438
      • Milan, Italy, 20132
        • Recruiting
        • IRCCS Ospedale San Raffaele ( Site 2012)
        • Contact:
          • Study Coordinator
          • Phone Number: +39 02 2643 7649
      • Milan, Italy, 20141
        • Recruiting
        • IEO Istituto Europeo di Oncologia ( Site 2009)
        • Contact:
          • Study Coordinator
          • Phone Number: +39 02 94371079
      • Novara, Italy, 28100
        • Recruiting
        • Azienda Ospedaliero Universitaria Maggiore della Carità ( Site 2004)
        • Contact:
          • Study Coordinator
          • Phone Number: +3903213733127
      • Palermo, Italy, 90146
        • Recruiting
        • Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO ( Site 2005)
        • Contact:
          • Study Coordinator
          • Phone Number: +390916802773
      • Ravenna, Italy, 48121
        • Recruiting
        • Ospedale Santa Maria delle Croci ( Site 2006)
        • Contact:
          • Study Coordinator
          • Phone Number: +390544285722
      • Roma, Italy, 00168
        • Recruiting
        • Fondazione Policlinico Universitario Agostino Gemelli IRCCS - Università Cattolica del Sacro Cuore ( Site 2003)
        • Contact:
          • Study Coordinator
          • Phone Number: 00390630154180
    • Lombardy
      • Monza, Lombardy, Italy, 20900
        • Recruiting
        • Fondazione IRCCS San Gerardo dei Tintori ( Site 2008)
        • Contact:
          • Study Coordinator
          • Phone Number: +390392333539
    • Potenza
      • Rionero in Vulture, Potenza, Italy, 85028
        • Recruiting
        • IRCCS Crob ( Site 2002)
        • Contact:
          • Study Coordinator
          • Phone Number: +390972726685
    • Torino
      • Candiolo, Torino, Italy, 10060
        • Recruiting
        • Istituto di Candiolo IRCCS - Fondazione del Piemonte per l'Oncologia ( Site 2010)
        • Contact:
          • Study Coordinator
          • Phone Number: +390119933250
  • Japan
      • Chiba, Japan, 260-8717
        • Recruiting
        • Chiba Cancer Center ( Site 3314)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-43-264-5431
      • Fukuoka, Japan, 812-8582
        • Recruiting
        • Kyushu University Hospital ( Site 3313)
        • Contact:
          • Study Coordinator
          • Phone Number: +8192-641-1151
      • Hiroshima, Japan, 730-8619
        • Recruiting
        • Hiroshima Red Cross Hospital & Atomic-bomb Survivors Hospital ( Site 3322)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-82-241-3111
      • Kyoto, Japan, 602-8566
        • Recruiting
        • University Hospital,Kyoto Prefectural University of Medicine ( Site 3315)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-75-251-5111
      • Miyazaki, Japan, 889-1692
        • Recruiting
        • University of Miyazaki Hospital ( Site 3319)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-985-85-1510
      • Okayama, Japan, 700-8558
        • Recruiting
        • Okayama University Hospital ( Site 3311)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-86-223-7151
      • Osaka, Japan, 545-8586
        • Recruiting
        • Osaka Metropolitan University Hospital ( Site 3317)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-6-6645-2121
      • Yamagata, Japan, 990-9585
        • Recruiting
        • Yamagata University Hospital ( Site 3312)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-23-633-1122
    • Aichi-ken
      • Nagoya, Aichi-ken, Japan, 466-8560
        • Recruiting
        • Nagoya University Hospital ( Site 3309)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-52-741-2111
    • Chiba
      • Kashiwa, Chiba, Japan, 277-8577
        • Recruiting
        • National Cancer Center Hospital East ( Site 3303)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-4-7133-1111
    • Ehime
      • Matsuyama, Ehime, Japan, 791-0280
        • Recruiting
        • National Hospital Organization Shikoku Cancer Center ( Site 3321)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-89-999-1111
    • Hyōgo
      • Kobe, Hyōgo, Japan, 650-0047
        • Recruiting
        • Kobe City Medical Center General Hospital ( Site 3318)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-78-302-4321
    • Ishikawa-ken
      • Kanazawa, Ishikawa-ken, Japan, 920-8641
        • Recruiting
        • Kanazawa University Hospital ( Site 3308)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-76-265-2000
    • Kanagawa
      • Isehara, Kanagawa, Japan, 259-1193
        • Recruiting
        • Tokai University Hospital ( Site 3302)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-463-93-1121
    • Miyagi
      • Sendai, Miyagi, Japan, 980-8574
        • Recruiting
        • Tohoku University Hospital ( Site 3301)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-22-717-7000
    • Osaka
      • Sakai, Osaka, Japan, 590-0197
        • Recruiting
        • Kindai University Hospital ( Site 3310)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-72-288-7222
    • Saitama
      • Iruma-gun, Saitama, Japan, 350-0495
        • Recruiting
        • Saitama Medical University Hospital ( Site 3305)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-49-276-1111
    • Tokyo
      • Bunkyo, Tokyo, Japan, 113-8431
        • Recruiting
        • Juntendo University Hospital ( Site 3307)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3813-3111
      • Bunkyo, Tokyo, Japan, 113-8677
        • Recruiting
        • Tokyo Metropolitan Komagome Hospital ( Site 3323)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-3-3823-2101
    • Yamanashi
      • Chūō, Yamanashi, Japan, 409-3898
        • Recruiting
        • University of Yamanashi Hospital ( Site 3320)
        • Contact:
          • Study Coordinator
          • Phone Number: +81-55-273-1111
  • Malaysia
    • Sabah
      • Kota Kinabalu, Sabah, Malaysia, 88586
        • Recruiting
        • Queen Elizabeth Hospital ( Site 3405)
        • Contact:
          • Study Coordinator
          • Phone Number: +6088517555
    • Sarawak
      • Kuching, Sarawak, Malaysia, 93586
        • Recruiting
        • Sarawak General Hospital ( Site 3402)
        • Contact:
          • Study Coordinator
          • Phone Number: +6082276666
      • Miri, Sarawak, Malaysia, 98000
        • Recruiting
        • Hospital Miri ( Site 3403)
        • Contact:
          • Study Coordinator
          • Phone Number: +6085460600
    • Selangor
      • Petaling Jaya, Selangor, Malaysia, 47500
        • Recruiting
        • Sunway Medical Centre ( Site 3406)
        • Contact:
          • Study Coordinator
          • Phone Number: +60386011080
      • Selangor Darul Ehsan, Selangor, Malaysia, 68000
        • Recruiting
        • Hospital Ampang ( Site 3404)
        • Contact:
          • Study Coordinator
          • Phone Number: +60342896559
  • Mexico
      • Oaxaca City, Mexico, 68020
        • Recruiting
        • Centro de Investigacion Clinica de Oaxaca ( Site 0805)
        • Contact:
          • Study Coordinator
          • Phone Number: 52 9515473137
    • Coahuila
      • Torreón, Coahuila, Mexico, 27000
        • Completed
        • CIMAB SA de CV ( Site 0807)
    • Hidalgo
      • Pachuca, Hidalgo, Mexico, 42000
        • Completed
        • Grupo Ollin Care ( Site 0806)
    • Mexico City
      • Mexico City, Mexico City, Mexico, 03100
        • Recruiting
        • Health Pharma Professional Research S.A. de C.V. ( Site 0801)
        • Contact:
          • Study Coordinator
          • Phone Number: +52 5575864856
      • Mexico City, Mexico City, Mexico, 03104
        • Recruiting
        • Centro de Infusion Superare ( Site 0804)
        • Contact:
          • Study Coordinator
          • Phone Number: 52 5552646440
    • Michoacán
      • Morelia, Michoacán, Mexico, 58260
        • Recruiting
        • Centro de Investigacion Clinica Chapultepec ( Site 0803)
        • Contact:
          • Study Coordinator
          • Phone Number: 52 4431478545
    • Nuevo León
      • Monterrey, Nuevo León, Mexico, 64460
        • Recruiting
        • Hospital Universitario ""Dr. Jose Eleuterio Gonzalez"" ( Site 0802)
        • Contact:
          • Study Coordinator
          • Phone Number: 52 8183486136
  • Netherlands
    • South Holland
      • Dordrecht, South Holland, Netherlands, 3318 AT
        • Recruiting
        • Albert Schweitzer Ziekenhuis ( Site 2103)
        • Contact:
          • Study Coordinator
          • Phone Number: +31(0)786523013
    • Utrecht
      • Amersfoort, Utrecht, Netherlands, 3813 TZ
        • Recruiting
        • Meander Medisch Centrum ( Site 2101)
        • Contact:
          • Study Coordinator
          • Phone Number: +31(0)338502129
  • Peru
      • Lima, Peru, 15072
        • Recruiting
        • Clínica San Felipe ( Site 0906)
        • Contact:
          • Study Coordinator
          • Phone Number: 511 2039900 Ext 131
      • Lima, Peru, 15087
        • Recruiting
        • Hospital Nacional Dos De Mayo ( Site 0905)
        • Contact:
          • Study Coordinator
          • Phone Number: +51944464618
      • Lima, Peru, 15072
        • Recruiting
        • Hospital Nacional Edgardo Rebagliati Martins ( Site 0903)
        • Contact:
          • Study Coordinator
          • Phone Number: +51991895682
    • Lambayeque
      • Chiclayo, Lambayeque, Peru, 14001
        • Recruiting
        • Clínicas AUNA Sede Chiclayo ( Site 0904)
        • Contact:
          • Study Coordinator
          • Phone Number: 51 74748333 Ext 7832
    • Muni Metro de Lima
      • Surquillo, Muni Metro de Lima, Peru, 15038
        • Active, not recruiting
        • INSTITUTO NACIONAL DE ENFERMEDADES NEOPLASICAS ( Site 0901)
  • Poland
    • Lower Silesian Voivodeship
      • Wroclaw, Lower Silesian Voivodeship, Poland, 50-019
        • Recruiting
        • Pratia Onkologia Wroclaw ( Site 2211)
        • Contact:
          • Study Coordinator
          • Phone Number: 502 278 782
    • Masovian Voivodeship
      • Warsaw, Masovian Voivodeship, Poland, 02-781
        • Completed
        • Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2201)
    • Pomeranian Voivodeship
      • Słupsk, Pomeranian Voivodeship, Poland, 76-200
        • Recruiting
        • Wojewódzki Szpital Specjalistyczny im. J. Korczaka w Słupsku ( Site 2210)
        • Contact:
          • Study Coordinator
          • Phone Number: 59 84 60 390
    • Silesian Voivodeship
      • Gliwice, Silesian Voivodeship, Poland, 44-102
        • Recruiting
        • Narodowy Instytut Onkologii - Oddzial w Gliwicach ( Site 2208)
        • Contact:
          • Study Coordinator
          • Phone Number: +48322789794
      • Katowice, Silesian Voivodeship, Poland, 40-519
        • Recruiting
        • Pratia Onkologia Katowice ( Site 2204)
        • Contact:
          • Study Coordinator
          • Phone Number: +48327462500
    • Warmian-Masurian Voivodeship
      • Olsztyn, Warmian-Masurian Voivodeship, Poland, 10-228
        • Recruiting
        • Szpital Kliniczny Ministerstwa Spraw Wewnętrznych i Administracji z Warmińsko-Mazurskim Centrum Onko ( Site 2205)
        • Contact:
          • Study Coordinator
          • Phone Number: +48895398428
  • Portugal
      • Braga, Portugal, 4710-243
        • Recruiting
        • Unidade Local de Saude de Braga - Hospital de Braga ( Site 2306)
        • Contact:
          • Study Coordinator
          • Phone Number: +351253 027 249
      • Lisbon, Portugal, 1649-035
        • Recruiting
        • Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 2308)
        • Contact:
          • Study Coordinator
          • Phone Number: +351 217 805 000
      • Porto, Portugal, 4200-072
        • Recruiting
        • Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 2302)
        • Contact:
          • Study Coordinator
          • Phone Number: +351 22 508 4000
  • Puerto Rico
      • Mayagüez, Puerto Rico, 00682
        • Recruiting
        • BRCR Global - Mayaguez ( Site 1003)
        • Contact:
          • Study Coordinator
          • Phone Number: 1 561 437 6038
      • San Juan, Puerto Rico, 00918
        • Recruiting
        • Auxilio Mutuo Cancer Center ( Site 1001)
        • Contact:
          • Study Coordinator
          • Phone Number: 787 758 2000
  • Romania
      • Brasov, Romania, 500052
        • Recruiting
        • Centrul de Diagnostic si Tratament Oncologic Brasov ( Site 2402)
        • Contact:
          • Study Coordinator
          • Phone Number: +40268 960
      • Sibiu, Romania, 557260
        • Recruiting
        • Spital Judetean Sibiu ( Site 2405)
        • Contact:
          • Study Coordinator
          • Phone Number: +40269215050
    • Bucharest
      • Bucharest, Bucharest, Romania, 030171
        • Recruiting
        • Spitalul Clinic Colțea ( Site 2401)
        • Contact:
          • Study Coordinator
          • Phone Number: +40213874100
    • Cluj
      • Cluj-Napoca, Cluj, Romania, 4003437
        • Recruiting
        • Institutul Oncologic Cluj ( Site 2404)
        • Contact:
          • Study Coordinator
          • Phone Number: +40264598362
  • Singapore
    • Central Singapore
      • Singapore, Central Singapore, Singapore, 168583
        • Recruiting
        • National Cancer Centre Singapore ( Site 3701)
        • Contact:
          • Study Coordinator
          • Phone Number: 6564368000
      • Singapore, Central Singapore, Singapore, 119074
        • Recruiting
        • National University Hospital ( Site 3702)
        • Contact:
          • Study Coordinator
          • Phone Number: 6569082222
  • South Africa
    • Gauteng
      • Pretoria, Gauteng, South Africa, 0181
        • Recruiting
        • Netcare Pretoria East Hospital ( Site 2502)
        • Contact:
          • Study Coordinator
          • Phone Number: +27129932555
      • Pretoria, Gauteng, South Africa, 0181
        • Recruiting
        • LIFE GROENKLOOF-Mary Potter Cancer Centre ( Site 2506)
        • Contact:
          • Study Coordinator
          • Phone Number: +27 (0)12 346 6701
    • Western Cape
      • Cape Town, Western Cape, South Africa, 7580
        • Recruiting
        • Haemalife ( Site 2501)
        • Contact:
          • Study Coordinator
          • Phone Number: +27 21 900 6277
      • Cape Town, Western Cape, South Africa, 7925
        • Recruiting
        • Groote Schuur Hospital ( Site 2504)
        • Contact:
          • Study Coordinator
          • Phone Number: +27214043077
  • South Korea
      • Seoul, South Korea, 05505
        • Recruiting
        • Asan Medical Center ( Site 3803)
        • Contact:
          • Study Coordinator
          • Phone Number: +82230105940
      • Seoul, South Korea, 07345
        • Recruiting
        • St.Mary's H., Youido ( Site 3805)
        • Contact:
          • Study Coordinator
          • Phone Number: +82237791049
      • Seoul, South Korea, 03722
        • Completed
        • Severance Hospital, Yonsei University Health System ( Site 3802)
      • Seoul, South Korea, 06351
        • Completed
        • Samsung Medical Center ( Site 3807)
    • Kyonggi-do
      • Goyang-si, Kyonggi-do, South Korea, 10408
        • Recruiting
        • National Cancer Center- Center for Hemotologic malignancy ( Site 3806)
        • Contact:
          • Study Coordinator
          • Phone Number: 8231-920-1505
    • Pusan-Kwangyokshi
      • Busan, Pusan-Kwangyokshi, South Korea, 49241
        • Recruiting
        • Pusan National University Hospital ( Site 3804)
        • Contact:
          • Study Coordinator
          • Phone Number: +8251-240-7839
    • Taejon-Kwangyokshi
      • Daejeon, Taejon-Kwangyokshi, South Korea, 35015
        • Recruiting
        • Chungnam National University Hospital ( Site 3801)
        • Contact:
          • Study Coordinator
          • Phone Number: 82422806922
  • Spain
      • Barcelona, Spain, 08003
        • Recruiting
        • Hospital del Mar ( Site 2610)
        • Contact:
          • Study Coordinator
          • Phone Number: 34932483343
      • Madrid, Spain, 28046
        • Recruiting
        • Hospital Universitario La Paz ( Site 2611)
        • Contact:
          • Study Coordinator
          • Phone Number: 34912071518
      • Madrid, Spain, 28041
        • Recruiting
        • Hospital General Universitario 12 de Octubre ( Site 2605)
        • Contact:
          • Study Coordinator
          • Phone Number: +34605532453
      • Málaga, Spain, 29010
        • Recruiting
        • Hospital Virgen de la Victoria ( Site 2609)
        • Contact:
          • Study Coordinator
          • Phone Number: 0034951032508
      • Zaragoza, Spain, 50009
        • Recruiting
        • Hospital Universitario Miguel Servet ( Site 2607)
        • Contact:
          • Study Coordinator
          • Phone Number: 34976765500
    • Andalusia
      • Seville, Andalusia, Spain, 41009
        • Recruiting
        • Hospital Universitario Virgen Macarena ( Site 2608)
        • Contact:
          • Study Coordinator
          • Phone Number: 34955054993
    • Barcelona
      • L'Hospitalet de Llobregat, Barcelona, Spain, 08908
        • Recruiting
        • ICO L Hospitalet ( Site 2601)
        • Contact:
          • Study Coordinator
          • Phone Number: 932607750
    • Las Palmas
      • Las Palmas de Gran Canaria, Las Palmas, Spain, 35016
        • Recruiting
        • H. Insular de Gran Canaria ( Site 2606)
        • Contact:
          • Study Coordinator
          • Phone Number: 0034928441738
    • Madrid
      • Majadahonda, Madrid, Spain, 28222
        • Recruiting
        • Hospital Universitario Puerta de Hierro ( Site 2615)
        • Contact:
          • Study Coordinator
          • Phone Number: 34911916000
    • Valenciana, Comunitat
      • Alicante, Valenciana, Comunitat, Spain, 03010
        • Recruiting
        • Hospital General Universitario Dr. Balmis ( Site 2604)
        • Contact:
          • Study Coordinator
          • Phone Number: 34965913727
  • Switzerland
    • Canton Ticino
      • Bellinzona, Canton Ticino, Switzerland, 6501
        • Recruiting
        • Ospedale Regionale Bellinzona e Valli ( Site 2701)
        • Contact:
          • Study Coordinator
          • Phone Number: +41 91 811 89 31
      • Lugano, Canton Ticino, Switzerland, 6900
        • Recruiting
        • Ospedale Italiano Lugano (OIL) ( Site 2705)
        • Contact:
          • Study Coordinator
          • Phone Number: 0041918118612
    • Canton of Aargau
      • Baden, Canton of Aargau, Switzerland, 5404
        • Recruiting
        • Kantonspital Baden ( Site 2703)
        • Contact:
          • Study Coordinator
          • Phone Number: 0041564862111
    • Canton of St. Gallen
      • Sankt Gallen, Canton of St. Gallen, Switzerland, 9000
        • Recruiting
        • Cantonal Hospital St.Gallen-Oncology & Hematology ( Site 2702)
        • Contact:
          • Study Coordinator
          • Phone Number: 41714941111
  • Taiwan
      • Kaohsiung City, Taiwan, 83301
        • Recruiting
        • Chang Gung Memorial Hospital at Kaohsiung ( Site 3905)
        • Contact:
          • Study Coordinator
          • Phone Number: 886-7-7317123
      • Tainan, Taiwan, 704
        • Recruiting
        • National Cheng Kung University Hospital ( Site 3902)
        • Contact:
          • Study Coordinator
          • Phone Number: +88662353535x4620
      • Taipei, Taiwan, 10002
        • Recruiting
        • National Taiwan University Hospital ( Site 3901)
        • Contact:
          • Study Coordinator
          • Phone Number: +88623123456
      • Taipei, Taiwan, 114
        • Recruiting
        • Tri-Service General Hospital ( Site 3906)
        • Contact:
          • Study Coordinator
          • Phone Number: +886287927208x12903
      • Taipei, Taiwan, 10449
        • Completed
        • Mackay Memorial Hospital ( Site 3908)
    • Taoyuan
      • Taoyuan City, Taoyuan, Taiwan, 333
        • Recruiting
        • Chang Gung Memorial Hospital - Linkou Branch ( Site 3903)
        • Contact:
          • Study Coordinator
          • Phone Number: +88633281200x2555
  • Thailand
    • Bangkok
      • Bangkoknoi, Bangkok, Thailand, 10700
        • Recruiting
        • Faculty of Medicine Siriraj Hospital ( Site 4001)
        • Contact:
          • Study Coordinator
          • Phone Number: +6624194448
      • Pathumwan, Bangkok, Thailand, 10330
        • Recruiting
        • Chulalongkorn University ( Site 4003)
        • Contact:
          • Study Coordinator
          • Phone Number: +6622564000
    • Chiang Mai
      • Muang, Chiang Mai, Thailand, 50200
        • Recruiting
        • Maharaj Nakorn Chiang Mai Hospital ( Site 4002)
        • Contact:
          • Study Coordinator
          • Phone Number: +6653935488
  • Turkey (Türkiye)
      • Adana, Turkey (Türkiye), 01120
        • Completed
        • Baskent Universitesi Adana Dr. Turgut Noyan UAM ( Site 2809)
      • Ankara, Turkey (Türkiye), 06200
        • Recruiting
        • Dr. Abdurrahman Yurtaslan Ankara Onkoloji Egitim ve Arastırma Hastanesi ( Site 2803)
        • Contact:
          • Study Coordinator
          • Phone Number: +90 (0312) 336 09 09
      • Ankara, Turkey (Türkiye), 06230
        • Recruiting
        • Hacettepe Universite Hastaneleri ( Site 2810)
        • Contact:
          • Study Coordinator
          • Phone Number: 05322276104
      • Ankara, Turkey (Türkiye), 06620
        • Recruiting
        • Ankara University Faculty of Medicine ( Site 2801)
        • Contact:
          • Study Coordinator
          • Phone Number: +903125956593
      • Antalya, Turkey (Türkiye), 7100
        • Completed
        • Antalya Egitim ve Arastirma Hastanesi ( Site 2805)
      • Istanbul, Turkey (Türkiye), 34722
        • Recruiting
        • Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi ( Site 2804)
        • Contact:
          • Study Coordinator
          • Phone Number: 0090 532 408 9525
    • Samsun
      • Korfez Mahallesi, Samsun, Turkey (Türkiye), 55270
        • Recruiting
        • Ondokuz Mayıs Universitesi ( Site 2806)
        • Contact:
          • Study Coordinator
          • Phone Number: +905052722289
    • Tekirdas
      • Suleymanpasa, Tekirdas, Turkey (Türkiye), 59030
        • Recruiting
        • Namık Kemal University Medical Faculty ( Site 2807)
        • Contact:
          • Study Coordinator
          • Phone Number: +905326347632
  • Ukraine
      • Kyiv, Ukraine, 03022
        • Recruiting
        • SNPE National Cancer Institute ( Site 2902)
        • Contact:
          • Study Coordinator
          • Phone Number: 380443346418
      • Kyiv, Ukraine, 04112
        • Recruiting
        • Public Non-Profit Enterprise Kyiv City Clinical Hospital #9 under the Executive Body of Kyiv City Co ( Site 2905)
        • Contact:
          • Study Coordinator
          • Phone Number: +38 044 4671989
      • Kyiv, Ukraine, 03115
        • Completed
        • SI National Research Center of Radiation Medicine, Hematology, Oncology ( Site 2901)
      • Kyiv, Ukraine, 03057
        • Completed
        • Universal Clinic Oberig ( Site 2908)
    • Cherkasy Oblast
      • Cherkasy, Cherkasy Oblast, Ukraine, 18009
        • Recruiting
        • MNPE ClinCenter of Oncology,Hematology,Transplantology and Palliative Care of CherkasyRegCouncil ( Site 2904)
        • Contact:
          • Study Coordinator
          • Phone Number: +38 047 2370025
    • Ivano-Frankivsk Oblast
      • Ivano-Frankivsk, Ivano-Frankivsk Oblast, Ukraine, 76008
        • Recruiting
        • Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 2906)
        • Contact:
          • Study Coordinator
          • Phone Number: +380342 528029
    • Khmelnytskyi Oblast
      • Khmelnytskiy, Khmelnytskyi Oblast, Ukraine, 29000
        • Recruiting
        • Khmelnytskyi Regional Hospital ( Site 2907)
        • Contact:
          • Study Coordinator
          • Phone Number: +380382649001
    • Lviv Oblast
      • Lviv, Lviv Oblast, Ukraine, 79057
        • Recruiting
        • Institute of Blood Pathology and Transfusion Medicine AMS Ukraine ( Site 2903)
        • Contact:
          • Study Coordinator
          • Phone Number: +380322373917
  • United States
    • Arizona
      • Gilbert, Arizona, United States, 85234
        • Recruiting
        • Banner MD Anderson Cancer Center ( Site 0165)
        • Contact:
          • Study Coordinator
          • Phone Number: 480-256-6444
      • Phoenix, Arizona, United States, 85006
        • Recruiting
        • Banner MD Anderson Cancer Center - University Medical Center Phoenix ( Site 0167)
        • Contact:
          • Study Coordinator
          • Phone Number: 480-256-6444
      • Tucson, Arizona, United States, 85719
        • Recruiting
        • The University of Arizona Cancer Center - North Campus ( Site 0124)
        • Contact:
          • Study Coordinator
          • Phone Number: 520-621-5497
    • California
      • Fullerton, California, United States, 92835
        • Recruiting
        • Providence Medical Foundation-Oncology ( Site 0168)
        • Contact:
          • Study Coordinator
          • Phone Number: 714-446-5900
      • Long Beach, California, United States, 90806
        • Recruiting
        • MemorialCare Health System - Long Beach Medical Center ( Site 9559)
        • Contact:
          • Study Coordinator
          • Phone Number: 652-241-9755
      • Los Alamitos, California, United States, 90720
        • Recruiting
        • Cancer Blood and Specialty Clinic ( Site 0109)
        • Contact:
          • Study Coordinator
          • Phone Number: 562-200-0203
      • Los Angeles, California, United States, 90048
        • Recruiting
        • Cedars-Sinai Medical Center ( Site 0115)
        • Contact:
          • Study Coordinator
          • Phone Number: 310-423-3277
      • San Francisco, California, United States, 94115
        • Recruiting
        • Pacific Hematology Oncology Associates ( Site 0131)
        • Contact:
          • Study Coordinator
          • Phone Number: 415-923-3012
    • Colorado
      • Golden, Colorado, United States, 80401
        • Recruiting
        • Lutheran Hospital - Cancer Centers of Colorado ( Site 0180)
        • Contact:
          • Study Coordinator
          • Phone Number: 303-403-6381
    • Florida
      • Clermont, Florida, United States, 34711
        • Recruiting
        • Clermont Oncology Center ( Site 0182)
        • Contact:
          • Study Coordinator
          • Phone Number: 352-242-1366
      • Hialeah, Florida, United States, 33013
        • Recruiting
        • Bioresearch Partner ( Site 0157)
        • Contact:
          • Study Coordinator
          • Phone Number: 833-489-4968
      • Ocoee, Florida, United States, 34761
        • Recruiting
        • Orlando Health Cancer Institute ( Site 0169)
        • Contact:
          • Study Coordinator
          • Phone Number: 321-843-7497
      • Orange City, Florida, United States, 32763
        • Recruiting
        • Mid Florida Hematology and Oncology Center ( Site 0172)
        • Contact:
          • Study Coordinator
          • Phone Number: 386-774-1223
    • Illinois
      • O'Fallon, Illinois, United States, 62269
        • Recruiting
        • Cancer Care Specialists of Illinois ( Site 0152)
        • Contact:
          • Study Coordinator
          • Phone Number: 618-416-7970
    • Indiana
      • Fort Wayne, Indiana, United States, 46804
        • Recruiting
        • Fort Wayne Medical Oncology and Hematology ( Site 0149)
        • Contact:
          • Study Coordinator
          • Phone Number: 260-436-0800
    • Kansas
      • Topeka, Kansas, United States, 66606
        • Recruiting
        • Cotton O'Neil Cancer Center ( Site 0108)
        • Contact:
          • Study Coordinator
          • Phone Number: 785-478-9495
    • Kentucky
      • Lexington, Kentucky, United States, 40536
        • Recruiting
        • University of Kentucky ( Site 0106)
        • Contact:
          • Study Coordinator
          • Phone Number: 859-257-6006
      • Louisville, Kentucky, United States, 40207
        • Recruiting
        • Norton Women's and Children's Hospital-Norton Cancer Institute - St. Matthews ( Site 0163)
        • Contact:
          • Study Coordinator
          • Phone Number: 502-899-3366
      • Owensboro, Kentucky, United States, 42303
        • Recruiting
        • Owensboro Medical Health System ( Site 0195)
        • Contact:
          • Study Coordinator
          • Phone Number: 270-688-1938
    • Louisiana
      • Alexandria, Louisiana, United States, 71301
        • Recruiting
        • CHRISTUS St. Frances Cabrini Hospital Center for Cancer Care ( Site 0184)
        • Contact:
          • Study Coordinator
          • Phone Number: 318-448-6917
    • Maryland
      • Bethesda, Maryland, United States, 20817
        • Recruiting
        • American Oncology Partners, P.A. ( Site 0185)
        • Contact:
          • Study Coordinator
          • Phone Number: 301-571-2016
    • Michigan
      • Detroit, Michigan, United States, 48201
        • Recruiting
        • Karmanos Cancer Institute ( Site 0174)
        • Contact:
          • Study Coordinator
          • Phone Number: 800-527-6266
      • Grand Rapids, Michigan, United States, 49503
        • Recruiting
        • Corewell Health ( Site 0130)
        • Contact:
          • Study Coordinator
          • Phone Number: 616-486-6180
    • Mississippi
      • Jackson, Mississippi, United States, 39216
        • Recruiting
        • The University of Mississippi Medical Center ( Site 0161)
        • Contact:
          • Study Coordinator
          • Phone Number: 601-984-5601
    • Missouri
      • Bridgeton, Missouri, United States, 63044
        • Recruiting
        • Circuit Clinical - SSM Health Cancer Care DePaul ( Site 0166)
        • Contact:
          • Study Coordinator
          • Phone Number: 636-673-3083
      • Kansas City, Missouri, United States, 64108
        • Recruiting
        • Truman Medical Center ( Site 0122)
        • Contact:
          • Study Coordinator
          • Phone Number: 816-404-4418
    • Montana
      • Billings, Montana, United States, 59102
        • Recruiting
        • Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana ( Site 0178)
        • Contact:
          • Study Coordinator
          • Phone Number: 406-238-6685
    • Nevada
      • Las Vegas, Nevada, United States, 89102
        • Recruiting
        • OptumCare Cancer Care ( Site 0121)
        • Contact:
          • Study Coordinator
          • Phone Number: 702-724-8787
      • Las Vegas, Nevada, United States, 89169
        • Recruiting
        • Comprehensive Cancer Centers of Nevada ( Site 0113)
        • Contact:
          • Study Coordinator
          • Phone Number: 702-622-9699
    • New York
      • Albany, New York, United States, 12206
        • Recruiting
        • New York Oncology Hematology, P.C. ( Site 0129)
        • Contact:
          • Study Coordinator
          • Phone Number: 518-262-6696
      • New York, New York, United States, 10029
        • Recruiting
        • Icahn School of Medicine at Mount Sinai ( Site 0164)
        • Contact:
          • Study Coordinator
          • Phone Number: 212-241-6500
    • North Dakota
      • Fargo, North Dakota, United States, 58102
        • Recruiting
        • Sanford Health Roger Maris Cancer Center ( Site 0189)
        • Contact:
          • Study Coordinator
          • Phone Number: 701-234-6161
    • South Carolina
      • Greenville, South Carolina, United States, 29605
        • Recruiting
        • Prisma Health - Upstate ( Site 0158)
        • Contact:
          • Study Coordinator
          • Phone Number: 864-679-3900
    • South Dakota
      • Sioux Falls, South Dakota, United States, 57104
        • Recruiting
        • Sanford Cancer Center ( Site 0143)
        • Contact:
          • Study Coordinator
          • Phone Number: 605-328-8000
    • Tennessee
      • Knoxville, Tennessee, United States, 37920
        • Recruiting
        • The University of Tennessee Medical Center ( Site 0142)
        • Contact:
          • Study Coordinator
          • Phone Number: 865-305-9000
    • Texas
      • Houston, Texas, United States, 77030
        • Recruiting
        • Center for Oncology and Blood Disorders ( Site 0153)
        • Contact:
          • Study Coordinator
          • Phone Number: 713-301-8964
      • Houston, Texas, United States, 77030
        • Recruiting
        • Houston Methodist Cancer Center ( Site 0154)
        • Contact:
          • Study Coordinator
          • Phone Number: 713-363-8009
    • Virginia
      • Charlottesville, Virginia, United States, 22903
        • Recruiting
        • University of Virginia Cancer Center ( Site 0138)
        • Contact:
          • Study Coordinator
          • Phone Number: 434-243-7773
      • Richmond, Virginia, United States, 23229
        • Recruiting
        • Virginia Cancer Institute ( Site 0148)
        • Contact:
          • Study Coordinator
          • Phone Number: 804-287-3000
      • Roanoke, Virginia, United States, 24014
        • Recruiting
        • Blue Ridge Cancer Care ( Site 0132)
        • Contact:
          • Study Coordinator
          • Phone Number: 540-982-0237
    • Washington
      • Olympia, Washington, United States, 98506
        • Recruiting
        • Vista Oncology ( Site 4201)
        • Contact:
          • Study Coordinator
          • Phone Number: 360-413-8880
    • Wisconsin
      • Madison, Wisconsin, United States, 53715
        • Recruiting
        • SSM Health Dean Medical Group ( Site 0140)
        • Contact:
          • Study Coordinator
          • Phone Number: 608-410-2700

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Has histologically confirmed diagnosis of diffuse large B-cell lymphoma (DLBCL), by prior biopsy, based on local testing according to the WHO classification of neoplasms of the hematopoietic and lymphoid tissues
  • Has positron emission tomography (PET) positive disease at screening, defined as 4 to 5 on the Lugano 5-point scale
  • Has received no prior treatment for their DLBCL
  • Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2 assessed within 7 days before randomization
  • Has an ejection fraction ≥45% as determined by either echocardiogram (ECHO) or multigated acquisition (MUGA)
  • Human immunodeficiency virus (HIV) infected participants must have well controlled HIV on antiretroviral therapy (ART)
  • Who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy and have undetectable HBV viral load prior to randomization
  • Participants with history of hepatitis C virus (HCV) infection are eligible if HCV viral load is undetectable at screening

Exclusion Criteria:

  • Has a history of transformation of indolent disease to DLBCL
  • Has received a diagnosis of primary mediastinal B-cell lymphoma (PMBCL) or Grey zone lymphoma
  • Has Ann Arbor Stage I DLBCL
  • Has clinically significant (i.e., active) cardiovascular disease: cerebral vascular accident/stroke (<6 months prior to enrollment), myocardial infarction (<6 months prior to enrollment), unstable angina, congestive heart failure (New York Heart Association Classification Class ≥II), or serious cardiac arrhythmia requiring medication
  • Has clinically significant pericardial or pleural effusion
  • Has ongoing Grade >1 peripheral neuropathy
  • Has a demyelinating form of Charcot-Marie-Tooth disease
  • HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease
  • Has ongoing corticosteroid therapy
  • Has received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines is allowed
  • Known additional malignancy that is progressing or has required active treatment within the past 2 years
  • Known active central nervous system (CNS) lymphoma
  • Has active autoimmune disease that has required systemic treatment in the past 2 years
  • Has active infection requiring systemic therapy
  • Has concurrent active HBV (defined as HBsAg positive and detectable HBV DNA) and HCV (defined as anti-HCV antibody positive and detectable HCV ribonucleic acid (RNA)) infection
  • Has history of allogeneic tissue/solid organ transplant

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Zilovertamab vedotin + Rituximab + Cyclophosphamide, Doxorubicin, Prednisone (R-CHP)
Participants receive a dose of zilovertamab vedotin (1.75 mg/kg) plus 750 mg/m^2 cyclophosphamide, 50 mg/m^2 doxorubicin, and 375 mg/m^2 rituximab or rituximab biosimilar administered by intravenous (IV) infusion on Day 1 of each 21-day cycle (Q3W) for up to 6 cycles (up to approximately 4 months) plus 2 cycles of rituximab or biosimilar for participants with high risk DLBCL. Participants also receive 100 mg prednisone, prednisolone, or methylprednisolone via oral tablet per day during Days 1-5 of each 21-day cycle for up to 6 cycles (up to approximately 4 months).
Biological: Zilovertamab vedotin
IV infusion
Other Names:
  • MK-2140
  • VLS-101
Biological: Rituximab
IV infusion
Other Names:
  • RITUXAN®
Drug: Cyclophosphamide
IV infusion
Other Names:
  • CYTOXAN®
  • NEOSAR®
Drug: Doxorubicin
IV infusion
Other Names:
  • ADRIAMYCIN®
Biological: Rituximab Biosimilar
IV infusion
Other Names:
  • TRUXIMA®
  • RUXIENCE®
  • RIABNI®
Drug: Prednisolone
Oral administration
Drug: Prednisone
Per Approved Product Label
Drug: Rescue medication
Participants receive rescue medication per approved product label. The rescue medication is granulocyte colony-stimulating factor (G-CSF).
Drug: Methylprednisolone
Per Approved Product Label
Active Comparator: Rituximab + Cyclophosphamide, Doxorubicin, Vincristine, Prednisone (R-CHOP)
Participants receive 750 mg/m^2 cyclophosphamide, 50 mg/m^2 doxorubicin, and 375 mg/m^2 rituximab or rituximab biosimilar, 1.4 mg/m^2 vincristine administered by intravenous (IV) infusion on Day 1 of each 21-day cycle (Q3W) for up to 6 cycles (up to approximately 4 months) plus 2 cycles of rituximab or biosimilar for participants with high risk DLBCL. Participants also receive 100 mg prednisone, prednisolone, or methylprednisolone via oral tablet per day during Days 1-5 of each 21-day cycle for up to 6 cycles (up to approximately 4 months).
Biological: Rituximab
IV infusion
Other Names:
  • RITUXAN®
Drug: Cyclophosphamide
IV infusion
Other Names:
  • CYTOXAN®
  • NEOSAR®
Drug: Doxorubicin
IV infusion
Other Names:
  • ADRIAMYCIN®
Biological: Rituximab Biosimilar
IV infusion
Other Names:
  • TRUXIMA®
  • RUXIENCE®
  • RIABNI®
Drug: Prednisolone
Oral administration
Drug: Vincristine
IV infusion
Drug: Prednisone
Per Approved Product Label
Drug: Methylprednisolone
Per Approved Product Label

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Progression-free survival (PFS)
Time Frame: Up to ~ 50 months
PFS is defined as the time from randomization to the first documented disease progression per Lugano response criteria by blinded independent central review (BICR) or death due to any cause, whichever occurs first.
Up to ~ 50 months

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Complete Response at End of Treatment (CR at EOT)
Time Frame: Up to ~ 32 months
CR at EOT is defined as a CR per Lugano response criteria as assessed by BICR at end of treatment. Participants with missing data or who discontinue treatment or study prior to reaching EOT will be considered non-responders and included in the total number of participants.
Up to ~ 32 months
Overall Survival (OS)
Time Frame: Up to ~ 74 months
OS is defined as the time from randomization to death due to any cause.
Up to ~ 74 months
Event-free Survival (EFS)
Time Frame: Up to ~ 74 months
EFS is defined as the time from randomization to any of the following events: progressive disease that precludes surgery, local or distant recurrence, second primary malignancy or death due to any cause. The EFS for all participants will be presented.
Up to ~ 74 months
Change From Baseline in HRQoL on FACT-Lym Total Score
Time Frame: Baseline and Week 25
The FACT-Lym is a 42-item questionnaire designed to measure HRQoL and cancer-specific symptoms in non-Hodgkin lymphoma patients. Subscales include FACT-General (FACT-G), FACT-Trial Outcome Index (FACT-TOI), FACT-Lym total score (FACT-Lym TS), and the Lymphoma subscale (Lym S). The Lym S has a single domain consisting of 15 items specific to lymphoma burden with a score ranging from 0 to 60. FACT-G has 4 well-being domains, physical (7 items), social/family (7), emotional (6), and functional (7), with scores ranging from 0 to 108. FACT-TOI combines FACT-G's physical and functional domains with Lym S, with scores ranging from 0 to 116. FACT-Lym TS combines FACT-G with Lym S, with scores ranging from 0 to 168. The scoring of FACT-Lym is on a 5-point Likert scale from 0 to 4, with 0= not at all, 1= a little bit, 2= somewhat, 3=quite a bit, 4=very much. The higher the score the better the quality of life.
Baseline and Week 25
Change From Baseline in HRQoL on Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-NTX) Neurotoxicity Subscale Score
Time Frame: Baseline and Week 25
The FACT GOG-NTX provides a targeted assessment of symptoms of peripheral neuropathy, including sensory, motor, and auditory problems and cold sensitivity. It is an 11-item questionnaire designed to measure the neurotoxicity subscale. The scoring of FACT GOG-NTX is on a 5-point Likert scale from 0 to 4, with 0= not at all, 1= a little bit, 2= somewhat, 3=quite a bit, 4=very much. To produce a Neurotoxicity Subscale score (range 0-44), multiply the sum of the item scores by the number of items in the subscale, then divide by the number of items answered.
Baseline and Week 25
Duration of Complete Response (DurCR)
Time Frame: Up to ~ 74 months
For participants who demonstrate CR at EOT per Lugano response criteria by BICR, duration of complete response is defined as the time from the first documented evidence of CR at or before EOT until disease progression or death due to any cause, whichever occurs first.
Up to ~ 74 months
Number of Participants Who Experience an Adverse Event (AE)
Time Frame: Up to ~ 9 months
An AE is defined as any untoward medical occurrence in a participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. The number of participants who experience at least one AE will be presented.
Up to ~ 9 months
Number of Participants Who Discontinue Study Treatment Due to an AE
Time Frame: Up to ~ 6 months
An AE is defined as any untoward medical occurrence in a participant, temporally associated with the use of study treatment, whether or not considered related to the study treatment. The number of participants who discontinue study treatment due to an AE will be presented.
Up to ~ 6 months
Change From Baseline in Health-Related Quality Of Life (HRQoL) on Functional Assessment of Cancer Therapy Lymphoma (FACT-Lym) Trial Outcome Index (TOI) Score
Time Frame: Baseline and Week 25
The FACT-Lym is a 42-item questionnaire designed to measure HRQoL and cancer-specific symptoms in non-Hodgkin lymphoma patients. Subscales include FACT-General (FACT-G), FACT-Trial Outcome Index (FACT-TOI), FACT-Lym total score (FACT-Lym TS), and the Lymphoma subscale (Lym S). The Lym S has a single domain consisting of 15 items specific to lymphoma burden with a score ranging from 0 to 60. FACT-G has 4 well-being domains, physical (7 items), social/family (7), emotional (6), and functional (7), with scores ranging from 0 to 108. FACT-TOI combines FACT-G's physical and functional domains with Lym S, with scores ranging from 0 to 116. FACT-Lym TS combines FACT-G with Lym S, with scores ranging from 0 to 168. The scoring of FACT-Lym is on a 5-point Likert scale from 0 to 4, with 0= not at all, 1= a little bit, 2= somewhat, 3=quite a bit, 4=very much. The higher the score the better the quality of life.
Baseline and Week 25
Change From Baseline in HRQoL on FACT-Lym Physical Wellbeing (PWB) Score
Time Frame: Baseline and Week 25
The FACT-Lym is a 42-item questionnaire designed to measure HRQoL and cancer-specific symptoms in non-Hodgkin lymphoma patients. Subscales include FACT-General (FACT-G), FACT-Trial Outcome Index (FACT-TOI), FACT-Lym total score (FACT-Lym TS), and the Lymphoma subscale (Lym S). The Lym S has a single domain consisting of 15 items specific to lymphoma burden with a score ranging from 0 to 60. FACT-G has 4 well-being domains, physical (7 items), social/family (7), emotional (6), and functional (7), with scores ranging from 0 to 108. FACT-TOI combines FACT-G's physical and functional domains with Lym S, with scores ranging from 0 to 116. FACT-Lym TS combines FACT-G with Lym S, with scores ranging from 0 to 168. The scoring of FACT-Lym is on a 5-point Likert scale from 0 to 4, with 0= not at all, 1= a little bit, 2= somewhat, 3=quite a bit, 4=very much. The higher the score the better the quality of life.
Baseline and Week 25

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Merck Sharp & Dohme LLC

Investigators

  • Study Director: Medical Director, Merck Sharp & Dohme LLC

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

January 27, 2025

Primary Completion (Estimated)

July 2, 2029

Study Completion (Estimated)

March 29, 2032

Study Registration Dates

First Submitted

December 2, 2024

First Submitted That Met QC Criteria

December 3, 2024

First Posted (Actual)

December 5, 2024

Study Record Updates

Last Update Posted (Actual)

June 8, 2026

Last Update Submitted That Met QC Criteria

June 5, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 2140-010
  • MK-2140-010 (Other Identifier: MSD)
  • U1111-1309-3971 (Registry Identifier: UTN)
  • 2024-515566-13-00 (Registry Identifier: EU CT)
  • jRCT2061240099 (Other Identifier: jRCT)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

https://trialstransparency.msdclinicaltrials.com/pdf/ProcedureAccessClinicalTrialData.pdf

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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