Comparative Effectiveness of Oxiris Hemofilters Versus Conventional Hemofilters in Septic Patients

Comparative Effectiveness of Oxiris Filters Versus Conventional Hemofilters in Septic Patients: a Retrospective Cohort Study

We divided patients in 2 groups. First group was the patients who received Oxiris filters during CRRT. Second group was the patiens who have received CRRT filters other than Oxiris.

We compared the lab parameters (Urea, Creatinin, Lactate, ABG parameters and SOFA escore with together.

Study Overview

• Status: Completed
• Conditions: Cytokine; Hemodiafiltration; Sepsis - to Reduce Mortality in the Intensive Care Unit
• Intervention / Treatment: Other: CRRT

• Study Type: Observational
• Enrollment (Actual): 426

Contacts and Locations

Study Locations

• Turkey
  • Istanbul, Turkey
    • Bakirkoy Dr Sadi Konuk Research and Training Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

study population includes patients who have admission on our clinic for more than 5 days and diagnosed with sepsis who has CRRT indication

Description

Inclusion Criteria:

sepsis diagnosis CRRT indication

Exclusion Criteria:

patients under age of 18

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Oxiris; The group which we used oxiris filter for CRRT.	Other: CRRT; Hemodiafiltration
Non-Oxiris; The group which we used other filters like M150 for CRRT.	Other: CRRT; Hemodiafiltration

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
SOFA Score	We compared SOFA scores of patients on admission and on 5th day.	6 month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Survival comparison	We compared patients survival rates between two group.	6 month

Collaborators and Investigators

• Sponsor: Bakirkoy Dr. Sadi Konuk Research and Training Hospital

Study record dates

Study Major Dates

• Study Start (Actual): May 23, 2024
• Primary Completion (Actual): November 1, 2024
• Study Completion (Actual): December 1, 2024

Study Registration Dates

• First Submitted: December 11, 2024
• First Submitted That Met QC Criteria: December 11, 2024
• First Posted (Actual): March 25, 2025

Study Record Updates

• Last Update Posted (Actual): March 25, 2025
• Last Update Submitted That Met QC Criteria: December 26, 2024
• Last Verified: December 1, 2024

More Information

Terms related to this study

• Other Study ID Numbers: 2024-05-02

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No