- ICH GCP
- US Clinical Trials Registry
- Clinical Trial NCT02470520
Essential Nutrients in Critically Ill Patients With Severe AKI Treated With and Without CRRT
Observational Study Measuring Essential Nutrients in Critically Ill Patients With Severe Acute Kidney Injury Treated With and Without Continuous Haemofiltration
Study Overview
Detailed Description
Background: Critically ill patients with acute kidney injury (AKI) have a high risk of dying, especially if renal replacement therapy (RRT) is needed. It remains uncertain whether essential trace elements, vitamins and amino acids are lost during RRT in sufficient amounts to result in clinically significant deficiencies. At present, nutrition guidelines for patients with AKI on RRT do not account for any potential losses of micronutrients across the filter.
Hypothesis:
Critically ill patients with AKI have inadequate plasma nutrient levels. If continuous renal replacement therapy (CRRT) is required, there are additional losses of essential nutrients.
Aims:
To serially measure plasma levels of essential vitamins, trace elements and amino acids in critically ill patients with severe AKI and to evaluate whether there are any additional losses into the filtrate during CRRT
Objectives:
To perform serial measurements of plasma levels of selenium, zinc, copper, iron, vitamins B1, B6, B12, C and D, folic acid and essential amino acids in all patients with severe AKI and to measure any losses of the same nutrients in the filtrate in a cohort of patients on CRRT for >24 hours.
Patient population:
level 3 critically ill adult patients with severe AKI
Study size:
40 patients of whom 20 patients are treated with CRRT for >24 hours.
Study design:
observational non-interventional study in at least 2 large tertiary care centres in the United Kingdom
Outcomes:
Primary outcome: difference in plasma concentrations of essential trace elements and vitamins between patients with and without CRRT.
Secondary outcomes: a) concentrations of trace elements, vitamins and amino acids in filtrate in patients on CRRT; b) differences in filtrate losses between patients on CRRT ≤30ml/kg/hr versus >30ml/kg/hr.
Laboratory measurements:
Measurement of baseline plasma Selenium, Zinc, Copper, iron, Vitamins B1, B6, B12, C and D, folic acid and essential amino acids levels and repeat serial measurement of the same panel of nutrients in all patients for up to 6 days with additional concomitant measurement of nutrient levels in filtrate in cohort of patients on CRRT. In addition, daily measurement of serum electrolytes, liver profile, serum albumin and c-reactive protein.
Data collection:
Recording of the following potential confounders: type of nutrition, dose of CRRT, type of membrane.
Statistics:
Determination of the change in plasma nutrient levels over 6 days, and between baseline and 24 - 144 hours after initiation of CRRT. The estimates will be used to inform the design of an intervention study exploring the value of nutrient supplementation.
Study Type
Enrollment (Actual)
Participation Criteria
Eligibility Criteria
Ages Eligible for Study
Accepts Healthy Volunteers
Genders Eligible for Study
Sampling Method
Study Population
Description
Inclusion Criteria:
- adult patients in the Critical Care Unit with severe AKI
Exclusion Criteria:
- pre-existing dialysis dependent renal failure
- life expectancy <48 hours
- need for total parenteral nutrition
- need for supplementation with intravenous multivitamins or trace elements
- Jehovah's witness
- patients with haemoglobin <7g/dL (unless being transfused for clinical reasons)
Study Plan
How is the study designed?
Design Details
- Observational Models: Cohort
- Time Perspectives: Prospective
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
---|---|
AKI without CRRT
Patients with AKI who are not treated with continuous renal replacement therapy
|
|
AKI with CRRT
Patients with AKI who are treated with continuous renal replacement therapy
|
continuous renal replacement therapy
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Time Frame |
---|---|
serum levels of essential nutrients
Time Frame: up to 6 days
|
up to 6 days
|
Secondary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
---|---|---|
levels of essential nutrients in filtrate
Time Frame: up to 6 days
|
concentrations of trace elements, vitamins and amino acids in filtrate in patients on CRRT
|
up to 6 days
|
Collaborators and Investigators
Study record dates
Study Major Dates
Study Start
Primary Completion (Actual)
Study Completion (Actual)
Study Registration Dates
First Submitted
First Submitted That Met QC Criteria
First Posted (Estimate)
Study Record Updates
Last Update Posted (Estimate)
Last Update Submitted That Met QC Criteria
Last Verified
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- RJ113/N062
This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.
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