Hemoglobin-to-red Blood Cell Distribution Width Ratio and Hypothermia for Elderly Patient

Temperature Measurement for Transurethral Prostatectomy Surgery in Elderly Patient

As individuals age, they often enter a phase of increased "frailty." Elderly and frail patients represent a population that requires heightened sensitivity and close monitoring during surgical procedures. This study aims to investigate the relationship between the Hemoglobin-to-Red Blood Cell Distribution Width (Hb/RDW) ratio and perioperative hypothermia in elderly patients undergoing transurethral prostatectomy. This is an observational study. Preoperative blood test results and intraoperative body temperature measurements of the patients will be recorded in our data forms.

Study Overview

• Status: Completed
• Conditions: General Anesthetic; Elderly (People Aged 65 or More); Transurethral Resection of Prostate Syndrome
• Intervention / Treatment: Other: body temperature

• Study Type: Observational
• Enrollment (Actual): 60

Contacts and Locations

Study Locations

• Turkey
  • Ankara, Turkey, 06170
    • Etlik City Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Probability Sample

Study Population

Etlik City Hospital, Urology Operating Rooms

Description

Inclusion Criteria:

• Patients who provided informed consent.
• Patients scheduled for transurethral prostatectomy surgery.
• Patients classified as ASA-PS 1, 2, or 3.
• Male patients aged 65 years or older.
• Patients undergoing elective surgery.
• Patients receiving general anesthesia.

Exclusion Criteria:

• Patients who did not provide informed consent.
• Patients undergoing emergency surgery.
• Patients with conditions that disrupt thermoregulation (e.g., intracranial mass, peripheral vascular diseases, sepsis).
• Patients with a body temperature of <34℃ or >38℃ upon arrival at the preoperative waiting room.
• Patients who used heating methods other than the routine cotton cover in the preoperative waiting room.
• Patients who received additional heating methods other than the routinely applied intraoperative hot air blower drapes.
• Patients undergoing surgery under any type of anesthesia other than general anesthesia.
• Patients who were taken out of the operating room while intubated.

Study Plan

How is the study designed?

Number of groups / cohorts

2

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Low hemoglobin to red cell distribution width ratio (HRR); Patients whose HRR rate is below 9.97 and are considered frail	Other: body temperature; Body temperature measurement will be performed in the preoperative and intraoperative periods.
High hemoglobin to red cell distribution width ratio (HRR); Patients whose HRR ratio is above 9.97 and are considered non-frail	Other: body temperature; Body temperature measurement will be performed in the preoperative and intraoperative periods.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Perioperative Hypothermia	Perioperative hypothermia is defined as any core temperature less than 96.8°F (36.0°C)	1 hour before anesthesia and intraoperative

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Frailty	The relationship between hemoglobin to red cell distribution width ratio (HRR) and frailty	preoperative
Red blood cell distribution width	The relationship between red blood cell distribution width (RDW) and hypothermia	1 hour before anesthesia and intraoperative

Collaborators and Investigators

• Sponsor: Ankara Etlik City Hospital
• Investigators: Principal Investigator: Gokcen KULTUROGLU, Ankara Etlik City Hospital

Publications and helpful links

General Publications

• Zhu M, Wei C, Yang X, Huang Y, Xu Y, Xiong Z. Lower haemoglobin-to-red blood cell distribution width ratio is independently associated with frailty in community-dwelling older adults: a cross-sectional study. BMJ Open. 2023 Jul 9;13(7):e069141. doi: 10.1136/bmjopen-2022-069141.
• Qu J, Zhou T, Xue M, Sun H, Shen Y, Chen Y, Tang L, Qian L, You J, Yang R, Liu Y. Correlation Analysis of Hemoglobin-to-Red Blood Cell Distribution Width Ratio and Frailty in Elderly Patients With Coronary Heart Disease. Front Cardiovasc Med. 2021 Aug 27;8:728800. doi: 10.3389/fcvm.2021.728800. eCollection 2021.

Study record dates

Study Major Dates

• Study Start (Actual): April 9, 2025
• Primary Completion (Actual): June 1, 2025
• Study Completion (Actual): June 11, 2025

Study Registration Dates

• First Submitted: January 9, 2025
• First Submitted That Met QC Criteria: January 22, 2025
• First Posted (Actual): January 23, 2025

Study Record Updates

• Last Update Posted (Actual): June 12, 2025
• Last Update Submitted That Met QC Criteria: June 11, 2025
• Last Verified: June 1, 2025

More Information

Terms related to this study

• Keywords: elderly; hypothermia
• Additional Relevant MeSH Terms: Body Temperature Changes; Hypothermia
• Other Study ID Numbers: AESH-EK1-2024-0082

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: The data that support the findings of this study are available on request from the corresponding author, (GK). The data are not publicly available due to our participants' informed consent forms.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No