Comparing Montiroing Cardiac Index by Transpulmonary Thermodilution and Transesophageal Echocardiography During Liver Transplantation

March 21, 2025 updated by: Hospices Civils de Lyon

Is Cardiac Index, Assessed by Transpulmonary Thermodilution, Reliable During Liver Transplantation Compared to Transesophageal Echocardiography : a Monocentric Cohort

Liver transplantation poses challenges due to hemodynamic changes throughout different surgical phases. Monitoring devices are essential for therapeutic adjustments. Transpulmonary thermodilution and transesophageal echocardiography are commonly used, but thermodilution may have limitations depending on the surgery.

This study aims to compare cardiac index variations between thermodilution and transesophageal echocardiography during liver transplantation. Patients undergo monitoring with both techniques. Measurements are recorded and reported at multiple time points.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Observational

Enrollment (Estimated)

30

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • France
    • Lyon
      • France, Lyon, France, 69004
        • Recruiting
        • Croix Rousse Hsopital
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

N/A

Sampling Method

Non-Probability Sample

Study Population

age > 18 years old, undergoing liver transplantation at Croix-Rousse hospital, HCL, Lyon

Description

Inclusion Criteria:

  • liver transplantation
  • adults

Exclusion Criteria:

  • - Oesophageal varice ligation < 14 days
  • Mediastinal radiotherapy
  • Femoral bypass
  • Severe lower extremity artery disease

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
Intervention / Treatment
Patients undergoing liver transplantation at Croix-Rousse University Hospital, HCL, Lyon.
  • Monitoring transesophageal echography, transpulmonary thermodilution
  • Measuring cardiac index, preload dependence (end-expiratory test) at 4 steps of surgery
  • Surgical anastomosis echography
  • Demographic data, biological data, post operation data
Other: Measure of cardiac index with thermodilution and transesophageal echocardiography
At 4 times of surgery, end-expiratory occlusion (EEO) test and measure of cardiac index before and after test with ETO and thermodilution
Other: Surgical anastomosis echography
Visualisation of surgical anastomosis through transesophageal echocardiography : stenosis, doppler velocity, collar diameter

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Cardiac index variation measured by thermodilution compared with transesophageal echography
Time Frame: At 4 times of surgery: after starting anesthesia, anhepatic phase, reperfusion and surgical anastomosis of biliary ducts. Data reported : - Cardiac Index before and after end-expiratory test. - Transoesophageal echography measurement of cardiac function
At 4 times of surgery: after starting anesthesia, anhepatic phase, reperfusion and surgical anastomosis of biliary ducts. Data reported : - Cardiac Index before and after end-expiratory test. - Transoesophageal echography measurement of cardiac function

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Hospices Civils de Lyon

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

November 27, 2023

Primary Completion (Actual)

July 1, 2024

Study Completion (Estimated)

November 1, 2025

Study Registration Dates

First Submitted

March 21, 2025

First Submitted That Met QC Criteria

March 21, 2025

First Posted (Actual)

March 28, 2025

Study Record Updates

Last Update Posted (Actual)

March 28, 2025

Last Update Submitted That Met QC Criteria

March 21, 2025

Last Verified

March 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • 24-5431

Drug and device information, study documents

product manufactured in and exported from the U.S.

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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