Efficacy and Prognosis of Auxiliary Liver Transplantation

December 9, 2025 updated by: Zhi-Jun Zhu

Efficacy and Long-term Prognosis of Auxiliary Liver Transplantation

The objective of this observational study is to systematically compare the efficacy and patient prognosis between auxiliary liver transplantation and living donor liver transplantation, and to explore the postoperative recovery, survival rate, rejection, postoperative complications, and long-term prognosis of patients undergoing auxiliary liver transplantation.

Study Overview

Status

Not yet recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

100

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child
  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Non-Probability Sample

Study Population

Patients who were treated at the Liver Transplantation Center of Beijing Friendship Hospital, Capital Medical University between December 2025 and December 2028, and who underwent either auxiliary liver transplantation (study group) or conventional liver transplantation (control group).

Description

Inclusion Criteria:

  1. Patients who underwent auxiliary liver transplantation or living donor liver transplantation (LDLT).
  2. Patients with complete medical records and follow-up data.

Exclusion Criteria:

  1. Patients who underwent retransplantation.
  2. Patients who underwent other organ transplantation (or multiorgan transplantation).
  3. Patients with severe missing postoperative follow-up data or loss to follow-up.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

Cohorts and Interventions

Group / Cohort
auxiliary liver transplantation
Patients who underwent auxiliary liver transplantation at our center during the study period
living donor liver transplantation
Patients who underwent traditional orthotopic living donor liver transplantation at our center during the study period.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
Overall survival
Time Frame: Within one year after liver transplantation
Within one year after liver transplantation

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Complications
Time Frame: Within one year after liver transplantation
Rejection, vascular, biliary and other related complications
Within one year after liver transplantation
changes in peripheral blood lymphocytes
Time Frame: within 3 months after liver transplantation
Peripheral blood lymphocytes during the early post-transplant period were compared between the auxiliary and living donor liver transplantation groups to identify differences.
within 3 months after liver transplantation

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Zhi-Jun Zhu

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

December 1, 2025

Primary Completion (Estimated)

December 31, 2028

Study Completion (Estimated)

December 31, 2029

Study Registration Dates

First Submitted

November 27, 2025

First Submitted That Met QC Criteria

December 9, 2025

First Posted (Actual)

December 10, 2025

Study Record Updates

Last Update Posted (Actual)

December 10, 2025

Last Update Submitted That Met QC Criteria

December 9, 2025

Last Verified

November 1, 2025

More Information

Terms related to this study

Other Study ID Numbers

  • BFH20251127004

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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