Apple Health Study

The Apple Health Study aims to build a diverse and inclusive group of participants to help researchers advance our understanding of how signals and information collected from apps and devices relate to health and may be used to predict, detect, monitor, and manage changes in health.

To enroll, US residents who have an iPhone can download the Apple Research app from the App Store and go through the introduction and informed consent for the Apple Health Study. This study is fully remote, and all are invited to enroll if the eligibility criteria are met.

Participants will be asked to complete tasks and surveys, using their iPhone and Apple Research app which include:

• Selecting the types of data they would like to share with the study such as health and sensor data
• Completing tasks and surveys including areas such as personal demographic information, personal medical history, family history, and social determinants of health

Study Overview

• Status: Recruiting
• Conditions: Wellbeing; Sleep; Exercise; Aging; Mental Health; Women's Health; Functional Capacity; Hormones; Neurological Conditions; General Health; Lifestyle Factors; Metabolic Health; Hearing

• Study Type: Observational
• Enrollment (Estimated): 500000

Contacts and Locations

• Study Contact: Name: MCRA Study Call Center; Phone Number: 833-600-6993; Email: applehealthstudy@bwh.harvard.edu

Study Locations

• United States
  • District of Columbia
    • Washington, District of Columbia, United States, 20001
      • Recruiting
      • MCRA
      • Contact: Study Call Center; Phone Number: 833-600-6993
      • Principal Investigator: Tiffany Avery, MD
  • Massachusetts
    • Boston, Massachusetts, United States, 02115
      • Recruiting
      • Brigham and Women's Hospital
      • Contact: Angela Spillane, MS; Email: applehealthstudy@bwh.harvard.edu
      • Principal Investigator: Calum MacRae, MD, PhD

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

• Sampling Method: Non-Probability Sample

Study Population

The Study aims to enroll a large and representative group of at least 500,000 participants across the United States of America willing to contribute information about health and wellness over time.

Description

Inclusion Criteria:

• Be at least 18 years old (at least 19 years old in Alabama and Nebraska, at least 21 years old in Puerto Rico);
• Live in the United States of America;
• Have an iPhone;
• Have installed Apple Research app on your iPhone;
• Be comfortable communicating in written and spoken English;
• Be willing and able to provide informed consent to participate in the Study.

Exclusion Criteria:

• Share your iCloud account, iPhone, or devices that collect health data such as Apple Watch with anyone else, because it could result in sharing another person's health information with the Study, making it challenging for researchers to use your information.

Study Plan

How is the study designed?

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Health Status	Assessed by participant self-report as well as clinical health records and claims data. The initial count and change over time in the number and type of health conditions such as cardiovascular, circulatory, cognition, hearing, mental health, metabolic, mobility, neurologic, respiratory, sex and gender, reproduction, hormones, sleep, and health events such as hospitalizations, procedures or falls.	Baseline and every 6 months until study end (up to 5 years)

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Participant Population: Demographic Characteristics of Study Participants	Results of surveys to report participant demographics.	Baseline and annually until study end (up to 5 years)
Social Determinants of Health: Lifestyle & Environment Survey	Results of surveys that collect information about social determinants of health.	Baseline and every 6 months until study end (up to 5 years)
Family Health History in Health Conditions and Health Events	Results of self-reported family health history of first-degree biologic family.	Baseline and have option to update if needed (up to 5 years)

Collaborators and Investigators

• Sponsor: Apple Inc.
• Collaborators: Brigham and Women's Hospital; MCRA
• Investigators: Principal Investigator: Calum MacRae, MD, PhD, Brigham and Women's Hospital; Principal Investigator: Tiffany Avery, MD, MCRA

Publications and helpful links

Helpful Links

• Apple Health Study Website

Study record dates

Study Major Dates

• Study Start (Actual): February 12, 2025
• Primary Completion (Estimated): February 1, 2030
• Study Completion (Estimated): February 1, 2030

Study Registration Dates

• First Submitted: March 5, 2025
• First Submitted That Met QC Criteria: April 26, 2025
• First Posted (Actual): May 6, 2025

Study Record Updates

• Last Update Posted (Actual): July 29, 2025
• Last Update Submitted That Met QC Criteria: July 24, 2025
• Last Verified: July 1, 2025

More Information

Terms related to this study

• Keywords: iPhone; Digital Biomarkers; Apple Health Study; Large Scale Digital Study; Research App; Apple Research App
• Other Study ID Numbers: Pro00081895; 2024P003608 (Other Identifier: Brigham and Women's Hospital IRB)

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No
• product manufactured in and exported from the U.S.: No