Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites

Primary Stability and Peri-implant Outcomes of Short Implants in Post-extraction Single-tooth Sites: a Randomized Controlled Trial.

The placement of short implants in post-extraction sockets is a valuable option when residual bone height is limited, minimizing morbidity and treatment time. The management of the peri-implant gap and soft tissues may influence primary stability, hard/soft tissue remodeling, and implant success.

Study Overview

• Status: Recruiting
• Conditions: Tooth Loss; Edentulous Jaw; Toothless Mouth
• Intervention / Treatment: Procedure: Insertion of implants in post-extraction tooth

• Study Type: Interventional
• Enrollment (Estimated): 10
• Phase: Not Applicable

Contacts and Locations

• Study Contact: Name: Giuseppe D'Albis, Dr; Phone Number: +393495103642; Email: giuseppe.dalbis@uniba.it
• Study Contact Backup: Name: Saverio Capodiferro; Email: saverio.capodiferro@uniba.it

Study Locations

• Italy
  • Bari, Italy, 70021
    • Recruiting
    • University of Bari Aldo Moro
    • Contact: Giuseppe D'Albis; Phone Number: +393495103642; Email: dalbisgiuseppe@hotmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Age ≥18 years.
• Single-tooth post-extraction sites requiring immediate implant placement in posterior regions (premolars/molars) or selected anterior sites.
• Planned short implant (≤7-8 mm length, 3.5-5.0 mm diameter).
• Adequate oral hygiene, no active periodontal disease.
• Written informed consent.

Exclusion Criteria:

• Heavy smoking (>20 cigarettes/day).

  • Uncontrolled diabetes or systemic conditions affecting bone healing.
  • Current bisphosphonate/antiresorptive therapy.
  • Immunosuppression, pregnancy.
  • Poor oral hygiene or acute infection at site.
  • Severe bone dehiscence preventing primary stability.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Treatment
• Allocation: Randomized
• Interventional Model: Parallel Assignment
• Masking: Single

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: Group 1; Socket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate).	Procedure: Insertion of implants in post-extraction tooth; Two widely used approaches include: Socket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate).; Socket grafting with a xenograft and a custom Sealing Socket Abutment (SSA) with a concave emergence profile. No randomized controlled trials have yet compared these protocols with integrated outcomes including resonance frequency analysis, peri-implant health indices, radiographic bone level changes, and digital intraoral scanning (IOS)-based morphometric analysis.
Active Comparator: Group 2; Socket grafting with a xenograft and a custom Sealing Socket Abutment with a concave emergence profile.	Procedure: Insertion of implants in post-extraction tooth; Two widely used approaches include: Socket grafting with a fully resorbable synthetic biomaterial (β-tricalcium phosphate + calcium sulfate).; Socket grafting with a xenograft and a custom Sealing Socket Abutment (SSA) with a concave emergence profile. No randomized controlled trials have yet compared these protocols with integrated outcomes including resonance frequency analysis, peri-implant health indices, radiographic bone level changes, and digital intraoral scanning (IOS)-based morphometric analysis.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Primary stability	To compare the primary stability (ISQ values at implant insertion) of short implants placed in post-extraction sockets using the two grafting protocols.	1 month

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Clinical Indices	To assess peri-implant health indices (PD)	12 months
Clinical Indices	To assess peri-implant health indices (BoP)	12 month

Collaborators and Investigators

• Sponsor: University of Bari Aldo Moro
• Investigators: Principal Investigator: Giuseppe D'Albis, Dr, University of Bari Aldo Moro; Study Chair: Saverio Capodiferro, Prof, University of Bari Aldo Moro

Study record dates

Study Major Dates

• Study Start (Actual): January 10, 2025
• Primary Completion (Estimated): June 1, 2026
• Study Completion (Estimated): August 10, 2026

Study Registration Dates

• First Submitted: September 8, 2025
• First Submitted That Met QC Criteria: September 16, 2025
• First Posted (Actual): September 17, 2025

Study Record Updates

• Last Update Posted (Actual): January 27, 2026
• Last Update Submitted That Met QC Criteria: January 23, 2026
• Last Verified: January 1, 2026

More Information

Terms related to this study

• Additional Relevant MeSH Terms: Musculoskeletal Diseases; Periodontal Diseases; Mouth Diseases; Stomatognathic Diseases; Jaw Diseases; Tooth Diseases; Tooth Loss; Mouth, Edentulous; Jaw, Edentulous
• Other Study ID Numbers: Post-extraction-implants

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No