Efficacy and Safety of Eloralintide (LY3841136) in Participants With Osteoarthritis Knee Pain and Obesity or Overweight (ENLIGHTEN-4)

May 20, 2026 updated by: Eli Lilly and Company

A Master Protocol for Phase 3 Randomized, Double-Blind, Placebo-Controlled Studies to Investigate the Efficacy and Safety of Once Weekly Eloralintide in Adult Participants With Osteoarthritis Knee Pain, and Obesity or Overweight (ENLIGHTEN-4)

The YDAN master protocol will support two independent studies, J3R-MC-YOA1 and J3R-MC-YOA2. Each study will investigate how well and safely Eloralintide (LY3841136) works in adults with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 75 weeks, including screening.

Study Overview

Status

Recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

900

Phase

  • Phase 3

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

  • Name: Trial questions or participation questions: 1-877-CTLILLY (1-877-285-4559) or
  • Phone Number: 317-615-4559
  • Email: LillyTrials@Lilly.com

Study Locations

  • Argentina
      • Buenos Aires, Argentina, C1427CCL
        • Not yet recruiting
        • Centro Médico Arsema
        • Contact:
          • Phone Number: 1124691447
        • Principal Investigator:
          • Federico Ariel
      • Buenos Aires, Argentina, C1023AAB
        • Not yet recruiting
        • Stat Research S.A.
        • Principal Investigator:
          • ALEJANDRO ARROYO
        • Contact:
          • Phone Number: 54 9 1167063598
      • Buenos Aires, Argentina, C1015ABO
        • Not yet recruiting
        • Organizacion Medica de Investigacion
        • Principal Investigator:
          • Patricio Tate
        • Contact:
          • Phone Number: 541143720308
      • Buenos Aires, Argentina, C1014ACP
        • Not yet recruiting
        • CARDIAMET Investigaciones Médicas
        • Principal Investigator:
          • Virginia Durigan
        • Contact:
          • Phone Number: 5491169139814
      • Buenos Aires, Argentina, 1417
        • Not yet recruiting
        • Centro Privado de Medicina Familiar / Mindout Research
        • Contact:
          • Phone Number: 541145023759
        • Principal Investigator:
          • Leonardo Naftal
      • CABA, Argentina, 1406
        • Not yet recruiting
        • APRILLUS Asistencia E Investigacion
        • Contact:
          • Phone Number: 0541149512763
        • Principal Investigator:
          • Pablo Mannucci Walter
      • Granadero Baigorria, Argentina, 2152
        • Not yet recruiting
        • Centro de Investigaciones Clínicas Baigorria
        • Contact:
          • Phone Number: 543415593898
        • Principal Investigator:
          • Juan Escalante
      • Rosario, Argentina, 2000
        • Not yet recruiting
        • INECO Neurociencias Oroño
        • Contact:
          • Phone Number: 3415597777
        • Principal Investigator:
          • Florencia Garavelli
      • Rosario, Argentina, 2000
        • Not yet recruiting
        • Instituto Especialidades de la Salud Rosario
        • Contact:
          • Phone Number: 341- 6011549
        • Principal Investigator:
          • Julieta Gentiletti
      • SAN M. de Tucuman, Argentina, T4000AXL
        • Not yet recruiting
        • Centro de Investigaciones Médicas Tucuman
        • Principal Investigator:
          • Walter Spindler
        • Contact:
          • Phone Number: 54-9-381-5537820
      • San Fernando, Argentina, 1646
        • Not yet recruiting
        • Medicina Reumatológica
        • Contact:
          • Phone Number: 541169956547
        • Principal Investigator:
          • Maria Cusa
      • San Isidro, Argentina, 1642
        • Not yet recruiting
        • Instituto de Alta Complejidad San Isidro
        • Contact:
          • Phone Number: 54 9 1164620494
        • Principal Investigator:
          • Maria Lazaro
      • San Juan, Argentina, 5400
        • Not yet recruiting
        • Centro Polivalente de Asistencia e Investigacion Clinica - CER San Juan
        • Contact:
          • Phone Number: 2644211086
        • Principal Investigator:
          • Rodolfo Pardo Hidalgo
      • San Miguel de Tucumán, Argentina, 4000
        • Not yet recruiting
        • Centro de Investigaciones Reumatológicas
        • Contact:
          • Phone Number: 543814301098
        • Principal Investigator:
          • Luciana Gonzalez Lucero
      • San Nicolás, Argentina, 2900
        • Not yet recruiting
        • Go Centro Medico San Nicolas
        • Contact:
          • Phone Number: 5493364571637
        • Principal Investigator:
          • Paulina Lanchiotti
  • Belgium
      • Edegem, Belgium, 2650
        • Not yet recruiting
        • Antwerp University Hospital
        • Contact:
          • Phone Number: 3238213478
        • Principal Investigator:
          • eveline dirinck
      • Genk, Belgium, 3600
        • Not yet recruiting
        • Reuma Clinic, Locatie Jaarbeurslaan
        • Principal Investigator:
          • Johan Vanhoof
        • Contact:
          • Phone Number: 089362977
      • Ghent, Belgium, 9000
        • Recruiting
        • UZ Gent
        • Contact:
          • Phone Number: +3293320582
        • Principal Investigator:
          • Ruth Wittoek
      • Kluisbergen, Belgium, 9690
        • Recruiting
        • KORMONT
        • Principal Investigator:
          • Klaas Vercruysse
        • Contact:
          • Phone Number: 32 496 376259
      • Leuven, Belgium, 3000
        • Recruiting
        • UZ Leuven
        • Contact:
          • Phone Number: +3216342541
        • Principal Investigator:
          • Kurt de Vlam
      • Mechelen, Belgium, 2800
        • Recruiting
        • Meclinas
        • Contact:
          • Phone Number: 003215792797
        • Principal Investigator:
          • Julie Casaer
      • Merksem, Belgium, 2170
        • Not yet recruiting
        • ZNA Jan Palfijn
        • Contact:
          • Phone Number: +326402851
        • Principal Investigator:
          • Alla Ishchenko
      • Sint-Martens-Latem, Belgium, 9830
        • Not yet recruiting
        • Medisch Centrum Latem (Hip Clinic) - Algemeen Ziekenhuis Maria Middelares Location
        • Principal Investigator:
          • Pieter Vansintjan
        • Contact:
          • Phone Number: 09 220 88 68
  • Brazil
      • Campinas, Brazil, 13060-803
        • Not yet recruiting
        • Centro de Pesquisa Sao Lucas
        • Principal Investigator:
          • Danilo Villagelin Neto
        • Contact:
          • Phone Number: 55 19 3343-8688
      • Rio de Janeiro, Brazil, 20241-180
        • Not yet recruiting
        • IBPClin - Instituto Brasil de Pesquisa Clínica
        • Contact:
          • Phone Number: +552125277979
        • Principal Investigator:
          • Ana Claudia Cauceglia Melazzi
      • São Paulo, Brazil, 04266-010
        • Not yet recruiting
        • CEPIC - Centro Paulista de Investigacao Clinica
        • Principal Investigator:
          • Andrea Lomonte
      • São Paulo, Brazil, 05403-000
        • Not yet recruiting
        • Hospital das Clinicas FMUSP
        • Principal Investigator:
          • Cintia Cercato
        • Contact:
          • Phone Number: +551126617845
      • São Paulo, Brazil, 01228-000
        • Not yet recruiting
        • CPHosp Medicina, Ensino e Pesquisa (CPQuali)
        • Principal Investigator:
          • Gustavo Augusto
        • Contact:
          • Phone Number: 55 11 2776-6801
      • São Paulo, Brazil, 04039-002
        • Not yet recruiting
        • INTEGRA - Pesquisa Clínica e Infusões
        • Contact:
          • Phone Number: +5511998392949
        • Principal Investigator:
          • Carolina Janovsky
  • Canada
      • Guelph, Canada, N1G 0B4
        • Recruiting
        • Apex Trials
        • Contact:
          • Phone Number: 519-341-3367
        • Principal Investigator:
          • Ken Woo
      • Québec, Canada, G1V 3M7
        • Not yet recruiting
        • G.R.M.O. (Groupe de recherche en maladies osseuses) Inc.
        • Principal Investigator:
          • Louis Bessette
        • Contact:
          • Phone Number: 418 650-2661
      • Québec, Canada, G1V 4T3
        • Recruiting
        • Diex Recherche Inc. Division Quebec
        • Principal Investigator:
          • Caroline Rheaume
        • Contact:
          • Phone Number: 5144773439
      • Stouffville, Canada, L4A 1H2
        • Recruiting
        • Stouffville Medical Research Institute Inc.
        • Principal Investigator:
          • Nima Mirtorabi
        • Contact:
          • Phone Number: (905) 640-3100
      • Toronto, Canada, M5G 1K2
        • Recruiting
        • Maple Leaf Research
        • Principal Investigator:
          • Mona Loutfy
      • Toronto, Canada, M9V 4B4
        • Recruiting
        • Dr. Anil K. Gupta Medicine Professional Corporation
        • Contact:
          • Phone Number: 6473442020
        • Principal Investigator:
          • Anil Gupta
      • Victoriaville, Canada, G6P 3Z8
        • Recruiting
        • Diex Recherche Inc. Division Victoriaville
        • Contact:
          • Phone Number: 819-260-1172
        • Principal Investigator:
          • Eve Betit
  • China
      • Beijing, China, 100035
        • Not yet recruiting
        • Beijing Ji Shui Tan Hospital
        • Principal Investigator:
          • Xiaoli Deng
      • Bengbu, China, 233004
        • Not yet recruiting
        • The First Afflilated Hospital of Bengbu Medical College
        • Principal Investigator:
          • Xiaoyun Fan
      • Changchun, China, 130041
        • Not yet recruiting
        • The Second Hospital of Jilin University
        • Principal Investigator:
          • Hanqing Cai
      • Changchun, China, 130021
        • Not yet recruiting
        • Jilin Province People's Hospital
        • Principal Investigator:
          • Guoping Jiang
      • Changsha, China, 410008
        • Not yet recruiting
        • Xiangya Hospital Central South University
        • Principal Investigator:
          • Wenfeng Xiao
      • Chongqing, China, 400000
        • Not yet recruiting
        • 2nd Affiliated Hospital Chongqing Medical Universi
        • Principal Investigator:
          • Mao Nie
      • Hangzhou, China, 310052
        • Not yet recruiting
        • The Second Affiliated Hospital of Zhejiang University School of Medicine
        • Principal Investigator:
          • Haobo Wu
      • Hefei, China, 230011
        • Not yet recruiting
        • The Second People's hospital of Hefei
        • Principal Investigator:
          • Jun Ye
        • Contact:
          • Phone Number: 86-13956099720
      • Jinan, China, 250013
        • Not yet recruiting
        • Jinan Central Hospital
        • Principal Investigator:
          • Nianrong Mi
      • Luoyang, China, 471003
        • Not yet recruiting
        • The First Affiliated Hospital of Henan University of Science &Technology
        • Principal Investigator:
          • Xiaofei Shi
        • Contact:
          • Phone Number: 86 13663884080
      • Nanjing, China, 210029
        • Not yet recruiting
        • Jiangsu Province Hospital
        • Principal Investigator:
          • Hongwen Zhou
      • Nanjing, China, 210009
        • Not yet recruiting
        • Zhongda Hospital Southeast University
        • Principal Investigator:
          • Jun Lu
      • Nanjing, China, 210006
        • Not yet recruiting
        • Nanjing First Hospital
        • Principal Investigator:
          • Qian Li
      • Nanjing, China, 210011
        • Not yet recruiting
        • The Second Affiliated Hospital of Nanjing Medical University
        • Principal Investigator:
          • Yibing Lu
        • Contact:
          • Phone Number: 18951762960
      • Ningbo, China, 315010
        • Not yet recruiting
        • The First Affiliated Hospital of Ningbo University
        • Principal Investigator:
          • Xiudi Wu
      • Shanghai, China, 200032
        • Not yet recruiting
        • Zhongshan Hospital,Fudan University
        • Principal Investigator:
          • Yunchao Shao
      • Shanghai, China, 200040
        • Not yet recruiting
        • Huashan Hospital, Fudan University
        • Principal Investigator:
          • Yu Xue
      • Shanghai, China, 200023
        • Not yet recruiting
        • Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine
        • Principal Investigator:
          • Jie Zhao
      • Suzhou, China, 215004
        • Not yet recruiting
        • The Second Affiliated Hospital of Soochow University
        • Principal Investigator:
          • Zhichun Liu
      • Tianjin, China, 300211
        • Not yet recruiting
        • Tianjin Hospital
        • Principal Investigator:
          • Jun Liu
        • Contact:
          • Phone Number: 13389987163
      • Wenzhou, China, 315100
        • Not yet recruiting
        • The 2nd Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University
        • Contact:
          • Phone Number: 13806542929
        • Principal Investigator:
          • Chaoming Wu
      • Wuhan, China, 430030
        • Not yet recruiting
        • Tongji Hospital Tongji Medical,Science & Technology
        • Contact:
          • Phone Number: 18672912727
        • Principal Investigator:
          • Lingli Dong
      • Xianyang, China, 712000
        • Not yet recruiting
        • Xianyang Hospital of Yan'an University
        • Principal Investigator:
          • Fang Wang
  • Czechia
      • Brno, Czechia, 602 00
        • Recruiting
        • Pratia Brno
        • Contact:
          • Phone Number: +420515550902
        • Principal Investigator:
          • Simona Pappova
      • Brno, Czechia, 63800
        • Recruiting
        • Revmatologie.s.r.o.
        • Principal Investigator:
          • Leona Prochazkova
        • Contact:
          • Phone Number: +42545214556
      • Ostrava, Czechia, 70300
        • Recruiting
        • INREA s.r.o.
        • Contact:
          • Phone Number: 420776153321
        • Principal Investigator:
          • Martina Malcova
      • Pardubice, Czechia, 53002
        • Recruiting
        • Pratia Pardubice a.s.
        • Principal Investigator:
          • Marcela Svobodova
        • Contact:
          • Phone Number: 777691225
      • Uherské Hradiště, Czechia, 686 01
        • Recruiting
        • Medical Plus Research
        • Principal Investigator:
          • Eva Dokoupilova
  • Denmark
      • Gandrup, Denmark, 9362
        • Recruiting
        • Sanos Clinic - Nordjylland
        • Principal Investigator:
          • Janani Umachanger
      • Herlev, Denmark, 2730
        • Recruiting
        • Sanos Clinic
        • Principal Investigator:
          • Linda Bracher
      • Vejle, Denmark, 7100
        • Recruiting
        • Sanos Clinic - Syddanmark
        • Principal Investigator:
          • SIDSEL BOLL
  • Germany
      • Bochum, Germany, 44787
        • Not yet recruiting
        • Siteworks GmbH - Bochum
        • Contact:
          • Phone Number: +49 234 60144350
        • Principal Investigator:
          • Annemone Koechel
      • Bünde, Germany, 32257
        • Not yet recruiting
        • Private Practice - Dr. Kai Könemann & Dr. Henrik Könemann
        • Contact:
          • Phone Number: 0049522314438
        • Principal Investigator:
          • Kai Koenemann
      • Duisburg, Germany, 47269
        • Not yet recruiting
        • StudyPoint Duisburg
        • Contact:
          • Phone Number: +491725448897
        • Principal Investigator:
          • Matthias Kuenster
      • Hamburg, Germany, 20095
        • Not yet recruiting
        • HRF II - Hamburger Rheuma Forschungszentrum II MVZ für Rheumatologie und Autoimmunmedizin Hamburg GmbH / -T
        • Principal Investigator:
          • Andrea Everding
        • Contact:
          • Phone Number: 004940323103166
      • Karlsruhe, Germany, 76137
        • Not yet recruiting
        • Siteworks - Karlsruhe
        • Contact:
          • Phone Number: 0049 721 619004 90
        • Principal Investigator:
          • Julia Chevts
      • Leipzig, Germany, 04107
        • Not yet recruiting
        • AmBeNet GmbH
        • Contact:
          • Phone Number: 4934196276326
        • Principal Investigator:
          • Hans-Detlev Stahl
      • München, Germany, 80809
        • Not yet recruiting
        • CDG Studienambulanz Hartard
        • Principal Investigator:
          • Manfred Hartard
        • Contact:
          • Phone Number: 00498935819977
      • Offenbach, Germany, 63065
        • Not yet recruiting
        • Dedicated Research Site FutureMeds
        • Principal Investigator:
          • Christel Contzen
        • Contact:
          • Phone Number: 0049 69 247433849
  • Japan
      • Chiba, Japan, 260-8606
        • Recruiting
        • National Hospital Organization Chiba Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Akihiko Okawa
      • Chūōku, Japan, 103-0027
        • Recruiting
        • Tokyo-Eki Center-building Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Arihiro Kiyosue
      • Chūōku, Japan, 104-0031
        • Recruiting
        • Tokyo Asbo Clinic
        • Principal Investigator:
          • Akiyoshi Uchiyama
        • Contact:
          • Phone Number: 81120023812
      • Kitakyushu-Shi, Japan, 800-0057
        • Recruiting
        • Shin Komonji Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Motonori Sato
      • Miyazaki, Japan, 880-0835
        • Recruiting
        • Goto Orthopedic Surgery Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Keisuke Goto
      • Nagareyama, Japan, 270-0113
        • Recruiting
        • Komagidai Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Hideki Iizuka
      • Saitama, Japan, 336-8522
        • Recruiting
        • Saitama City Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kentaro Takeda
      • Sashima, Japan, 306-0433
        • Not yet recruiting
        • Ibaraki Seinan Medical Center Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Masafumi Uesugi
      • Sendai, Japan, 980-0011
        • Recruiting
        • Ogura Orthopedics Surgery
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Ken Ogura
      • Sendai, Japan, 981-3134
        • Recruiting
        • Katsura Garden Orthopedics
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Masakazu Kogawa
      • Shinagawa-ku Tokyo, Japan, 140-0014
        • Not yet recruiting
        • Ooimachi Orthopedic Surgery and surgery Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Omata Masanari
      • Suginami City, Japan, 167-0051
        • Recruiting
        • Masumoto Orthopedics Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Kou Masumoto
      • Toyohashi, Japan, 440-8510
        • Recruiting
        • National Hospital Organization Toyohashi Medical Center
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Yasuhiro Shibata
      • Yamagata, Japan, 990-0834
        • Recruiting
        • Yamagata Tokushukai Hospital
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Eita Togashi
      • Ōita, Japan, 870-0942
        • Recruiting
        • Fujigaki Clinic
        • Contact:
          • Phone Number: 81120023812
        • Principal Investigator:
          • Toru Fujigaki
  • Mexico
      • Chihuahua City, Mexico, 31000
        • Not yet recruiting
        • Investigacion y Biomedicina de Chihuahua
        • Contact:
          • Phone Number: 526144373003
        • Principal Investigator:
          • Cesar Pacheco-Tena
      • Ciudad Madero, Mexico, 89440
        • Not yet recruiting
        • Centro de Estudios de Investigacion Metabolicos y Cardiovasculares, S.C.
        • Principal Investigator:
          • Rafael Violante Ortiz
        • Contact:
          • Phone Number: 52 1 833 126 00 55
      • Guadalajara, Mexico, 44600
        • Not yet recruiting
        • Diseno y Planeacion en Investigacion Medica - Guadalajara - Calle Amado Nervo
        • Contact:
          • Phone Number: 5233305493
        • Principal Investigator:
          • Cesar Calvo Vargas
      • Guadalajara, Mexico, 44670
        • Not yet recruiting
        • Unidad de Investigación Clínica y Atención Médica HEPA S.C.
        • Contact:
          • Phone Number: 523336422886
        • Principal Investigator:
          • Marisol Herrera Marmolejo
      • Mexico City, Mexico, 03100
        • Not yet recruiting
        • RM Pharma Specialists - Unidad Especializada en Datos
        • Principal Investigator:
          • Juan Jose Morales Virgen
        • Contact:
          • Phone Number: 5518669106
      • Monterrey, Mexico, 64460
        • Not yet recruiting
        • UBAM Unidad Biomedica Avanzada Monterrey
        • Contact:
          • Phone Number: 8113578896
        • Principal Investigator:
          • Raymundo García Reza
      • Monterrey, Mexico, 66465
        • Not yet recruiting
        • Centro de investigación y control metabólico
        • Principal Investigator:
          • Jorge Acosta Rodriguez
      • Monterrey, Mexico, 64020
        • Not yet recruiting
        • IMED Internal Medicine Clin Trials
        • Contact:
          • Phone Number: 8183470078
        • Principal Investigator:
          • Jose Garza Ruiz
      • Mérida, Mexico, 97070
        • Not yet recruiting
        • Kohler & Milstein Research S.A. de C.V.
        • Principal Investigator:
          • Jesus Simon Campos
        • Contact:
          • Phone Number: +529999204004
  • Puerto Rico
      • Dorado, Puerto Rico, 00646
        • Recruiting
        • Dorado Medical Complex
        • Principal Investigator:
          • Luis Pagan-Cardona
        • Contact:
          • Phone Number: 787278-1576
      • San Juan, Puerto Rico, 00917
        • Recruiting
        • GCM Medical Group, PSC - Hato Rey Site
        • Principal Investigator:
          • Karina Vila-Rivera
        • Contact:
          • Phone Number: 17877268396
  • South Korea
      • Daegu, South Korea, 42601
        • Not yet recruiting
        • Keimyung University Dongsan Hospital
        • Principal Investigator:
          • Ki Cheor Bae
      • Dongjak-gu, South Korea, 07061
        • Not yet recruiting
        • Boramae Medical Center
        • Principal Investigator:
          • Moonjong Chang
      • Seoul, South Korea, 03080
        • Not yet recruiting
        • Seoul National University Hospital
        • Principal Investigator:
          • Hyuk-Soo Han
      • Seoul, South Korea, 03722
        • Not yet recruiting
        • Severance Hospital, Yonsei University Health System
        • Contact:
          • Phone Number: +821047054262
        • Principal Investigator:
          • Sunghwan Kim
      • Seoul, South Korea, 06591
        • Not yet recruiting
        • The Catholic Univ. of Korea Seoul St. Mary's Hospital
        • Contact:
          • Phone Number: 010-9044-5228
        • Principal Investigator:
          • yong in
      • Seoul, South Korea, 05505
        • Not yet recruiting
        • Asan Medical Center
        • Principal Investigator:
          • JONG-MIN KIM
        • Contact:
          • Phone Number: +82-2-3010-3897
      • Seoul, South Korea, 07441
        • Not yet recruiting
        • Hallym University Kangnam Sacred Heart Hospital
        • Contact:
          • Phone Number: 82-10-8762-7089
        • Principal Investigator:
          • Joongil Kim
      • Uijeongbu-si, South Korea, 11765
        • Not yet recruiting
        • The Catholic University of Korea, Uijeongbu St. Mary's Hospital
        • Principal Investigator:
          • SEOK JUNG KIM
  • Taiwan
      • Changhua County, Taiwan, 50006
        • Not yet recruiting
        • Changhua Christian Hospital
        • Principal Investigator:
          • Ing-Lin Chang
      • Kaohsiung Niao Sung Dist, Taiwan, 83301
        • Not yet recruiting
        • Chang Gung Memorial Hospital at Kaohsiung
        • Contact:
          • Phone Number: 8860975056125
        • Principal Investigator:
          • Ying-Chou Chen
      • Taichung, Taiwan, 404332
        • Not yet recruiting
        • China Medical University Hospital
        • Contact:
          • Phone Number: 886923832500
        • Principal Investigator:
          • Wen-Yuan Lin
      • Tainan, Taiwan, 704
        • Not yet recruiting
        • National Cheng Kung University Hospital
        • Contact:
          • Phone Number: 06-2353535
        • Principal Investigator:
          • Po-Ting Wu
      • Taipei, Taiwan, 10002
        • Not yet recruiting
        • National Taiwan University Hospital
        • Principal Investigator:
          • Chia-Wen Lu
      • Taipei, Taiwan, 110
        • Not yet recruiting
        • Taipei Medical University Hospital
        • Principal Investigator:
          • Chi-Ching Chang
      • Taipei, Taiwan, 114
        • Not yet recruiting
        • Tri-Service General Hospital
        • Contact:
          • Phone Number: 88687927135
        • Principal Investigator:
          • Yu-Hsiu Chen
  • United Kingdom
      • Bristol, United Kingdom, BS8 2RA
        • Not yet recruiting
        • Velocity Clinical Research, Bristol
        • Principal Investigator:
          • Kirsten Peacey
        • Contact:
          • Phone Number: +44 1174 611208
      • Glasgow, United Kingdom, G20 7BE
        • Not yet recruiting
        • FutureMeds Glasgow - CPS Research
        • Contact:
          • Phone Number: 0141 9467888
        • Principal Investigator:
          • Kristen Laing
      • London, United Kingdom, NW10 2PB
        • Not yet recruiting
        • FutureMeds - London
        • Principal Investigator:
          • Pembe Ozunlu
        • Contact:
          • Phone Number: 07858413118
      • Newcastle, United Kingdom, NE6 1SG
        • Not yet recruiting
        • Futuremeds-Newcastle
        • Principal Investigator:
          • William Aspinall
      • Penzance, United Kingdom, TR18 3DX
        • Not yet recruiting
        • Atlantic Medical
        • Principal Investigator:
          • Alex Dewdney
      • Rotherham, United Kingdom, S61 1AH
        • Not yet recruiting
        • Woodstock Bower Surgery
        • Contact:
          • Phone Number: 07551985998
        • Principal Investigator:
          • Shahbaz Ali
      • Sheffield, United Kingdom, S2 5FX
        • Not yet recruiting
        • Panthera Biopartners - Sheffield
        • Contact:
          • Phone Number: 01143503730
        • Principal Investigator:
          • Hannah Collins
      • York, United Kingdom, YO24 4LJ
        • Not yet recruiting
        • Panthera Clinic - York
        • Contact:
          • Phone Number: 01772 237822
        • Principal Investigator:
          • Mahadev Ramjee
  • United States
    • Alabama
      • Mobile, Alabama, United States, 36608
        • Recruiting
        • AMR Clinical
        • Contact:
          • Phone Number: 251-414-1984
        • Principal Investigator:
          • Harry Studdard
    • Arizona
      • Mesa, Arizona, United States, 85206
        • Recruiting
        • Care Access - 801 South Power Road, Mesa
        • Principal Investigator:
          • Michael Waters
        • Contact:
          • Phone Number: 949-929-4703
      • Mesa, Arizona, United States, 85209
        • Recruiting
        • Elite Pain and Spine Institute - South Crimson Road
        • Principal Investigator:
          • Zeeshan Malik
      • Tucson, Arizona, United States, 85712
        • Recruiting
        • Tucson Orthopaedic Institute - North Wyatt Drive
        • Principal Investigator:
          • Nebojsa Skrepnik
        • Contact:
          • Phone Number: 520-404-0276
    • California
      • Fountain Valley, California, United States, 92708
        • Recruiting
        • Ark Clinical Research - Fountain Valley
        • Principal Investigator:
          • Mark Leibowitz
        • Contact:
          • Phone Number: 714-988-2021
      • Santa Ana, California, United States, 92706
        • Recruiting
        • Wolverine Clinical Trials
        • Contact:
          • Phone Number: 714-617-2426
        • Principal Investigator:
          • Behnam Khaleghi
      • Spring Valley, California, United States, 91978
        • Recruiting
        • Encompass Clinical Research
        • Contact:
          • Phone Number: 619-660-9068
        • Principal Investigator:
          • Hanid Audish
      • Walnut Creek, California, United States, 94598
        • Recruiting
        • Diablo Clinical Research, Inc.
        • Contact:
          • Phone Number: 925-930-7267
        • Principal Investigator:
          • Helen Stacey
    • Florida
      • Jacksonville, Florida, United States, 32205
        • Recruiting
        • Westside Center for Clinical Research
        • Principal Investigator:
          • Matthew Braddock
        • Contact:
          • Phone Number: 904-693-1490
      • St. Petersburg, Florida, United States, 33710
        • Recruiting
        • Care Access - St. Petersburg
        • Principal Investigator:
          • Gigi Lefebvre
        • Contact:
          • Phone Number: 877-791-0656
      • Winter Park, Florida, United States, 32789
        • Recruiting
        • Conquest Research
        • Principal Investigator:
          • Anand Patel
        • Contact:
          • Phone Number: 407-916-0060
    • Georgia
      • Decatur, Georgia, United States, 30034
        • Recruiting
        • Orita Clinical Research
        • Principal Investigator:
          • Ahmad Jingo
    • Illinois
      • Chicago, Illinois, United States, 60640
        • Recruiting
        • Great Lakes Clinical Trials - Ravenswood
        • Contact:
          • Phone Number: 773-275-3500
        • Principal Investigator:
          • Manish Jain
    • Indiana
      • Evansville, Indiana, United States, 47715
        • Recruiting
        • Qualmedica Research, LLC
        • Contact:
          • Phone Number: 812-205-2475
        • Principal Investigator:
          • Moges Sisay
    • Kansas
      • Newton, Kansas, United States, 67114
        • Recruiting
        • AMR Clinical
        • Contact:
          • Phone Number: 316-804-7304
        • Principal Investigator:
          • Troy Holdeman
    • Kentucky
      • Louisville, Kentucky, United States, 40213
        • Recruiting
        • Monroe Biomedical Research - Louisville
        • Contact:
          • Phone Number: 502-515-5672
        • Principal Investigator:
          • Harold Bays
    • Massachusetts
      • Burlington, Massachusetts, United States, 01803
        • Recruiting
        • Skylight Health Research - Burlington
        • Principal Investigator:
          • Timothy McAlindon
        • Contact:
          • Phone Number: 781-653-4281
      • Quincy, Massachusetts, United States, 02169
        • Recruiting
        • Care Access - Quincy
        • Contact:
          • Phone Number: 877-791-0656
        • Principal Investigator:
          • Chih Chao Yang
    • New York
      • Brooklyn, New York, United States, 11215
        • Recruiting
        • Ellipsis Research Group - Brooklyn - 7th Street
        • Principal Investigator:
          • Jorge Serje
        • Contact:
          • Phone Number: 347-422-0317
      • Buffalo, New York, United States, 14127
        • Recruiting
        • Rochester Clinical Research - Buffalo
        • Principal Investigator:
          • Rajiv Jain
      • Long Island City, New York, United States, 11106
        • Recruiting
        • NYC Research Inc
        • Principal Investigator:
          • Anastasios Manessis
        • Contact:
          • Phone Number: 516-574-9232
      • Rochester, New York, United States, 14609
        • Recruiting
        • Rochester Clinical Research, LLC
        • Contact:
          • Phone Number: 585-288-0890
        • Principal Investigator:
          • Patrick Connors
    • Oklahoma
      • Tulsa, Oklahoma, United States, 74136
        • Recruiting
        • Central States Research
        • Contact:
          • Phone Number: 918-645-5400
        • Principal Investigator:
          • Sarah Land
    • Pennsylvania
      • Beaver, Pennsylvania, United States, 15009
        • Not yet recruiting
        • Heritage Valley Multispecialty Group, Inc
        • Contact:
          • Phone Number: 724-770-0935
        • Principal Investigator:
          • Michael Oliver
      • Plymouth Meeting, Pennsylvania, United States, 19462
        • Recruiting
        • Keystone Clinical Studies
        • Principal Investigator:
          • Cameron Olezene
    • Texas
      • Bellaire, Texas, United States, 77401
        • Recruiting
        • JCCT - Juno Bellaire Site
        • Contact:
          • Phone Number: 713-779-5494
        • Principal Investigator:
          • Rocio Harbison
      • DeSoto, Texas, United States, 75115
        • Recruiting
        • Epic Medical Research - DeSoto
        • Principal Investigator:
          • HARESH BOGHARA
        • Contact:
          • Phone Number: 197-277-7695
      • Fort Worth, Texas, United States, 76164
        • Recruiting
        • Valley Institute of Research - Fort Worth
        • Contact:
          • Phone Number: 817-625-7733
        • Principal Investigator:
          • Alex Guevara
      • Houston, Texas, United States, 77054
        • Recruiting
        • Care Access - Houston
        • Principal Investigator:
          • Ali Bajwa
        • Contact:
          • Phone Number: 877-791-0656
      • San Antonio, Texas, United States, 78240
        • Recruiting
        • Endeavor Clinical Trials
        • Principal Investigator:
          • Nitendra Agarwal
        • Contact:
          • Phone Number: 518-428-6859
      • San Antonio, Texas, United States, 78230
        • Recruiting
        • VIP Trials
        • Contact:
          • Phone Number: 210-569-2672
        • Principal Investigator:
          • Juan Garza
      • Shavano Park, Texas, United States, 78231
        • Recruiting
        • Consano Clinical Research, LLC
        • Contact:
          • Phone Number: 210-545-4900
        • Principal Investigator:
          • Michelle Welch
      • Weslaco, Texas, United States, 78596
        • Recruiting
        • Texas Valley Clinical Research
        • Principal Investigator:
          • Eduardo Luna
        • Contact:
          • Phone Number: 956-431-8090
    • Utah
      • South Jordan, Utah, United States, 84095
        • Recruiting
        • AMR Clinical
        • Principal Investigator:
          • Curtis Andrews
    • Virginia
      • Charlottesville, Virginia, United States, 22911
        • Not yet recruiting
        • Charlottesville Medical Research
        • Contact:
          • Phone Number: 434-817-2442
        • Principal Investigator:
          • James Clark
    • Washington
      • Kirkland, Washington, United States, 98034
        • Not yet recruiting
        • Paramount Clinical Research - Data Point Clinical Research
        • Principal Investigator:
          • Javier Nazar
        • Contact:
          • Phone Number: 425-577-1107

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  • Have a body mass index (BMI) of 27 kilograms per square meter (kg/m²) or higher at screening
  • Have a stable body weight (less than 5% body weight change) for 90 days prior to screening
  • Have tried at least once to lose weight through diet but were unsuccessful

  • Have osteoarthritis of the knee and at least one of the following conditions:

    • Be over 50 years old
    • Have morning knee stiffness that lasts about 30 minutes
    • Have a crackling or grinding sound or feeling in the knee

Exclusion Criteria:

  • Have a prior or planned surgical treatment for obesity (liposuction, cryolipolysis, or abdominoplasty allowed if performed greater than 1 year before screening)
  • Have a prior or planned endoscopic procedure and/or device-based therapy for obesity (prior device-based therapy acceptable if device removal was more than 6 months prior to screening)
  • Have type 1 diabetes, type 2 diabetes, or any other type of diabetes
  • Have an active knee infection

  • Have had within 90 days prior to screening:

    • heart attack
    • stroke
    • coronary artery revascularization
    • unstable angina, or
    • hospitalization due to congestive heart failure
  • Have a history or diagnosis of New York Heart Association Functional Classification Class IV congestive heart failure
  • Have taken medications or alternative remedies intended for weight loss within 90 days of screening

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Double

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: Eloralintide (YOA1)
Participants will receive eloralintide subcutaneously (SC)
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Placebo Comparator: Placebo (YOA1)
Participants will receive placebo SC
Drug: Placebo
Placebo administered SC
Experimental: Eloralintide (YOA2)
Participants will receive eloralintide SC
Drug: Eloralintide
Administered SC
Other Names:
  • LY3841136
Placebo Comparator: Placebo (YOA2)
Participants will receive placebo SC
Drug: Placebo
Placebo administered SC

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Percent Change from Baseline in Body Weight
Time Frame: Baseline, Week 64
Percent Change from Baseline in Body Weight
Baseline, Week 64
Change from Baseline in the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain Subscale Score
Time Frame: Baseline, Week 64
Change from Baseline in the WOMAC Pain Subscale Score
Baseline, Week 64

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Change from Baseline in Systolic Blood Pressure (SBP)
Time Frame: Baseline, Week 64
Change from Baseline in SBP
Baseline, Week 64
Percent Change from Baseline in Triglycerides
Time Frame: Baseline, Week 64
Percent Change in Baseline in Triglycerides
Baseline, Week 64
Change from Baseline in Short Form-36 (SF-36 v2) Acute Form Physical Functioning Domain Score
Time Frame: Baseline, Week 64
Change from Baseline in SF-36 v2 Score
Baseline, Week 64
Percent Change from Baseline in High Sensitivity, C-reactive Protein (hsCRP)
Time Frame: Baseline, Week 64
Percent Change from Baseline in hsCRP
Baseline, Week 64
Change from Baseline in the WOMAC Physical Function Subscale Score
Time Frame: Baseline, Week 40, Week 64
Change from Baseline in the WOMAC Physical Function Subscale Score
Baseline, Week 40, Week 64
Change from Baseline WOMAC Pain Subscale Score
Time Frame: Baseline, Week 40
Change from Baseline WOMAC Pain Subscale Score
Baseline, Week 40
Change from Baseline in Distance Walked During the 6-Minute Walk Test
Time Frame: Baseline, Week 64
Change from Baseline in Distance Walked During the 6-Minute Walk Test
Baseline, Week 64
Change from Baseline in Body Mass Index (BMI)
Time Frame: Baseline, Week 64
Change from Baseline in BMI
Baseline, Week 64
Change in Medication Use
Time Frame: Baseline, Week 64
Change in Medication Use
Baseline, Week 64
Change from Baseline in SF-36v2 Acute Form Domain Scores With Exception of the Physical Functioning Domain Score
Time Frame: Baseline, Week 64
Change from Baseline in SF-36v2 Acute Form Domain Scores With Exception of the Physical Functioning Domain Score
Baseline, Week 64
Change from Baseline in Health Status EQ-5D-5L Health State Utility
Time Frame: Baseline, Week 64
Change from Baseline in Health Status EQ-5D-5L Health State Utility
Baseline, Week 64
Percent Change from Baseline in Fasting Insulin
Time Frame: Baseline, Week 64
Percent Change from Baseline in Fasting Insulin
Baseline, Week 64
Percent Change from Baseline in Total Cholesterol
Time Frame: Baseline, Week 64
Percent Change from Baseline in Total Cholesterol
Baseline, Week 64
Change from Baseline in Waist Circumference
Time Frame: Baseline, Week 64
Change from Baseline in Waist Circumference
Baseline, Week 64
Percent Change from Baseline in Hemoglobin A1c (HbA1c)
Time Frame: Baseline, Week 64
Percent Change from Baseline in HbA1c
Baseline, Week 64
Change from Baseline in WOMAC Stiffness Subscale Score
Time Frame: Baseline, Week 64
Change from Baseline in WOMAC Stiffness Subscale Score
Baseline, Week 64
Change from Baseline in WOMAC Total Score
Time Frame: Baseline, Week 64
Change from Baseline in WOMAC Total Score
Baseline, Week 64
Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) - Target Knee Pain
Time Frame: Baseline, Week 64
Achievement of Improved Categorical Shift in PGIS - Target Knee Pain
Baseline, Week 64
Achievement of Improved Categorical Shift in Patient Global Impression of Severity (PGIS) - Target Knee Function
Time Frame: Baseline, Week 64
Achievement of Improved Categorical Shift in PGIS - Target Knee Function
Baseline, Week 64
Change from Baseline in Average Pain Intensity Numeric Rating Scale (API-NRS) Score
Time Frame: Baseline, Week 64
Change from Baseline in API-NRS Score
Baseline, Week 64
Change from Baseline in Worst Pain Intensity Numeric Rating Scale (WPI-NRS) Score
Time Frame: Baseline, Week 64
Change from Baseline in WPI-NRS Score
Baseline, Week 64
Pharmacokinetics (PK): Maximum Concentration at Steady State (Cmax, ss)
Time Frame: Baseline through Week 64
PK: Cmax, ss
Baseline through Week 64
PK: Area Under the Concentration Versus Time Curve for One Dosing Interval at Steady State (AUC(0-T)ss)
Time Frame: Baseline through Week 64
PK: AUC(0-T)ss
Baseline through Week 64
Number of Participants with Allowed Concomitant Pain Medication
Time Frame: Baseline, Week 64
Number of Participants with Allowed Concomitant Pain Medication
Baseline, Week 64

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Eli Lilly and Company

Investigators

  • Study Director: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 8 AM - 8 PM Eastern time (UTC/GMT - 5 hours, EST), Eli Lilly and Company

Publications and helpful links

The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.

Helpful Links

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 9, 2026

Primary Completion (Estimated)

March 1, 2028

Study Completion (Estimated)

May 1, 2028

Study Registration Dates

First Submitted

January 16, 2026

First Submitted That Met QC Criteria

January 16, 2026

First Posted (Actual)

January 21, 2026

Study Record Updates

Last Update Posted (Actual)

May 22, 2026

Last Update Submitted That Met QC Criteria

May 20, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 27761
  • 2025-523768-19-00 (Ctis)
  • J3R-MC-YDAN (Other Identifier: Eli Lilly and Company)
  • J3R-MC-YOA1 (Other Identifier: Eli Lilly and Company)
  • J3R-MC-YOA2 (Other Identifier: Eli Lilly and Company)

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

YES

IPD Plan Description

Anonymized individual patient level data will be provided in a secure access environment upon approval of a research proposal and a signed data sharing agreement.

IPD Sharing Time Frame

Data are available 6 months after the primary publication or approval of the indication studied in the US and EU, whichever is later. Data will be indefinitely available for requesting.

IPD Sharing Access Criteria

A research proposal must be approved by an independent review panel and researchers must sign a data sharing agreement.

IPD Sharing Supporting Information Type

  • STUDY_PROTOCOL
  • SAP
  • CSR

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

Yes

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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