A Crossover Exploratory Study of NatureU Cheers Friends Curcumin on Acute Alcohol Hangover Symptoms (NUZY)

A Single-Center, Open-Label, Crossover Exploratory Study of NatureU Cheers Friends Curcumin on Acute Alcohol Hangover Symptoms in Healthy Adult Men

This was a single-center, open-label, exploratory crossover study evaluating acute hangover symptoms after use of NatureU Cheers Friends Curcumin compared with an active comparator product in healthy adult men. Participants completed two independent test-food sessions separated by at least 48 hours. Sixteen participants were recruited, 12 were screened and enrolled, and 12 were included in the effectiveness analysis. In the control session, participants took Herbsense hangover relief tablets 30 minutes before alcohol intake. In the NatureU Cheers Friends Curcumin session, participants took NatureU Cheers Friends Curcumin 30 minutes before alcohol intake. The main outcome was the Acute Hangover Scale (AHS) assessed the morning after each test session. Safety was monitored during the test procedures.

Study Overview

• Status: Completed
• Conditions: Alcohol Misuse; Alcohol Hangover
• Intervention / Treatment: Dietary supplement: NatureU Cheers Friends Curcumin; Dietary supplement: Herbsense Hangover Relief Tablet

Detailed Description

The study was designed as an exploratory human evaluation of a functional food product intended to support post-alcohol hangover relief. Eligible healthy adult male participants completed two independent test-food sessions under researcher supervision. Screening was performed on June 19, 2024, eligible participants were enrolled on June 20, 2024, and the final next-morning questionnaire assessment was completed on June 21, 2024. Participants were instructed not to drink alcohol for 24 hours before each test day and not to eat during the 3 hours before testing. On each test day, participants arrived at the study center at approximately 18:00, completed check-in and baseline assessments including blood pressure, pulse rate, and breath alcohol measurement, and received the assigned test product at approximately 18:30. At approximately 19:00, participants consumed 100 mL of commercially available 52% Chinese baijiu within 10-15 minutes and consumed a standardized meal within 30 minutes. Blood pressure and pulse rate were measured 30, 60, and 120 minutes after alcohol intake. Participants completed the Acute Hangover Scale the next morning after waking. The study was open-label and exploratory, with no masking. Analyses compared AHS scores after NatureU Cheers Friends Curcumin with scores after the comparator product.

• Study Type: Interventional
• Enrollment (Actual): 12
• Phase: Not Applicable

Contacts and Locations

Study Locations

• China
  • Hunan
    • Yongzhou, Hunan, China, 425300
      • Dao County People's Hospital

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult
• Accepts Healthy Volunteers: Yes

Description

Inclusion Criteria:

• Signed informed consent before the study and understood the study content, procedures, and possible adverse reactions.
• Healthy adult man aged 20 to 48 years, inclusive.
• Normal social drinking lifestyle and no alcohol dependence.
• Aspartate aminotransferase and alanine aminotransferase values within two standard deviations of the normal range.
• Able to maintain normal healthy routines during the study.
• Able to avoid other interfering supplements for 2 weeks before and during the study.
• Abstained from alcohol for 24 hours before the study.
• Abstained from caffeinated beverages, including coffee, tea, and energy drinks, for 12 hours before the study.

Exclusion Criteria:

• Known allergy or hypersensitivity to product ingredients, including magnolia bark, milk thistle extract, turmeric, or alcohol.
• History of multiple drug or food allergies.
• Acute or chronic inflammatory disease, including influenza A, within the previous month.
• Hypertension.
• Participation in any other clinical trial within 1 month before first use of the study product.
• Clinically significant gastrointestinal, renal, hepatic, neurologic, hematologic, endocrine, oncologic, pulmonary, immune, psychiatric, cardiovascular, cerebrovascular, or metabolic disease within the previous 6 months.
• Acute illness or concomitant medication use from screening to first use of the study product.
• Surgery within the previous 3 months.
• Blood donation or major blood loss greater than 450 mL within the previous 3 months.
• Difficulty swallowing.
• Use of prescription or non-prescription medications affecting nutritional supplements or alcohol metabolism.
• Any other factor judged by the investigator to make participation inappropriate.

Study Plan

How is the study designed?

Design Details

• Primary Purpose: Other
• Allocation: Non-Randomized
• Interventional Model: Crossover Assignment
• Masking: None (Open Label)

Number of Arms

2

Arms and Interventions

Participant Group / Arm	Intervention / Treatment
Experimental: NatureU Cheers Friends Curcumin; Participants received NatureU Cheers Friends Curcumin, three tablets orally 30 minutes before alcohol intake.	Dietary supplement: NatureU Cheers Friends Curcumin; NatureU Cheers Friends Curcumin is an oral functional food product containing magnolia bark extract, milk thistle extract, high-concentration turmeric, and related ingredients. Participants took three tablets 30 minutes before alcohol intake.
Active Comparator: Herbsense Hangover Relief Tablet; Participants received Herbsense hangover relief tablets, two tablets orally 30 minutes before alcohol intake.	Dietary supplement: Herbsense Hangover Relief Tablet; The comparator product was Herbsense hangover relief tablet. Participants took two tablets 30 minutes before alcohol intake during the comparator session.

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Difference in Acute Hangover Scale Total Score Between NatureU Cheers Friends Curcumin and Comparator Product	The Acute Hangover Scale includes nine items scored from 0 to 7, with higher scores indicating more severe hangover symptoms. The primary endpoint was the difference in total AHS score after NatureU Cheers Friends Curcumin compared with the comparator product.	12 hours after alcohol intake in each test-food session

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Difference in Individual Acute Hangover Scale Item Scores Between NatureU Cheers Friends Curcumin and Comparator Product	Individual AHS item scores included hangover, thirst, fatigue, headache, dizziness, appetite loss, stomachache, nausea, and heart racing. Each item was scored from 0 to 7, with higher scores indicating more severe symptoms.	12 hours after alcohol intake in each test-food session

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
Safety and Tolerability During Test-Food Sessions	Safety monitoring included participant status and vital sign assessments, including blood pressure and pulse rate, during the supervised test procedures.	Baseline, 30 minutes, 60 minutes, and 120 minutes after alcohol intake during each test session

Collaborators and Investigators

• Sponsor: OmniSolutions Laboratory Holdings Limited
• Investigators: Study Director: Luke Law, Dr, OmniSolutions Laboratory Holdings Limited

Study record dates

Study Major Dates

• Study Start (Actual): June 20, 2024
• Primary Completion (Actual): June 21, 2024
• Study Completion (Actual): June 21, 2024

Study Registration Dates

• First Submitted: April 30, 2026
• First Submitted That Met QC Criteria: May 6, 2026
• First Posted (Actual): May 14, 2026

Study Record Updates

• Last Update Posted (Actual): May 14, 2026
• Last Update Submitted That Met QC Criteria: May 6, 2026
• Last Verified: May 1, 2026

More Information

Terms related to this study

• Keywords: hangover; functional food; NatureU Cheers Friends Curcumin; acute hangover scale; magnolia bark; milk thistle; turmeric
• Other Study ID Numbers: 2024060001 (Other Identifier: Dao County People's Hospital Ethics Committee)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO
• IPD Plan Description: Individual participant data will not be shared due to privacy protection and ethical considerations.

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No