Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay (CIILOS)

May 18, 2026 updated by: Max Bell, Karolinska Institutet

CIILOS - Continuous Renal Replacement Therapy, Impact on Intensive Care Unit Length of Stay

This large national cohort study, including over 500,000 patients, where around 5% are treated with continuous renal replacement therapy (CRRT) , aims to evaluate the association between time to initiation of CRRT and intensive care unit (ICU) length of stay (LOS).

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

This large national cohort study, including over 500,000 patients, aims to evaluate the association between time to initiation of continuous renal replacement therapy (CRRT) and intensive care unit (ICU) length of stay (LOS).

The investigators hypothesize that earlier start of CRRT is associated with shorter length of stay among critically ill patients.

CRRT is seen as a costly intervention, and after studies failing to demonstrate a mortality benefit from earlier initiation, the trend is to push, or postpone the start of CRRT. In Sweden the additional cost of CRRT amounts to around 5000 SEK, approximately 500 dollars/euros per 24 hours. However, the 24-hour cost of staying in the ICU is around 58000 SEK or 5800 dollars/euros.

Study Type

Observational

Enrollment (Estimated)

500000

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Sampling Method

Probability Sample

Study Population

All adult critically ill patients in Swedish ICUs from 2010-2023, with- and without the need of CRRT forms this cohort.

Within the cohort, a nested case-control type of study can be performed. Two groups:

Group 1: Patients with CRRT initiation time less than 30 hours (early CRRT) Group 2: Patients with CRRT initiation time 30 hours or more (late CRRT)

Description

Inclusion Criteria:

  • Patients with critical illness
  • Admitted to Swedish ICUs from 2010-2023
  • Adult (18 years or older)

Exclusion Criteria:

*Patients under 18 years of age

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Intensive care unit (ICU) length of stay (LOS) measured in hours
Time Frame: ICU LOS during the study period, from admission to discharge, average 168 hours (one week)
Hours from baseline, i.e. ICU admission (time=0) to ICU discharge (time=0+hours in ICU)
ICU LOS during the study period, from admission to discharge, average 168 hours (one week)

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Mortality
Time Frame: ONE-YEAR Mortality post admission
Days from baseline, i.e. ICU admission to 30, 90,180 and 365 day mortality
ONE-YEAR Mortality post admission
Mechanical ventilation
Time Frame: Time on mechanical ventilation during the study period, average one week, but up to ICU discharge
Hours from baseline, i.e. start of ventilation (time=0) until end of ventilation, hours
Time on mechanical ventilation during the study period, average one week, but up to ICU discharge

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Karolinska Institutet

Investigators

  • Principal Investigator: Max Bell, MD, PhD, Karolinska University Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

August 1, 2026

Primary Completion (Estimated)

December 31, 2026

Study Completion (Estimated)

December 31, 2026

Study Registration Dates

First Submitted

December 18, 2025

First Submitted That Met QC Criteria

May 7, 2026

First Posted (Actual)

May 14, 2026

Study Record Updates

Last Update Posted (Actual)

May 20, 2026

Last Update Submitted That Met QC Criteria

May 18, 2026

Last Verified

May 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • CIILOS

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Swedish law prohibits IPD sharing using extracted quality register data, when this has not been stated in the primary ethics application. However, other researchers can theoretically apply for data extraction from the Swedish Intensive Care Register.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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