Functional Progressive Resistive Training and Cerebral Palsy

June 26, 2026 updated by: Alaa Fahmy Hassan Al Nemr, Cairo University

Effect of Functional Progressive Resistance Training on Bone Mineral Density and Balance in Children With Cerebral Palsy

Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance. It involves performing task-oriented exercises, such as sit-to-stand, stair climbing, and walking-related activities, while gradually increasing the load to enhance muscle strength, endurance, and functional performance. FPRE is widely used in rehabilitation programs to improve mobility and the ability to perform activities of daily living in various populations, including children with neurological and musculoskeletal disorders.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Study Type

Interventional

Enrollment (Estimated)

60

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Child

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

  1. A diagnosis of spastic diplegic CP
  2. Degree of spasticity ranges from 1+ and 2, according to modified Ashworth scale (MAS)
  3. The age of the selected children will range from 6 to 10 years old.
  4. Children are levels II and III according to GMFCS

Exclusion Criteria:

1 - Children with visual or auditory problems. 2. Children with severe intellectual disability (IQ less than 65 according to Stanford Binet intelligence scale).

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: Single

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Experimental: designed physical therapy program
Other: designed physical therapy program
conventional physical therapy program including reinforcement of the normal motor development, reflex inhibiting patterns, postural reaction, stretching, strengthening exercises, and gait training was applied to children in the control group
Experimental: functional progressive resistive exercise and designed physical therapy program
Other: functional progressive resistive exercise and designed physical therapy program

specially designed physical therapy program in addition to functional progressive resistive exercises for 60 min (30 min designed P.T program and other 30 min for brain gym exercises), 3 sessions/ week for 3 successive months. 6 functional progressive resistive exercises will be selected:

  1. Sit-to-Stand Exercise
  2. Step-Up Exercise
  3. Squats
  4. Lunges
  5. Stair Climbing
  6. Loaded Walking

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Dual-energy X-ray absorptiometry (DXA)
Time Frame: 3month

The most common test for bone mineral density is a Dual-energy X-ray absorptiometry (DXA) scan. It is:

Painless and non-invasive Quick (usually 10-20 minutes) Low radiation exposure Most often performed on the hip and lower spine. Bone mineral density (BMD) is a measure of the amount of mineral (mainly calcium and phosphorus) present in a specific volume of bone. It reflects bone strength and is used to assess the risk of fractures and diagnose osteoporosis.
3month
biodex balance system
Time Frame: 3 month
The Biodex Balance System is a computerized device used to assess and improve static and dynamic balance, postural stability, and neuromuscular control. It consists of a movable platform that can be adjusted to different levels of stability, allowing clinicians and researchers to evaluate an individual's ability to maintain balance under varying conditions.
3 month

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Cairo University

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

July 1, 2026

Primary Completion (Estimated)

August 11, 2026

Study Completion (Estimated)

November 9, 2026

Study Registration Dates

First Submitted

June 23, 2026

First Submitted That Met QC Criteria

June 26, 2026

First Posted (Actual)

June 30, 2026

Study Record Updates

Last Update Posted (Actual)

June 30, 2026

Last Update Submitted That Met QC Criteria

June 26, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • P.T.REC/012/006023

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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