Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery (RIRS-VENT)

July 10, 2026 updated by: Tuna Erturk, Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Comparison of Different Ventilation Modes for Reducing Kidney Motion During Retrograde Intrarenal Surgery: A Prospective Randomized Controlled Trial

This randomized clinical trial will compare four ventilation strategies during retrograde intrarenal surgery performed under general anesthesia. The study aims to determine whether reducing respiratory-related kidney movement improves surgical success and decreases perioperative complications. Eighty adult patients will be randomly assigned to standard ventilation, hypoventilation, intermittent apnea ventilation, or one-lung ventilation. Surgical outcomes and perioperative complications will be compared between groups.

Study Overview

Status

Not yet recruiting

Conditions

Intervention / Treatment

Detailed Description

Retrograde intrarenal surgery is commonly performed under general anesthesia, but respiratory movement may interfere with kidney stability during the procedure. This prospective, randomized, single-center trial will compare standard ventilation, hypoventilation, intermittent apnea ventilation, and one-lung ventilation in adult patients undergoing retrograde intrarenal surgery. The primary objective is to determine whether different ventilation strategies improve surgical success by reducing kidney movement. Secondary outcomes include operative time, stone access time, fluoroscopy time, laser use time, complications, length of hospital stay, and postoperative stone-free rate.

Study Type

Interventional

Enrollment (Estimated)

80

Phase

  • Not Applicable

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Contact Backup

Study Locations

  • Turkey (Türkiye)
    • Istanbul
      • Istanbul, Istanbul, Turkey (Türkiye), 34668
        • Sultan Abdulhamid Han Training and Research Hospital
        • Contact:
        • Contact:
        • Principal Investigator:
          • Tuna Ertürk, MD
        • Sub-Investigator:
          • Hakan Emirkadı, MD

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

No

Description

Inclusion Criteria:

Age 18-75 years. ASA physical status I-III. Scheduled for elective RIRS/RIRC under general anesthesia. No obstructive or restrictive pulmonary disease. No history of pneumothorax. No pulmonary mass or other significant respiratory disease. Normal coagulation parameters and not receiving antithrombotic therapy. No active urinary tract infection. Written informed consent.

Exclusion Criteria:

Age <18 or >75 years. ASA IV. Obstructive or restrictive pulmonary disease. History of pneumothorax. Pulmonary mass or significant respiratory disease. Receiving antithrombotic therapy or abnormal coagulation. Active urinary tract infection or urinary tract anatomical abnormality. Refusal or inability to provide informed consent.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

  • Primary Purpose: Treatment
  • Allocation: Randomized
  • Interventional Model: Parallel Assignment
  • Masking: None (Open Label)

Arms and Interventions

Participant Group / Arm
Intervention / Treatment
Active Comparator: Standard Ventilation
Patients will receive standard volume-controlled mechanical ventilation during retrograde intrarenal surgery under general anesthesia.
Procedure: Standard Ventilation
Volume-controlled mechanical ventilation using standard ventilator settings during general anesthesia.
Experimental: Hypoventilation
Patients will receive hypoventilation with reduced tidal volume and respiratory rate during retrograde intrarenal surgery under general anesthesia.
Procedure: Hypoventilation
Volume-controlled mechanical ventilation using reduced tidal volume and respiratory rate during general anesthesia.
Experimental: Intermittent Apnea Ventilation
Patients will receive intermittent apnea periods during selected surgical steps, in coordination with the surgeon.
Procedure: Intermittent Apnea Ventilation
Intermittent apnea periods applied during selected stages of retrograde intrarenal surgery to reduce kidney motion.
Experimental: One-Lung Ventilation
Patients will receive one-lung ventilation during selected surgical steps, in coordination with the surgeon.
Procedure: One-Lung Ventilation
One-lung ventilation applied during selected stages of retrograde intrarenal surgery to reduce kidney motion.

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Kidney Motion During Retrograde Intrarenal Surgery
Time Frame: During surgery
Kidney motion during surgery will be evaluated and compared among the four ventilation strategies.
During surgery

Secondary Outcome Measures

Outcome Measure
Measure Description
Time Frame
Stone-free Rate
Time Frame: Postoperative Day 30
Percentage of patients who are stone-free after retrograde intrarenal surgery.
Postoperative Day 30
Operative Time
Time Frame: During surgery
Total duration of surgery measured from the beginning to the end of the surgical procedure.
During surgery
Fluoroscopy Time
Time Frame: During surgery
Total fluoroscopy exposure time recorded during the procedure.
During surgery
Laser Activation Time
Time Frame: During surgery
Total duration of laser use during stone fragmentation.
During surgery
Perioperative Complications
Time Frame: Periprocedural
Occurrence of intraoperative and postoperative complications.
Periprocedural
Length of Hospital Stay
Time Frame: Periprocedural
Number of days of hospitalization.
Periprocedural

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey

Investigators

  • Principal Investigator: Tuna Ertürk, MD, University of Health Sciences Sultan 2. Abdulhamid Han Training and Research Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Estimated)

July 15, 2026

Primary Completion (Estimated)

November 15, 2026

Study Completion (Estimated)

November 30, 2026

Study Registration Dates

First Submitted

July 5, 2026

First Submitted That Met QC Criteria

July 10, 2026

First Posted (Actual)

July 15, 2026

Study Record Updates

Last Update Posted (Actual)

July 15, 2026

Last Update Submitted That Met QC Criteria

July 10, 2026

Last Verified

July 1, 2026

More Information

Terms related to this study

Keywords

Additional Relevant MeSH Terms

Other Study ID Numbers

  • 21-64

Plan for Individual participant data (IPD)

Plan to Share Individual Participant Data (IPD)?

NO

IPD Plan Description

Individual participant data will not be made publicly available to protect participant confidentiality.

Drug and device information, study documents

Studies a U.S. FDA-regulated drug product

No

Studies a U.S. FDA-regulated device product

No

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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