Relationship Between Frontal QRS-T Angle and Collateral Circulation in Coronary Artery Chronic Total Occlusion
August 2, 2026 updated by: Tarek Yaser Fathi, Assiut University
Frontal QRS-T Angle as an Electrocardiographic Marker for Collateral Circulation in Coronary Artery Chronic Total Occlusion
• Aim of the work: To examine the relationship between collateral circulation and the frontal QRS-T angle in patients with chronic total occlusion (CTO)
Study Overview
Status
Not yet recruiting
Conditions
Intervention / Treatment
Detailed Description
i. Study Objectives
Primary Objective:
• To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO).
Secondary Objectives:
- To identify other independent clinical and laboratory predictors (such as serum albumin levels and neutrophil counts) associated with an increased frontal QRS-T angle in patients with CTO.
- To compare echocardiographic parameters (such as left ventricular ejection fraction and left ventricular dimensions) between patients with a normal QRS-T angle and those with an increased QRS-T angle.
Study Type
Observational
Enrollment (Estimated)
100
Contacts and Locations
This section provides the contact details for those conducting the study, and information on where this study is being conducted.
Study Contact
- Name: Tarek Yaser
- Phone Number: +201005094712
- Email: tarek.18313588@med.aun.edu.eg
Study Contact Backup
- Name: Hosam Hasan
Study Locations
-
-
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Asyut, Egypt
- AssiutU
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Participation Criteria
Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.
Eligibility Criteria
Ages Eligible for Study
- Adult
- Older Adult
Accepts Healthy Volunteers
No
Sampling Method
Non-Probability Sample
Study Population
The study population consists of adult patients presenting to the cardiology department who have experienced stable angina for a minimum of three months and are subsequently diagnosed with a chronic total occlusion (CTO) in at least one coronary artery during routine diagnostic coronary angiography.
Description
Inclusion Criteria:
- Patients undergoing diagnostic coronary angiography due to stable angina persisting for a minimum duration of three months.
- Patients diagnosed with total occlusion in at least one coronary artery, assessed to have chronic total occlusion (CTO) based on clinical and angiographic findings.
Exclusion Criteria:
- Patients presenting with malignancies, atrial fibrillation, connective tissue disorders, hepatic failure, or renal failure.
- A documented history of cardiac pacemaker implantation, prior bypass surgeries, or surgical valve replacements.
- Congenital heart anomalies.
- Patients receiving pharmacological interventions that affect ventricular repolarization (other than beta-adrenergic antagonists).
- Individuals exhibiting abnormal electrolyte levels at the time of admission.
Study Plan
This section provides details of the study plan, including how the study is designed and what the study is measuring.
How is the study designed?
Design Details
Cohorts and Interventions
Group / Cohort |
Intervention / Treatment |
|---|---|
|
Increased QRS-T Angle
Subjects exhibiting an increased frontal QRS-T angle (≥110° for men, >90° for women).
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A 12-lead ECG is performed to calculate the frontal QRS-T angle, and coronary angiography is performed to evaluate the coronary collateral circulation using the Rentrop Classification.
|
|
Normal QRS-T Angle
Subjects presenting with a normative frontal QRS-T angle (<110° for men, <90° for women).
|
A 12-lead ECG is performed to calculate the frontal QRS-T angle, and coronary angiography is performed to evaluate the coronary collateral circulation using the Rentrop Classification.
|
What is the study measuring?
Primary Outcome Measures
Outcome Measure |
Measure Description |
Time Frame |
|---|---|---|
|
correlation between frontal QRS-T angle and collateral circulation in CTO patients
Time Frame: baseline ( at the time of the diagnosis )
|
• To examine the relationship between coronary collateral circulation and the electrocardiographic frontal QRS-T angle in patients diagnosed with chronic total occlusion (CTO).
|
baseline ( at the time of the diagnosis )
|
Collaborators and Investigators
This is where you will find people and organizations involved with this study.
Sponsor
Publications and helpful links
The person responsible for entering information about the study voluntarily provides these publications. These may be about anything related to the study.
General Publications
- Ozturk M, Emlek N, Ozyildiz AG, Ergul E, Durak H, Ozyildiz A, Cetin M. The Relationship Between Collateral Circulation and Electrocardiographic Frontal QRS-T Angle in Patients with Coronary Artery Chronic Total Occlusion. J Clin Med. 2025 Dec 24;15(1):148. doi: 10.3390/jcm15010148.
- Sawant AC, Bhardwaj A, Srivatsa S, Sridhara S, Prakash MPH, Kanwar N, Rodriguez J, Tse G, Liu T, Kumar A, Beck H, Srivatsa SS. Prognostic value of frontal QRS-T angle in predicting survival after primary percutaneous coronary revascularization/coronary artery bypass grafting for ST-elevation myocardial infarction. Indian Heart J. 2019 Nov-Dec;71(6):481-487. doi: 10.1016/j.ihj.2019.09.008. Epub 2019 Sep 9.
- Attar A, Sayadi M, Hosseinpour A, Brilakis ES, Mehdizade F, Namvar Z, Khosravi A, Boshtam M, Noohi F, Assareh A, Kazemi T, Farshidi H, Khaledifar A, Abbaszadeh M, Sarrafzadegan N. Prevalence and Clinical Parameters Associated With Chronic Total Occlusions in Patients With Chronic Coronary Syndromes: Insights From a Nationwide Registry. Health Sci Rep. 2025 Mar 18;8(3):e70583. doi: 10.1002/hsr2.70583. eCollection 2025 Mar.
Study record dates
These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.
Study Major Dates
Study Start (Estimated)
August 1, 2026
Primary Completion (Estimated)
August 1, 2028
Study Completion (Estimated)
September 1, 2028
Study Registration Dates
First Submitted
July 29, 2026
First Submitted That Met QC Criteria
July 29, 2026
First Posted (Actual)
August 3, 2026
Study Record Updates
Last Update Posted (Actual)
August 4, 2026
Last Update Submitted That Met QC Criteria
August 2, 2026
Last Verified
August 1, 2026
More Information
Terms related to this study
Additional Relevant MeSH Terms
Other Study ID Numbers
- QRS-T Angle in CTO Patients
Drug and device information, study documents
Studies a U.S. FDA-regulated drug product
No
Studies a U.S. FDA-regulated device product
No
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