Common Carotid Artery-Renal Artery-Femoral Artery Survey for Hypertension (CRF Survey)

Common Carotid Artery-Renal Artery-Femoral Artery Survey for Hypertension (CRF Survey)

To evaluate both sides of the common carotid artery, renal artery, and femoral artery in Hypertension patient that cause of systemic arterial hypertension and/or the effects of target organ damage, both structural and functional markers.

Study Overview

• Status: Not yet recruiting
• Conditions: Hypertension; Hypertension (HTN); Artery Disease; Target Organ Damage
• Intervention / Treatment: Other: Diameter measurement; Other: Velocity

Detailed Description

The study of the first degree, both sides in some of the aortic branch group, the effect and/or cause of systemic arterial hypertension compared to normotension. According to the theory of systemic arterial hypertension, the arterial resistance and high blood volume flow causing systemic arterial hypertension, the cause of arterial resistance and high blood volume flow evaluation may trace back to the possible actual cause of systemic arterial hypertension by backward investigation. Despite the fact that target organ damage is the crucial maneuver of hypertension evaluation, both sides of the common carotid artery, renal artery, and femoral artery may cause systemic arterial hypertension and may imply that feasible to predict the end organ of stroke, ESRD, and amputated-type arterial occlusion, respectively.

This study belongs to 2 questions

1. Can the main aortic branch be evidence of a cause of systemic arterial hypertension following high resistance and/or high fluid flow by theory?
2. Can the main aortic branch be a marker of evidence of endpoint organ damage?

• Study Type: Observational
• Enrollment (Estimated): 100

Contacts and Locations

• Study Contact: Name: Nathaphong Dejthida, Medical Degree; Phone Number: +66819220662; Email: bnnatto@gmail.com

Study Locations

• Thailand
  • Bangkok
    • Vadhana, Bangkok, Thailand, 10110
      • Invstigation center
      • Contact: Nathaphong Dejthida, Medical Degree; Phone Number: 0819220662; Email: bnnatto@gmail.com

Participation Criteria

Eligibility Criteria

• Ages Eligible for Study: Adult; Older Adult
• Accepts Healthy Volunteers: No

• Sampling Method: Non-Probability Sample

Study Population

Hypertensive patient who underwent the radiographic measurement of structure and function of carotid artery, renal artery or femoral artery

Description

Inclusion Criteria:

• Adults ≥18 years with diagnosed hypertension by a clinician, both untreated and treated, including successfully treated participants.

• Imaging evidence of at least 1 list of

  • Common carotid artery
  • Renal artery
  • Femoral artery

Exclusion Criteria:

• Fatal pathology and imaging
• Pediatric or pregnant participants
• Small vessel angiogram
• Intravascular endoscopy
• Intra-operative estimation

Study Plan

How is the study designed?

Number of groups / cohorts

3

Cohorts and Interventions

Group / Cohort	Intervention / Treatment
Common Carotid Artery; The group of hypertensive patients were underwent in angiographic imaging such as ultrasonography, CR/MR, real-time intravascular contrast media angiography of any side of Common Carotid Artery.	Other: Diameter measurement; Radiographic diameter in cm. of each side of one of Common Carotid Artery, Renal Artery and Femoral Artery; Other: Velocity; Any kind of radiographic measurement of Peak Systolic Velocity and/or End Diastolic Velocity (cm/s)
Renal Artery; The group of hypertensive patients were underwent in angiographic imaging such as ultrasonography, CR/MR, real-time intravascular contrast media angiography of any side of Renal Artery.	Other: Diameter measurement; Radiographic diameter in cm. of each side of one of Common Carotid Artery, Renal Artery and Femoral Artery; Other: Velocity; Any kind of radiographic measurement of Peak Systolic Velocity and/or End Diastolic Velocity (cm/s)
Femoral Artery; The group of hypertensive patients were underwent in angiographic imaging such as ultrasonography, CR/MR, real-time intravascular contrast media angiography of any side of Femoral Artery.	Other: Diameter measurement; Radiographic diameter in cm. of each side of one of Common Carotid Artery, Renal Artery and Femoral Artery; Other: Velocity; Any kind of radiographic measurement of Peak Systolic Velocity and/or End Diastolic Velocity (cm/s)

What is the study measuring?

Primary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Median of diameter of common carotid artery, renal artery and femoral artery in hypertension patients.	Radiographic measurement includes ultrasonography, CT/MR imaging, and intravascular contrast media imaging that measure the diameter in cm. unit of any side of common carotid artery and/or renal artery and/or femoral artery in hypertension patients.	1 years

Secondary Outcome Measures

Outcome Measure	Measure Description	Time Frame
Common Carotid Artery Function	Any kind of radiographic measurement one of Peak Systolic Velocity (cm/s) or End Diastolic Velocity (cm/s) of any side of Common Carotid Artery	1 year
Renal Artery Function	Any kind of radiographic measurement one of Peak Systolic Velocity (cm/s) or End Diastolic Velocity (cm/s) of any side of Renal Artery	1 year
Femoral Artery Function	Any kind of radiographic measurement one of Peak Systolic Velocity (cm/s) or End Diastolic Velocity (cm/s) of any side of Femoral Artery	1 year

Other Outcome Measures

Outcome Measure	Measure Description	Time Frame
All-cause mortality outcomes	Incidence of mortality rate (case per 1,000 person-year) of hypertensive participants were underwent measurement the diameter one side of one of common carotid artery and/or renal artery and/or femoral artery	1 year

Collaborators and Investigators

• Sponsor: DejthidaNathaphong

Publications and helpful links

Helpful Links

• Related Info

Study record dates

Study Major Dates

• Study Start (Estimated): August 1, 2026
• Primary Completion (Estimated): December 31, 2026
• Study Completion (Estimated): May 18, 2027

Study Registration Dates

• First Submitted: July 30, 2026
• First Submitted That Met QC Criteria: August 5, 2026
• First Posted (Actual): August 12, 2026

Study Record Updates

• Last Update Posted (Actual): August 12, 2026
• Last Update Submitted That Met QC Criteria: August 5, 2026
• Last Verified: August 1, 2026

More Information

Terms related to this study

• Keywords: hypertension; renal artery; common carotid artery; femmoral artery; vascular resistant
• Additional Relevant MeSH Terms: Vascular Diseases; Cardiovascular Diseases; Hypertension; Diagnostic Techniques and Procedures; Diagnosis; Circulatory and Respiratory Physiological Phenomena; Diagnostic Techniques, Cardiovascular; Hemodynamics; Cardiovascular Physiological Phenomena; Hemorheology; Blood Flow Velocity
• Other Study ID Numbers: NathaphongD; PROSPERO (Other Identifier: CRD420261464383)

Plan for Individual participant data (IPD)

• Plan to Share Individual Participant Data (IPD)?: NO

Drug and device information, study documents

• Studies a U.S. FDA-regulated drug product: No
• Studies a U.S. FDA-regulated device product: No