The Shengjing Lung Cancer Cohort (SJ-LCC) Study on Risk Factors for Disease Development and Progression (SJ-LCC)

August 19, 2026 updated by: Huanhuan Chen, Shengjing Hospital

The Shengjing Lung Cancer Cohort (SJ-LCC) Study

Modifiable risk factors, including smoking, alcohol consumption, and diet, play critical roles in cancer progression and patient prognosis. In patients diagnosed with lung cancer, these risk factors not only directly modulate host metabolism and immune regulation, but also exert indirect effects by altering the internal milieu, such as the gut microbiota-potentially exerting a profound impact on long-term clinical trajectories.

Leveraging a well-characterized, longitudinally followed cohort of confirmed lung cancer patients, this study systematically assesses habitual dietary intake, emotional well-being, lifestyle behaviors, and related variables using validated instruments, including the Food Frequency Questionnaire (FFQ). Furthermore, the study integrates multidimensional biomarker profiling across tumor tissue, blood, urine, and fecal samples. By linking exposure profiles, multi-omics data, and long-term clinical follow-up records, this project aims to:

  1. Evaluate Prognostic Associations: Investigate the relationships between exposure profiles (e.g., dietary patterns) and long-term clinical outcomes in lung cancer patients, including progression-free survival (PFS), overall survival (OS), and recurrence risk.
  2. Elucidate Biological Mechanisms: Unravel the underlying mechanisms by which the "exposure profile-multi-omics" axis mediates lung cancer progression, and identify candidate biomarkers with predictive value for clinical prognosis.

Ultimately, this study aims to establish evidence-based healthy lifestyle recommendations for patients and provide healthcare professionals with translational insights to inform precision nutrition and targeted intervention strategies across the continuum of lung cancer care.

Study Overview

Status

Recruiting

Conditions

Study Type

Observational

Enrollment (Estimated)

1500

Contacts and Locations

This section provides the contact details for those conducting the study, and information on where this study is being conducted.

Study Contact

Study Locations

  • China
    • Liaoning
      • Shenyang, Liaoning, China, 110000
        • Recruiting
        • Shengjing Hospital affiliated to China Medical University
        • Contact:

Participation Criteria

Researchers look for people who fit a certain description, called eligibility criteria. Some examples of these criteria are a person's general health condition or prior treatments.

Eligibility Criteria

Ages Eligible for Study

  • Adult
  • Older Adult

Accepts Healthy Volunteers

Yes

Sampling Method

Non-Probability Sample

Study Population

Starting in February 2019, patients with histologically or cytologically confirmed lung cancer who received treatment and follow-up at Shengjing Hospital of China Medical University were enrolled in this study. Clinical and demographic characteristics were extracted from the electronic medical record (EMR) system, lifestyle habits and related exposure data were collected using a validated Food Frequency Questionnaire (FFQ), and high-quality follow-up was conducted on a regular basis.

Description

Inclusion Criteria:

  1. Patients aged between 18 and 75 years;
  2. Patients with newly, pathologically confirmed lung cancer;
  3. Patients diagnosed within the preceding 6 months (time since confirmed diagnosis < 6 months).

Exclusion Criteria:

  1. Individuals aged outside the range of 18-75 years, or those in poor general physical condition who are unable to cooperate with the questionnaire survey;
  2. Patients with non-primary lung cancer, non-newly diagnosed lung cancer, or those unable to provide definitive pathological confirmation;
  3. Individuals with severe depression, pregnant women, or those diagnosed with severe cardiovascular/cerebrovascular diseases or severe metabolic dysfunctions affecting the liver, kidneys, or other major organs;
  4. Individuals unwilling to participate in the study.

Study Plan

This section provides details of the study plan, including how the study is designed and what the study is measuring.

How is the study designed?

Design Details

What is the study measuring?

Primary Outcome Measures

Outcome Measure
Time Frame
6-Month Progression-Free Survival (PFS) Rate
Time Frame: 6 months
6 months
Overall Survival (OS)
Time Frame: From enrollment through study completion, up to 10 years
From enrollment through study completion, up to 10 years

Collaborators and Investigators

This is where you will find people and organizations involved with this study.

Sponsor

Shengjing Hospital

Study record dates

These dates track the progress of study record and summary results submissions to ClinicalTrials.gov. Study records and reported results are reviewed by the National Library of Medicine (NLM) to make sure they meet specific quality control standards before being posted on the public website.

Study Major Dates

Study Start (Actual)

February 1, 2019

Primary Completion (Actual)

December 30, 2024

Study Completion (Estimated)

December 31, 2029

Study Registration Dates

First Submitted

August 19, 2026

First Submitted That Met QC Criteria

August 19, 2026

First Posted (Actual)

August 21, 2026

Study Record Updates

Last Update Posted (Actual)

August 21, 2026

Last Update Submitted That Met QC Criteria

August 19, 2026

Last Verified

June 1, 2026

More Information

Terms related to this study

Other Study ID Numbers

  • 2020PS556K

This information was retrieved directly from the website clinicaltrials.gov without any changes. If you have any requests to change, remove or update your study details, please contact register@clinicaltrials.gov. As soon as a change is implemented on clinicaltrials.gov, this will be updated automatically on our website as well.

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